YAP–VGLL4 antagonism defines the major physiological function of the Hippo signaling effector YAP

YAP1 and its fusion proteins in cancer initiation, progression and therapeutic resistance

(2021) Frank Szulzewsky et al.   DEVELOPMENTAL BIOLOGY

Biochemical properties of VGLL4 from Homo sapiens and Tgi from Drosophila melanogaster and possible biological implications

(2021) Yannick Mesrouze et al.   PROTEIN SCIENCE

VGLL4 with low YAP expression is associated with favorable prognosis in colorectal cancer

(2020) Joo Young Kim et al.   APMIS

Regeneration Defects in Yap and Taz Mutant Mouse Livers Are Caused by Bile Duct Disruption and Cholestasis

(2020) Elisabeth Verboven et al.   GASTROENTEROLOGY

Hippo signaling promotes lung epithelial lineage commitment by curbing Fgf10 and β-catenin signaling

(2019) Thomas Volckaert et al.   DEVELOPMENT

Hippo signalling during development

(2019) John Robert Davis et al.   DEVELOPMENT

The Hippo Signaling Pathway in Development and Disease

(2019) Yonggang Zheng et al.   DEVELOPMENTAL CELL

Hippo–YAP/TAZ signalling in organ regeneration and regenerative medicine

(2018) Iván M. Moya et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

VGLL4 targets a TCF4–TEAD4 complex to coregulate Wnt and Hippo signalling in colorectal cancer

(2017) Shi Jiao et al.   Nature Communications

YAP is essential for mechanical force production and epithelial cell proliferation during lung branching morphogenesis

(2017) Chuwen Lin et al.   eLife

YAP/TAZ at the Roots of Cancer

(2016) Francesca Zanconato et al.   CANCER CELL

Impaired liver regeneration in aged mice can be rescued by silencing Hippo core kinases MST1 and MST2

(2016) Giulio Loforese et al.   EMBO Molecular Medicine

Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration

(2016) Fuqin Fan et al.   Science Translational Medicine

Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer

(2015) Fa-Xing Yu et al.   CELL

A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis

(2015) Toshiro Moroishi et al.   GENES & DEVELOPMENT

Homeostatic control of Hippo signaling activity revealed by an endogenous activating mutation in YAP

(2015) Qian Chen et al.   GENES & DEVELOPMENT

A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer

(2014) Shi Jiao et al.   CANCER CELL

VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex

(2014) Wenjing Zhang et al.   CELL RESEARCH

Downregulation of VGLL4 in the progression of esophageal squamous cell carcinoma

(2014) Wei Jiang et al.   TUMOR BIOLOGY

The Hippo Effector Yorkie Controls Normal Tissue Growth by Antagonizing Scalloped-Mediated Default Repression

(2013) Laura M. Koontz et al.   DEVELOPMENTAL CELL

The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment

(2013) Randy Johnson et al.   NATURE REVIEWS DRUG DISCOVERY

Yes-associated protein regulates the hepatic response after bile duct ligation

(2012) Haibo Bai et al.   HEPATOLOGY

The Merlin/NF2 Tumor Suppressor Functions through the YAP Oncoprotein to Regulate Tissue Homeostasis in Mammals

(2010) Nailing Zhang et al.   DEVELOPMENTAL CELL

Fate mapping Nkx2.1-lineage cells in the mouse telencephalon

(2007) Qing Xu et al.   JOURNAL OF COMPARATIVE NEUROLOGY