Microbiota-derived tryptophan metabolism: Impacts on health, aging, and disease
Published 2023 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Microbiota-derived tryptophan metabolism: Impacts on health, aging, and disease
Authors
Keywords
-
Journal
EXPERIMENTAL GERONTOLOGY
Volume 183, Issue -, Pages 112319
Publisher
Elsevier BV
Online
2023-11-04
DOI
10.1016/j.exger.2023.112319
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Lactobacillus plantarum-derived indole-3-lactic acid ameliorates colorectal tumorigenesis via epigenetic regulation of CD8+ T cell immunity
- (2023) Qingqing Zhang et al. Cell Metabolism
- Epirubicin toxicity in rat's ovary and uterus: A protective role of 3-Indolepropionic acid supplementation
- (2023) Solomon E. Owumi et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Natural Product Skatole Ameliorates Lipotoxicity-Induced Multiple Hepatic Damage under Hyperlipidemic Conditions in Hepatocytes
- (2023) Sin-Hyoung Hong et al. Nutrients
- GPR35 promotes neutrophil recruitment in response to serotonin metabolite 5-HIAA
- (2022) Marco De Giovanni et al. CELL
- Biological Effects of Indole-3-Propionic Acid, a Gut Microbiota-Derived Metabolite, and Its Precursor Tryptophan in Mammals’ Health and Disease
- (2022) Piotr Konopelski et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Matrikines as mediators of tissue remodelling
- (2022) Nathan Jariwala et al. ADVANCED DRUG DELIVERY REVIEWS
- Microbiota-derived tryptophan metabolites in vascular inflammation and cardiovascular disease
- (2022) Nadja Paeslack et al. AMINO ACIDS
- Bifidobacterium longum mediated tryptophan metabolism to improve atopic dermatitis via the gut-skin axis
- (2022) Zhifeng Fang et al. Gut Microbes
- Dual Effect of Tryptamine on Prostate Cancer Cell Growth Regulation: A Pilot Study
- (2022) Zhuangzhuang Li et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Extensive Summary of the Important Roles of Indole Propionic Acid, a Gut Microbial Metabolite in Host Health and Disease
- (2022) Hui Jiang et al. Nutrients
- Skatole: A thin red line between its benefits and toxicity
- (2022) Eliška Zgarbová et al. BIOCHIMIE
- Gut-Derived Metabolite Indole-3-Propionic Acid Modulates Mitochondrial Function in Cardiomyocytes and Alters Cardiac Function
- (2021) Maren Gesper et al. Frontiers in Medicine
- Cumulative Protective Effect of Melatonin and Indole-3-Propionic Acid against KIO3—Induced Lipid Peroxidation in Porcine Thyroid
- (2021) Paulina Iwan et al. Toxics
- Somatization in patients with predominant diarrhoea irritable bowel syndrome: the role of the intestinal barrier function and integrity
- (2021) Laura Prospero et al. BMC GASTROENTEROLOGY
- Tryptophan: From Diet to Cardiovascular Diseases
- (2021) Nada Joe Melhem et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Indoles as essential mediators in the gut-brain axis. Their role in Alzheimer's disease
- (2021) Miguel A. Pappolla et al. NEUROBIOLOGY OF DISEASE
- The Roles of the Gut Microbiota and Chronic Low-Grade Inflammation in Older Adults With Frailty
- (2021) YuShuang Xu et al. Frontiers in Cellular and Infection Microbiology
- Melatonin and Indole-3-Propionic Acid Reduce Oxidative Damage to Membrane Lipids Induced by High Iron Concentrations in Porcine Skin
- (2021) Aleksandra Rynkowska et al. Membranes
- Tryptophan: A Unique Role in the Critically Ill
- (2021) Marcela Kanova et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Indole-3-Propionic Acid, a Functional Metabolite of Clostridium sporogenes, Promotes Muscle Tissue Development and Reduces Muscle Cell Inflammation
- (2021) Lei Du et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Proteomic Characterization of the Cellular Effects of AhR Activation by Microbial Tryptophan Catabolites in Endotoxin-Activated Human Macrophages
- (2021) Katharina Walter et al. International Journal of Environmental Research and Public Health
- Anti-Inflammatory and Anti-Oxidative Activity of Indole-3-Acetic Acid Involves Induction of HO-1 and Neutralization of Free Radicals in RAW264.7 Cells
- (2020) Yun Ji et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Microbial Metabolite Indole-3-Propionic Acid Supplementation Does Not Protect Mice from the Cardiometabolic Consequences of a Western Diet
- (2020) Dustin M Lee et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Protective Effects of Short-Chain Fatty Acids on Endothelial Dysfunction Induced by Angiotensin II
- (2020) Iñaki Robles-Vera et al. Frontiers in Physiology
- Human Umbilical Mesenchymal Stem Cells Display Therapeutic Potential in Rheumatoid Arthritis by Regulating Interactions Between Immunity and Gut Microbiota via the Aryl Hydrocarbon Receptor
- (2020) Xiaoya Li et al. Frontiers in Cell and Developmental Biology
- Potential Effects of Indole-3-Lactic Acid, a Metabolite of Human Bifidobacteria, on NGF-Induced Neurite Outgrowth in PC12 Cells
- (2020) Chyn Boon Wong et al. Microorganisms
- A patent review of myeloperoxidase inhibitors for treating chronic inflammatory syndromes (focus on cardiovascular diseases, 2013-2019)
- (2020) Jalal Soubhye et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- IL4I1 Is a Metabolic Immune Checkpoint that Activates the AHR and Promotes Tumor Progression
- (2020) Ahmed Sadik et al. CELL
- Indolepropionic Acid, a Metabolite of the Microbiome, Has Cytostatic Properties in Breast Cancer by Activating AHR and PXR Receptors and Inducing Oxidative Stress
- (2020) Zsanett Sári et al. Cancers
- Indole-3-propionic Acid Improved the Intestinal Barrier by Enhancing Epithelial Barrier and Mucus Barrier
- (2020) Jiaojiao Li et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Indole-3-Propionic Acid, a Tryptophan-Derived Bacterial Metabolite, Reduces Weight Gain in Rats
- (2019) Piotr Konopelski et al. Nutrients
- Intestinal dysbiosis compromises alveolar macrophage immunity to Mycobacterium tuberculosis
- (2019) Nargis Khan et al. Mucosal Immunology
- Skatole regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38
- (2019) Koichi Kurata et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Gut microbiome and its role in obesity and insulin resistance
- (2019) Clare J. Lee et al. Annals of the New York Academy of Sciences
- Metabolites of lactic acid bacteria present in fermented foods are highly potent agonists of human hydroxycarboxylic acid receptor 3
- (2019) Anna Peters et al. PLoS Genetics
- Dynamic Modulation of the Gut Microbiota and Metabolome by Bacteriophages in a Mouse Model
- (2019) Bryan B. Hsu et al. Cell Host & Microbe
- The pregnane X receptor and its microbiota-derived ligand indole 3-propionic acid regulate endothelium-dependent vasodilation
- (2019) Vivek Krishna Pulakazhi Venu et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Indole-3-propionic acid inhibits gut dysbiosis and endotoxin leakage to attenuate steatohepatitis in rats
- (2019) Ze-Hua Zhao et al. EXPERIMENTAL AND MOLECULAR MEDICINE
- Homeostasis and dysbiosis of the gut microbiome in health and disease
- (2019) Bhabatosh Das et al. JOURNAL OF BIOSCIENCES
- Propionic acid counteracts the inflammation of human subcutaneous adipose tissue: a new avenue for drug development
- (2019) Sa’ad Al-Lahham et al. DARU-Journal of Pharmaceutical Sciences
- Butyric acid, a gut bacteria metabolite, lowers arterial blood pressure via colon-vagus nerve signaling and GPR41/43 receptors
- (2019) Maksymilian Onyszkiewicz et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Indole-3-Acetic Acid Alleviates Nonalcoholic Fatty Liver Disease in Mice via Attenuation of Hepatic Lipogenesis, and Oxidative and Inflammatory Stress
- (2019) Yun Ji et al. Nutrients
- Microbiota-Derived Indole Metabolites Promote Human and Murine Intestinal Homeostasis through Regulation of Interleukin-10 Receptor
- (2018) Erica E. Alexeev et al. AMERICAN JOURNAL OF PATHOLOGY
- Antiedematogenic activity of the indole derivative N-salicyloyltryptamine in animal models
- (2018) BENEDITO P. SOUSA-NETO et al. ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
- Lactobacillus accelerates ISCs regeneration to protect the integrity of intestinal mucosa through activation of STAT3 signaling pathway induced by LPLs secretion of IL-22
- (2018) Qihang Hou et al. CELL DEATH AND DIFFERENTIATION
- Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease
- (2018) Allison Agus et al. Cell Host & Microbe
- Gut Microbiota-Produced Tryptamine Activates an Epithelial G-Protein-Coupled Receptor to Increase Colonic Secretion
- (2018) Yogesh Bhattarai et al. Cell Host & Microbe
- Indoles - gut bacteria metabolites of tryptophan with pharmacotherapeutic potential
- (2018) Piotr Konopelski et al. CURRENT DRUG METABOLISM
- Aryl hydrocarbon receptor and intestinal immunity
- (2018) Bruno Lamas et al. Mucosal Immunology
- Beneficial actions of microbiota-derived tryptophan metabolites
- (2018) J. J. Galligan NEUROGASTROENTEROLOGY AND MOTILITY
- Gut Microbiota-Derived Tryptophan Metabolites Modulate Inflammatory Response in Hepatocytes and Macrophages
- (2018) Smitha Krishnan et al. Cell Reports
- Associations of serum indolepropionic acid, a gut microbiota metabolite, with type 2 diabetes and low-grade inflammation in high-risk individuals
- (2018) Marjo Tuomainen et al. Nutrition & Diabetes
- Impact of the Gut Microbiota on Intestinal Immunity Mediated by Tryptophan Metabolism
- (2018) Jing Gao et al. Frontiers in Cellular and Infection Microbiology
- Microbial tryptophan catabolites in health and disease
- (2018) Henrik M. Roager et al. Nature Communications
- Microbiome-Modulated Metabolites at the Interface of Host Immunity
- (2017) Eran Blacher et al. JOURNAL OF IMMUNOLOGY
- Plasma microbiome-modulated indole- and phenyl-derived metabolites associate with advanced atherosclerosis and postoperative outcomes
- (2017) Cori A. Cason et al. JOURNAL OF VASCULAR SURGERY
- A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites
- (2017) Dylan Dodd et al. NATURE
- Salt-responsive gut commensal modulates TH17 axis and disease
- (2017) Nicola Wilck et al. NATURE
- Microbiota-derived tryptophan indoles increase after gastric bypass surgery and reduce intestinal permeability in vitro and in vivo
- (2017) M. Jennis et al. NEUROGASTROENTEROLOGY AND MOTILITY
- Lactobacillus reuteriinduces gut intraepithelial CD4+CD8αα+T cells
- (2017) Luisa Cervantes-Barragan et al. SCIENCE
- Modulation of a Circulating Uremic Solute via Rational Genetic Manipulation of the Gut Microbiota
- (2016) A. Sloan Devlin et al. Cell Host & Microbe
- Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor
- (2016) Veit Rothhammer et al. NATURE MEDICINE
- CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands
- (2016) Bruno Lamas et al. NATURE MEDICINE
- Microbial short chain fatty acid metabolites lower blood pressure via endothelial G protein-coupled receptor 41
- (2016) Niranjana Natarajan et al. PHYSIOLOGICAL GENOMICS
- Microbial metabolism of dietary components to bioactive metabolites: opportunities for new therapeutic interventions
- (2016) Linda S. Zhang et al. Genome Medicine
- Pregnane X Receptor (PXR)-Mediated Gene Repression and Cross-Talk of PXR with Other Nuclear Receptors via Coactivator Interactions
- (2016) Petr Pavek Frontiers in Pharmacology
- Folates and aging: Role in mild cognitive impairment, dementia and depression
- (2015) João Ricardo Araújo et al. AGEING RESEARCH REVIEWS
- Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin Biosynthesis
- (2015) Jessica M. Yano et al. CELL
- An Integrative View of Microbiome-Host Interactions in Inflammatory Bowel Diseases
- (2015) Marta Wlodarska et al. Cell Host & Microbe
- Control of Brain Development, Function, and Behavior by the Microbiome
- (2015) Timothy R. Sampson et al. Cell Host & Microbe
- Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome
- (2015) Benoit Chassaing et al. NATURE
- Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles
- (2015) Troy D. Hubbard et al. Scientific Reports
- Discovery and Characterization of Gut Microbiota Decarboxylases that Can Produce the Neurotransmitter Tryptamine
- (2014) Brianna B. Williams et al. Cell Host & Microbe
- Bile acids and the gut microbiome
- (2014) Jason M. Ridlon et al. CURRENT OPINION IN GASTROENTEROLOGY
- The Immunomodulatory Role of Bile Acids
- (2014) Sándor Sipka et al. INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
- Prevention of UVB-Induced Production of the Inflammatory Mediator in Human Keratinocytes by Lactic Acid Derivatives Generated from Aromatic Amino Acids
- (2013) Ayako AOKI-YOSHIDA et al. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
- Tryptamine and dimethyltryptamine inhibit indoleamine 2,3 dioxygenase and increase the tumor-reactive effect of peripheral blood mononuclear cells
- (2013) Melissa Cavalheiro Tourino et al. CELL BIOCHEMISTRY AND FUNCTION
- Effect of N-salicyloyltryptamine (STP), a novel tryptamine analogue, on parameters of cell viability, oxidative stress, and immunomodulation in RAW 264.7 macrophages
- (2013) Juciano Gasparotto et al. CELL BIOLOGY AND TOXICOLOGY
- The expanding roles of 1-methyl-tryptophan (1-MT): in addition to inhibiting kynurenine production, 1-MT activates the synthesis of melatonin in skin cells
- (2013) Ana C. R. Moreno et al. FEBS Journal
- Tryptophan Catabolites from Microbiota Engage Aryl Hydrocarbon Receptor and Balance Mucosal Reactivity via Interleukin-22
- (2013) Teresa Zelante et al. IMMUNITY
- Two Weeks of Reduced Activity Decreases Leg Lean Mass and Induces “Anabolic Resistance” of Myofibrillar Protein Synthesis in Healthy Elderly
- (2013) Leigh Breen et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Evidence-Based Recommendations for Optimal Dietary Protein Intake in Older People: A Position Paper From the PROT-AGE Study Group
- (2013) Jürgen Bauer et al. Journal of the American Medical Directors Association
- Major phenylpropanoid-derived metabolites in the human gut can arise from microbial fermentation of protein
- (2013) Wendy R. Russell et al. MOLECULAR NUTRITION & FOOD RESEARCH
- A Family of Indoles Regulate Virulence and Shiga Toxin Production in Pathogenic E. coli
- (2013) Bettina Bommarius et al. PLoS One
- Vitamin B6 deficiency and diseases in elderly people – a study in nursing homes
- (2013) Ida K Kjeldby et al. BMC Geriatrics
- Effects and Side Effects Associated with the Non-Nutritional Use of Tryptophan by Humans
- (2012) John D. Fernstrom JOURNAL OF NUTRITION
- The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner
- (2012) G Clarke et al. MOLECULAR PSYCHIATRY
- A metagenome-wide association study of gut microbiota in type 2 diabetes
- (2012) Junjie Qin et al. NATURE
- Tryptamine derivatives as novel non-nucleosidic inhibitors against hepatitis B virus
- (2011) Shi-Jin Qu et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment
- (2011) Jacques Amar et al. EMBO Molecular Medicine
- The Commensal Microbiota and Enteropathogens in the Pathogenesis of Inflammatory Bowel Diseases
- (2011) Benoit Chassaing et al. GASTROENTEROLOGY
- Natural Aryl Hydrocarbon Receptor Ligands Control Organogenesis of Intestinal Lymphoid Follicles
- (2011) E. A. Kiss et al. SCIENCE
- Impact of healthy lifestyle on mortality in people with normal blood pressure, LDL cholesterol, and C-reactive protein
- (2011) Dana E King et al. European Journal of Preventive Cardiology
- Tryptophan metabolism, from nutrition to potential therapeutic applications
- (2010) Nathalie Le Floc’h et al. AMINO ACIDS
- Through Ageing, and Beyond: Gut Microbiota and Inflammatory Status in Seniors and Centenarians
- (2010) Elena Biagi et al. PLoS One
- Indole-3-propionic acid attenuates neuronal damage and oxidative stress in the ischemic hippocampus
- (2009) In Koo Hwang et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites
- (2009) W. R. Wikoff et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Role of serotonin in intestinal inflammation: knockout of serotonin reuptake transporter exacerbates 2,4,6-trinitrobenzene sulfonic acid colitis in mice
- (2008) Stephan C. Bischoff et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Serum activity of alanine aminotransferase (ALT) as an indicator of health and disease
- (2008) W. Ray Kim et al. HEPATOLOGY
- A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity
- (2008) Marina Cella et al. NATURE
- Trace amine-associated receptors and their ligands
- (2006) R Zucchi et al. BRITISH JOURNAL OF PHARMACOLOGY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationPublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More