Microbiota-derived tryptophan metabolites in vascular inflammation and cardiovascular disease

Vascular Endothelial Dysfunction in the Thoracic Aorta of Rats with Ischemic Acute Kidney Injury: Contribution of Indoxyl Sulfate

(2022) Keisuke Nakagawa et al.   Oxidative Medicine and Cellular Longevity

Microbiota-Derived Metabolites, Indole-3-aldehyde and Indole-3-acetic Acid, Differentially Modulate Innate Cytokines and Stromal Remodeling Processes Associated with Autoimmune Arthritis

(2021) David Langan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

IL-17 controls central nervous system autoimmunity through the intestinal microbiome

(2021) Tommy Regen et al.   Science Immunology

Gut-Derived Metabolite Indole-3-Propionic Acid Modulates Mitochondrial Function in Cardiomyocytes and Alters Cardiac Function

(2021) Maren Gesper et al.   Frontiers in Medicine

Development and in vitro-in vivo performances of an inhalable indole-3-carboxaldehyde dry powder to target pulmonary inflammation and infection

(2021) Matteo Puccetti et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

The Interplay between Nutrition, Innate Immunity, and the Commensal Microbiota in Adaptive Intestinal Morphogenesis

(2021) Franziska Bayer et al.   Nutrients

Indole-3-propionic acid, a tryptophan-derived bacterial metabolite, increases blood pressure via cardiac and vascular mechanisms in rats

(2021) Piotr Konopelski et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Indole-3-Propionic Acid, a Functional Metabolite of Clostridium sporogenes, Promotes Muscle Tissue Development and Reduces Muscle Cell Inflammation

(2021) Lei Du et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Peripheral serotonin lacks effects on endothelial adhesion molecule expression in acute inflammation

(2021) Maximilian Mauler et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

High-coverage metabolomics uncovers microbiota-driven biochemical landscape of interorgan transport and gut-brain communication in mice

(2021) Yunjia Lai et al.   Nature Communications

The gut microbiota instructs the hepatic endothelial cell transcriptome

(2021) Henning Formes et al.   iScience

The gut microbiota modulates brain network connectivity under physiological conditions and after acute brain ischemia

(2021) Markus Aswendt et al.   iScience

Microbial Metabolite Indole-3-Propionic Acid Supplementation Does Not Protect Mice from the Cardiometabolic Consequences of a Western Diet

(2020) Dustin M Lee et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Microbiota-Induced Type I Interferons Instruct a Poised Basal State of Dendritic Cells

(2020) Laura Schaupp et al.   CELL

Microbiota-Derived Metabolites Suppress Arthritis by Amplifying Aryl-Hydrocarbon Receptor Activation in Regulatory B Cells

(2020) Elizabeth C. Rosser et al.   Cell Metabolism

From Association to Causality: the Role of the Gut Microbiota and Its Functional Products on Host Metabolism

(2020) Ara Koh et al.   MOLECULAR CELL

Statin therapy is associated with lower prevalence of gut microbiota dysbiosis

(2020) Sara Vieira-Silva et al.   NATURE

Gut microbiota dysbiosis and altered tryptophan catabolism contribute to autoimmunity in lupus-susceptible mice

(2020) Seung-Chul Choi et al.   Science Translational Medicine

Cross-omics analysis revealed gut microbiome-related metabolic pathways underlying atherosclerosis development after antibiotics treatment

(2020) Ben Arpad Kappel et al.   Molecular Metabolism

Germ-free housing conditions do not affect aortic root and aortic arch lesion size of late atherosclerotic low-density lipoprotein receptor-deficient mice

(2020) Klytaimnistra Kiouptsi et al.   Gut Microbes

Aryl Hydrocarbon Receptor (AHR) Ligands as Selective AHR Modulators (SAhRMs)

(2020) Stephen Safe et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gut Microbiota in Hypertension and Atherosclerosis: A Review

(2020) Barbara J. H. Verhaar et al.   Nutrients

Gut dysbiosis induced by cardiac pressure overload enhances adverse cardiac remodeling in a T cell-dependent manner

(2020) Francisco J Carrillo-Salinas et al.   Gut Microbes

Endothelial Cell Indoleamine 2, 3-Dioxygenase 1 Alters Cardiac Function Following Myocardial Infarction Through Kynurenine

(2020) Nada Joe Melhem et al.   CIRCULATION

Amino Acids and Their Metabolism in Atherosclerosis

(2019) Katrin Nitz et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Platelet Serotonin Aggravates Myocardial Ischemia/Reperfusion Injury via Neutrophil Degranulation

(2019) Maximilian Mauler et al.   CIRCULATION

Interleukin-22 protects intestinal stem cells against genotoxic stress

(2019) Konrad Gronke et al.   NATURE

Vascular Inflammation and Oxidative Stress: Major Triggers for Cardiovascular Disease

(2019) Sebastian Steven et al.   Oxidative Medicine and Cellular Longevity

The pregnane X receptor and its microbiota-derived ligand indole 3-propionic acid regulate endothelium-dependent vasodilation

(2019) Vivek Krishna Pulakazhi Venu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Indole-3-propionic acid inhibits gut dysbiosis and endotoxin leakage to attenuate steatohepatitis in rats

(2019) Ze-Hua Zhao et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

MYC promotes tryptophan uptake and metabolism by the kynurenine pathway in colon cancer

(2019) Niranjan Venkateswaran et al.   GENES & DEVELOPMENT

Tryptophan Dietary Impacts Gut Barrier and Metabolic Diseases

(2019) Soraya Taleb   Frontiers in Immunology

The Microbiota Promotes Arterial Thrombosis in Low-Density Lipoprotein Receptor-Deficient Mice

(2019) Klytaimnistra Kiouptsi et al.   mBio

Dietary tryptophan links encephalogenicity of autoreactive T cells with gut microbial ecology

(2019) Jana K. Sonner et al.   Nature Communications

Anti-VEGF Signalling Mechanism in HUVECs by Melatonin, Serotonin, Hydroxytyrosol and Other Bioactive Compounds

(2019) Ana B. Cerezo et al.   Nutrients

Tryptophan Metabolism: A Link Between the Gut Microbiota and Brain

(2019) Kan Gao et al.   Advances in Nutrition

Microbiota-Derived Indole Metabolites Promote Human and Murine Intestinal Homeostasis through Regulation of Interleukin-10 Receptor

(2018) Erica E. Alexeev et al.   AMERICAN JOURNAL OF PATHOLOGY

COLONIC INDOLE, GUT BACTERIA METABOLITE OF TRYPTOPHAN, INCREASES PORTAL BLOOD PRESSURE IN RATS.

(2018) Tomasz Huc et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Impact of Gut Microbiota and Diet on the Development of Atherosclerosis inApoe−/−Mice

(2018) Annika Lindskog Jonsson et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease

(2018) Allison Agus et al.   Cell Host & Microbe

Indoles - gut bacteria metabolites of tryptophan with pharmacotherapeutic potential

(2018) Piotr Konopelski et al.   CURRENT DRUG METABOLISM

The role of diet for prevention and management of hypertension

(2018) Cemal Ozemek et al.   CURRENT OPINION IN CARDIOLOGY

Regulation of the Immune Response by the Aryl Hydrocarbon Receptor

(2018) Cristina Gutiérrez-Vázquez et al.   IMMUNITY

Genetic deficiency of indoleamine 2,3-dioxygenase promotes gut microbiota-mediated metabolic health

(2018) Ludivine Laurans et al.   NATURE MEDICINE

Indole and indoxyl sulfate, gut bacteria metabolites of tryptophan, change arterial blood pressure via peripheral and central mechanisms in rats

(2018) Tomasz Huć et al.   PHARMACOLOGICAL RESEARCH

Gut microbiota regulates maturation of the adult enteric nervous system via enteric serotonin networks

(2018) Filipe De Vadder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gut Microbiota-Derived Tryptophan Metabolites Modulate Inflammatory Response in Hepatocytes and Macrophages

(2018) Smitha Krishnan et al.   Cell Reports

Indoles derived from intestinal microbiota act via type I interferon signaling to limit Graft-versus-Host-Disease

(2018) Alyson Swimm et al.   BLOOD

Branched-chain amino acids promote endothelial dysfunction through increased reactive oxygen species generation and inflammation

(2018) Olha Zhenyukh et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Fourth Universal Definition of Myocardial Infarction (2018)

(2018) Kristian Thygesen et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Environment dominates over host genetics in shaping human gut microbiota

(2018) Daphna Rothschild et al.   NATURE

Microbial tryptophan catabolites in health and disease

(2018) Henrik M. Roager et al.   Nature Communications

Identification of TMAO-producer phenotype and host–diet–gut dysbiosis by carnitine challenge test in human and germ-free mice

(2018) Wei-Kai Wu et al.   GUT

An Interleukin-23-Interleukin-22 Axis Regulates Intestinal Microbial Homeostasis to Protect from Diet-Induced Atherosclerosis

(2018) Aliia R. Fatkhullina et al.   IMMUNITY

Indoleacetate decarboxylase is a glycyl radical enzyme catalysing the formation of malodorant skatole

(2018) Dazhi Liu et al.   Nature Communications

2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation

(2017) Borja Ibanez et al.   EUROPEAN HEART JOURNAL

Increased Tryptophan Metabolism Is Associated With Activity of Inflammatory Bowel Diseases

(2017) Susanna Nikolaus et al.   GASTROENTEROLOGY

Modulation der intestinalen Mikrobiota durch Ernährungsinterventionen

(2017) S. Derer et al.   INTERNIST

Global, Regional, and National Burden of Cardiovascular Diseases for 10 Causes, 1990 to 2015

(2017) Gregory A. Roth et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Plasma microbiome-modulated indole- and phenyl-derived metabolites associate with advanced atherosclerosis and postoperative outcomes

(2017) Cori A. Cason et al.   JOURNAL OF VASCULAR SURGERY

A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites

(2017) Dylan Dodd et al.   NATURE

Salt-responsive gut commensal modulates TH17 axis and disease

(2017) Nicola Wilck et al.   NATURE

Feedback control of AHR signalling regulates intestinal immunity

(2017) Chris Schiering et al.   NATURE

Hypertension in rats is associated with an increased permeability of the colon to TMA, a gut bacteria metabolite

(2017) Kinga Jaworska et al.   PLoS One

Lactobacillus reuteriinduces gut intraepithelial CD4+CD8αα+T cells

(2017) Luisa Cervantes-Barragan et al.   SCIENCE

The gut microbiome in atherosclerotic cardiovascular disease

(2017) Zhuye Jie et al.   Nature Communications

Interleukin 22 Promotes Blood Pressure Elevation and Endothelial Dysfunction in Angiotensin II–Treated Mice

(2017) Jing Ye et al.   Journal of the American Heart Association

Gut microbiota dysbiosis contributes to the development of hypertension

(2017) Jing Li et al.   Microbiome

Modulation of a Circulating Uremic Solute via Rational Genetic Manipulation of the Gut Microbiota

(2016) A. Sloan Devlin et al.   Cell Host & Microbe

Crucial Role of the Aryl Hydrocarbon Receptor (AhR) in Indoxyl Sulfate-Induced Vascular Inflammation

(2016) Shunsuke Ito et al.   Journal of Atherosclerosis and Thrombosis

Indoxyl sulfate suppresses endothelial progenitor cell–mediated neovascularization

(2016) Szu-Chun Hung et al.   KIDNEY INTERNATIONAL

Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor

(2016) Veit Rothhammer et al.   NATURE MEDICINE

CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands

(2016) Bruno Lamas et al.   NATURE MEDICINE

Signals from the gut microbiota to distant organs in physiology and disease

(2016) Bjoern O Schroeder et al.   NATURE MEDICINE

Intracolonic hydrogen sulfide lowers blood pressure in rats

(2016) Lenka Tomasova et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Gut Microbiota Promote Angiotensin II–Induced Arterial Hypertension and Vascular Dysfunction

(2016) Susanne H. Karbach et al.   Journal of the American Heart Association

Intestinal Microbial Metabolites Are Linked to Severity of Myocardial Infarction in Rats

(2016) Vy Lam et al.   PLoS One

Metabolic footprinting for investigation of antifungal properties of Lactobacillus paracasei

(2015) Anders H. Honoré et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Macrophages in vascular inflammation – From atherosclerosis to vasculitis

(2015) Tsuyoshi Shirai et al.   AUTOIMMUNITY

Serotonin, tryptophan metabolism and the brain-gut-microbiome axis

(2015) S.M. O’Mahony et al.   BEHAVIOURAL BRAIN RESEARCH

Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin Biosynthesis

(2015) Jessica M. Yano et al.   CELL

Indoleamine 2,3-Dioxygenase Fine-Tunes Immune Homeostasis in Atherosclerosis and Colitis through Repression of Interleukin-10 Production

(2015) Sarvenaz Metghalchi et al.   Cell Metabolism

Kynurenines as predictors of acute coronary events in the Hordaland Health Study

(2015) Simone J.P.M. Eussen et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

The Influence of CKD on Colonic Microbial Metabolism

(2015) R. Poesen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Interferon-λ and interleukin 22 act synergistically for the induction of interferon-stimulated genes and control of rotavirus infection

(2015) Pedro P Hernández et al.   NATURE IMMUNOLOGY

Indoleamine 2,3-dioxygenase-1 is protective in atherosclerosis and its metabolites provide new opportunities for drug development

(2015) Jennifer E. Cole et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small molecules from the human microbiota

(2015) M. S. Donia et al.   SCIENCE

A gut-vascular barrier controls the systemic dissemination of bacteria

(2015) Ilaria Spadoni et al.   SCIENCE

Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles

(2015) Troy D. Hubbard et al.   Scientific Reports

Discovery and Characterization of Gut Microbiota Decarboxylases that Can Produce the Neurotransmitter Tryptamine

(2014) Brianna B. Williams et al.   Cell Host & Microbe

eNOS Uncoupling in Cardiovascular Diseases - the Role of Oxidative Stress and Inflammation

(2014) Susanne Karbach et al.   CURRENT PHARMACEUTICAL DESIGN

Symbiotic Bacterial Metabolites Regulate Gastrointestinal Barrier Function via the Xenobiotic Sensor PXR and Toll-like Receptor 4

(2014) Madhukumar Venkatesh et al.   IMMUNITY

Interleukin-22 alleviates metabolic disorders and restores mucosal immunity in diabetes

(2014) Xiaoting Wang et al.   NATURE

Indoxyl Sulfate Induces IL-6 Expression in Vascular Endothelial and Smooth Muscle Cells through OAT3-Mediated Uptake and Activation of AhR/NF-κB Pathway

(2014) Yelixiati Adelibieke et al.   NEPHRON EXPERIMENTAL NEPHROLOGY

Bacterial Metabolite Indole Modulates Incretin Secretion from Intestinal Enteroendocrine L Cells

(2014) Catalin Chimerel et al.   Cell Reports

Differential Effects of Indoxyl Sulfate and Inorganic Phosphate in a Murine Cerebral Endothelial Cell Line (bEnd.3)

(2014) Andréa Stinghen et al.   Toxins

Tryptophan Feeding of the IDO1-AhR Axis in Host–Microbial Symbiosis

(2014) Teresa Zelante et al.   Frontiers in Immunology

Tryptophan Catabolites from Microbiota Engage Aryl Hydrocarbon Receptor and Balance Mucosal Reactivity via Interleukin-22

(2013) Teresa Zelante et al.   IMMUNITY

A metabolomic view of how the human gut microbiota impacts the host metabolome using humanized and gnotobiotic mice

(2013) A Marcobal et al.   ISME Journal

Resistant hypertension: patient characteristics, risk factors, co-morbidities and outcomes

(2013) A Oliveras et al.   JOURNAL OF HUMAN HYPERTENSION

Indolic uremic solutes increase tissue factor production in endothelial cells by the aryl hydrocarbon receptor pathway

(2013) Bertrand Gondouin et al.   KIDNEY INTERNATIONAL

Major phenylpropanoid-derived metabolites in the human gut can arise from microbial fermentation of protein

(2013) Wendy R. Russell et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Defining a Healthy Human Gut Microbiome: Current Concepts, Future Directions, and Clinical Applications

(2012) Fredrik Bäckhed et al.   Cell Host & Microbe

Uremic Serum and Solutes Increase Post–Vascular Interventional Thrombotic Risk Through Altered Stability of Smooth Muscle Cell Tissue Factor

(2012) Vipul C. Chitalia et al.   CIRCULATION

The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner

(2012) G Clarke et al.   MOLECULAR PSYCHIATRY

ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation

(2012) Tatsuo Hashimoto et al.   NATURE

Interactions Between the Microbiota and the Immune System

(2012) L. V. Hooper et al.   SCIENCE

Hipertensão arterial e exercício físico

(2012) Jorge A. Ruivo et al.   Revista Portuguesa de Cardiologia

Lysozyme M–Positive Monocytes Mediate Angiotensin II–Induced Arterial Hypertension and Vascular Dysfunction

(2011) Philip Wenzel et al.   CIRCULATION

Plasmacytoid Dendritic Cells Protect Against Atherosclerosis by Tuning T-Cell Proliferation and Activity

(2011) Isabelle T.M.N. Daissormont et al.   CIRCULATION RESEARCH

AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch

(2011) Jacob S Lee et al.   NATURE IMMUNOLOGY

Natural Aryl Hydrocarbon Receptor Ligands Control Organogenesis of Intestinal Lymphoid Follicles

(2011) E. A. Kiss et al.   SCIENCE

Systemic Markers of Interferon-γ–Mediated Immune Activation and Long-Term Prognosis in Patients With Stable Coronary Artery Disease

(2010) Eva Ringdal Pedersen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Indoxyl Sulfate-Induced Endothelial Dysfunction in Patients with Chronic Kidney Disease via an Induction of Oxidative Stress

(2010) M. Yu et al.   Clinical Journal of the American Society of Nephrology

Human NKp44+IL-22+cells and LTi-like cells constitute a stable RORC+lineage distinct from conventional natural killer cells

(2010) Natasha K. Crellin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Activation of indoleamine 2,3-dioxygenase-induced tryptophan degradation in advanced atherosclerotic plaques: Tampere Vascular Study

(2009) Petri Niinisalo et al.   ANNALS OF MEDICINE

Serum Indoxyl Sulfate Is Associated with Vascular Disease and Mortality in Chronic Kidney Disease Patients

(2009) F. C. Barreto et al.   Clinical Journal of the American Society of Nephrology

Inflammation in Atherosclerosis

(2009) Peter Libby et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites

(2009) W. R. Wikoff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Catabolic Pathway for the Production of Skatole and Indoleacetic Acid by the Acetogen Clostridium drakei, Clostridium scatologenes, and Swine Manure

(2008) T. R. Whitehead et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

The kynurenines are associated with oxidative stress, inflammation and the prevalence of cardiovascular disease in patients with end-stage renal disease

(2008) Krystyna Pawlak et al.   ATHEROSCLEROSIS

A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity

(2008) Marina Cella et al.   NATURE

Indoxyl sulphate promotes aortic calcification with expression of osteoblast-specific proteins in hypertensive rats

(2008) A. Adijiang et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

5-Hydroxytryptamine and cardiovascular regulation

(2008) A RAMAGE et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Trace amine-associated receptors and their ligands

(2006) R Zucchi et al.   BRITISH JOURNAL OF PHARMACOLOGY