Skatole: A thin red line between its benefits and toxicity

Unraveling the skatole biodegradation process in an enrichment consortium using integrated omics and culture-dependent strategies

(2022) Qiao Ma et al.   Journal of Environmental Sciences-China

Somatization in patients with predominant diarrhoea irritable bowel syndrome: the role of the intestinal barrier function and integrity

(2021) Laura Prospero et al.   BMC GASTROENTEROLOGY

Consumption of red meat and processed meat and cancer incidence: a systematic review and meta-analysis of prospective studies

(2021) Maryam S. Farvid et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Biodegradation of skatole by Burkholderia sp. IDO3 and its successful bioaugmentation in activated sludge systems

(2020) Qiao Ma et al.   ENVIRONMENTAL RESEARCH

Differential activation of human pregnane X receptor PXR by isomeric mono-methylated indoles in intestinal and hepatic in vitro models

(2020) Barbora Vyhlídalová et al.   TOXICOLOGY LETTERS

Gut Microbial Catabolites of Tryptophan Are Ligands and Agonists of the Aryl Hydrocarbon Receptor: A Detailed Characterization

(2020) Barbora Vyhlídalová et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

High-Meat-Protein High-Fat Diet Induced Dysbiosis of Gut Microbiota and Tryptophan Metabolism in Wistar Rats

(2020) Jie Shi et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Intestinal microbiota-derived tryptophan metabolites are predictive of Ah receptor activity

(2020) Fangcong Dong et al.   Gut Microbes

Characterization of the key aroma compounds in Laoshan green teas by application of odour activity value (OAV), gas chromatography-mass spectrometry-olfactometry (GC-MS-O) and comprehensive two-dimensional gas chromatography mass spectrometry (GC × GC-qMS)

(2020) JianCai Zhu et al.   FOOD CHEMISTRY

Isolation and characterization of two Acinetobacter species able to degrade 3-methylindole

(2019) Tujuba Ayele Tesso et al.   PLoS One

Skatole regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38

(2019) Koichi Kurata et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mono-methylindoles induce CYP1A genes and inhibit CYP1A1 enzyme activity in human hepatocytes and HepaRG cells

(2019) Barbora Vyhlídalová et al.   TOXICOLOGY LETTERS

The ability of human intestinal anaerobes to metabolize different oligosaccharides: Novel means for microbiota modulation?

(2018) Riichi Ose et al.   ANAEROBE

Consumer acceptance of minced meat patties from boars in four European countries

(2018) M. Aluwé et al.   MEAT SCIENCE

Methylindoles and Methoxyindoles are Agonists and Antagonists of Human Aryl Hydrocarbon Receptor

(2018) Martina Stepankova et al.   MOLECULAR PHARMACOLOGY

Review of synthetic human faeces and faecal sludge for sanitation and wastewater research

(2018) Roni Penn et al.   WATER RESEARCH

Impact of the Gut Microbiota on Intestinal Immunity Mediated by Tryptophan Metabolism

(2018) Jing Gao et al.   Frontiers in Cellular and Infection Microbiology

An open-label, randomized, placebo-controlled study on the effectiveness of a novel probiotics administration protocol (ProbiotiCKD) in patients with mild renal insufficiency (stage 3a of CKD)

(2018) Mariadelina Simeoni et al.   EUROPEAN JOURNAL OF NUTRITION

Microbial tryptophan catabolites in health and disease

(2018) Henrik M. Roager et al.   Nature Communications

Aryl Hydrocarbon Receptor Regulates Apoptosis and Inflammation in a Murine Model of Experimental Autoimmune Uveitis

(2018) Yike Huang et al.   Frontiers in Immunology

Improved water quality and reduction of odorous compounds in anaerobic lagoon columns receiving pre-treated pig wastewater

(2017) Ariel A. Szogi et al.   ENVIRONMENTAL TECHNOLOGY

Faecalimonas umbilicata gen. nov., sp. nov., isolated from human faeces, and reclassification of Eubacterium contortum, Eubacterium fissicatena and Clostridium oroticum as Faecalicatena contorta gen. nov., comb. nov., Faecalicatena fissicatena comb. nov. and Faecalicatena orotica comb. nov.

(2017)   INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY

Salt-responsive gut commensal modulates TH17 axis and disease

(2017) Nicola Wilck et al.   NATURE

Lactobacillus reuteriinduces gut intraepithelial CD4+CD8αα+T cells

(2017) Luisa Cervantes-Barragan et al.   SCIENCE

Activation of the aryl hydrocarbon receptor decreases rifampicin-induced CYP3A4 expression in primary human hepatocytes and HepaRG

(2017) Martin Krøyer Rasmussen et al.   TOXICOLOGY LETTERS

Links between Dietary Protein Sources, the Gut Microbiota, and Obesity

(2017) Lise Madsen et al.   Frontiers in Physiology

Effect of slurry treatment approaches on the reduction of major odorant emissions at a hog barn facility in South Korea

(2016) Min-Hee Lee et al.   ENVIRONMENTAL TECHNOLOGY

Death in the intestinal epithelium-basic biology and implications for inflammatory bowel disease

(2016) J. Magarian Blander   FEBS Journal

AHR Activation Is Protective against Colitis Driven by T Cells in Humanized Mice

(2016) Jeremy A. Goettel et al.   Cell Reports

Skatole (3-Methylindole) Is a Partial Aryl Hydrocarbon Receptor Agonist and Induces CYP1A1/2 and CYP1B1 Expression in Primary Human Hepatocytes

(2016) Martin Krøyer Rasmussen et al.   PLoS One

Aerobic biotransformation of 3-methylindole to ring cleavage products by Cupriavidus sp. strain KK10

(2015) Kimiko Fukuoka et al.   BIODEGRADATION

Aryl Hydrocarbon Receptor Activation Down-Regulates IL-7 and Reduces Inflammation in a Mouse Model of DSS-Induced Colitis

(2015) Tao Ji et al.   DIGESTIVE DISEASES AND SCIENCES

Olsenella scatoligenes sp. nov., a 3-methylindole- (skatole) and 4-methylphenol- (p-cresol) producing bacterium isolated from pig faeces

(2015) Xiaoqiong Li et al.   INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY

The aryl hydrocarbon receptor (AhR) mediates resistance to apoptosis induced in breast cancer cells

(2015) Kanae Bekki et al.   PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY

Intestinal steroidogenesis

(2015) Guillaume Bouguen et al.   STEROIDS

Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles

(2015) Troy D. Hubbard et al.   Scientific Reports

Faecal metabolite profiling identifies medium-chain fatty acids as discriminating compounds in IBD

(2014) Vicky De Preter et al.   GUT

Diet, Metabolites, and “Western-Lifestyle” Inflammatory Diseases

(2014) Alison N. Thorburn et al.   IMMUNITY

Minireview: Gut Microbiota: The Neglected Endocrine Organ

(2014) Gerard Clarke et al.   MOLECULAR ENDOCRINOLOGY

Removal of 3-methylindole by lactic acid bacteria in vitro

(2013) XIAO MENG et al.   Experimental and Therapeutic Medicine

Honor Thy Gut Symbionts Redux

(2012) J. I. Gordon   SCIENCE

Swine Odor Analyzed by Odor Panels and Chemical Techniques

(2011) Steven Trabue et al.   JOURNAL OF ENVIRONMENTAL QUALITY

Identification of odorous compounds in reclaimed water using FPA combined with sensory GC-MS

(2011) Zhiming Yan et al.   JOURNAL OF ENVIRONMENTAL SCIENCES

Review of analytical methods to measure boar taint compounds in porcine adipose tissue: The need for harmonised methods

(2011) J.-E. Haugen et al.   MEAT SCIENCE

Potent Mutagenicity of 3-Methylindole Requires Pulmonary Cytochrome P450-Mediated Bioactivation: A Comparison to the Prototype Cigarette Smoke Mutagens B(a)P and NNK

(2010) Jessica M. Weems et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Odorant Receptor from the Southern House Mosquito Narrowly Tuned to the Oviposition Attractant Skatole

(2010) David T. Hughes et al.   JOURNAL OF CHEMICAL ECOLOGY

3-Methylindole is Mutagenic and a Possible Pulmonary Carcinogen

(2009) Jessica M. Weems et al.   TOXICOLOGICAL SCIENCES

Anaerobic digestion technology in poultry and livestock waste treatment — a literature review

(2009) Suleyman Sakar et al.   WASTE MANAGEMENT & RESEARCH

Catabolic Pathway for the Production of Skatole and Indoleacetic Acid by the Acetogen Clostridium drakei, Clostridium scatologenes, and Swine Manure

(2008) T. R. Whitehead et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Cytochrome P450 and Chemical Toxicology

(2007) F. Peter Guengerich   CHEMICAL RESEARCH IN TOXICOLOGY