GPR35 promotes neutrophil recruitment in response to serotonin metabolite 5-HIAA

G-protein coupled receptor 35 (GPR35) regulates the colonic epithelial cell response to enterotoxigenic Bacteroides fragilis

(2021) Annemarie Boleij et al.   Communications Biology

Impact of plasma 5-hydroxyindoleacetic acid, a serotonin metabolite, on clinical outcome in septic shock, and its effect on vascular permeability

(2021) Takeshi Tanaka et al.   Scientific Reports

Human Mast Cell Proteome Reveals Unique Lineage, Putative Functions, and Structural Basis for Cell Ablation

(2020) Thomas Plum et al.   IMMUNITY

Genetic deletion of mast cell serotonin synthesis prevents the development of obesity and insulin resistance

(2020) Julian M. Yabut et al.   Nature Communications

Mast Cells in Inflammation and Disease: Recent Progress and Ongoing Concerns

(2020) Stephen J. Galli et al.   Annual Review of Immunology

Microbiota-Derived Metabolites Suppress Arthritis by Amplifying Aryl-Hydrocarbon Receptor Activation in Regulatory B Cells

(2020) Elizabeth C. Rosser et al.   Cell Metabolism

Stromal Cells Covering Omental Fat-Associated Lymphoid Clusters Trigger Formation of Neutrophil Aggregates to Capture Peritoneal Contaminants

(2020) Lucy Helen Jackson-Jones et al.   IMMUNITY

Platelets trigger perivascular mast cell degranulation to cause inflammatory responses and tissue injury

(2020) Jörn Karhausen et al.   Science Advances

Platelet Gene Expression and Function in COVID-19 Patients

(2020) Bhanu Kanth Manne et al.   BLOOD

Single-cell transcriptome profiling reveals neutrophil heterogeneity in homeostasis and infection

(2020) Xuemei Xie et al.   NATURE IMMUNOLOGY

Lysophosphatidic Acid-Mediated GPR35 Signaling in CX3CR1+ Macrophages Regulates Intestinal Homeostasis

(2020) Berna Kaya et al.   Cell Reports

Activation of the G-protein coupled receptor GPR35 by human milk oligosaccharides through different pathways

(2020) Francis Foata et al.   Scientific Reports

Receptor selectivity between the G proteins Gα12 and Gα13 is defined by a single leucine-to-isoleucine variation

(2019) Amanda E. Mackenzie et al.   FASEB JOURNAL

GPR35 promotes glycolysis, proliferation, and oncogenic signaling by engaging with the sodium potassium pump

(2019) Georg Schneditz et al.   Science Signaling

S-Geranylgeranyl-l-glutathione is a ligand for human B cell-confinement receptor P2RY8

(2019) Erick Lu et al.   NATURE

Neutrophil transendothelial migration: updates and new perspectives

(2019) Marie-Dominique Filippi   BLOOD

Activation of Mast-Cell-Expressed Mas-Related G-Protein-Coupled Receptors Drives Non-histaminergic Itch

(2019) James Meixiong et al.   IMMUNITY

Primary and secondary prophylaxis of spontaneous bacterial peritonitis: current state of the art

(2019) Antonio Facciorusso et al.   Expert Review of Gastroenterology & Hepatology

The Orphan Receptor GPR35 Contributes to Angiotensin II–Induced Hypertension and Cardiac Dysfunction in Mice

(2018) Nina Divorty et al.   AMERICAN JOURNAL OF HYPERTENSION

Kynurenic Acid and Gpr35 Regulate Adipose Tissue Energy Homeostasis and Inflammation

(2018) Leandro Z. Agudelo et al.   Cell Metabolism

Comparison of serum serotonin and serum 5-HIAA LC-MS/MS assays in the diagnosis of serotonin producing neuroendocrine neoplasms: A pilot study

(2018) Mikael Lindström et al.   CLINICA CHIMICA ACTA

Development of Novel Monoamine Oxidase-B (MAO-B) Inhibitors with Reduced Blood-Brain Barrier Permeability for the Potential Management of Non-Central Nervous System (CNS) Diseases

(2018) Ronan GEALAGEAS et al.   JOURNAL OF MEDICINAL CHEMISTRY

Neutrophils recruited through high endothelial venules of the lymph nodes via PNAd intercept disseminatingStaphylococcus aureus

(2018) Ania Bogoslowski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting the IDO1/TDO2–KYN–AhR Pathway for Cancer Immunotherapy – Challenges and Opportunities

(2018) Jae Eun Cheong et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Kynurenic Acid: The Janus-Faced Role of an Immunomodulatory Tryptophan Metabolite and Its Link to Pathological Conditions

(2018) Elisa Wirthgen et al.   Frontiers in Immunology

Disruption of GPR35 Exacerbates Dextran Sulfate Sodium-Induced Colitis in Mice

(2018) Shukkur M. Farooq et al.   DIGESTIVE DISEASES AND SCIENCES

Start a fire, kill the bug: The role of platelets in inflammation and infection

(2018) Carsten Deppermann et al.   Innate Immunity

Distinct Compartmentalization of the Chemokines CXCL1 and CXCL2 and the Atypical Receptor ACKR1 Determine Discrete Stages of Neutrophil Diapedesis

(2018) Tamara Girbl et al.   IMMUNITY

Organ-Specific Mechanisms of Transendothelial Neutrophil Migration in the Lung, Liver, Kidney, and Aorta

(2018) Sanne L. Maas et al.   Frontiers in Immunology

The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors

(2017) Emma Lefrançais et al.   NATURE

G protein-coupled receptor 35 contributes to mucosal repair in mice via migration of colonic epithelial cells

(2017) Takuya Tsukahara et al.   PHARMACOLOGICAL RESEARCH

Protection from septic peritonitis by rapid neutrophil recruitment through omental high endothelial venules

(2016) Konrad Buscher et al.   Nature Communications

Directed transport of neutrophil-derived extracellular vesicles enables platelet-mediated innate immune response

(2016) Jan Rossaint et al.   Nature Communications

Single platelets seal neutrophil-induced vascular breaches via GPVI during immune-complex-mediated inflammation in mice

(2015) A. Gros et al.   BLOOD

Imaging the dynamic platelet-neutrophil response in sterile liver injury and repair in mice

(2015) Ingrid Slaba et al.   HEPATOLOGY

Systemic Regulation of RAS/MAPK Signaling by the Serotonin Metabolite 5-HIAA

(2015) Tobias Schmid et al.   PLoS Genetics

Leukocyte Migration into Inflamed Tissues

(2014) Sussan Nourshargh et al.   IMMUNITY

Severe skin complications in patients treated with antidepressants: a literature review

(2014) Marta Herstowska et al.   Postepy Dermatologii i Alergologii

Depression, antidepressant medications, and risk of Clostridium difficileinfection

(2013) Mary AM Rogers et al.   BMC Medicine

Analytical and preanalytical validation of a new mass spectrometric serum 5-hydroxyindoleacetic acid assay as neuroendocrine tumor marker

(2013) Niina Tohmola et al.   CLINICA CHIMICA ACTA

Neutrophil and platelet complexes and their relevance to neutrophil recruitment and activation

(2013) Clive Page et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Regulation of Circulating Neutrophil Numbers under Homeostasis and in Disease

(2013) Natasha Strydom et al.   Journal of Innate Immunity

Platelets can enhance vascular permeability

(2012) N. Cloutier et al.   BLOOD

Platelet serotonin promotes the recruitment of neutrophils to sites of acute inflammation in mice

(2012) D. Duerschmied et al.   BLOOD

Critical Role for MyD88-Mediated Neutrophil Recruitment during Clostridium difficile Colitis

(2012) Irene Jarchum et al.   INFECTION AND IMMUNITY

Tryptophan hydroxylase-1 regulates immune tolerance and inflammation

(2012) Elizabeth C. Nowak et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Francisella tularensis Alters Human Neutrophil Gene Expression: Insights into the Molecular Basis of Delayed Neutrophil Apoptosis

(2012) Justin T. Schwartz et al.   Journal of Innate Immunity

Multiple tyrosine metabolites are GPR35 agonists

(2012) Huayun Deng et al.   Scientific Reports

The MAO inhibitor phenelzine improves functional outcomes in mice with experimental autoimmune encephalomyelitis (EAE)

(2011) Travis Musgrave et al.   BRAIN BEHAVIOR AND IMMUNITY

GPR35 is a novel lysophosphatidic acid receptor

(2010) Saori Oka et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Agonist activation of the G protein-coupled receptor GPR35 involves transmembrane domain III and is transduced via Gα13 and β-arrestin-2

(2010) Laura Jenkins et al.   BRITISH JOURNAL OF PHARMACOLOGY

Circulating platelet-neutrophil complexes are important for subsequent neutrophil activation and migration

(2010) Kristin N. Kornerup et al.   JOURNAL OF APPLIED PHYSIOLOGY

Targeting of the Orphan Receptor GPR35 by Pamoic Acid: A Potent Activator of Extracellular Signal-Regulated Kinase and  -Arrestin2 with Antinociceptive Activity

(2010) P. Zhao et al.   MOLECULAR PHARMACOLOGY

The Expanded Biology of Serotonin

(2009) Miles Berger et al.   Annual Review of Medicine

Genetic etiologies of leukocyte adhesion defects

(2009) Amos Etzioni   CURRENT OPINION IN IMMUNOLOGY

Kynurenic Acid Triggers Firm Arrest of Leukocytes to Vascular Endothelium under Flow Conditions

(2009) Marita C. Barth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Monoamine oxidase inactivation: From pathophysiology to therapeutics☆

(2008) Marco Bortolato et al.   ADVANCED DRUG DELIVERY REVIEWS

GPR35 is a functional receptor in rat dorsal root ganglion neurons

(2007) Hiroyuki Ohshiro et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS