A patent review of myeloperoxidase inhibitors for treating chronic inflammatory syndromes (focus on cardiovascular diseases, 2013-2019)

Inhibition of complement activation, myeloperoxidase, NET formation and oxidant activity by PIC1 peptide variants

(2020) Pamela S. Hair et al.   PLoS One

Safety, tolerability, pharmacokinetics and effect on serum uric acid of the myeloperoxidase inhibitor AZD4831 in a randomized, placebo-controlled, phase 1 study in healthy volunteers

(2019) Li-Ming Gan et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Myeloperoxidase inhibition in mice alters atherosclerotic lesion composition

(2019) Rachel J. Roth Flach et al.   PLoS One

Targeting Myeloperoxidase Disrupts Mitochondrial Redox Balance and Overcomes Cytarabine Resistance in Human Acute Myeloid Leukemia

(2019) Mohsen Hosseini et al.   CANCER RESEARCH

Myeloperoxidase – A bridge linking inflammation and oxidative stress with cardiovascular disease

(2019) Gjin Ndrepepa   CLINICA CHIMICA ACTA

Methoxyphenol derivatives as reversible inhibitors of myeloperoxidase as potential antiatherosclerotic agents

(2019) Premkumar Jayaraj et al.   Future Medicinal Chemistry

Neutrophil myeloperoxidase harbors distinct site-specific peculiarities in its glycosylation

(2019) Karli R. Reiding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacological myeloperoxidase (MPO) inhibition in an obese/hypertensive mouse model attenuates obesity and liver damage, but not cardiac remodeling

(2019) Arnold Piek et al.   Scientific Reports

Myeloperoxidase: Its role for host defense, inflammation, and neutrophil function

(2018) Yasuaki Aratani   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Biosynthesis of human myeloperoxidase

(2018) William M. Nauseef   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Inhibition of Myeloperoxidase and MPO Reverses Microvascular Insulin Resistance in High-Fat Diet (HFD)-Fed Rats

(2018) EUGENE BARRETT et al.   DIABETES

OUP accepted manuscript

(2018)   EUROPEAN HEART JOURNAL

Inhibition of myeloperoxidase might be a novel therapeutic target in the treatment of atherosclerosis

(2018) Wei Wang et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Myeloperoxidase: A promising therapeutic target in prevention of atherosclerosis

(2018) Lili Long et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Myeloperoxidase-derived oxidants damage artery wall proteins in an animal model of chronic kidney disease–accelerated atherosclerosis

(2018) Lixia Zeng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Population Pharmacokinetic Modeling With Enterohepatic Circulation for AZD3241 in Healthy Subjects and Patients With Multiple System Atrophy

(2018) Xiao Tong et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Inhibition of myeloperoxidase by N-acetyl lysyltyrosylcysteine amide reduces experimental autoimmune encephalomyelitis-induced injury and promotes oligodendrocyte regeneration and neurogenesis in a murine model of progressive multiple sclerosis

(2018) Guoliang Yu et al.   NEUROREPORT

High-resolution Imaging of Myeloperoxidase Activity Sensors in Human Cerebrovascular Disease

(2018) Youssef Z. Wadghiri et al.   Scientific Reports

Targeting myeloperoxidase in inflammatory atherosclerosis

(2018) Max L Senders et al.   EUROPEAN HEART JOURNAL

Potent Triazolopyridine Myeloperoxidase Inhibitors

(2018) Nicholas R. Wurtz et al.   ACS Medicinal Chemistry Letters

Discovery of Novel Potent Reversible and Irreversible Myeloperoxidase Inhibitors Using Virtual Screening Procedure

(2017) Jalal Soubhye et al.   JOURNAL OF MEDICINAL CHEMISTRY

Induction of human cytochrome P450 3A4 by the irreversible myeloperoxidase inactivator PF-06282999 is mediated by the pregnane X receptor

(2017) Jamie E. Moscovitz et al.   XENOBIOTICA

Oxidative Stress-Mediated Atherosclerosis: Mechanisms and Therapies

(2017) Xinyu Yang et al.   Frontiers in Physiology

Inhibition of Myeloperoxidase Activity in Cystic Fibrosis Sputum by Peptide Inhibitor of Complement C1 (PIC1)

(2017) Pamela S. Hair et al.   PLoS One

Clarity on the Isoform-Specific Roles of NADPH Oxidases and NADPH Oxidase-4 in Atherosclerosis

(2016) David J.R. Fulton et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Mitochondrial Reactive Oxygen Species Mediate Lysophosphatidylcholine-Induced Endothelial Cell ActivationHighlights

(2016) Xinyuan Li et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Myeloperoxidase as a Target for the Treatment of Inflammatory Syndromes: Mechanisms and Structure Activity Relationships of Inhibitors

(2016) Jalal Soubhye et al.   CURRENT MEDICINAL CHEMISTRY

Novel bis-arylalkylamines as myeloperoxidase inhibitors: Design, synthesis, and structure-activity relationship study

(2016) Iyas Aldib et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Characterization of chemical features of potent myeloperoxidase inhibitors

(2016) Jalal Soubhye et al.   Future Medicinal Chemistry

Inhibition of myeloperoxidase oxidant production by N-acetyl lysyltyrosylcysteine amide reduces brain damage in a murine model of stroke

(2016) Guoliang Yu et al.   Journal of Neuroinflammation

The roles of myeloperoxidase in coronary artery disease and its potential implication in plaque rupture

(2016) Nathaniel Teng et al.   REDOX REPORT

From Dynamic Combinatorial Chemistry to in Vivo Evaluation of Reversible and Irreversible Myeloperoxidase Inhibitors

(2016) Jalal Soubhye et al.   ACS Medicinal Chemistry Letters

Effect of the myeloperoxidase inhibitor AZD3241 on microglia: a PET study in Parkinson’s disease

(2015) Aurelija Jucaite et al.   BRAIN

Myeloperoxidase Inhibitors as Potential Drugs

(2015) Tamara Lazarevic-Pasti et al.   CURRENT DRUG METABOLISM

Rational drug design applied to myeloperoxidase inhibition

(2015) P. Van Antwerpen et al.   FREE RADICAL RESEARCH

Discovery of 2-(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide (PF-06282999): A Highly Selective Mechanism-Based Myeloperoxidase Inhibitor for the Treatment of Cardiovascular Diseases

(2015) Roger B. Ruggeri et al.   JOURNAL OF MEDICINAL CHEMISTRY

Failure of Neuroprotection Despite Microglial Suppression by Delayed-Start Myeloperoxidase Inhibition in a Model of Advanced Multiple System Atrophy: Clinical Implications

(2015) Christine Kaindlstorfer et al.   NEUROTOXICITY RESEARCH

Thioxo-dihydroquinazolin-one Compounds as Novel Inhibitors of Myeloperoxidase

(2015) Yang Li et al.   ACS Medicinal Chemistry Letters

Inhibition of myeloperoxidase activity by the alkaloids of Peganum harmala L. (Zygophyllaceae)

(2014) Sihem Bensalem et al.   JOURNAL OF ETHNOPHARMACOLOGY

Hybrid molecules inhibiting myeloperoxidase activity and serotonin reuptake: a possible new approach of major depressive disorders with inflammatory syndrome

(2014) Jalal Soubhye et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Inactivation of human myeloperoxidase by hydrogen peroxide

(2013) Martina Paumann-Page et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Mechanistic Characterization of a 2-Thioxanthine Myeloperoxidase Inhibitor and Selectivity Assessment Utilizing Click Chemistry–Activity-Based Protein Profiling

(2013) Jessica Ward et al.   BIOCHEMISTRY

Candida albicans escapes from mouse neutrophils

(2013) David Ermert et al.   JOURNAL OF LEUKOCYTE BIOLOGY

N-acetyl lysyltyrosylcysteine amide inhibits myeloperoxidase, a novel tripeptide inhibitor

(2013) Hao Zhang et al.   JOURNAL OF LIPID RESEARCH

Design, Synthesis, and Structure–Activity Relationship Studies of Novel 3-Alkylindole Derivatives as Selective and Highly Potent Myeloperoxidase Inhibitors

(2013) Jalal Soubhye et al.   JOURNAL OF MEDICINAL CHEMISTRY

Measuring Myeloperoxidase Activity in Biological Samples

(2013) Benjamin Pulli et al.   PLoS One

The Human Lactoferrin-Derived Peptide hLF1-11 Exerts Immunomodulatory Effects by Specific Inhibition of Myeloperoxidase Activity

(2012) A. M. van der Does et al.   JOURNAL OF IMMUNOLOGY

Myeloperoxidase: a front-line defender against phagocytosed microorganisms

(2012) S. J. Klebanoff et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Evaluation of New Scaffolds of Myeloperoxidase Inhibitors by Rational Design Combined with High-Throughput Virtual Screening

(2012) Iyas Aldib et al.   JOURNAL OF MEDICINAL CHEMISTRY

Oxidative stress and inflammation biomarkers in the blood of patients with Huntington’s disease

(2012) Fernando Sánchez-López et al.   NEUROLOGICAL RESEARCH

Exposure of Endothelial Cells to Physiological Levels of Myeloperoxidase-Modified LDL Delays Pericellular Fibrinolysis

(2012) Karim Zouaoui Boudjeltia et al.   PLoS One

Effects of a Novel Pharmacologic Inhibitor of Myeloperoxidase in a Mouse Atherosclerosis Model

(2012) Cuiqing Liu et al.   PLoS One

The role of peroxidases in the pathogenesis of atherosclerosis

(2011) Jong-Gil Park et al.   BMB Reports

2-Thioxanthines Are Mechanism-based Inactivators of Myeloperoxidase That Block Oxidative Stress during Inflammation

(2011) Anna-Karin Tidén et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased myeloperoxidase plasma levels in rheumatoid arthritis

(2011) Raissa Maria Sampaio Neves Fernandes et al.   RHEUMATOLOGY INTERNATIONAL

Myeloperoxidase is required for neutrophil extracellular trap formation: implications for innate immunity

(2010) K. D. Metzler et al.   BLOOD

Subclinical responses in healthy cyclists briefly exposed to traffic-related air pollution: an intervention study

(2010) Lotte Jacobs et al.   Environmental Health

Glycosylation Pattern of Mature Dimeric Leukocyte and Recombinant Monomeric Myeloperoxidase

(2010) Pierre Van Antwerpen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure-Based Design, Synthesis, and Pharmacological Evaluation of 3-(Aminoalkyl)-5-fluoroindoles as Myeloperoxidase Inhibitors

(2010) Jalal Soubhye et al.   JOURNAL OF MEDICINAL CHEMISTRY

Serotonin as a physiological substrate for myeloperoxidase and its superoxide-dependent oxidation to cytotoxic tryptamine-4,5-dione

(2009) Valdecir F. Ximenes et al.   BIOCHEMICAL JOURNAL

Myeloperoxidase serves as a redox switch that regulates apoptosis in epithelial ovarian cancer

(2009) Ghassan M. Saed et al.   GYNECOLOGIC ONCOLOGY

Importance of the lipid peroxidation biomarkers and methodological aspects FOR malondialdehyde quantification

(2009) Denise Grotto et al.   QUIMICA NOVA

The Pathology of Atherosclerosis: Plaque Development and Plaque Responses to Medical Treatment

(2008) William Insull   AMERICAN JOURNAL OF MEDICINE