Indoles as essential mediators in the gut-brain axis. Their role in Alzheimer's disease

The impact of the microbiota-gut-brain axis on Alzheimer’s disease pathophysiology

(2020) Tejaswini Doifode et al.   PHARMACOLOGICAL RESEARCH

Tau PET imaging in neurodegenerative tauopathies—still a challenge

(2019) Antoine Leuzy et al.   MOLECULAR PSYCHIATRY

The neuroprotective action of 3,3′-diindolylmethane against ischemia involves an inhibition of apoptosis and autophagy that depends on HDAC and AhR/CYP1A1 but not ERα/CYP19A1 signaling

(2019) J. Rzemieniec et al.   APOPTOSIS

Oxidative Stress in Neurodegenerative Diseases: From a Mitochondrial Point of View

(2019) Giovanna Cenini et al.   Oxidative Medicine and Cellular Longevity

ITE, an endogenous aryl hydrocarbon receptor ligand, suppresses endometrial cancer cell proliferation and migration

(2019) Yiding Bian et al.   TOXICOLOGY

Melatonin: Clinical Perspectives in Neurodegeneration

(2019) Daniel P. Cardinali   Frontiers in Endocrinology

Circulating levels of the anti-oxidant indoleproprionic acid are associated with higher gut microbiome diversity

(2019) Cristina Menni et al.   Gut Microbes

Aryl hydrocarbon receptor modulates stroke-induced astrogliosis and neurogenesis in the adult mouse brain

(2019) Wan-Ci Chen et al.   Journal of Neuroinflammation

The microbiota-immune axis as a central mediator of gut-brain communication

(2019) Thomas C. Fung   NEUROBIOLOGY OF DISEASE

6-Formylindolo(3,2- b )carbazole induced aryl hydrocarbon receptor activation prevents intestinal barrier dysfunction through regulation of claudin-2 expression

(2018) Yuanhang Ma et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Benzofuran and Indole: Promising Scaffolds for Drug Development in Alzheimer's Disease

(2018) Deepti Goyal et al.   ChemMedChem

Melatonin Treatment Enhances Aβ Lymphatic Clearance in a Transgenic Mouse Model of Amyloidosis

(2018) M.A. Pappolla et al.   Current Alzheimer Research

Regulation of the Immune Response by the Aryl Hydrocarbon Receptor

(2018) Cristina Gutiérrez-Vázquez et al.   IMMUNITY

Aryl hydrocarbon receptor/IL-22/Stat3 signaling pathway is involved in the modulation of intestinal mucosa antimicrobial molecules by commensal microbiota in mice

(2018) Jiwei Wang et al.   Innate Immunity

Alzheimer’s Disease: A Journey from Amyloid Peptides and Oxidative Stress, to Biomarker Technologies and Disease Prevention Strategies—Gains from AIBL and DIAN Cohort Studies

(2018) Ralph N. Martins et al.   JOURNAL OF ALZHEIMERS DISEASE

Cerebrospinal Fluid and Plasma Levels of Inflammation Differentially Relate to CNS Markers of Alzheimer’s Disease Pathology and Neuronal Damage

(2018) Brianne M. Bettcher et al.   JOURNAL OF ALZHEIMERS DISEASE

Multiscale Analysis of Independent Alzheimer’s Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus

(2018) Ben Readhead et al.   NEURON

Alzheimer’s disease and gut microbiota modifications: The long way between preclinical studies and clinical evidence

(2018) Cesare Mancuso et al.   PHARMACOLOGICAL RESEARCH

Gut Microbiota-Derived Tryptophan Metabolites Modulate Inflammatory Response in Hepatocytes and Macrophages

(2018) Smitha Krishnan et al.   Cell Reports

Associations of serum indolepropionic acid, a gut microbiota metabolite, with type 2 diabetes and low-grade inflammation in high-risk individuals

(2018) Marjo Tuomainen et al.   Nutrition & Diabetes

Impact of the Gut Microbiota on Intestinal Immunity Mediated by Tryptophan Metabolism

(2018) Jing Gao et al.   Frontiers in Cellular and Infection Microbiology

The tryptophan derivative 6-formylindolo[3,2-b]carbazole, FICZ, a dynamic mediator of endogenous aryl hydrocarbon receptor signaling, balances cell growth and differentiation

(2018) Agneta Rannug et al.   CRITICAL REVIEWS IN TOXICOLOGY

Microbial tryptophan catabolites in health and disease

(2018) Henrik M. Roager et al.   Nature Communications

Gut microbiota, cognitive frailty and dementia in older individuals: a systematic review

(2018) Andrea Ticinesi et al.   Clinical Interventions in Aging

A tryptophan metabolite of the skin microbiota attenuates inflammation in patients with atopic dermatitis through the aryl hydrocarbon receptor

(2018) Jinlei Yu et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Indole-3-Pyruvic Acid, an Aryl Hydrocarbon Receptor Activator, Suppresses Experimental Colitis in Mice

(2018) Reiji Aoki et al.   JOURNAL OF IMMUNOLOGY

The aryl hydrocarbon receptor: a multifunctional chemical sensor for host defense and homeostatic maintenance

(2017) Kaname KAWAJIRI et al.   EXPERIMENTAL ANIMALS

Feedback control of AHR signalling regulates intestinal immunity

(2017) Chris Schiering et al.   NATURE

Interactions between the microbiota, immune and nervous systems in health and disease

(2017) Thomas C Fung et al.   NATURE NEUROSCIENCE

Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly

(2017) Annamaria Cattaneo et al.   NEUROBIOLOGY OF AGING

Postmenopausal hormone therapy and Alzheimer disease

(2017) Bushra Imtiaz et al.   NEUROLOGY

Indoles from commensal bacteria extend healthspan

(2017) Robert Sonowal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lactobacillus reuteriinduces gut intraepithelial CD4+CD8αα+T cells

(2017) Luisa Cervantes-Barragan et al.   SCIENCE

Two likely targets for the anti-cancer effect of indole derivatives from cruciferous vegetables: PI3K/Akt/mTOR signalling pathway and the aryl hydrocarbon receptor

(2017) Ada Popolo et al.   SEMINARS IN CANCER BIOLOGY

Indolepropionic acid and novel lipid metabolites are associated with a lower risk of type 2 diabetes in the Finnish Diabetes Prevention Study

(2017) Vanessa D. de Mello et al.   Scientific Reports

Novel indole-based melatonin analogues: Evaluation of antioxidant activity and protective effect against amyloid β-induced damage

(2016) Hande Gurer-Orhan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease

(2016) Timothy R. Sampson et al.   CELL

Role of AhR in positive regulation of cell proliferation and survival

(2016) Jiuheng Yin et al.   CELL PROLIFERATION

Non-Demented Individuals with Alzheimer's Disease Neuropathology: Resistance to Cognitive Decline May Reveal New Treatment Strategies

(2016) Olga Zolochevska et al.   CURRENT PHARMACEUTICAL DESIGN

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Meta-analysis of randomized, double-blind, placebo-controlled trials of melatonin in Alzheimer's disease

(2016) Yuan-Yuan Wang et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Early Postmenopausal Transdermal 17β-Estradiol Therapy and Amyloid-β Deposition

(2016) Kejal Kantarci et al.   JOURNAL OF ALZHEIMERS DISEASE

Microbes and Alzheimer’s Disease

(2016) Ruth F. Itzhaki et al.   JOURNAL OF ALZHEIMERS DISEASE

Two Healthy Diets Modulate Gut Microbial Community Improving Insulin Sensitivity in a Human Obese Population

(2016) Carmen Haro et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The amyloid cascade hypothesis: are we poised for success or failure?

(2016) Eric Karran et al.   JOURNAL OF NEUROCHEMISTRY

A PHASE 1 RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTIPLE ASCENDING DOSE STUDY TO EVALUATE SAFETY, TOLERABILITY AND PHARMACOKINETICS OF THE LIVER-SELECTIVE TR-BETA AGONIST VK2809 (MB07811) IN HYPERCHOLESTEROLEMIC SUBJECTS

(2016) Brian Lian et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Constitutive aryl hydrocarbon receptor signaling constrains type I interferon–mediated antiviral innate defense

(2016) Taisho Yamada et al.   NATURE IMMUNOLOGY

Neuronal activity enhances tau propagation and tau pathology in vivo

(2016) Jessica W Wu et al.   NATURE NEUROSCIENCE

Microbial metabolism of dietary components to bioactive metabolites: opportunities for new therapeutic interventions

(2016) Linda S. Zhang et al.   Genome Medicine

Naturally Occurring Marine Brominated Indoles Are Aryl Hydrocarbon Receptor Ligands/Agonists

(2015) Danica E. DeGroot et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Biosynthetic Manipulation of Tryptophan in Bacteria: Pathways and Mechanisms

(2015) Lona M. Alkhalaf et al.   CHEMISTRY & BIOLOGY

Aryl hydrocarbon receptor deletion in cerebellar granule neuron precursors impairs neurogenesis

(2015) Daniel P. Dever et al.   Developmental Neurobiology

Endogenous ligands of the aryl hydrocarbon receptor regulate lung dendritic cell function

(2015) Thomas H. Thatcher et al.   IMMUNOLOGY

Selective Aryl Hydrocarbon Receptor Modulator 3,3′-Diindolylmethane Impairs AhR and ARNT Signaling and Protects Mouse Neuronal Cells Against Hypoxia

(2015) J. Rzemieniec et al.   MOLECULAR NEUROBIOLOGY

Prophylactic melatonin significantly reduces Alzheimer’s neuropathology and associated cognitive deficits independent of antioxidant pathways in AβPPswe/PS1 mice

(2015) G. O’Neal-Moffitt et al.   Molecular Neurodegeneration

Disruption of Ah Receptor Signaling during Mouse Development Leads to Abnormal Cardiac Structure and Function in the Adult

(2015) Vinicius S. Carreira et al.   PLoS One

L-Kynurenine/Aryl Hydrocarbon Receptor Pathway Mediates Brain Damage After Experimental Stroke

(2014) María I. Cuartero et al.   CIRCULATION

Activation of the aryl hydrocarbon receptor affects activation and function of human monocyte-derived dendritic cells

(2014) C. Wang et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Pathogens Penetrating the Central Nervous System: Infection Pathways and the Cellular and Molecular Mechanisms of Invasion

(2014) Samantha J. Dando et al.   CLINICAL MICROBIOLOGY REVIEWS

Role of Gut Microbiota in Obesity, Type 2 Diabetes and Alzheimer’s Disease

(2014) Muhammad Naseer et al.   CNS & Neurological Disorders-Drug Targets

Mild cognitive impairment: a concept in evolution

(2014) R. C. Petersen et al.   JOURNAL OF INTERNAL MEDICINE

A Clinician's Primer on the Role of the Microbiome in Human Health and Disease

(2014) Sahil Khanna et al.   MAYO CLINIC PROCEEDINGS

An integrated catalog of reference genes in the human gut microbiome

(2014) Junhua Li et al.   NATURE BIOTECHNOLOGY

Gut microbiota–generated metabolites in animal health and disease

(2014) Won-Jae Lee et al.   Nature Chemical Biology

Effects of indole-3-carbinol on clonidine-induced neurotoxicity in rats: Impact on oxidative stress, inflammation, apoptosis and monoamine levels

(2014) Reem N. El-Naga et al.   NEUROTOXICOLOGY

Decreased Bacterial Diversity Characterizes the Altered Gut Microbiota in Patients With Psoriatic Arthritis, Resembling Dysbiosis in Inflammatory Bowel Disease

(2014) Jose U. Scher et al.   Arthritis & Rheumatology

Microbial shifts in the aging mouse gut

(2014) Morgan GI Langille et al.   Microbiome

Tryptophan Catabolites from Microbiota Engage Aryl Hydrocarbon Receptor and Balance Mucosal Reactivity via Interleukin-22

(2013) Teresa Zelante et al.   IMMUNITY

Mild cognitive impairment in a community sample: The Sydney Memory and Ageing Study

(2012) Henry Brodaty et al.   Alzheimers & Dementia

Indoxyl sulfate upregulates renal expression of MCP-1 via production of ROS and activation of NF-κB, p53, ERK, and JNK in proximal tubular cells

(2012) Hidehisa Shimizu et al.   LIFE SCIENCES

Gut microbiota composition correlates with diet and health in the elderly

(2012) Marcus J. Claesson et al.   NATURE

Outcomes of Mild Cognitive Impairment by Definition

(2011) Mary Ganguli et al.   ARCHIVES OF NEUROLOGY

A Role of the Aryl Hydrocarbon Receptor in Attenuation of Colitis

(2011) Keisuke Furumatsu et al.   DIGESTIVE DISEASES AND SCIENCES

Ligand Displaces Heat Shock Protein 90 from Overlapping Binding Sites within the Aryl Hydrocarbon Receptor Ligand-binding Domain

(2011) Anatoly Soshilov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alzheimer’s disease: pathological mechanisms and the beneficial role of melatonin

(2011) Sergio A. Rosales-Corral et al.   JOURNAL OF PINEAL RESEARCH

Exactly the Same but Different: Promiscuity and Diversity in the Molecular Mechanisms of Action of the Aryl Hydrocarbon (Dioxin) Receptor

(2011) Michael S. Denison et al.   TOXICOLOGICAL SCIENCES

Indole-3-Carbinol Triggers Aryl Hydrocarbon Receptor-dependent Estrogen Receptor (ER)α Protein Degradation in Breast Cancer Cells Disrupting an ERα-GATA3 Transcriptional Cross-Regulatory Loop

(2010) Crystal N. Marconett et al.   MOLECULAR BIOLOGY OF THE CELL

A Novel Endogenous Indole Protects Rodent Mitochondria and Extends Rotifer Lifespan

(2010) Burkhard Poeggeler et al.   PLoS One

Mild Cognitive Impairment

(2009) Ronald C. Petersen et al.   ARCHIVES OF NEUROLOGY

The Uremic Toxin 3-Indoxyl Sulfate Is a Potent Endogenous Agonist for the Human Aryl Hydrocarbon Receptor

(2009) Jennifer C. Schroeder et al.   BIOCHEMISTRY

Knockdown of the aryl hydrocarbon receptor attenuates excitotoxicity and enhances NMDA-induced BDNF expression in cortical neurons

(2009) Chun-Hua Lin et al.   JOURNAL OF NEUROCHEMISTRY

Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites

(2009) W. R. Wikoff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AhR-mediated gene expression in the developing mouse telencephalon

(2009) Julia M. Gohlke et al.   REPRODUCTIVE TOXICOLOGY

The Effect of Diet on the Human Gut Microbiome: A Metagenomic Analysis in Humanized Gnotobiotic Mice

(2009) P. J. Turnbaugh et al.   Science Translational Medicine

Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor

(2008) Francisco J. Quintana et al.   NATURE

Indole glucosinolate breakdown and its biological effects

(2008) Niels Agerbirk et al.   PHYTOCHEMISTRY REVIEWS