3D environment controls H3K4 methylation and the mechanical response of the nucleus in acute lymphoblastic leukemia cells

Fast H3K9 methylation promoted by CXCL12 contributes to nuclear changes and invasiveness of T-acute lymphoblastic leukemia cells

(2022) Elena Madrazo et al.   ONCOGENE

Atypical CXCL12 signaling enhances neutrophil migration by modulating nuclear deformability

(2022) Bianca Calì et al.   Science Signaling

H3K4 methylation at active genes mitigates transcription-replication conflicts during replication stress

(2020) Shin Yen Chong et al.   Nature Communications

Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage

(2020) Michele M. Nava et al.   CELL

Lamin A/C and the Immune System: One Intermediate Filament, Many Faces

(2020) Angela Saez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

WDR5 Promotes Proliferation and Correlates with Poor Prognosis in Oesophageal Squamous Cell Carcinoma

(2020) Di Huang et al.   OncoTargets and Therapy

Adaptive F-Actin Polymerization and Localized ATP Production Drive Basement Membrane Invasion in the Absence of MMPs

(2019) Laura C. Kelley et al.   DEVELOPMENTAL CELL

Physicochemical mechanotransduction alters nuclear shape and mechanics via heterochromatin formation

(2019) Andrew D. Stephens et al.   MOLECULAR BIOLOGY OF THE CELL

Modifications of H3K4 methylation levels are associated with DNA hypermethylation in acute myeloid leukemia

(2019) Stefania Scalea et al.   FEBS Journal

Mechanisms of 3D cell migration

(2019) Kenneth M. Yamada et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

T cell acute lymphoblastic leukemia (T-ALL): New insights into the cellular origins and infiltration mechanisms common and unique among hematologic malignancies

(2018) Eduardo Vadillo et al.   BLOOD REVIEWS

Chromatin histone modifications and rigidity affect nuclear morphology independent of lamins

(2018) Andrew D. Stephens et al.   MOLECULAR BIOLOGY OF THE CELL

Regulation of cell cycle progression by cell–cell and cell–matrix forces

(2018) Marina Uroz et al.   NATURE CELL BIOLOGY

Emerging views of the nucleus as a cellular mechanosensor

(2018) Tyler J. Kirby et al.   NATURE CELL BIOLOGY

WDR5 modulates cell motility and morphology and controls nuclear changes induced by a 3D environment

(2018) Pengbo Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

WDR5 Stabilizes Actin Architecture to Promote Multiciliated Cell Formation

(2018) Saurabh S. Kulkarni et al.   DEVELOPMENTAL CELL

G9a Correlates with VLA-4 Integrin and Influences the Migration of Childhood Acute Lymphoblastic Leukemia Cells

(2018) Elena Madrazo et al.   Cancers

The Heterochromatin Landscape in Migrating Cells and the Importance of H3K27me3 for Associated Transcriptome Alterations

(2018) Tamar Segal et al.   Cells

Sensing the mechano-chemical properties of the extracellular matrix

(2017) Pia Ringer et al.   MATRIX BIOLOGY

Not All H3K4 Methylations Are Created Equal: Mll2/COMPASS Dependency in Primordial Germ Cell Specification

(2017) Deqing Hu et al.   MOLECULAR CELL

PI3K/AKT-mediated upregulation of WDR5 promotes colorectal cancer metastasis by directly targeting ZNF407

(2017) Xin Tan et al.   Cell Death & Disease

Advances in understanding the acute lymphoblastic leukemia bone marrow microenvironment: From biology to therapeutic targeting

(2016) Francesca Chiarini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Myosin-IIA regulates leukemia engraftment and brain infiltration in a mouse model of acute lymphoblastic leukemia

(2016) Eric J. Wigton et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Nongenetic functions of the genome

(2016) M. Bustin et al.   SCIENCE

Nuclear envelope rupture and repair during cancer cell migration

(2016) C. M. Denais et al.   SCIENCE

WDR5 high expression and its effect on tumorigenesis in leukemia

(2016) Zheng Ge et al.   Oncotarget

The H3K4-Methyl Epigenome Regulates Leukemia Stem Cell Oncogenic Potential

(2015) Stephen H.K. Wong et al.   CANCER CELL

WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in Neuroblastoma

(2015) Y. Sun et al.   CANCER RESEARCH

Integrated methylome and transcriptome analysis reveals novel regulatory elements in pediatric acute lymphoblastic leukemia

(2015) Md Almamun et al.   Epigenetics

WD Repeat-containing Protein 5 (WDR5) Localizes to the Midbody and Regulates Abscission

(2015) Jeffrey K. Bailey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interaction with WDR5 Promotes Target Gene Recognition and Tumorigenesis by MYC

(2015) Lance R. Thomas et al.   MOLECULAR CELL

Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth

(2015) Jiajun Zhu et al.   NATURE

Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia

(2015) Florian Grebien et al.   Nature Chemical Biology

Mechanisms of clonal evolution in childhood acute lymphoblastic leukemia

(2015) Srividya Swaminathan et al.   NATURE IMMUNOLOGY

Integrin α4β1 controls G9a activity that regulates epigenetic changes and nuclear properties required for lymphocyte migration

(2015) Xiaohong Zhang et al.   NUCLEIC ACIDS RESEARCH

A Role for WDR5 in Integrating Threonine 11 Phosphorylation to Lysine 4 Methylation on Histone H3 during Androgen Signaling and in Prostate Cancer

(2014) Ji-Young Kim et al.   MOLECULAR CELL

Mutations in epigenetic regulators including SETD2 are gained during relapse in paediatric acute lymphoblastic leukaemia

(2014) Brenton G. Mar et al.   Nature Communications

Contractile Forces Sustain and Polarize Hematopoiesis from Stem and Progenitor Cells

(2013) Jae-Won Shin et al.   Cell Stem Cell

Physical limits of cell migration: Control by ECM space and nuclear deformation and tuning by proteolysis and traction force

(2013) Katarina Wolf et al.   JOURNAL OF CELL BIOLOGY

Integrated genetic and epigenetic analysis of childhood acute lymphoblastic leukemia

(2013) Maria E. Figueroa et al.   JOURNAL OF CLINICAL INVESTIGATION

Acute lymphoblastic leukaemia

(2013) Hiroto Inaba et al.   LANCET

Biophysical regulation of epigenetic state and cell reprogramming

(2013) Timothy L. Downing et al.   NATURE MATERIALS

Cell geometric constraints induce modular gene-expression patterns via redistribution of HDAC3 regulated by actomyosin contractility

(2013) N. Jain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cfp1 integrates both CpG content and gene activity for accurate H3K4me3 deposition in embryonic stem cells

(2012) T. Clouaire et al.   GENES & DEVELOPMENT

Sphingosine-1-phosphate activates chemokine-promoted myeloma cell adhesion and migration involving α4β1 integrin function

(2012) David García-Bernal et al.   JOURNAL OF PATHOLOGY

Two Distinct Repressive Mechanisms for Histone 3 Lysine 4 Methylation through Promoting 3′-End Antisense Transcription

(2012) Thanasis Margaritis et al.   PLoS Genetics

Mechanosignaling to the Cell Nucleus and Gene Regulation

(2011) G.V. Shivashankar   Annual Review of Biophysics

High VLA-4 expression is associated with adverse outcome and distinct gene expression changes in childhood B-cell precursor acute lymphoblastic leukemia at first relapse

(2011) S. Shalapour et al.   HAEMATOLOGICA

MLCK regulates Schwann cell cytoskeletal organization, differentiation and myelination

(2011) E. M. Leitman et al.   JOURNAL OF CELL SCIENCE

Epigenetic modifications and human disease

(2010) Anna Portela et al.   NATURE BIOTECHNOLOGY

CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia

(2009) Silvia Buonamici et al.   NATURE

WDR5, a complexed protein

(2009) Raymond C Trievel et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Nuclear Shape, Mechanics, and Mechanotransduction

(2008) Kris Noel Dahl et al.   CIRCULATION RESEARCH