Physicochemical mechanotransduction alters nuclear shape and mechanics via heterochromatin formation

Mechanosensing by the Lamina Protects against Nuclear Rupture, DNA Damage, and Cell-Cycle Arrest

(2019) Sangkyun Cho et al.   DEVELOPMENTAL CELL

Chromatin’s physical properties shape the nucleus and its functions

(2019) Andrew D Stephens et al.   CURRENT OPINION IN CELL BIOLOGY

Chromatin histone modifications and rigidity affect nuclear morphology independent of lamins

(2018) Andrew D. Stephens et al.   MOLECULAR BIOLOGY OF THE CELL

Constricted migration increases DNA damage and independently represses cell cycle

(2018) Charlotte R. Pfeifer et al.   MOLECULAR BIOLOGY OF THE CELL

Emerging views of the nucleus as a cellular mechanosensor

(2018) Tyler J. Kirby et al.   NATURE CELL BIOLOGY

PIEZO channel protein naturally expressed in human breast cancer cell MDA-MB-231 as probed by atomic force microscopy

(2018) Yuanqi Weng et al.   AIP Advances

Nuclear rupture at sites of high curvature compromises retention of DNA repair factors

(2018) Yuntao Xia et al.   JOURNAL OF CELL BIOLOGY

Compressive force induces reversible chromatin condensation and cell geometry dependent transcriptional response

(2018) Karthik Damodaran et al.   MOLECULAR BIOLOGY OF THE CELL

Migration through a small pore disrupts inactive chromatin organization in neutrophil-like cells

(2018) Elsie C. Jacobson et al.   BMC BIOLOGY

The Heterochromatin Landscape in Migrating Cells and the Importance of H3K27me3 for Associated Transcriptome Alterations

(2018) Tamar Segal et al.   Cells

Mechanosensing by the nucleus: From pathways to scaling relationships

(2017) Sangkyun Cho et al.   JOURNAL OF CELL BIOLOGY

Membrane Tubulation in Lipid Vesicles Triggered by the Local Application of Calcium Ions

(2017) Baharan Ali Doosti et al.   LANGMUIR

Chromatin and lamin A determine two different mechanical response regimes of the cell nucleus

(2017) Andrew D. Stephens et al.   MOLECULAR BIOLOGY OF THE CELL

Separate roles for chromatin and lamins in nuclear mechanics

(2017) Andrew D. Stephens et al.   Nucleus

Separate roles for chromatin and lamins in nuclear mechanics

(2017) Andrew D. Stephens et al.   Nucleus

Epsin N-terminal Homology Domain (ENTH) Activity as a Function of Membrane Tension

(2016) Martin Gleisner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclear envelope rupture is induced by actin-based nucleus confinement

(2016) Emily M. Hatch et al.   JOURNAL OF CELL BIOLOGY

Mechanical regulation of transcription controls Polycomb-mediated gene silencing during lineage commitment

(2016) Huy Quang Le et al.   NATURE CELL BIOLOGY

Transcription upregulation via force-induced direct stretching of chromatin

(2016) Arash Tajik et al.   NATURE MATERIALS

ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death

(2016) M. Raab et al.   SCIENCE

Nuclear envelope rupture and repair during cancer cell migration

(2016) C. M. Denais et al.   SCIENCE

Differentiation alters stem cell nuclear architecture, mechanics, and mechano-sensitivity

(2016) Su-Jin Heo et al.   eLife

In silico synchronization reveals regulators of nuclear ruptures in lamin A/C deficient model cells

(2016) J. Robijns et al.   Scientific Reports

Structural organization of nuclear lamins A, C, B1, and B2 revealed by superresolution microscopy

(2015) Takeshi Shimi et al.   MOLECULAR BIOLOGY OF THE CELL

Mechanically Activated Ion Channels

(2015) Sanjeev S. Ranade et al.   NEURON

Chromatin decompaction by the nucleosomal binding protein HMGN5 impairs nuclear sturdiness

(2015) Takashi Furusawa et al.   Nature Communications

Mechanosensitive TRPM7 mediates shear stress and modulates osteogenic differentiation of mesenchymal stromal cells through Osterix pathway

(2015) Yi-Shiuan Liu et al.   Scientific Reports

Distinct mechanisms regulating mechanical force-induced Ca2+ signals at the plasma membrane and the ER in human MSCs

(2015) Tae-Jin Kim et al.   eLife

Gene-rich chromosomal regions are preferentially localized in the lamin B deficient nuclear blebs of atypical progeria cells

(2015) Katrin Bercht Pfleghaar et al.   Nucleus

Gene-rich chromosomal regions are preferentially localized in the lamin B deficient nuclear blebs of atypical progeria cells

(2015) Katrin Bercht Pfleghaar et al.   Nucleus

Biophysical Regulation of Chromatin Architecture Instills a Mechanical Memory in Mesenchymal Stem Cells

(2015) Su-Jin Heo et al.   Scientific Reports

Loss of lamin B1 results in prolongation of S phase and decondensation of chromosome territories

(2014) Jordi Camps et al.   FASEB JOURNAL

Prolonged Mechanical Stretch Initiates Intracellular Calcium Oscillations in Human Mesenchymal Stem Cells

(2014) Tae-Jin Kim et al.   PLoS One

Osmotic Challenge Drives Rapid and Reversible Chromatin Condensation in Chondrocytes

(2013) Jerome Irianto et al.   BIOPHYSICAL JOURNAL

Nuclear Mechanics and Mechanotransduction in Health and Disease

(2013) Philipp Isermann et al.   CURRENT BIOLOGY

Cell geometric constraints induce modular gene-expression patterns via redistribution of HDAC3 regulated by actomyosin contractility

(2013) N. Jain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Soft substrates normalize nuclear morphology and prevent nuclear rupture in fibroblasts from a laminopathy patient with compound heterozygous LMNA mutations

(2013) Chiara Tamiello et al.   Nucleus

Correlated alterations in genome organization, histone methylation, and DNA-lamin A/C interactions in Hutchinson-Gilford progeria syndrome

(2012) R. P. McCord et al.   GENOME RESEARCH

Nuclear lamin functions and disease

(2012) Veronika Butin-Israeli et al.   TRENDS IN GENETICS

Spatial coordination between cell and nuclear shape within micropatterned endothelial cells

(2012) Marie Versaevel et al.   Nature Communications

Transient nuclear envelope rupturing during interphase in human cancer cells

(2012) Jesse D. Vargas et al.   Nucleus

The Mechanosensitive Ion Channel Piezo1 Is Inhibited by the Peptide GsMTx4

(2011) Chilman Bae et al.   BIOCHEMISTRY

Repetitive disruptions of the nuclear envelope invoke temporary loss of cellular compartmentalization in laminopathies

(2011) Winnok H. De Vos et al.   HUMAN MOLECULAR GENETICS

Chromosomal regions associated with prostate cancer risk localize to lamin B-deficient microdomains and exhibit reduced gene transcription

(2011) Brian T Helfand et al.   JOURNAL OF PATHOLOGY

Gadolinium Ions Block Mechanosensitive Channels by Altering the Packing and Lateral Pressure of Anionic Lipids

(2010) Yury A. Ermakov et al.   BIOPHYSICAL JOURNAL

Efficient cell migration requires global chromatin condensation

(2010) G. Gerlitz et al.   JOURNAL OF CELL SCIENCE

Increased expression of the Hutchinson–Gilford progeria syndrome truncated lamin A transcript during cell aging

(2009) Sofia Rodriguez et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation

(2009) T. B. Miranda et al.   MOLECULAR CANCER THERAPEUTICS

A perinuclear actin cap regulates nuclear shape

(2009) Shyam B. Khatau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A progeria mutation reveals functions for lamin A in nuclear assembly, architecture, and chromosome organization

(2009) P. Taimen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nonlinear Osmotic Properties of the Cell Nucleus

(2008) John D. Finan et al.   ANNALS OF BIOMEDICAL ENGINEERING

The A- and B-type nuclear lamin networks: microdomains involved in chromatin organization and transcription

(2008) T. Shimi et al.   GENES & DEVELOPMENT