Relation between flexibility and intrinsically disorder regions in thermosensitive TRP channels reveal allosteric effects

Non-canonical helical transitions and conformational switching are associated with characteristic flexibility and disorder indices in TRP and Kv channels

(2023) Abigail García-Morales et al.   Channels

Peptide Flexibility and the Hydrophobic Moment are Determinants to Evaluate the Clinical Potential of Magainins

(2023) Daniel Balleza   JOURNAL OF MEMBRANE BIOLOGY

Intrinsically disordered proteins/regions and insight into their biomolecular interactions

(2022) Pinak Chakrabarti et al.   BIOPHYSICAL CHEMISTRY

Structural insights into TRPV2 activation by small molecules

(2022) Ruth A. Pumroy et al.   Nature Communications

Structures of a mammalian TRPM8 in closed state

(2022) Cheng Zhao et al.   Nature Communications

TRP channels: a journey towards a molecular understanding of pain

(2022) Tamara Rosenbaum et al.   NATURE REVIEWS NEUROSCIENCE

Structural basis of TRPV3 inhibition by an antagonist

(2022) Junping Fan et al.   Nature Chemical Biology

Heat-dependent opening of TRPV1 in the presence of capsaicin

(2021) Do Hoon Kwon et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Antioxidative and Analgesic Effects of Naringin through Selective Inhibition of Transient Receptor Potential Vanilloid Member 1

(2021) Sanung Eom et al.   Antioxidants

A specialized pore turret in the mammalian cation channel TRPV1 is responsible for distinct and species-specific heat activation thresholds

(2020) Guangxu Du et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

UCSF ChimeraX : Structure visualization for researchers, educators, and developers

(2020) Eric F. Pettersen et al.   PROTEIN SCIENCE

Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel

(2019) Ying Yin et al.   SCIENCE

Structural and Evolutionary Insights Point to Allosteric Regulation of TRP Ion Channels

(2019) Jacob K. Hilton et al.   ACCOUNTS OF CHEMICAL RESEARCH

Cryo-EM structure of TRPC5 at 2.8-Å resolution reveals unique and conserved structural elements essential for channel function

(2019) Jingjing Duan et al.   Science Advances

Structural insights into TRPM8 inhibition and desensitization

(2019) Melinda M. Diver et al.   SCIENCE

Structures of TRPV2 in distinct conformations provide insight into role of the pore turret

(2018) Timothy L. Dosey et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

TRPV1 pore turret dictates distinct DkTx and capsaicin gating

(2018) Matan Geron et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Side chain flexibility and coupling between the S4-S5 linker and the TRP domain in thermo-sensitive TRP channels: Insights from protein modeling

(2017) Sergio Romero-Romero et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Structure of the cold- and menthol-sensing ion channel TRPM8

(2017) Ying Yin et al.   SCIENCE

TRPV1 temperature activation is specifically sensitive to strong decreases in amino acid hydrophobicity

(2017) Jason O. Sosa-Pagán et al.   Scientific Reports

Structural determinants of 5′,6′-epoxyeicosatrienoic acid binding to and activation of TRPV4 channel

(2017) Alejandro Berna-Erro et al.   Scientific Reports

Allosterism and Structure in Thermally Activated Transient Receptor Potential Channels

(2016) Ignacio Diaz-Franulic et al.   Annual Review of Biophysics

Effect of Linker Length and Flexibility on the Clostridium thermocellum Esterase Displayed on Bacillus subtilis Spores

(2016) Huayou Chen et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Extracellular Linkers Completely Transplant the Voltage Dependence from Kv1.2 Ion Channels to Kv2.1

(2016) Fredrik Elinder et al.   BIOPHYSICAL JOURNAL

Protein Allostery and Conformational Dynamics

(2016) Jingjing Guo et al.   CHEMICAL REVIEWS

The Role of Protein Loops and Linkers in Conformational Dynamics and Allostery

(2016) Elena Papaleo et al.   CHEMICAL REVIEWS

TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action

(2016) Yuan Gao et al.   NATURE

Activation of Transient Receptor Potential Ankyrin-1 by Insoluble Particulate Material and Association with Asthma

(2015) Cassandra E. Deering-Rice et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Effect of linker flexibility and length on the functionality of a cytotoxic engineered antibody fragment

(2015) Maximilian Klement et al.   JOURNAL OF BIOTECHNOLOGY

Intrinsically disordered proteins in cellular signalling and regulation

(2015) Peter E. Wright et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural modeling and patch-clamp analysis of pain-related mutation TRPA1-N855S reveal inter-subunit salt bridges stabilizing the channel open state

(2015) Vlastimil Zíma et al.   NEUROPHARMACOLOGY

L596–W733 bond between the start of the S4–S5 linker and the TRP box stabilizes the closed state of TRPV4 channel

(2015) Jinfeng Teng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Classification of Intrinsically Disordered Regions and Proteins

(2014) Robin van der Lee et al.   CHEMICAL REVIEWS

TRPV1 structures in distinct conformations reveal activation mechanisms

(2013) Erhu Cao et al.   NATURE

Single Residues in the Outer Pore of TRPV1 and TRPV3 Have Temperature-Dependent Conformations

(2013) Sung Eun Kim et al.   PLoS One

N-Glycosylation of TRPM8 Ion Channels Modulates Temperature Sensitivity of Cold Thermoreceptor Neurons

(2012) María Pertusa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism of Voltage Gating in Potassium Channels

(2012) M. O. Jensen et al.   SCIENCE

Transient receptor potential cation channel, subfamily C, member 5 (TRPC5) is a cold-transducer in the peripheral nervous system

(2011) K. Zimmermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A thermodynamic framework for understanding temperature sensing by transient receptor potential (TRP) channels

(2011) D. E. Clapham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic Allostery: Linkers Are Not Merely Flexible

(2011) Buyong Ma et al.   STRUCTURE

Down-State Model of the Voltage-Sensing Domain of a Potassium Channel

(2010) Eric V. Schow et al.   BIOPHYSICAL JOURNAL

Fast and slow voltage sensor rearrangements during activation gating in Kv1.2 channels detected using tetramethylrhodamine fluorescence

(2010) Andrew James Horne et al.   JOURNAL OF GENERAL PHYSIOLOGY

Temperature-induced opening of TRPV1 ion channel is stabilized by the pore domain

(2010) Jörg Grandl et al.   NATURE NEUROSCIENCE

Thermosensitive TRP channel pore turret is part of the temperature activation pathway

(2010) F. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA