Side chain flexibility and coupling between the S4-S5 linker and the TRP domain in thermo-sensitive TRP channels: Insights from protein modeling

Allosterism and Structure in Thermally Activated Transient Receptor Potential Channels

(2016) Ignacio Diaz-Franulic et al.   Annual Review of Biophysics

Physiological significance of TRPV2 as a mechanosensor, thermosensor and lipid sensor

(2016) Koji Shibasaki   Journal of Physiological Sciences

TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action

(2016) Yuan Gao et al.   NATURE

Crystal structure of the epithelial calcium channel TRPV6

(2016) Kei Saotome et al.   NATURE

Cryo-electron microscopy structure of the TRPV2 ion channel

(2016) Lejla Zubcevic et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Toward elucidating the heat activation mechanism of the TRPV1 channel gating by molecular dynamics simulation

(2016) Han Wen et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Structure of the full-length TRPV2 channel by cryo-EM

(2016) Kevin W. Huynh et al.   Nature Communications

Cryo-electron microscopy structure of the TRPV2 ion channel

(2016) Lejla Zubcevic et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Temperature-sensitive gating of TRPV1 channel as probed by atomistic simulations of its trans- and juxtamembrane domains

(2016) Anton O. Chugunov et al.   Scientific Reports

The Integrity of the TRP Domain Is Pivotal for Correct TRPV1 Channel Gating

(2015) Lucia Gregorio-Teruel et al.   BIOPHYSICAL JOURNAL

Rigidity versus flexibility: the dilemma of understanding protein thermal stability

(2015) Andrey Karshikoff et al.   FEBS Journal

Decoding the Mobility and Time Scales of Protein Loops

(2015) Yina Gu et al.   Journal of Chemical Theory and Computation

Amphipathic Solvation of Indole: Implications for the Role of Tryptophan in Membrane Proteins

(2015) Andrew J. Johnston et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Structure of the TRPA1 ion channel suggests regulatory mechanisms

(2015) Candice E. Paulsen et al.   NATURE

The I-TASSER Suite: protein structure and function prediction

(2015) Jianyi Yang et al.   NATURE METHODS

L596–W733 bond between the start of the S4–S5 linker and the TRP box stabilizes the closed state of TRPV4 channel

(2015) Jinfeng Teng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Determinants of Phosphatidylinositol 4,5-Bisphosphate (PI(4,5)P2) Binding to Transient Receptor Potential V1 (TRPV1) Channels

(2014) Horacio Poblete et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Region Adjacent to the C-end of the Inner Gate in Transient Receptor Potential Melastatin 8 (TRPM8) Channels Plays a Central Role in Allosteric Channel Activation

(2014) Francisco José Taberner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutation of I696 and W697 in the TRP box of vanilloid receptor subtype I modulates allosteric channel activation

(2014) Lucia Gregorio-Teruel et al.   JOURNAL OF GENERAL PHYSIOLOGY

Conservation analysis of residues in the S4–S5 linker and the terminal part of the S5-P-S6 pore modulus in Kv and HCN channels: flexible determinants for the electromechanical coupling

(2014) Daniel Balleza et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Conserved Gating Elements in TRPC4 and TRPC5 Channels

(2013) Andreas Beck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MEGA6: Molecular Evolutionary Genetics Analysis Version 6.0

(2013) Koichiro Tamura et al.   MOLECULAR BIOLOGY AND EVOLUTION

TRPV1 structures in distinct conformations reveal activation mechanisms

(2013) Erhu Cao et al.   NATURE

Structure of the TRPV1 ion channel determined by electron cryo-microscopy

(2013) Maofu Liao et al.   NATURE

Exploring structure-function relationships between TRP and Kv channels

(2013) Jeet Kalia et al.   Scientific Reports

Dual Effect of Phosphatidyl (4,5)-Bisphosphate PIP2on Shaker K+Channels

(2012) Fayal Abderemane-Ali et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism of Electromechanical Coupling in Voltage-Gated Potassium Channels

(2012) Rikard Blunck et al.   Frontiers in Pharmacology

Being Flexible: The Voltage-Controllable Activation Gate of Kv Channels

(2012) Alain J. Labro et al.   Frontiers in Pharmacology

A Cool Channel in Cold Transduction

(2011) Ramón Latorre et al.   PHYSIOLOGY

Transient receptor potential cation channel, subfamily C, member 5 (TRPC5) is a cold-transducer in the peripheral nervous system

(2011) K. Zimmermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modular thermal sensors in temperature-gated transient receptor potential (TRP) channels

(2011) J. Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Bivalent Tarantula Toxin Activates the Capsaicin Receptor, TRPV1, by Targeting the Outer Pore Domain

(2010) Christopher J. Bohlen et al.   CELL

The helical character of the S6 segment of TRPV1 channels

(2010) Léon D. Islas et al.   Channels

Conserved Residues within the Putative S4–S5 Region Serve Distinct Functions among Thermosensitive Vanilloid Transient Receptor Potential (TRPV) Channels

(2010) Stepana Boukalova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural determinants of gating in the TRPV1 channel

(2009) Héctor Salazar et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cooperative nature of gating transitions in K+ channels as seen from dynamic importance sampling calculations

(2009) Elizabeth J. Denning et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

On the relation between residue flexibility and local solvent accessibility in proteins

(2009) Hua Zhang et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Vanilloid Transient Receptor Potential Cation Channels: An Overview

(2008) Bernd Nilius et al.   CURRENT PHARMACEUTICAL DESIGN

Identification of molecular determinants of channel gating in the transient receptor potential box of vanilloid receptor I

(2008) Pierluigi Valente et al.   FASEB JOURNAL

TRPC5 channels undergo changes in gating properties during the activation-deactivation cycle

(2008) Alexander G. Obukhov et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Hypoosmotic- and pressure-induced membrane stretch activate TRPC5 channels

(2008) Ana Gomis et al.   JOURNAL OF PHYSIOLOGY-LONDON

TRPV5: an ingeniously controlled calcium channel

(2008) Theun de Groot et al.   KIDNEY INTERNATIONAL

Another role of proline: stabilization interactions in proteins and protein complexes concerning proline and tryptophane

(2008) Lada Biedermannova et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS