Cryo-EM structure of TRPC5 at 2.8-Å resolution reveals unique and conserved structural elements essential for channel function

Structure of the receptor-activated human TRPC6 and TRPC3 ion channels

(2018) Qinglin Tang et al.   CELL RESEARCH

Treatment with HC-070, a potent inhibitor of TRPC4 and TRPC5, leads to anxiolytic and antidepressant effects in mice

(2018) Stefan Just et al.   PLoS One

Structure of a TRPM2 channel in complex with Ca2+ explains unique gating regulation

(2018) Zhe Zhang et al.   eLife

Electron cryo-microscopy structure of the canonical TRPC4 ion channel

(2018) Deivanayagabarathy Vinayagam et al.   eLife

Structure of the human lipid-gated cation channel TRPC3

(2018) Chen Fan et al.   eLife

Structure of the mouse TRPC4 ion channel

(2018) Jingjing Duan et al.   Nature Communications

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

Structure of the human TRPM4 ion channel in a lipid nanodisc

(2017) Henriette E. Autzen et al.   SCIENCE

A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models

(2017) Yiming Zhou et al.   SCIENCE

Molecular Determinants of the Sensitivity to Gq/11-Phospholipase C-dependent Gating, Gd3+Potentiation, and Ca2+Permeability in the Transient Receptor Potential Canonical Type 5 (TRPC5) Channel

(2016) Xingjuan Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action

(2016) Yuan Gao et al.   NATURE

Critical roles of Gi/oproteins and phospholipase C-δ1 in the activation of receptor-operated TRPC4 channels

(2016) Dhananjay P. Thakur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic NHERF interaction with TRPC4/5 proteins is required for channel gating by diacylglycerol

(2016) Ursula Storch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRP channels interaction with lipids and its implications in disease

(2015) Francisco J. Taberner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Molecular Mechanism of V(D)J Recombination from Synaptic RAG1-RAG2 Complex Structures

(2015) Heng Ru et al.   CELL

Psychiatric Disorders and TRP Channels: Focus on Psychotropic Drugs

(2015) Mustafa Nazıroglu et al.   Current Neuropharmacology

CTFFIND4: Fast and accurate defocus estimation from electron micrographs

(2015) Alexis Rohou et al.   JOURNAL OF STRUCTURAL BIOLOGY

Transient Receptor Potential Channels Contribute to Pathological Structural and Functional Remodeling After Myocardial Infarction

(2014) Catherine A. Makarewich et al.   CIRCULATION RESEARCH

Decreased Anxiety-Like Behavior and G q/11-Dependent Responses in the Amygdala of Mice Lacking TRPC4 Channels

(2014) A. Riccio et al.   JOURNAL OF NEUROSCIENCE

Extracellular disulfide bridges stabilize TRPC5 dimerization, trafficking, and activity

(2014) Chansik Hong et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Conserved Gating Elements in TRPC4 and TRPC5 Channels

(2013) Andreas Beck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRPV1 structures in distinct conformations reveal activation mechanisms

(2013) Erhu Cao et al.   NATURE

Structure of the TRPV1 ion channel determined by electron cryo-microscopy

(2013) Maofu Liao et al.   NATURE

Quantifying the local resolution of cryo-EM density maps

(2013) Alp Kucukelbir et al.   NATURE METHODS

Selective GαiSubunits as Novel Direct Activators of Transient Receptor Potential Canonical (TRPC)4 and TRPC5 Channels

(2012) Jae-Pyo Jeon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

A TRPC5-regulated calcium signaling pathway controls dendrite patterning in the mammalian brain

(2011) S. V. Puram et al.   GENES & DEVELOPMENT

Transient receptor potential cation channel, subfamily C, member 5 (TRPC5) is a cold-transducer in the peripheral nervous system

(2011) K. Zimmermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Essential Role for TRPC5 in Amygdala Function and Fear-Related Behavior

(2009) Antonio Riccio et al.   CELL

TRPC channel activation by extracellular thioredoxin

(2008) Shang-Zhong Xu et al.   NATURE