Intrinsically disordered proteins/regions and insight into their biomolecular interactions

O‧‧‧C═O interaction, its occurrence and implications for protein structure and folding

(2022) Jesmita Dhar et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Effects of pH on an IDP conformational ensemble explored by molecular dynamics simulation

(2021) Richard J. Lindsay et al.   BIOPHYSICAL CHEMISTRY

Seeing Atoms by Single-Particle Cryo-EM

(2021) Xiao-chen Bai   TRENDS IN BIOCHEMICAL SCIENCES

Fuzziness and Frustration in the Energy Landscape of Protein Folding, Function, and Assembly

(2021) Stefano Gianni et al.   ACCOUNTS OF CHEMICAL RESEARCH

Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer’s Disease, Parkinson’s Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis

(2021) Phuong H. Nguyen et al.   CHEMICAL REVIEWS

Frustration in Fuzzy Protein Complexes Leads to Interaction Versatility

(2021) Maria I. Freiberger et al.   JOURNAL OF PHYSICAL CHEMISTRY B

The Amazing World of IDPs in Human Diseases

(2021) Simona Maria Monti et al.   Biomolecules

Multivalent binding of the partially disordered SARS-CoV-2 nucleocapsid phosphoprotein dimer to RNA

(2021) Heather M. Forsythe et al.   BIOPHYSICAL JOURNAL

Critical assessment of protein intrinsic disorder prediction

(2021) Marco Necci et al.   NATURE METHODS

On the roles of intrinsically disordered proteins and regions in cell communication and signaling

(2021) Sarah E. Bondos et al.   Cell Communication and Signaling

Critical Assessment of Methods of Protein Structure Prediction ( CASP ) – Round XIV

(2021) Andriy Kryshtafovych et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Effect of gold nanoparticles on the structure and neuroprotective function of protein L-isoaspartyl methyltransferase (PIMT)

(2021) Tanaya Chatterjee et al.   Scientific Reports

Interactions between SARS-CoV-2 N-Protein and α-Synuclein Accelerate Amyloid Formation

(2021) Slav A. Semerdzhiev et al.   ACS Chemical Neuroscience

Transient disorder along pathways to amyloid

(2021) Gareth J. Morgan   BIOPHYSICAL CHEMISTRY

Dynamic protein structures in normal function and pathologic misfolding in systemic amyloidosis

(2021) Emily Lewkowicz et al.   BIOPHYSICAL CHEMISTRY

Disorder-to-order transition of the amyloid-β peptide upon lipid binding

(2021) Hebah Fatafta et al.   BIOPHYSICAL CHEMISTRY

Kinetics theories to understand the mechanism of aggregation of a protein and to design strategies for its inhibition

(2021) Shilpa Sharma et al.   BIOPHYSICAL CHEMISTRY

Surveying over 100 predictors of intrinsic disorder in proteins

(2021) Bi Zhao et al.   Expert Review of Proteomics

Aggregation and the Intrinsic Structural Disorder of Dipeptide Repeat Peptides of C9orf72-Related Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Characterized by NMR

(2021) Bankala Krishnarjuna et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Protein–Protein Interactions Mediated by Intrinsically Disordered Protein Regions Are Enriched in Missense Mutations

(2020) Eric T. C. Wong et al.   Biomolecules

Interactions by Disorder – A Matter of Context

(2020) Katrine Bugge et al.   Frontiers in Molecular Biosciences

Structures of the intrinsically disordered Aβ, tau and α-synuclein proteins in aqueous solution from computer simulations

(2020) Phuong H. Nguyen et al.   BIOPHYSICAL CHEMISTRY

Disorder under stress: Role of polyol osmolytes in modulating fibrillation and aggregation of intrinsically disordered proteins

(2020) Geetika Verma et al.   BIOPHYSICAL CHEMISTRY

The interplay between GCase, α-synuclein and lipids in human models of Parkinson’s disease

(2020) Sonia Sanz Muñoz et al.   BIOPHYSICAL CHEMISTRY

αα-hub domains and intrinsically disordered proteins – a decisive combo

(2020) Katrine Bugge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MobiDB: intrinsically disordered proteins in 2021

(2020) Damiano Piovesan et al.   NUCLEIC ACIDS RESEARCH

UniProt: the universal protein knowledgebase in 2021

(2020) et al.   NUCLEIC ACIDS RESEARCH

Functional and Regulatory Roles of Fold-Switching Proteins

(2020) Allen K. Kim et al.   STRUCTURE

Biophysical processes underlying cross-seeding in amyloid aggregation and implications in amyloid pathology

(2020) Magdalena I. Ivanova et al.   BIOPHYSICAL CHEMISTRY

Disordered Protein Kinase Regions in Regulation of Kinase Domain Cores

(2019) Gergő Gógl et al.   TRENDS IN BIOCHEMICAL SCIENCES

Modulation of Disordered Proteins with a Focus on Neurodegenerative Diseases and Other Pathologies

(2019) Anne Martinelli et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Electric Field Disruption of Amyloid Aggregation: Potential Noninvasive Therapy for Alzheimer’s Disease

(2019) Jahnu Saikia et al.   ACS Chemical Neuroscience

Sequential, Structural and Functional Properties of Protein Complexes Are Defined by How Folding and Binding Intertwine

(2019) Bálint Mészáros et al.   JOURNAL OF MOLECULAR BIOLOGY

Delineation of a new structural motif involving NHN γ‐turn

(2019) Jesmita Dhar et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Unveiling invisible protein states with NMR spectroscopy

(2019) T Reid Alderson et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

How large B-factors can be in protein crystal structures

(2018) Oliviero Carugo   BMC BIOINFORMATICS

IDPs in macromolecular complexes: the roles of multivalent interactions in diverse assemblies

(2018) Ho Yee Joyce Fung et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structural changes in DNA-binding proteins on complexation

(2018) Sayan Poddar et al.   NUCLEIC ACIDS RESEARCH

Extant fold-switching proteins are widespread

(2018) Lauren L. Porter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The contribution of intrinsically disordered regions to protein function, cellular complexity, and human disease

(2016) M. Madan Babu   BIOCHEMICAL SOCIETY TRANSACTIONS

Monomeric Aβ1–40 and Aβ1–42 Peptides in Solution Adopt Very Similar Ramachandran Map Distributions That Closely Resemble Random Coil

(2016) Julien Roche et al.   BIOCHEMISTRY

The Structure and Dynamics of Higher-Order Assemblies: Amyloids, Signalosomes, and Granules

(2016) Hao Wu et al.   CELL

Proteomic approaches to uncovering virus–host protein interactions during the progression of viral infection

(2016) Krystal K Lum et al.   Expert Review of Proteomics

Structural disorder of monomeric α-synuclein persists in mammalian cells

(2016) Francois-Xavier Theillet et al.   NATURE

Structure and Functional Characterization of the Conserved JAK Interaction Region in the Intrinsically Disordered N-Terminus of SOCS5

(2015) Indu R. Chandrashekaran et al.   BIOCHEMISTRY

Characterization of the p300 Taz2–p53 TAD2 Complex and Comparison with the p300 Taz2–p53 TAD1 Complex

(2015) Lisa M. Miller Jenkins et al.   BIOCHEMISTRY

How do disordered regions achieve comparable functions to structured domains?

(2015) Natasha S. Latysheva et al.   PROTEIN SCIENCE

Polybivalency and disordered proteins in ordering macromolecular assemblies

(2015) Elisar Barbar et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Changes in protein structure at the interface accompanying complex formation

(2015) Devlina Chakravarty et al.   IUCrJ

Physicochemical Properties of Cells and Their Effects on Intrinsically Disordered Proteins (IDPs)

(2014) Francois-Xavier Theillet et al.   CHEMICAL REVIEWS

Classification of Intrinsically Disordered Regions and Proteins

(2014) Robin van der Lee et al.   CHEMICAL REVIEWS

Extended String Binding Mode of the Phosphorylated Transactivation Domain of Tumor Suppressor p53

(2014) Masahiko Okuda et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Sweeping Away Protein Aggregation with Entropic Bristles: Intrinsically Disordered Protein Fusions Enhance Soluble Expression

(2012) Aaron A. Santner et al.   BIOCHEMISTRY

An α Helix to β Barrel Domain Switch Transforms the Transcription Factor RfaH into a Translation Factor

(2012) Björn M. Burmann et al.   CELL

Oncogenic Mutations Counteract Intrinsic Disorder in the EGFR Kinase and Promote Receptor Dimerization

(2012) Yibing Shan et al.   CELL

Versatility from Protein Disorder

(2012) M. M. Babu et al.   SCIENCE

HMGB1-Facilitated p53 DNA Binding Occurs via HMG-Box/p53 Transactivation Domain Interaction, Regulated by the Acidic Tail

(2012) John P. Rowell et al.   STRUCTURE

Intrinsically disordered proteins: a 10-year recap

(2012) Peter Tompa   TRENDS IN BIOCHEMICAL SCIENCES

Comparison of tertiary structures of proteins in protein-protein complexes with unbound forms suggests prevalence of allostery in signalling proteins

(2012) Lakshmipuram S Swapna et al.   BMC STRUCTURAL BIOLOGY

A partially folded structure of amyloid-beta(1–40) in an aqueous environment

(2011) Subramanian Vivekanandan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Disease mutations in disordered regions—exception to the rule?

(2011) Vladimir Vacic et al.   Molecular BioSystems

Allostery and Intrinsic Disorder Mediate Transcription Regulation by Conditional Cooperativity

(2010) Abel Garcia-Pino et al.   CELL

Proteins that switch folds

(2010) Philip N Bryan et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Protein binding specificity versus promiscuity

(2010) Gideon Schreiber et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

How viruses hijack cell regulation

(2010) Norman E. Davey et al.   TRENDS IN BIOCHEMICAL SCIENCES

Intrinsic Protein Disorder and Interaction Promiscuity Are Widely Associated with Dosage Sensitivity

(2009) Tanya Vavouri et al.   CELL

Functional aspects of protein flexibility

(2009) Kaare Teilum et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The structural basis of allosteric regulation in proteins

(2009) Roman A. Laskowski et al.   FEBS LETTERS

Kinetic Advantage of Intrinsically Disordered Proteins in Coupled Folding–Binding Process: A Critical Assessment of the “Fly-Casting” Mechanism

(2009) Yongqi Huang et al.   JOURNAL OF MOLECULAR BIOLOGY

Moonlighting proteins—an update

(2009) Constance J. Jeffery   Molecular BioSystems

Rejuvenation of CcdB-Poisoned Gyrase by an Intrinsically Disordered Protein Domain

(2009) Natalie De Jonge et al.   MOLECULAR CELL

Untangling the protein web

(2009) Nathan Blow   NATURE

Protein promiscuity and its implications for biotechnology

(2009) Irene Nobeli et al.   NATURE BIOTECHNOLOGY

The role of dynamic conformational ensembles in biomolecular recognition

(2009) David D Boehr et al.   Nature Chemical Biology

ELM: the status of the 2010 eukaryotic linear motif resource

(2009) Cathryn M. Gould et al.   NUCLEIC ACIDS RESEARCH

Improved Disorder Prediction by Combination of Orthogonal Approaches

(2009) Avner Schlessinger et al.   PLoS One

Intrinsically Disordered Proteins in Human Diseases: Introducing the D2 Concept

(2008) Vladimir N. Uversky et al.   Annual Review of Biophysics

Flexible nets: disorder and induced fit in the associations of p53 and 14-3-3 with their partners

(2008) Christopher J Oldfield et al.   BMC GENOMICS

Evolution and dynamics of protein interactions and networks

(2008) Emmanuel D Levy et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Insights into protein flexibility: The relationship between normal modes and conformational change upon protein-protein docking

(2008) S. E. Dobbins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tight Regulation of Unstructured Proteins: From Transcript Synthesis to Protein Degradation

(2008) J. Gsponer et al.   SCIENCE

Conformational Equilibria in Monomeric α-Synuclein at the Single-Molecule Level

(2008) Massimo Sandal et al.   PLOS BIOLOGY