Peptide Flexibility and the Hydrophobic Moment are Determinants to Evaluate the Clinical Potential of Magainins

Biomembrane lipids: When physics and chemistry join to shape biological activity

(2022) Francisco Ramos-Martín et al.   BIOCHIMIE

Flip-Flop Promotion Mechanisms by Model Transmembrane Peptides

(2022) Hiroyuki Nakao et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Single-Cell Analysis of the Antimicrobial and Bactericidal Activities of the Antimicrobial Peptide Magainin 2

(2022) Farzana Hossain et al.   Microbiology Spectrum

Rediscovery of antimicrobial peptides as therapeutic agents

(2021) Minkyung Ryu et al.   JOURNAL OF MICROBIOLOGY

Advances in Molecular Understanding of α-Helical Membrane-Active Peptides

(2021) Ivo Kabelka et al.   ACCOUNTS OF CHEMICAL RESEARCH

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

In vitro activity of the antimicrobial peptides h-Lf1-11, MSI-78, LL-37, fengycin 2B, and magainin-2 against clinically important bacteria

(2021) Laura Bedin Denardi et al.   BRAZILIAN JOURNAL OF MICROBIOLOGY

The Interactions between the Antimicrobial Peptide P-113 and Living Candida albicans Cells Shed Light on Mechanisms of Antifungal Activity and Resistance

(2020) Kuang-Ting Cheng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

NP213 (Novexatin®): A unique therapy candidate for onychomycosis with a differentiated safety and efficacy profile

(2020) Derry K Mercer et al.   MEDICAL MYCOLOGY

Antimicrobial peptides as therapeutic agents: opportunities and challenges

(2020) Margit Mahlapuu et al.   CRITICAL REVIEWS IN BIOTECHNOLOGY

Model lipid systems and their use to evaluate the phase state of biomembranes, their mechanical properties and the effect of non-conventional antibiotics: the case of daptomycin

(2020) Daniel Balleza et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

The value of antimicrobial peptides in the age of resistance

(2020) Maria Magana et al.   LANCET INFECTIOUS DISEASES

Utility of B-Factors in Protein Science: Interpreting Rigidity, Flexibility, and Internal Motion and Engineering Thermostability

(2019) Zhoutong Sun et al.   CHEMICAL REVIEWS

Role of Lipid Composition, Physicochemical Interactions, and Membrane Mechanics in the Molecular Actions of Microbial Cyclic Lipopeptides

(2019) Daniel Balleza et al.   JOURNAL OF MEMBRANE BIOLOGY

Comparative mode of action of the antimicrobial peptide melimine and its derivative Mel4 against Pseudomonas aeruginosa

(2019) Muhammad Yasir et al.   Scientific Reports

Magainin-H2 effects on the permeabilization and mechanical properties of giant unilamellar vesicles

(2019) Andrea Mescola et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Surface Grafted MSI-78A Antimicrobial Peptide has High Potential for Gastric Infection Management

(2019) Paula Parreira et al.   Scientific Reports

Intrinsic Curvature-Mediated Transbilayer Coupling in Asymmetric Lipid Vesicles

(2018) Barbara Eicher et al.   BIOPHYSICAL JOURNAL

Effects of the peptide Magainin H2 on Supported Lipid Bilayers studied by different biophysical techniques

(2018) Nathaly Marín-Medina et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Lipid topology and electrostatic interactions underpin lytic activity of linear cationic antimicrobial peptides in membranes

(2017) David J. Paterson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular mechanism of synergy between the antimicrobial peptides PGLa and magainin 2

(2017) Jonathan Zerweck et al.   Scientific Reports

Model parameters for simulation of physiological lipids

(2016) Ronald D. Hills et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

PEP-FOLD3: fasterde novostructure prediction for linear peptides in solution and in complex

(2016) Alexis Lamiable et al.   NUCLEIC ACIDS RESEARCH

Antimicrobial Peptide Potency is Facilitated by Greater Conformational Flexibility when Binding to Gram-negative Bacterial Inner Membranes

(2016) Sarah-Beth T. A. Amos et al.   Scientific Reports

Antimicrobial Peptide Structure and Mechanism of Action: A Focus on the Role of Membrane Structure

(2015) Tzong-Hsien Lee et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

The Importance of Membrane Defects—Lessons from Simulations

(2014) W. F. Drew Bennett et al.   ACCOUNTS OF CHEMICAL RESEARCH

3D Hydrophobic Moment Vectors as a Tool to Characterize the Surface Polarity of Amphiphilic Peptides

(2014) Sabine Reißer et al.   BIOPHYSICAL JOURNAL

A sub-nanometre view of how membrane curvature and composition modulate lipid packing and protein recruitment

(2014) Stefano Vanni et al.   Nature Communications

Lipid Ion Channels and the Role of Proteins

(2013) Lars D. Mosgaard et al.   ACCOUNTS OF CHEMICAL RESEARCH

Lipid Composition-Dependent Membrane Fragmentation and Pore-Forming Mechanisms of Membrane Disruption by Pexiganan (MSI-78)

(2013) Dong-Kuk Lee et al.   BIOCHEMISTRY

In VitroActivities of LTX-109, a Synthetic Antimicrobial Peptide, against Methicillin-Resistant, Vancomycin-Intermediate, Vancomycin-Resistant, Daptomycin-Nonsusceptible, and Linezolid-Nonsusceptible Staphylococcus aureus

(2012) Louis D. Saravolatz et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Does cholesterol suppress the antimicrobial peptide induced disruption of lipid raft containing membranes?

(2012) Austin J. McHenry et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Lipid shape is a key factor for membrane interactions of amphipathic helical peptides

(2012) Erik Strandberg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Selective Membrane Disruption: Mode of Action of C16G2, a Specifically Targeted Antimicrobial Peptide

(2011) Christopher W. Kaplan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

2H Solid-State Nuclear Magnetic Resonance Investigation of Whole Escherichia coli Interacting with Antimicrobial Peptide MSI-78

(2011) James Pius et al.   BIOCHEMISTRY

Fluid phase lipid areas and bilayer thicknesses of commonly used phosphatidylcholines as a function of temperature

(2011) Norbert Kučerka et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Influence of the membrane dipole potential on peptide binding to lipid bilayers

(2011) Huan Zhan et al.   BIOPHYSICAL CHEMISTRY

The expanding scope of antimicrobial peptide structures and their modes of action

(2011) Leonard T. Nguyen et al.   TRENDS IN BIOTECHNOLOGY

Antimicrobial peptide inhibition of Porphyromonas gingivalis 381-induced hemagglutination is improved with a synthetic decapeptide

(2009) Douglas R. Dixon et al.   PEPTIDES

Lipid domains in bacterial membranes and the action of antimicrobial agents

(2008) Richard M. Epand et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Structure, membrane orientation, mechanism, and function of pexiganan — A highly potent antimicrobial peptide designed from magainin

(2008) Lindsey M. Gottler et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

HELIQUEST: a web server to screen sequences with specific  -helical properties

(2008) R. Gautier et al.   BIOINFORMATICS

Examining the Contributions of Lipid Shape and Headgroup Charge on Bilayer Behavior

(2008) Allison Dickey et al.   BIOPHYSICAL JOURNAL

Lipid Bilayer Structure Determined by the Simultaneous Analysis of Neutron and X-Ray Scattering Data

(2008) Norbert Kučerka et al.   BIOPHYSICAL JOURNAL