Beyond energy and growth: the role of metabolism in developmental signaling, cell behavior and diapause

The impact of glucose on mitochondria and life span is determined by the integrity of proline catabolism in Caenorhabditis elegans

(2023) Xi Feng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lactate regulates cell cycle by remodelling the anaphase promoting complex

(2023) Weihai Liu et al.   NATURE

X‐linked pyruvate dehydrogenase complex deficiency due to a novel PDHA1 variant associated with structural brain abnormalities in a fetus

(2023) Laura M. Tanner et al.   PRENATAL DIAGNOSIS

Protein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase

(2023) Kevin G. Hicks et al.   SCIENCE

Dynamic metabolism during early mammalian embryogenesis

(2023) Jing Zhao et al.   DEVELOPMENT

Metabolic switches during development and regeneration

(2023) Ahmed I. Mahmoud   DEVELOPMENT

The role of metabolism in cellular quiescence

(2023) Yipeng Du et al.   JOURNAL OF CELL SCIENCE

Lactate enhances mouse ES cell differentiation towards XEN cells in vitro

(2022) Mohamed I Gatie et al.   STEM CELLS

Anorexia nervosa, fertility and medically assisted reproduction

(2022) Aurélie Letranchant et al.   ANNALES D ENDOCRINOLOGIE

The function of glucose metabolism in embryonic diapause of annual killifish

(2022) Xiaowen Gao et al.   Comparative Biochemistry and Physiology D-Genomics & Proteomics

Retinoic acid, RARs and early development

(2022) Marie Berenguer et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Compartmentalized metabolism supports midgestation mammalian development

(2022) Ashley Solmonson et al.   NATURE

A non-canonical tricarboxylic acid cycle underlies cellular identity

(2022) Paige K. Arnold et al.   NATURE

Ribosome biogenesis and the cellular energy economy

(2022) David Shore et al.   CURRENT BIOLOGY

Mechanisms and inhibition of Porcupine-mediated Wnt acylation

(2022) Yang Liu et al.   NATURE

Reducing the aneuploid cell burden – cell competition and the ribosome connection

(2022) Nicholas E. Baker et al.   Disease Models & Mechanisms

Glycolytic flux-signaling controls mouse embryo mesoderm development

(2022) Hidenobu Miyazawa et al.   eLife

Acetyl-CoA Synthetase 2: A Critical Linkage in Obesity-Induced Tumorigenesis in Myeloma

(2021) Zongwei Li et al.   Cell Metabolism

Role of Peroxisome Proliferator-Activated Receptors (PPARs) in Trophoblast Functions

(2021) Lin Peng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondria as Signaling Organelles Control Mammalian Stem Cell Fate

(2021) Ram Prosad Chakrabarty et al.   Cell Stem Cell

Fatty acid oxidation is required for embryonic stem cell survival during metabolic stress

(2021) Hualong Yan et al.   EMBO REPORTS

Metabolic plasticity drives development during mammalian embryogenesis

(2021) Mark S. Sharpley et al.   DEVELOPMENTAL CELL

Amino acids activate mTORC1 to release roe deer embryos from decelerated proliferation during diapause

(2021) Vera A. van der Weijden et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Regulation of Paused Pluripotency in Early Mammalian Embryos and Stem Cells

(2021) Vera A. van der Weijden et al.   Frontiers in Cell and Developmental Biology

Dispatched uses Na+ flux to power release of lipid-modified Hedgehog

(2021) Qianqian Wang et al.   NATURE

Structural insights into proteolytic activation of the human Dispatched1 transporter for Hedgehog morphogen release

(2021) Wanqiu Li et al.   Nature Communications

Metabolic Control over mTOR-Dependent Diapause-like State

(2020) Abdiasis M. Hussein et al.   DEVELOPMENTAL CELL

Insulin–PI3K signalling: an evolutionarily insulated metabolic driver of cancer

(2020) Benjamin D. Hopkins et al.   Nature Reviews Endocrinology

mTOR at the nexus of nutrition, growth, ageing and disease

(2020) Grace Y. Liu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Vertebrate diapause preserves organisms long term through Polycomb complex members

(2020) Chi-Kuo Hu et al.   SCIENCE

Compartmentalized acyl-CoA metabolism and roles in chromatin regulation

(2020) Sophie Trefely et al.   Molecular Metabolism

Metabolic Reprogramming Promotes Neural Crest Migration via Yap/Tead Signaling

(2020) Debadrita Bhattacharya et al.   DEVELOPMENTAL CELL

Metabolic reprogramming and cancer progression

(2020) Brandon Faubert et al.   SCIENCE

Metabolic characterization of a paused-like pluripotent state

(2020) Maria Inês Sousa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Myc as a Regulator of Ribosome Biogenesis and Cell Competition: A Link to Cancer

(2020) Francesca Destefanis et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Intracellular pH controls WNT downstream of glycolysis in amniote embryos

(2020) Masayuki Oginuma et al.   NATURE

Pyruvate dehydrogenase complex deficiency: updating the clinical, metabolic and mutational landscapes in a cohort of Portuguese patients

(2020) Hana Pavlu-Pereira et al.   Orphanet Journal of Rare Diseases

Metabolic Coordination of Cell Fate by α-Ketoglutarate-Dependent Dioxygenases

(2020) Sanjeethan C. Baksh et al.   TRENDS IN CELL BIOLOGY

The protein translation machinery is expressed for maximal efficiency in Escherichia coli

(2020) Xiao-Pan Hu et al.   Nature Communications

Increased demand for NAD+ relative to ATP drives aerobic glycolysis

(2020) Alba Luengo et al.   MOLECULAR CELL

Mechanistic basis of L-lactate transport in the SLC16 solute carrier family

(2019) Patrick D. Bosshart et al.   Nature Communications

Lactate and pyruvate promote oxidative stress resistance through hormetic ROS signaling

(2019) Arnaud Tauffenberger et al.   Cell Death & Disease

Mitochondrial plasticity in cell fate regulation

(2019) Amir Bahat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic heterogeneity confers differences in melanoma metastatic potential

(2019) Alpaslan Tasdogan et al.   NATURE

Serine Synthesis via PHGDH Is Essential for Heme Production in Endothelial Cells

(2018) Saar Vandekeere et al.   Cell Metabolism

Biochemical and clinical aspects of glycogen storage diseases

(2018) Sara S Ellingwood et al.   JOURNAL OF ENDOCRINOLOGY

Research advances on embryonic diapause in mammals

(2018) Liang Deng et al.   ANIMAL REPRODUCTION SCIENCE

The role of various peroxisome proliferator-activated receptors and their ligands in clinical practice

(2017) Giuseppe Derosa et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Nuclear Acetyl-CoA Production by ACLY Promotes Homologous Recombination

(2017) Sharanya Sivanand et al.   MOLECULAR CELL

Glucose feeds the TCA cycle via circulating lactate

(2017) Sheng Hui et al.   NATURE

AMPK: guardian of metabolism and mitochondrial homeostasis

(2017) Sébastien Herzig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Electron Transport Chain Remodeling by GSK3 during Oogenesis Connects Nutrient State to Reproduction

(2016) Matthew H. Sieber et al.   CELL

Metabolic control of methylation and acetylation

(2016) Xiaoyang Su et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression

(2016) Valerie A Gerriets et al.   NATURE IMMUNOLOGY

Fatty acylation of proteins: The long and the short of it

(2016) Marilyn D. Resh   PROGRESS IN LIPID RESEARCH

Repulsive cues combined with physical barriers and cell–cell adhesion determine progenitor cell positioning during organogenesis

(2016) Azadeh Paksa et al.   Nature Communications

Glucose-dependent anaplerosis in cancer cells is required for cellular redox balance in the absence of glutamine

(2016) Naniye Mallı Cetinbas et al.   Scientific Reports

Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation

(2016) Xinde Zheng et al.   eLife

The Regulation and Function of Lactate Dehydrogenase A: Therapeutic Potential in Brain Tumor

(2015) Cara J. Valvona et al.   BRAIN PATHOLOGY

Steroid Signaling Establishes a Female Metabolic State and Regulates SREBP to Control Oocyte Lipid Accumulation

(2015) Matthew H. Sieber et al.   CURRENT BIOLOGY

Integration of carbohydrate metabolism and redox state controls dauer larva formation in Caenorhabditis elegans

(2015) Sider Penkov et al.   Nature Communications

Single-Embryo Metabolomics and Systematic Prediction of Developmental Stage in Zebrafish

(2015) Shunsuke Hayashi et al.   ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES

Glutamine Oxidation Maintains the TCA Cycle and Cell Survival during Impaired Mitochondrial Pyruvate Transport

(2014) Chendong Yang et al.   MOLECULAR CELL

Regulation of Fatty Acid Oxidation in Mouse Cumulus-Oocyte Complexes during Maturation and Modulation by PPAR Agonists

(2014) Kylie R. Dunning et al.   PLoS One

Lipids and oocyte developmental competence: the role of fatty acids and β-oxidation

(2014) Kylie R Dunning et al.   REPRODUCTION

Coordinated Metabolic Transitions During Drosophila Embryogenesis and the Onset of Aerobic Glycolysis

(2014) Jason M. Tennessen et al.   G3-Genes Genomes Genetics

ROS play a critical role in the differentiation of alternatively activated macrophages and the occurrence of tumor-associated macrophages

(2013) Yan Zhang et al.   CELL RESEARCH

Stearoyl CoA Desaturase Is Required to Produce Active, Lipid-Modified Wnt Proteins

(2013) Jessica Rios-Esteves et al.   Cell Reports

MYC on the Path to Cancer

(2012) Chi V. Dang   CELL

Increased Levels of Hydrogen Peroxide Induce a HIF-1-dependent Modification of Lipid Metabolism in AMPK Compromised C. elegans Dauer Larvae

(2012) Meng Xie et al.   Cell Metabolism

Scube/You activity mediates release of dually lipid-modified Hedgehog signal in soluble form

(2012) A. Creanga et al.   GENES & DEVELOPMENT

The ribosome profiling strategy for monitoring translation in vivo by deep sequencing of ribosome-protected mRNA fragments

(2012) Nicholas T Ingolia et al.   Nature Protocols

Embryonic Diapause: Advances in Understanding the Enigma of Seasonal Delayed Implantation

(2012) BD Murphy   REPRODUCTION IN DOMESTIC ANIMALS

Dispatched and Scube Mediate the Efficient Secretion of the Cholesterol-Modified Hedgehog Ligand

(2012) Hanna Tukachinsky et al.   Cell Reports

The Drosophila Estrogen-Related Receptor Directs a Metabolic Switch that Supports Developmental Growth

(2011) Jason M. Tennessen et al.   Cell Metabolism

The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation

(2011) Ruoning Wang et al.   IMMUNITY

Drosophila Lipophorin Receptors Mediate the Uptake of Neutral Lipids in Oocytes and Imaginal Disc Cells by an Endocytosis-Independent Mechanism

(2011) Esmeralda Parra-Peralbo et al.   PLoS Genetics

Beta-Oxidation Is Essential for Mouse Oocyte Developmental Competence and Early Embryo Development1

(2010) Kylie R. Dunning et al.   BIOLOGY OF REPRODUCTION

Specific roles of Target of rapamycin in the control of stem cells and their progeny in the Drosophila ovary

(2010) L. LaFever et al.   DEVELOPMENT

Insulin signals control the competence of the Drosophila female germline stem cell niche to respond to Notch ligands

(2010) Hwei-Jan Hsu et al.   DEVELOPMENTAL BIOLOGY

pH dependence of the enzymatic processing of collagen I by MMP-1 (fibroblast collagenase), MMP-2 (gelatinase A), and MMP-14 ectodomain

(2010) Magda Gioia et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

The Role of Hypoxia in Development of the Mammalian Embryo

(2009) Sally L. Dunwoodie   DEVELOPMENTAL CELL

l-Serine synthesis in the central nervous system: A review on serine deficiency disorders

(2009) L. Tabatabaie et al.   MOLECULAR GENETICS AND METABOLISM

Reactive oxygen species prime Drosophila haematopoietic progenitors for differentiation

(2009) Edward Owusu-Ansah et al.   NATURE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Early fetal hypoxia leads to growth restriction and myocardial thinning

(2008) Margie Ream et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Mass spectrometric proteome analysis suggests anaerobic shift in metabolism of Dauer larvae of Caenorhabditis elegans

(2008) András Mádi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

C. elegans dauer formation and the molecular basis of plasticity

(2008) N. Fielenbach et al.   GENES & DEVELOPMENT