Protein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase

Combining CRISPRi and metabolomics for functional annotation of compound libraries

(2022) Miquel Anglada-Girotto et al.   Nature Chemical Biology

High‐throughput metabolomics predicts drug–target relationships for eukaryotic proteins

(2022) Duncan Holbrook‐Smith et al.   Molecular Systems Biology

Identification of small molecule allosteric modulators of 5,10-methylenetetrahydrofolate reductase (MTHFR) by targeting its unique regulatory domain

(2021) Gustavo A. Bezerra et al.   BIOCHIMIE

Sugar phosphate activation of the stress sensor eIF2B

(2021) Qi Hao et al.   Nature Communications

Crystal structure and interaction studies of human DHTKD1 provide insight into a mitochondrial megacomplex in lysine catabolism

(2020) Gustavo A. Bezerra et al.   IUCrJ

The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure

(2020) Ahmad A. Cluntun et al.   Cell Metabolism

BRENDA, the ELIXIR core data resource in 2021: new developments and updates

(2020) Antje Chang et al.   NUCLEIC ACIDS RESEARCH

Structure and allosteric regulation of human NAD-dependent isocitrate dehydrogenase

(2020) Pengkai Sun et al.   Cell Discovery

Malonylation of GAPDH is an inflammatory signal in macrophages

(2019) Silvia Galván-Peña et al.   Nature Communications

Structural, biochemical and biophysical characterization of recombinant human fumarate hydratase

(2019) Mariana A. Ajalla Aleixo et al.   FEBS Journal

Next-generation characterization of the Cancer Cell Line Encyclopedia

(2019) Mahmoud Ghandi et al.   NATURE

The landscape of cancer cell line metabolism

(2019) Haoxin Li et al.   NATURE MEDICINE

Systematic mapping of protein‐metabolite interactions in central metabolism of Escherichia coli

(2019) Maren Diether et al.   Molecular Systems Biology

Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix

(2019) Dorothee Liebschner et al.   Acta Crystallographica Section D-Structural Biology

MetaboLights: a resource evolving in response to the needs of its scientific community

(2019) Kenneth Haug et al.   NUCLEIC ACIDS RESEARCH

The reactome pathway knowledgebase

(2019) Bijay Jassal et al.   NUCLEIC ACIDS RESEARCH

Liver-Type Glutaminase GLS2 Is a Druggable Metabolic Node in Luminal-Subtype Breast Cancer

(2019) Michael J. Lukey et al.   Cell Reports

An allostatic mechanism for M2 pyruvate kinase as an amino-acid sensor

(2018) Meng Yuan et al.   BIOCHEMICAL JOURNAL

Recon3D enables a three-dimensional view of gene variation in human metabolism

(2018) Elizabeth Brunk et al.   NATURE BIOTECHNOLOGY

Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH)

(2017) Ganesha Rai et al.   JOURNAL OF MEDICINAL CHEMISTRY

Glucose feeds the TCA cycle via circulating lactate

(2017) Sheng Hui et al.   NATURE

mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer

(2017) Amaia Zabala-Letona et al.   NATURE

The Reactome Pathway Knowledgebase

(2017) Antonio Fabregat et al.   NUCLEIC ACIDS RESEARCH

HMDB 4.0: the human metabolome database for 2018

(2017) David S Wishart et al.   NUCLEIC ACIDS RESEARCH

qSVA framework for RNA quality correction in differential expression analysis

(2017) Andrew E. Jaffe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MolProbity: More and better reference data for improved all-atom structure validation

(2017) Christopher J. Williams et al.   PROTEIN SCIENCE

The self-inhibitory nature of metabolic networks and its alleviation through compartmentalization

(2017) Mohammad Tauqeer Alam et al.   Nature Communications

ENOblock Does Not Inhibit the Activity of the Glycolytic Enzyme Enolase

(2017) Nikunj Satani et al.   PLoS One

The Biochemistry and Physiology of Mitochondrial Fatty Acid β-Oxidation and Its Genetic Disorders

(2016) Sander M. Houten et al.   Annual Review of Physiology

The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway

(2016) Lynne Chantranupong et al.   CELL

Rational design and synthesis of substrate–product analogue inhibitors of α-methylacyl-coenzyme A racemase from Mycobacterium tuberculosis

(2016) Mohan Pal et al.   CHEMICAL COMMUNICATIONS

SIRT5 Regulates both Cytosolic and Mitochondrial Protein Malonylation with Glycolysis as a Major Target

(2015) Yuya Nishida et al.   MOLECULAR CELL

Sestrin2 is a leucine sensor for the mTORC1 pathway

(2015) R. L. Wolfson et al.   SCIENCE

AMPK: a cellular energy sensor primarily regulated by AMP

(2014) Graeme J. Gowans et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

CasOT: a genome-wide Cas9/gRNA off-target searching tool

(2014) A. Xiao et al.   BIOINFORMATICS

How good are my data and what is the resolution?

(2013) Philip R. Evans et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

UniChem: a unified chemical structure cross-referencing and identifier tracking system

(2013) Jon Chambers et al.   Journal of Cheminformatics

Structures of asymmetric complexes of human neuron specific enolase with resolved substrate and product and an analogous complex with two inhibitors indicate subunit interaction and inhibitor cooperativity

(2012) Jie Qin et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Serine is a natural ligand and allosteric activator of pyruvate kinase M2

(2012) Barbara Chaneton et al.   NATURE

A cross-platform toolkit for mass spectrometry and proteomics

(2012) Matthew C Chambers et al.   NATURE BIOTECHNOLOGY

iMOSFLM: a new graphical interface for diffraction-image processing withMOSFLM

(2011) T. Geoff G. Battye et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

High-Throughput, Accurate Mass Metabolome Profiling of Cellular Extracts by Flow Injection–Time-of-Flight Mass Spectrometry

(2011) Tobias Fuhrer et al.   ANALYTICAL CHEMISTRY

Revealing the Allosterome: Systematic Identification of Metabolite–Protein Interactions

(2011) Thomas Orsak et al.   BIOCHEMISTRY

Chiral inversion of 2-arylpropionyl-CoA esters by human α-methylacyl-CoA racemase 1A (P504S)—a potential mechanism for the anti-cancer effects of ibuprofen

(2011) Timothy J. Woodman et al.   CHEMICAL COMMUNICATIONS

Reversible High Affinity Inhibition of Phosphofructokinase-1 by Acyl-CoA

(2011) Christopher M. Jenkins et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Molecular replacement withMOLREP

(2009) Alexei Vagin et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Systematic phenome analysis of Escherichia coli multiple-knockout mutants reveals hidden reactions in central carbon metabolism

(2009) Kenji Nakahigashi et al.   Molecular Systems Biology

Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance

(2008) Timothy R. Koves et al.   Cell Metabolism

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

(2008) Heather R. Christofk et al.   NATURE

Long-chain fatty acyl-coenzyme A-induced inhibition of glucokinase in pancreatic islets from rats depleted in long-chain polyunsaturated ω3 fatty acids

(2007) Ying Zhang et al.   CELL BIOCHEMISTRY AND FUNCTION