Dynamic metabolism during early mammalian embryogenesis

Nutrient regulation of development and cell fate decisions

(2023) William B. Tu et al.   DEVELOPMENT

Beyond energy and growth: the role of metabolism in developmental signaling, cell behavior and diapause

(2023) Trevor S. Tippetts et al.   DEVELOPMENT

MTOR-mediated interaction between the oocyte and granulosa cells regulates the development and function of both compartments in mice

(2022) You-Qiang Su et al.   BIOLOGY OF REPRODUCTION

mTOR substrate phosphorylation in growth control

(2022) Stefania Battaglioni et al.   CELL

Maternal inheritance of glucose intolerance via oocyte TET3 insufficiency

(2022) Bin Chen et al.   NATURE

DNMT3A-dependent DNA methylation is required for spermatogonial stem cells to commit to spermatogenesis

(2022) Mathilde Dura et al.   NATURE GENETICS

Dynamic enlargement and mobilization of lipid droplets in pluripotent cells coordinate morphogenesis during mouse peri-implantation development

(2022) King Hang Tommy Mau et al.   Nature Communications

Metabolic control of histone acetylation for precise and timely regulation of minor ZGA in early mammalian embryos

(2022) Jingyu Li et al.   Cell Discovery

Mammalian DNA methylome dynamics: mechanisms, functions and new frontiers

(2022) Alex Wei et al.   DEVELOPMENT

Nutrient-sensing mTORC1 and AMPK pathways in chronic kidney diseases

(2022) Christopher Huynh et al.   Nature Reviews Nephrology

Acetyl‐CoA synthases are essential for maintaining histone acetylation under metabolic stress during zygotic genome activation in pigs

(2021) Wenjun Zhou et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Lipid droplets in mammalian eggs are utilized during embryonic diapause

(2021) Roberta Arena et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Lipid Metabolism and Signaling in Mammalian Oocyte Maturation, Quality, and Acquisition of Competence

(2021) Ranjha Khan et al.   Frontiers in Cell and Developmental Biology

Metabolic plasticity drives development during mammalian embryogenesis

(2021) Mark S. Sharpley et al.   DEVELOPMENTAL CELL

Amino acids activate mTORC1 to release roe deer embryos from decelerated proliferation during diapause

(2021) Vera A. van der Weijden et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amino Acids and the Early Mammalian Embryo: Origin, Fate, Function and Life-Long Legacy

(2021) Henry J. Leese et al.   International Journal of Environmental Research and Public Health

Nutrients in the fate of pluripotent stem cells

(2021) Vivian Lu et al.   Cell Metabolism

Mechanisms of lipid metabolism in uterine receptivity and embryo development

(2021) Qianhong Ye et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Hypoxic in vitro culture reduces histone lactylation and impairs pre-implantation embryonic development in mice

(2021) Wanting Yang et al.   Epigenetics & Chromatin

The Redox Theory of Development

(2020) Jason M. Hansen et al.   ANTIOXIDANTS & REDOX SIGNALING

Metabolic Control over mTOR-Dependent Diapause-like State

(2020) Abdiasis M. Hussein et al.   DEVELOPMENTAL CELL

mTOR at the nexus of nutrition, growth, ageing and disease

(2020) Grace Y. Liu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

NAD+ Repletion Rescues Female Fertility during Reproductive Aging

(2020) Michael J. Bertoldo et al.   Cell Reports

Nuclear accumulation of pyruvate dehydrogenase alpha 1 promotes histone acetylation and is essential for zygotic genome activation in porcine embryos

(2020) Wenjun Zhou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Glycolysis-Independent Glucose Metabolism Distinguishes TE from ICM Fate during Mammalian Embryogenesis

(2020) Fangtao Chi et al.   DEVELOPMENTAL CELL

Insights into epigenetic patterns in mammalian early embryos

(2020) Ruimin Xu et al.   Protein & Cell

Characterization of Metabolic Patterns in Mouse Oocytes during Meiotic Maturation

(2020) Ling Li et al.   MOLECULAR CELL

NSD1-deposited H3K36me2 directs de novo methylation in the mouse male germline and counteracts Polycomb-associated silencing

(2020) Kenjiro Shirane et al.   NATURE GENETICS

An evolutionary perspective on immunometabolism

(2019) Andrew Wang et al.   SCIENCE

Identification of bioactive metabolites using activity metabolomics

(2019) Markus M. Rinschen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

One-Carbon Metabolism Supports S-Adenosylmethionine and Histone Methylation to Drive Inflammatory Macrophages

(2019) Weiwei Yu et al.   MOLECULAR CELL

Maternal vitamin C regulates reprogramming of DNA methylation and germline development

(2019) Stephanie P. DiTroia et al.   NATURE

The diverse roles of DNA methylation in mammalian development and disease

(2019) Maxim V. C. Greenberg et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Alpha-ketoglutarate affects murine embryo development through metabolic and epigenetic modulations

(2019) Zhenzhen Zhang et al.   REPRODUCTION

Role of Lipid Droplets in the Development of Oocytes and Preimplantation Embryos in Mammals

(2019) E. Yu. Brusentsev et al.   Russian Journal of Developmental Biology

The role and mechanisms of DNA methylation in the oocyte

(2019) Gintarė Sendžikaitė et al.   Essays in Biochemistry

Metabolic regulation of gene expression by histone lactylation

(2019) Di Zhang et al.   NATURE

Composing the Early Embryonic Microenvironment: Physiology and Regulation of Oviductal Secretions

(2019) Marie Saint-Dizier et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The lipidome of endometrial fluid differs between implantative and non-implantative IVF cycles

(2019) Roberto Matorras et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence

(2018) Luis Rajman et al.   Cell Metabolism

Metabolism in Pluripotent Stem Cells and Early Mammalian Development

(2018) Jin Zhang et al.   Cell Metabolism

Cancer-associated 2-oxoglutarate analogues modify histone methylation by inhibiting histone lysine demethylases

(2018) Tuomas Laukka et al.   JOURNAL OF MOLECULAR BIOLOGY

Dynamics of the epigenetic landscape during the maternal-to-zygotic transition

(2018) Melanie A. Eckersley-Maslin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Metabolic regulation of pluripotency and germ cell fate through α‐ketoglutarate

(2018) Julia Tischler et al.   EMBO JOURNAL

Genetic Control of Early Cell Lineages in the Mammalian Embryo

(2018) Janet Rossant   Annual Review of Genetics

Revisiting the role of metabolism during development

(2018) Hidenobu Miyazawa et al.   DEVELOPMENT

Alpha‐ketoglutarate: a “magic” metabolite in early germ cell development

(2018) Vivian Lu et al.   EMBO JOURNAL

One-Carbon Metabolism: Linking Nutritional Biochemistry to Epigenetic Programming of Long-Term Development

(2018) Constance E. Clare et al.   Annual Review of Animal Biosciences

Studies on the Interaction of the Histone Demethylase KDM5B with Tricarboxylic Acid Cycle Intermediates

(2017) Hanna Tarhonskaya et al.   JOURNAL OF MOLECULAR BIOLOGY

Fateful triad of reactive oxygen species, mitochondrial dysfunction and lipid accumulation is associated with expression outline of the AMP-activated protein kinase pathway in bovine blastocysts

(2017) S. Prastowo et al.   REPRODUCTION FERTILITY AND DEVELOPMENT

Inhibition of Fatty Acid Synthase Reduces Blastocyst Hatching through Regulation of the AKT Pathway in Pigs

(2017) Jing Guo et al.   PLoS One

Live-cell quantification and comparison of mammalian oocyte cytosolic lipid content between species, during development, and in relation to body composition using nonlinear vibrational microscopy

(2016) Joshua Jasensky et al.   ANALYST

α-Ketoglutarate Accelerates the Initial Differentiation of Primed Human Pluripotent Stem Cells

(2016) Tara TeSlaa et al.   Cell Metabolism

Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation

(2016) In-Young Hwang et al.   Cell Metabolism

DNA methylation and chromatin accessibility profiling of mouse and human fetal germ cells

(2016) Hongshan Guo et al.   CELL RESEARCH

Quantitative imaging of lipids in live mouse oocytes and early embryos using CARS microscopy

(2016) Josephine Bradley et al.   DEVELOPMENT

Inhibition of mTOR induces a paused pluripotent state

(2016) Aydan Bulut-Karslioglu et al.   NATURE

Distinct features of H3K4me3 and H3K27me3 chromatin domains in pre-implantation embryos

(2016) Xiaoyu Liu et al.   NATURE

Allelic reprogramming of the histone modification H3K4me3 in early mammalian development

(2016) Bingjie Zhang et al.   NATURE

Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition

(2016) John Arne Dahl et al.   NATURE

Responses of bovine early embryos to S-adenosyl methionine supplementation in culture

(2016) Habib A Shojaei Saadi et al.   Epigenomics

Glycolysis-Mediated Changes in Acetyl-CoA and Histone Acetylation Control the Early Differentiation of Embryonic Stem Cells

(2015) Arieh Moussaieff et al.   Cell Metabolism

NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

(2015) Carles Cantó et al.   Cell Metabolism

Metabolic Reprogramming of Stem Cell Epigenetics

(2015) James G. Ryall et al.   Cell Stem Cell

One-carbon metabolism and epigenetic regulation of embryo development

(2015) Juan Xu et al.   REPRODUCTION FERTILITY AND DEVELOPMENT

History of oocyte and embryo metabolism

(2015) Henry J. Leese   REPRODUCTION FERTILITY AND DEVELOPMENT

A Nuclear Pyruvate Dehydrogenase Complex Is Important for the Generation of Acetyl-CoA and Histone Acetylation

(2014) Gopinath Sutendra et al.   CELL

Acetylation dynamics and stoichiometry in Saccharomyces cerevisiae

(2014) B. T. Weinert et al.   Molecular Systems Biology

Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells

(2014) Bryce W. Carey et al.   NATURE

Developmental plasticity, cell fate specification and morphogenesis in the early mouse embryo

(2014) I. Bedzhov et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Lipids and oocyte developmental competence: the role of fatty acids and β-oxidation

(2014) Kylie R Dunning et al.   REPRODUCTION

Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons

(2012) Kate D. Meyer et al.   CELL

Inhibition of  -KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors

(2012) M. Xiao et al.   GENES & DEVELOPMENT

Metabolism of the preimplantation embryo: 40 years on

(2012) Henry J Leese   REPRODUCTION

Influence of Threonine Metabolism on S-Adenosylmethionine and Histone Methylation

(2012) N. Shyh-Chang et al.   SCIENCE

A medium-chain fatty acid as an alternative energy source in mouse preimplantation development

(2012) Mitsutoshi Yamada et al.   Scientific Reports

Oleic Acid Prevents Detrimental Effects of Saturated Fatty Acids on Bovine Oocyte Developmental Competence1

(2011) Hilde Aardema et al.   BIOLOGY OF REPRODUCTION

Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

(2011) Wei Xu et al.   CANCER CELL

Leucine and arginine regulate trophoblast motility through mTOR-dependent and independent pathways in the preimplantation mouse embryo

(2011) Isabel M. González et al.   DEVELOPMENTAL BIOLOGY

Dynamic CpG island methylation landscape in oocytes and preimplantation embryos

(2011) Sébastien A Smallwood et al.   NATURE GENETICS

The role of fatty acids in oocyte and early embryo development

(2011) Paul J. McKeegan et al.   REPRODUCTION FERTILITY AND DEVELOPMENT

De novo DNA methylation: a germ cell perspective

(2011) Sébastien A. Smallwood et al.   TRENDS IN GENETICS

Beta-Oxidation Is Essential for Mouse Oocyte Developmental Competence and Early Embryo Development1

(2010) Kylie R. Dunning et al.   BIOLOGY OF REPRODUCTION

Post-translational modifications in signal integration

(2010) Yonathan Lissanu Deribe et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The pivotal role of glucose metabolism in determining oocyte developmental competence

(2010) Melanie L Sutton-McDowall et al.   REPRODUCTION

Assessing embryo viability by measurement of amino acid turnover

(2010) Roger G Sturmey et al.   REPRODUCTIVE BIOMEDICINE ONLINE

The Hippo Signaling Pathway Components Lats and Yap Pattern Tead4 Activity to Distinguish Mouse Trophectoderm from Inner Cell Mass

(2009) Noriyuki Nishioka et al.   DEVELOPMENTAL CELL

ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation

(2009) K. E. Wellen et al.   SCIENCE

Conserved Metabolic Regulatory Functions of Sirtuins

(2008) Bjoern Schwer et al.   Cell Metabolism

Nutrient Sensing by the Early Mouse Embryo: Hexosamine Biosynthesis and Glucose Signaling During Preimplantation Development1

(2007) Marie Pantaleon et al.   BIOLOGY OF REPRODUCTION