Metabolic switches during development and regeneration

What is cancer metabolism?

(2023) Lydia W.S. Finley   CELL

γ-Linolenic acid in maternal milk drives cardiac metabolic maturation

(2023) Ana Paredes et al.   NATURE

Lactate regulates cell cycle by remodelling the anaphase promoting complex

(2023) Weihai Liu et al.   NATURE

Mitochondrial pyruvate metabolism regulates the activation of quiescent adult neural stem cells

(2023) Francesco Petrelli et al.   Science Advances

A comprehensive molecular profiling approach reveals metabolic alterations that steer bone tissue regeneration

(2023) Julia Löffler et al.   Communications Biology

Dynamic metabolism during early mammalian embryogenesis

(2023) Jing Zhao et al.   DEVELOPMENT

Neural stem cell metabolism revisited: a critical role for mitochondria

(2023) Valentina Scandella et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The pentose phosphate pathway in health and disease

(2023) Tara TeSlaa et al.   Nature Metabolism

Metabolic lactate production coordinates vasculature development and progenitor behavior in the developing mouse neocortex

(2022) Xiaoxiang Dong et al.   NATURE NEUROSCIENCE

A regeneration-triggered metabolic adaptation is necessary for cell identity transitions and cell cycle re-entry to support blastema formation and bone regeneration

(2022) Ana S Brandão et al.   eLife

Neonatal ketone body elevation regulates postnatal heart development by promoting cardiomyocyte mitochondrial maturation and metabolic reprogramming

(2022) Danyang Chong et al.   Cell Discovery

Limb blastema formation: How much do we know at a genetic and epigenetic level?

(2022) Sangwon Min et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Malonate Promotes Adult Cardiomyocyte Proliferation and Heart Regeneration

(2021) Jiyoung Bae et al.   CIRCULATION

Mitochondria and metabolic transitions in cardiomyocytes: lessons from development for stem cell-derived cardiomyocytes

(2021) Jessica C. Garbern et al.   Stem Cell Research & Therapy

Metabolic plasticity drives development during mammalian embryogenesis

(2021) Mark S. Sharpley et al.   DEVELOPMENTAL CELL

When anaerobes encounter oxygen: mechanisms of oxygen toxicity, tolerance and defence

(2021) Zheng Lu et al.   NATURE REVIEWS MICROBIOLOGY

Perinatal development of innate immune topology

(2021) Philipp Henneke et al.   eLife

The Warburg effect is necessary to promote glycosylation in the blastema during zebrafish tail regeneration

(2021) Jason W. Sinclair et al.   npj Regenerative Medicine

The Role of Metabolism in Heart Failure and Regeneration

(2021) Jiyoung Bae et al.   Frontiers in Cardiovascular Medicine

mTOR at the nexus of nutrition, growth, ageing and disease

(2020) Grace Y. Liu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial TCA cycle metabolites control physiology and disease

(2020) Inmaculada Martínez-Reyes et al.   Nature Communications

A Metabolic Roadmap for Somatic Stem Cell Fate

(2020) C. Hai Ly et al.   Cell Metabolism

Cardiomyocyte Maturation

(2020) Yuxuan Guo et al.   CIRCULATION RESEARCH

Glycolysis-Independent Glucose Metabolism Distinguishes TE from ICM Fate during Mammalian Embryogenesis

(2020) Fangtao Chi et al.   DEVELOPMENTAL CELL

Metabolic changes in early neonatal life: NMR analysis of the neonatal metabolic profile to monitor postnatal metabolic adaptations

(2020) Ioanna Georgakopoulou et al.   Metabolomics

Metabolic Regulation of Tissue Stem Cells

(2020) Suzanne N. Shapira et al.   TRENDS IN CELL BIOLOGY

TET-Mediated Hypermethylation Primes SDH-Deficient Cells for HIF2α-Driven Mesenchymal Transition

(2020) Aurélie Morin et al.   Cell Reports

Metabolic regulation of epigenetic remodeling in immune cells

(2020) Emily C Britt et al.   CURRENT OPINION IN BIOTECHNOLOGY

Exploring the Influence of Cell Metabolism on Cell Fate through Protein Post-translational Modifications

(2020) Oscar A. Tarazona et al.   DEVELOPMENTAL CELL

Mechanisms of bone development and repair

(2020) Ankit Salhotra et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Metabolic Coordination of Cell Fate by α-Ketoglutarate-Dependent Dioxygenases

(2020) Sanjeethan C. Baksh et al.   TRENDS IN CELL BIOLOGY

A Single Metabolite which Modulates Lipid Metabolism Alters Hematopoietic Stem/Progenitor Cell Behavior and Promotes Lymphoid Reconstitution

(2020) Sonja Giger et al.   Stem Cell Reports

Functional Characterization of the Lin28/let-7 Circuit During Forelimb Regeneration in Ambystoma mexicanum and Its Influence on Metabolic Reprogramming

(2020) Hugo Varela-Rodríguez et al.   Frontiers in Cell and Developmental Biology

Glucose Metabolism Drives Histone Acetylation Landscape Transitions that Dictate Muscle Stem Cell Function

(2019) Nora Yucel et al.   Cell Reports

Recent advancements in understanding fin regeneration in zebrafish

(2019) Ivonne M. Sehring et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart

(2019) Hessel Honkoop et al.   eLife

Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging

(2018) Maria M. Mihaylova et al.   Cell Stem Cell

Characterizing the Key Metabolic Pathways of the Neonatal Mouse Heart Using a Quantitative Combinatorial Omics Approach

(2018) Maciej M. Lalowski et al.   Frontiers in Physiology

Maturation of Cardiac Energy Metabolism During Perinatal Development

(2018) Jérôme Piquereau et al.   Frontiers in Physiology

Krebs Cycle Reimagined: The Emerging Roles of Succinate and Itaconate as Signal Transducers

(2018) Michael P. Murphy et al.   CELL

Revisiting the role of metabolism during development

(2018) Hidenobu Miyazawa et al.   DEVELOPMENT

The metabolic programming of stem cells

(2017) Ng Shyh-Chang et al.   GENES & DEVELOPMENT

Role of Mitochondrial Metabolism in the Control of Early Lineage Progression and Aging Phenotypes in Adult Hippocampal Neurogenesis

(2017) Ruth Beckervordersandforth et al.   NEURON

A Fatty Acid Oxidation-Dependent Metabolic Shift Regulates Adult Neural Stem Cell Activity

(2017) Marlen Knobloch et al.   Cell Reports

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

(2016) Evanna L. Mills et al.   CELL

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

α-Ketoglutarate Accelerates the Initial Differentiation of Primed Human Pluripotent Stem Cells

(2016) Tara TeSlaa et al.   Cell Metabolism

Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

(2016) Vicky Lampropoulou et al.   Cell Metabolism

Molecular Criteria for Defining the Naive Human Pluripotent State

(2016) Thorold W. Theunissen et al.   Cell Stem Cell

Metabolic control of methylation and acetylation

(2016) Xiaoyang Su et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Relief of hypoxia by angiogenesis promotes neural stem cell differentiation by targeting glycolysis

(2016) Christian Lange et al.   EMBO JOURNAL

The importance of serine metabolism in cancer

(2016) Katherine R. Mattaini et al.   JOURNAL OF CELL BIOLOGY

Interplay between Metabolism and Epigenetics: A Nuclear Adaptation to Environmental Changes

(2016) Jean-Pierre Etchegaray et al.   MOLECULAR CELL

Metabolic regulation of stem cell function in tissue homeostasis and organismal ageing

(2016) Navdeep S. Chandel et al.   NATURE CELL BIOLOGY

The Warburg Effect: How Does it Benefit Cancer Cells?

(2016) Maria V. Liberti et al.   TRENDS IN BIOCHEMICAL SCIENCES

Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation

(2016) Xinde Zheng et al.   eLife

Glycolysis-Mediated Changes in Acetyl-CoA and Histone Acetylation Control the Early Differentiation of Embryonic Stem Cells

(2015) Arieh Moussaieff et al.   Cell Metabolism

Metabolic Switches Linked to Pluripotency and Embryonic Stem Cell Differentiation

(2015) Ng Shyh-Chang et al.   Cell Metabolism

The NAD+-Dependent SIRT1 Deacetylase Translates a Metabolic Switch into Regulatory Epigenetics in Skeletal Muscle Stem Cells

(2015) James G. Ryall et al.   Cell Stem Cell

The pluripotent state in mouse and human

(2015) K. C. Davidson et al.   DEVELOPMENT

T cell metabolism drives immunity

(2015) Michael D. Buck et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The metabolome regulates the epigenetic landscape during naive-to-primed human embryonic stem cell transition

(2015) Henrik Sperber et al.   NATURE CELL BIOLOGY

Metabolic determinants of embryonic development and stem cell fate

(2015) Clifford D. L. Folmes et al.   REPRODUCTION FERTILITY AND DEVELOPMENT

Blastocyst metabolism

(2015) David K. Gardner et al.   REPRODUCTION FERTILITY AND DEVELOPMENT

The Oxygen-Rich Postnatal Environment Induces Cardiomyocyte Cell-Cycle Arrest through DNA Damage Response

(2014) Bao N. Puente et al.   CELL

Cell-State-Specific Metabolic Dependency in Hematopoiesis and Leukemogenesis

(2014) Ying-Hua Wang et al.   CELL

Immune Modulation of Stem Cells and Regeneration

(2014) Arin B. Aurora et al.   Cell Stem Cell

Induction of autophagy supports the bioenergetic demands of quiescent muscle stem cell activation

(2014) Ann H Tang et al.   EMBO JOURNAL

Energetic and nutritional constraints on infant brain development: Implications for brain expansion during human evolution

(2014) Stephen C. Cunnane et al.   JOURNAL OF HUMAN EVOLUTION

Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells

(2014) Bryce W. Carey et al.   NATURE

Metabolic requirements for the maintenance of self-renewing stem cells

(2014) Keisuke Ito et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Writers and Readers of Histone Acetylation: Structure, Mechanism, and Inhibition

(2014) R. Marmorstein et al.   Cold Spring Harbor Perspectives in Biology

Erasers of Histone Acetylation: The Histone Deacetylase Enzymes

(2014) E. Seto et al.   Cold Spring Harbor Perspectives in Biology

Serine, but Not Glycine, Supports One-Carbon Metabolism and Proliferation of Cancer Cells

(2014) Christiaan F. Labuschagne et al.   Cell Reports

Regulation of the pentose phosphate pathway in cancer

(2014) Peng Jiang et al.   Protein & Cell

Parallels between embryo and cancer cell metabolism

(2013) Danielle G. Smith et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

SDH Mutations Establish a Hypermethylator Phenotype in Paraganglioma

(2013) Eric Letouzé et al.   CANCER CELL

Influence of Metabolism on Epigenetics and Disease

(2013) William G. Kaelin et al.   CELL

Mitochondrial Regulation in Pluripotent Stem Cells

(2013) Xiuling Xu et al.   Cell Metabolism

Satellite Cells and the Muscle Stem Cell Niche

(2013) Hang Yin et al.   PHYSIOLOGICAL REVIEWS

Succinate: a metabolic signal in inflammation

(2013) Evanna Mills et al.   TRENDS IN CELL BIOLOGY

Meis1 regulates the metabolic phenotype and oxidant defense of hematopoietic stem cells

(2012) F. Kocabas et al.   BLOOD

Metabolic Regulation of Epigenetics

(2012) Chao Lu et al.   Cell Metabolism

Physiology of Transition from Intrauterine to Extrauterine Life

(2012) Noah H. Hillman et al.   CLINICS IN PERINATOLOGY

HIF1α induced switch from bivalent to exclusively glycolytic metabolism during ESC-to-EpiSC/hESC transition

(2012) Wenyu Zhou et al.   EMBO JOURNAL

Inhibition of  -KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors

(2012) M. Xiao et al.   GENES & DEVELOPMENT

Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis

(2012) Marlen Knobloch et al.   NATURE

Metabolic differentiation in the embryonic retina

(2012) Michalis Agathocleous et al.   NATURE CELL BIOLOGY

Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation

(2011) Sophia Y. Lunt et al.   Annual Review of Cell and Developmental Biology

Specific metabolic rates of major organs and tissues across adulthood: evaluation by mechanistic model of resting energy expenditure

(2010) ZiMian Wang et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Histone Methyl Transferases and Demethylases; Can They Link Metabolism and Transcription?

(2010) Raffaele Teperino et al.   Cell Metabolism

The Distinct Metabolic Profile of Hematopoietic Stem Cells Reflects Their Location in a Hypoxic Niche

(2010) Tugba Simsek et al.   Cell Stem Cell

Primary contribution to zebrafish heart regeneration by gata4 + cardiomyocytes

(2010) Kazu Kikuchi et al.   NATURE

Advances in understanding tissue regenerative capacity and mechanisms in animals

(2010) Kenneth D. Poss   NATURE REVIEWS GENETICS

Physiological and biochemical aspects of hydroxylations and demethylations catalyzed by human 2-oxoglutarate oxygenases

(2010) Christoph Loenarz et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Role of Hypoxia in Development of the Mammalian Embryo

(2009) Sally L. Dunwoodie   DEVELOPMENTAL CELL

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Mitochondria in early mammalian development

(2008) Jonathan Van Blerkom   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY