Myc as a Regulator of Ribosome Biogenesis and Cell Competition: A Link to Cancer

Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis

(2020) Richard Y. Ebright et al.   SCIENCE

Myc is dispensable for cardiomyocyte development but rescues Mycn-deficient hearts through functional replacement and cell competition

(2019) Noelia Muñoz-Martín et al.   DEVELOPMENT

Drosophila melanogaster: A Model Organism to Study Cancer

(2019) Zhasmine Mirzoyan et al.   Frontiers in Genetics

Emerging Role of Eukaryote Ribosomes in Translational Control

(2019) Nicole Dalla Venezia et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Stem cell competition orchestrates skin homeostasis and ageing

(2019) Nan Liu et al.   NATURE

Distinct modes of cell competition shape mammalian tissue morphogenesis

(2019) Stephanie J. Ellis et al.   NATURE

Oncogenic MYC Induces the Impaired Ribosome Biogenesis Checkpoint and Stabilizes p53, Independent of Increased Ribosome Content.

(2019) Carmen Morcelle et al.   CANCER RESEARCH

The nucleolus: a central response hub for the stressors that drive cancer progression

(2019) Shannon E. Weeks et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Interspecies analysis of MYC targets identifies tRNA synthetases as mediators of growth and survival in MYC-overexpressing cells

(2019) Jonathan Zirin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ribosomopathies: Old Concepts, New Controversies

(2019) Katherine I. Farley-Barnes et al.   TRENDS IN GENETICS

Drosophila RpS12 controls translation, growth, and cell competition through Xrp1

(2019) Zhejun Ji et al.   PLoS Genetics

MYC-induced metabolic stress and tumorigenesis

(2018) Adam J. Wolpaw et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Mechanical cell competition

(2018) Catarina Brás-Pereira et al.   CURRENT OPINION IN CELL BIOLOGY

Translational Control in Cancer

(2018) Nathaniel Robichaud et al.   Cold Spring Harbor Perspectives in Biology

A Regulatory Response to Ribosomal Protein Mutations Controls Translation, Growth, and Cell Competition

(2018) Chang-Hyun Lee et al.   DEVELOPMENTAL CELL

Spatially Restricted Regulation of Spätzle/Toll Signaling during Cell Competition

(2018) Lale Alpar et al.   DEVELOPMENTAL CELL

The MYC transcription factor network: balancing metabolism, proliferation and oncogenesis

(2018) Patrick A. Carroll et al.   Frontiers of Medicine

The Genetic Landscape of Diamond-Blackfan Anemia

(2018) Jacob C. Ulirsch et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Cell competition: Emerging mechanisms to eliminate neighbors

(2018) Rina Nagata et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Inhibitors of ribosome biogenesis repress the growth of MYCN-amplified neuroblastoma

(2018) Øyvind H. Hald et al.   ONCOGENE

Xrp1 is a transcription factor required for cell competition-driven elimination of loser cells

(2018) Ludovic Baillon et al.   Scientific Reports

c-Myc-Dependent Cell Competition in Human Cancer Cells

(2017) Manish S. Patel et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Ribosomopathies: There’s strength in numbers

(2017) Eric W. Mills et al.   SCIENCE

A B Cell Regulome Links Notch to Downstream Oncogenic Pathways in Small B Cell Lymphomas

(2017) Russell J.H. Ryan et al.   Cell Reports

The Stearoyl-CoA Desaturase-1 (Desat1) in Drosophila cooperated with Myc to Induce Autophagy and Growth, a Potential New Link to Tumor Survival

(2017) Chiara Paiardi et al.   Genes

RNA Pseudouridylation in Physiology and Medicine: For Better and for Worse

(2017) et al.   Genes

Human Cancer Cells Signal Their Competitive Fitness Through MYC Activity

(2017) Simone Di Giacomo et al.   Scientific Reports

Cell Competition: Mechanisms and Physiological Roles

(2016) Cristina Clavería et al.   Annual Review of Cell and Developmental Biology

Long-Term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression

(2016) Tikvah K. Hayes et al.   CANCER CELL

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

Cell Competition and Its Role in the Regulation of Cell Fitness from Development to Cancer

(2016) Aida Di Gregorio et al.   DEVELOPMENTAL CELL

The relationship between the nucleolus and cancer: Current evidence and emerging paradigms

(2016) Ines Orsolic et al.   SEMINARS IN CANCER BIOLOGY

A liaison between mTOR signaling, ribosome biogenesis and cancer

(2015) Antonio Gentilella et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

snoRNAs are a novel class of biologically relevant Myc targets

(2015) Eva K Herter et al.   BMC BIOLOGY

Elimination of Unfit Cells Maintains Tissue Health and Prolongs Lifespan

(2015) Marisa M. Merino et al.   CELL

MYC and metabolism on the path to cancer

(2015) Annie L. Hsieh et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

‘View From A Bridge’: A New Perspective on Eukaryotic rRNA Base Modification

(2015) Sunny Sharma et al.   TRENDS IN BIOCHEMICAL SCIENCES

MYC, Metabolism, and Cancer

(2015) Z. E. Stine et al.   Cancer Discovery

Combination Therapy Targeting Ribosome Biogenesis and mRNA Translation Synergistically Extends Survival in MYC-Driven Lymphoma

(2015) J. R. Devlin et al.   Cancer Discovery

LKB1 promotes cell survival by modulating TIF-IA-mediated pre-ribosomal RNA synthesis under uridine downregulated conditions

(2015) Fakeng Liu et al.   Oncotarget

Supercompetitor Status of Drosophila Myc Cells Requires p53 as a Fitness Sensor to Reprogram Metabolism and Promote Viability

(2014) Claire de la Cova et al.   Cell Metabolism

Cell competition: how to eliminate your neighbours

(2014) M. Amoyel et al.   DEVELOPMENT

An ancient defense system eliminates unfit cells from developing tissues during cell competition

(2014) S. N. Meyer et al.   SCIENCE

Socializing with MYC: Cell Competition in Development and as a Model for Premalignant Cancer

(2014) L. A. Johnston   Cold Spring Harbor Perspectives in Medicine

MYC Regulation of Cell Growth through Control of Transcription by RNA Polymerases I and III

(2014) K. J. Campbell et al.   Cold Spring Harbor Perspectives in Medicine

MYC Activation Is a Hallmark of Cancer Initiation and Maintenance

(2014) M. Gabay et al.   Cold Spring Harbor Perspectives in Medicine

dMyc expression in the fat body affects DILP2 release and increases the expression of the fat desaturase Desat1 resulting in organismal growth

(2013) Federica Parisi et al.   DEVELOPMENTAL BIOLOGY

Eukaryotic ribosome biogenesis at a glance

(2013) E. Thomson et al.   JOURNAL OF CELL SCIENCE

Structures of the human and Drosophila 80S ribosome

(2013) Andreas M. Anger et al.   NATURE

Myc-driven endogenous cell competition in the early mammalian embryo

(2013) Cristina Clavería et al.   NATURE

Ribosomal protein S6 kinase activity controls the ribosome biogenesis transcriptional program

(2013) C Chauvin et al.   ONCOGENE

RNA polymerase I termination: Where is the end?

(2012) Attila Németh et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Rrp5p, Noc1p and Noc2p form a protein module which is part of early large ribosomal subunit precursors in S. cerevisiae

(2012) Thomas Hierlmeier et al.   NUCLEIC ACIDS RESEARCH

Translational Control in Cancer Etiology

(2012) D. Ruggero   Cold Spring Harbor Perspectives in Biology

Drosophila insulin and target of rapamycin (TOR) pathways regulate GSK3 beta activity to control Myc stability and determine Myc expression in vivo

(2011) Federica Parisi et al.   BMC BIOLOGY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Oncogenic PIK3CA-driven mammary tumors frequently recur via PI3K pathway–dependent and PI3K pathway–independent mechanisms

(2011) Pixu Liu et al.   NATURE MEDICINE

PI3K-targeted therapy can be evaded by gene amplification along the MYC-eukaryotic translation initiation factor 4E (eIF4E) axis

(2011) N. Ilic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AKT Promotes rRNA Synthesis and Cooperates with c-MYC to Stimulate Ribosome Biogenesis in Cancer

(2011) J. C. Chan et al.   Science Signaling

Eukaryotic 5S rRNA biogenesis

(2011) Martin Ciganda et al.   Wiley Interdisciplinary Reviews-RNA

The box C/D and H/ACA snoRNPs: key players in the modification, processing and the dynamic folding of ribosomal RNA

(2011) Nicholas J. Watkins et al.   Wiley Interdisciplinary Reviews-RNA

Ribosomopathies: human disorders of ribosome dysfunction

(2010) A. Narla et al.   BLOOD

The lethal giant larvae tumour suppressor mutation requires dMyc oncoprotein to promote clonal malignancy

(2010) Francesca Froldi et al.   BMC BIOLOGY

Evidence for a Growth-Stabilizing Regulatory Feedback Mechanism between Myc and Yorkie, the Drosophila Homolog of Yap

(2010) Ricardo M. Neto-Silva et al.   DEVELOPMENTAL CELL

Flower Forms an Extracellular Code that Reveals the Fitness of a Cell to its Neighbors in Drosophila

(2010) Christa Rhiner et al.   DEVELOPMENTAL CELL

Drosophila SPARC Is a Self-Protective Signal Expressed by Loser Cells during Cell Competition

(2010) Marta Portela et al.   DEVELOPMENTAL CELL

The Hippo Signaling Pathway in Development and Cancer

(2010) Duojia Pan   DEVELOPMENTAL CELL

Deregulation of oncogene-induced senescence and p53 translational control in X-linked dyskeratosis congenita

(2010) Cristian Bellodi et al.   EMBO JOURNAL

Linking pseudouridine synthases to growth, development and cell competition

(2010) Giuseppe Tortoriello et al.   FEBS Journal

dMyc Functions Downstream of Yorkie to Promote the Supercompetitive Behavior of Hippo Pathway Mutant Cells

(2010) Marcello Ziosi et al.   PLoS Genetics

Driving ribosome assembly

(2009) Dieter Kressler et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Super competition as a possible mechanism to pioneer precancerous fields

(2009) C. Rhiner et al.   CARCINOGENESIS

Intrinsic Tumor Suppression and Epithelial Maintenance by Endocytic Activation of Eiger/TNF Signaling in Drosophila

(2009) Tatsushi Igaki et al.   DEVELOPMENTAL CELL

Identification of Domains Responsible for Ubiquitin-Dependent Degradation of dMyc by Glycogen Synthase Kinase 3  and Casein Kinase 1 Kinases

(2009) M. Galletti et al.   MOLECULAR AND CELLULAR BIOLOGY

A  -catenin/TCF-coordinated chromatin loop at MYC integrates 5' and 3' Wnt responsive enhancers

(2009) G. S. Yochum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nucleolus, Ribosomes, and Cancer

(2008) Lorenzo Montanaro et al.   AMERICAN JOURNAL OF PATHOLOGY

eIF4E, the mRNA cap-binding protein: from basic discovery to translational researchThis paper is one of a selection of papers published in this Special Issue, entitled CSBMCB — Systems and Chemical Biology, and has undergone the Journal's usual peer review process.

(2008) Nahum Sonenberg   Biochemistry and Cell Biology

Myc's broad reach

(2008) M. Eilers et al.   GENES & DEVELOPMENT

Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency

(2008) Maria Barna et al.   NATURE

Translation initiation by the c-myc mRNA internal ribosome entry sequence and the poly(A) tail

(2008) C. Thoma et al.   RNA

Activation of cap-independent translation by variant eukaryotic initiation factor 4G in vivo

(2008) C. Kaiser et al.   RNA

Combined Analysis of Murine and Human Microarrays and ChIP Analysis Reveals Genes Associated with the Ability of MYC To Maintain Tumorigenesis

(2008) Chi-Hwa Wu et al.   PLoS Genetics

Drosophila growth and development in the absence of dMyc and dMnt

(2007) Sarah B. Pierce et al.   DEVELOPMENTAL BIOLOGY