Technoeconomic comparison of optimised bioreactor-filtration systems for mAb production

Integrated continuous biomanufacturing on pilot scale for acid‐sensitive monoclonal antibodies

(2022) Hubert Schwarz et al.   BIOTECHNOLOGY AND BIOENGINEERING

Dynamic simulation, optimisation AND ECONOMIC ANALYSIS of FED-BATCH vs. perfusion bioreactors for advanced mAb manufacturing

(2022) Wil Jones et al.   COMPUTERS & CHEMICAL ENGINEERING

Economic Analysis of Membrane-Based Separation of Biocatalyst: Mode of Operation and Stage Configuration

(2022) MSR Sridhar Kapavarapu et al.   INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH

Model predictive control for steady-state performance in integrated continuous bioprocesses

(2022) Magdalena Pappenreiter et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Process design of a fully integrated continuous biopharmaceutical process using economic and ecological impact assessment

(2022) Chaoying Ding et al.   BIOTECHNOLOGY AND BIOENGINEERING

Hybrid Modeling of CHO Cell Cultivation in Monoclonal Antibody Production with an Impurity Generation Module

(2022) Kozue Okamura et al.   INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH

mAb Production Modeling and Design Space Evaluation Including Glycosylation Process

(2021) Ou Yang et al.   Processes

Osmolality Effects on CHO Cell Growth, Cell Volume, Antibody Productivity and Glycosylation

(2021) Sakhr Alhuthali et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Recent advances in integrated process analytical techniques, modeling, and control strategies to enable continuous biomanufacturing of monoclonal antibodies

(2021) Viki Chopda et al.   JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY

Predictive macroscopic modeling of cell growth, metabolism and monoclonal antibody production: Case study of a CHO fed-batch production

(2021) Bassem Ben Yahia et al.   METABOLIC ENGINEERING

Integration and digitalization in the manufacturing of therapeutic proteins

(2021) Harini Narayanan et al.   CHEMICAL ENGINEERING SCIENCE

Integrated design of biopharmaceutical manufacturing processes: Operation modes and process configurations for monoclonal antibody production

(2021) Sara Badr et al.   COMPUTERS & CHEMICAL ENGINEERING

Cost–Benefit Analysis of Monoclonal Antibody Cultivation Scenarios in Terms of Life Cycle Environmental Impact and Operating Cost

(2021) Eri Amasawa et al.   ACS Sustainable Chemistry & Engineering

A dynamic model linking cell growth to intracellular metabolism and extracellular by‐product accumulation

(2020) João R. C. Ramos et al.   BIOTECHNOLOGY AND BIOENGINEERING

A dynamic EFM-based model for antibody producing cell lines and model based evaluation of fed-batch processes

(2020) Denizhan Yilmaz et al.   BIOCHEMICAL ENGINEERING JOURNAL

Pretreatments for enhancing clarification efficiency of depth filtration during production of monoclonal antibody therapeutics

(2020) Sandeep R. Hadpe et al.   BIOTECHNOLOGY PROGRESS

A PSE perspective for the efficient production of monoclonal antibodies: integration of process, cell, and product design aspects

(2020) Sara Badr et al.   Current Opinion in Chemical Engineering

Dynamic Modeling of CHO Cell Metabolism Using the Hybrid Cybernetic Approach With a Novel Elementary Mode Analysis Strategy

(2020) Juan A. Martínez et al.   Frontiers in Bioengineering and Biotechnology

Multi-stage and multi-objective decision-support tool for biopharmaceutical drug product manufacturing: Equipment technology evaluation

(2020) Philipp Zürcher et al.   CHEMICAL ENGINEERING RESEARCH & DESIGN

An update on antiviral antibody-based biopharmaceuticals

(2020) Shahrzad Ahangarzadeh et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Economic Analysis of Batch and Continuous Biopharmaceutical Antibody Production: a Review

(2019) Ou Yang et al.   Journal of Pharmaceutical Innovation

Comparison between Batch and Continuous Monoclonal Antibody Production and Economic Analysis

(2019) Ou Yang et al.   INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH

Repurposing fed‐batch media and feeds for highly productive CHO perfusion processes

(2019) Marcel Kuiper et al.   BIOTECHNOLOGY PROGRESS

Dynamic modelling, simulation and economic evaluation of two CHO cell-based production modes towards developing biopharmaceutical manufacturing processes

(2019) Haruku Shirahata et al.   CHEMICAL ENGINEERING RESEARCH & DESIGN

Implementation of Fully Integrated Continuous Antibody Processing: Effects on Productivity and COGm

(2018) Lindsay Arnold et al.   Biotechnology Journal

Model-Based Dynamic Optimization of Monoclonal Antibodies Production in Semibatch Operation—Use of Reformulation Techniques

(2018) Chrysoula D. Kappatou et al.   INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH

Implementation of Fully Integrated Continuous Antibody Processing: Effects on Productivity and COGm

(2018) Lindsay Arnold et al.   Biotechnology Journal

Progression of continuous downstream processing of monoclonal antibodies: current trends and challenges

(2018) Balaji Somasundaram et al.   BIOTECHNOLOGY AND BIOENGINEERING

The Current Scientific and Regulatory Landscape in Advancing Integrated Continuous Biopharmaceutical Manufacturing

(2018) Adam C. Fisher et al.   TRENDS IN BIOTECHNOLOGY

Process integration and control in continuous bioprocessing

(2018) Anurag S Rathore et al.   Current Opinion in Chemical Engineering

Recombinant Antibody Production in CHO and NS0 Cells: Differences and Similarities

(2018) Venkata Gayatri Dhara et al.   BIODRUGS

Combined effects of glycosylation precursors and lactate on the glycoprofile of IgG produced by CHO cells

(2018) Liang Zhang et al.   JOURNAL OF BIOTECHNOLOGY

Modeling of complex antibody elution behavior under high protein load densities in ion exchange chromatography using an asymmetric activity coefficient

(2017) Thiemo C. Huuk et al.   Biotechnology Journal

Techno-economic evaluation of a combined bioprocess for fermentative hydrogen production from food waste

(2016) Wei Han et al.   BIORESOURCE TECHNOLOGY

Life-cycle and cost of goods assessment of fed-batch and perfusion-based manufacturing processes for mAbs

(2016) Phumthep Bunnak et al.   BIOTECHNOLOGY PROGRESS

Assessment of Overall Heat Transfer Coefficient Models to Predict the Performance of Laboratory-Scale Jacketed Batch Reactors

(2016) Michael Johnson et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Continuous downstream processing for high value biological products: A Review

(2015) Andrew L. Zydney   BIOTECHNOLOGY AND BIOENGINEERING

Perspectives on integrated continuous bioprocessing—opportunities and challenges

(2015) Andrew L Zydney   Current Opinion in Chemical Engineering

Amino acid and glucose metabolism in fed-batch CHO cell culture affects antibody production and glycosylation

(2014) Yuzhou Fan et al.   BIOTECHNOLOGY AND BIOENGINEERING

On the model-based optimization of secreting mammalian cell (GS-NS0) cultures

(2014) A. Kiparissides et al.   BIOTECHNOLOGY AND BIOENGINEERING

Intracellular metabolic flux analysis of CHO cells supplemented with wheat hydrolysates for improved mAb production and cell-growth

(2014) Hae Woo Lee et al.   JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY

A tutorial review of economic model predictive control methods

(2014) Matthew Ellis et al.   JOURNAL OF PROCESS CONTROL

Maximizing mouse embryonic stem cell production in a stirred tank reactor by controlling dissolved oxygen concentration and continuous perfusion operation

(2013) Ana Fernandes-Platzgummer et al.   BIOCHEMICAL ENGINEERING JOURNAL

Metabolic pathway analysis and reduction for mammalian cell cultures—Towards macroscopic modeling

(2013) Hongxing Niu et al.   CHEMICAL ENGINEERING SCIENCE

Modeling and control of crystal shape in continuous protein crystallization

(2013) Joseph Sang-Il Kwon et al.   CHEMICAL ENGINEERING SCIENCE

Current status and future trends for disposable technology in the biopharmaceutical industry

(2013) Nigel Allison et al.   JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY

Integrated continuous production of recombinant therapeutic proteins

(2012) Veena Warikoo et al.   BIOTECHNOLOGY AND BIOENGINEERING

Single-use disposable technologies for biopharmaceutical manufacturing

(2012) Abhinav A. Shukla et al.   TRENDS IN BIOTECHNOLOGY

Techno-economic analysis of a membrane-integrated bioreactor system for production of lactic acid from sugarcane juice

(2011) Jaya Sikder et al.   BIOCHEMICAL ENGINEERING JOURNAL

Economic comparison of diagnostic antibody production in perfusion stirred tank and in hollow fiber bioreactor processes

(2011) Raisa Vermasvuori et al.   BIOTECHNOLOGY PROGRESS

Improvement of state profile accuracy in nonlinear dynamic optimization with the quasi-sequential approach

(2010) Martin Bartl et al.   AICHE JOURNAL

Systematic development of predictive mathematical models for animal cell cultures

(2010) Cleo Kontoravdi et al.   COMPUTERS & CHEMICAL ENGINEERING

Multi-Scale Modeling of Heterogeneities in Mammalian Cell Culture Processes

(2010) Srinivas Karra et al.   INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH

A detailed metabolic flux analysis of an underdetermined network of CHO cells

(2010) F. Zamorano et al.   JOURNAL OF BIOTECHNOLOGY

Modeling kinetics of a large-scale fed-batch CHO cell culture by Markov chain Monte Carlo method

(2009) Zizhuo Xing et al.   BIOTECHNOLOGY PROGRESS

Therapeutic antibodies: successes, limitations and hopes for the future

(2009) Patrick Chames et al.   BRITISH JOURNAL OF PHARMACOLOGY

Metabolic flux-based modeling of mAb production during batch and fed-batch operations

(2008) Penny Dorka et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Simpler noninstrumented batch and semicontinuous cultures provide mammalian cell kinetic data comparable to continuous and perfusion cultures

(2008) Olivier Henry et al.   BIOTECHNOLOGY PROGRESS

Water desalination cost literature: review and assessment

(2008) Ioannis C. Karagiannis et al.   DESALINATION

Upstream processes in antibody production: Evaluation of critical parameters

(2007) Era Jain et al.   BIOTECHNOLOGY ADVANCES