Integrated design of biopharmaceutical manufacturing processes: Operation modes and process configurations for monoclonal antibody production

Integrated design of biopharmaceutical manufacturing processes: Operation modes and process configurations for monoclonal antibody production

(2021) Sara Badr et al.   COMPUTERS & CHEMICAL ENGINEERING

A PSE perspective for the efficient production of monoclonal antibodies: integration of process, cell, and product design aspects

(2020) Sara Badr et al.   Current Opinion in Chemical Engineering

Multi-stage and multi-objective decision-support tool for biopharmaceutical drug product manufacturing: Equipment technology evaluation

(2020) Philipp Zürcher et al.   CHEMICAL ENGINEERING RESEARCH & DESIGN

Sustainability in the biopharmaceutical industry: Seeking a holistic perspective

(2019) Fergal Lalor et al.   BIOTECHNOLOGY ADVANCES

Dynamic modelling, simulation and economic evaluation of two CHO cell-based production modes towards developing biopharmaceutical manufacturing processes

(2019) Haruku Shirahata et al.   CHEMICAL ENGINEERING RESEARCH & DESIGN

Perfusion cell culture for the production of conjugated recombinant fusion proteins reduces clipping and quality heterogeneity compared to batch-mode processes

(2019) Jean-Marc Bielser et al.   JOURNAL OF BIOTECHNOLOGY

Evaluation of process simulation as a decisional tool for biopharmaceutical contract development and manufacturing organizations

(2019) Kristina Pleitt et al.   BIOCHEMICAL ENGINEERING JOURNAL

Quantitative characterization of leachables sinks in biopharmaceutical downstream processing

(2019) Kushal Paudel et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Economics and ecology: Modelling of continuous primary recovery and capture scenarios for recombinant antibody production

(2019) A.L. Cataldo et al.   JOURNAL OF BIOTECHNOLOGY

Engineering challenges in therapeutic protein product and process design

(2019) Maria M. Papathanasiou et al.   Current Opinion in Chemical Engineering

Perfusion Cell Culture Decreases Process and Product Heterogeneity in a Head-to-Head Comparison With Fed-Batch

(2018) Jason Walther et al.   Biotechnology Journal

Challenges and opportunities in biopharmaceutical manufacturing control

(2018) Moo Sun Hong et al.   COMPUTERS & CHEMICAL ENGINEERING

Continuous integrated manufacturing of therapeutic proteins

(2018) Daniel Johannes Karst et al.   CURRENT OPINION IN BIOTECHNOLOGY

The Increasingly Human and Profitable Monoclonal Antibody Market

(2018) António L. Grilo et al.   TRENDS IN BIOTECHNOLOGY

Perfusion Cell Culture Decreases Process and Product Heterogeneity in a Head-to-Head Comparison With Fed-Batch

(2018) Jason Walther et al.   Biotechnology Journal

The Current Scientific and Regulatory Landscape in Advancing Integrated Continuous Biopharmaceutical Manufacturing

(2018) Adam C. Fisher et al.   TRENDS IN BIOTECHNOLOGY

Process integration and control in continuous bioprocessing

(2018) Anurag S Rathore et al.   Current Opinion in Chemical Engineering

Biopharmaceutical benchmarks 2018

(2018) Gary Walsh   NATURE BIOTECHNOLOGY

Strategies to enhance productivity and modify product quality in therapeutic proteins

(2018) Devesh Radhakrishnan et al.   Current Opinion in Chemical Engineering

Mechanistic modeling and applications for CHO cell culture development and production

(2018) Sha Sha et al.   Current Opinion in Chemical Engineering

Alternative generation and multiobjective evaluation using a design framework: Case study on sterile filling processes of biopharmaceuticals

(2018) Haruku Shirahata et al.   COMPUTERS & CHEMICAL ENGINEERING

The Market of Biopharmaceutical Medicines: A Snapshot of a Diverse Industrial Landscape

(2017) Evelien Moorkens et al.   Frontiers in Pharmacology

Comparison of batch and continuous multi-column protein A capture processes by optimal design

(2016) Daniel Baur et al.   Biotechnology Journal

Life-cycle and cost of goods assessment of fed-batch and perfusion-based manufacturing processes for mAbs

(2016) Phumthep Bunnak et al.   BIOTECHNOLOGY PROGRESS

Cost evaluation of antibody production processes in different operation modes

(2016) Stephan Klutz et al.   CHEMICAL ENGINEERING SCIENCE

Downstream process development strategies for effective bioprocesses: Trends, progress, and combinatorial approaches

(2016) Pascal Baumann et al.   ENGINEERING IN LIFE SCIENCES

High-density mammalian cell cultures in stirred-tank bioreactor without external pH control

(2016) Sen Xu et al.   JOURNAL OF BIOTECHNOLOGY

Model based adaptive control of a continuous capture process for monoclonal antibodies production

(2016) Fabian Steinebach et al.   JOURNAL OF CHROMATOGRAPHY A

Comparison of batch and continuous multi-column protein A capture processes by optimal design

(2016) Daniel Baur et al.   Biotechnology Journal

The future of industrial bioprocessing: Batch or continuous?

(2015) Matthew S. Croughan et al.   BIOTECHNOLOGY AND BIOENGINEERING

Continuous downstream processing for high value biological products: A Review

(2015) Andrew L. Zydney   BIOTECHNOLOGY AND BIOENGINEERING

Very high cell density perfusion of CHO cells anchored in a non-woven matrix-based bioreactor

(2015) Ye Zhang et al.   JOURNAL OF BIOTECHNOLOGY

End-to-end integrated fully continuous production of recombinant monoclonal antibodies

(2015) Rahul Godawat et al.   JOURNAL OF BIOTECHNOLOGY

Optimising the design and operation of semi-continuous affinity chromatography for clinical and commercial manufacture

(2013) James Pollock et al.   JOURNAL OF CHROMATOGRAPHY A

Fed-batch and perfusion culture processes: Economic, environmental, and operational feasibility under uncertainty

(2012) James Pollock et al.   BIOTECHNOLOGY AND BIOENGINEERING

Integrated continuous production of recombinant therapeutic proteins

(2012) Veena Warikoo et al.   BIOTECHNOLOGY AND BIOENGINEERING

A fast and accurate solver for the general rate model of column liquid chromatography

(2010) Eric von Lieres et al.   COMPUTERS & CHEMICAL ENGINEERING