Economic Analysis of Batch and Continuous Biopharmaceutical Antibody Production: a Review

Perfusion mammalian cell culture for recombinant protein manufacturing – A critical review

(2018) Jean-Marc Bielser et al.   BIOTECHNOLOGY ADVANCES

Single pass diafiltration integrated into a fully continuous mAb purification process

(2018) Joanna Rucker-Pezzini et al.   BIOTECHNOLOGY AND BIOENGINEERING

Implementation of Fully Integrated Continuous Antibody Processing: Effects on Productivity and COGm

(2018) Lindsay Arnold et al.   Biotechnology Journal

Aqueous Two-Phase Systems at Large Scale: Challenges and Opportunities

(2018) Mario A. Torres-Acosta et al.   Biotechnology Journal

Modeling the Downstream Processing of Monoclonal Antibodies Reveals Cost Advantages for Continuous Methods for a Broad Range of Manufacturing Scales

(2018) Jonathan Hummel et al.   Biotechnology Journal

Economic evaluation of the primary recovery of tetracycline with traditional and novel aqueous two-phase systems

(2018) Mario A. Torres-Acosta et al.   SEPARATION AND PURIFICATION TECHNOLOGY

Implementation of Fully Integrated Continuous Antibody Processing: Effects on Productivity and COGm

(2018) Lindsay Arnold et al.   Biotechnology Journal

Aqueous Two-Phase Systems at Large Scale: Challenges and Opportunities

(2018) Mario A. Torres-Acosta et al.   Biotechnology Journal

Modeling the Downstream Processing of Monoclonal Antibodies Reveals Cost Advantages for Continuous Methods for a Broad Range of Manufacturing Scales

(2018) Jonathan Hummel et al.   Biotechnology Journal

Progression of continuous downstream processing of monoclonal antibodies: current trends and challenges

(2018) Balaji Somasundaram et al.   BIOTECHNOLOGY AND BIOENGINEERING

Multi-objective Optimisation for Biopharmaceutical Manufacturing under Uncertainty

(2018) Songsong Liu et al.   COMPUTERS & CHEMICAL ENGINEERING

The Current Scientific and Regulatory Landscape in Advancing Integrated Continuous Biopharmaceutical Manufacturing

(2018) Adam C. Fisher et al.   TRENDS IN BIOTECHNOLOGY

Process integration and control in continuous bioprocessing

(2018) Anurag S Rathore et al.   Current Opinion in Chemical Engineering

Non-protein A purification platform for continuous processing of monoclonal antibody therapeutics

(2018) Nikhil Kateja et al.   JOURNAL OF CHROMATOGRAPHY A

Transfer of a three step mAb chromatography process from batch to continuous: Optimizing productivity to minimize consumable requirements

(2017) Xhorxhi Gjoka et al.   JOURNAL OF BIOTECHNOLOGY

Novel aspects and future trends in the use of aqueous two-phase systems as a bioengineering tool

(2017) José González-Valdez et al.   JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY

Continuous countercurrent tangential chromatography for mixed mode post-capture operations in monoclonal antibody purification

(2017) Amit K. Dutta et al.   JOURNAL OF CHROMATOGRAPHY A

Investigation of single-pass tangential flow filtration (SPTFF) as an inline concentration step for cell culture harvest

(2017) Abhiram Arunkumar et al.   JOURNAL OF MEMBRANE SCIENCE

Development of a CHO-Based Cell-Free Platform for Synthesis of Active Monoclonal Antibodies

(2017) Rey W. Martin et al.   ACS Synthetic Biology

Monoclonal Antibodies Production Platforms: An Opportunity Study of a Non-Protein-A Chromatographic Platform Based on Process Economics

(2017) António L. Grilo et al.   Biotechnology Journal

Cell free protein synthesis: a viable option for stratified medicines manufacturing?

(2017) Olotu W .Ogonah et al.   Current Opinion in Chemical Engineering

Cell-free synthesis of functional antibodies using a coupled in vitro transcription-translation system based on CHO cell lysates

(2017) M. Stech et al.   Scientific Reports

Characterization and comparison of ATF and TFF in stirred bioreactors for continuous mammalian cell culture processes

(2016) Daniel J. Karst et al.   BIOCHEMICAL ENGINEERING JOURNAL

Integrated economic and experimental framework for screening of primary recovery technologies for high cell density CHO cultures

(2016) Daria Popova et al.   Biotechnology Journal

An integrated practical implementation of continuous aqueous two-phase systems for the recovery of human IgG: From the microdevice to a multistage bench-scale mixer-settler device

(2016) Edith Espitia-Saloma et al.   Biotechnology Journal

Continuous counter-current chromatography for capture and polishing steps in biopharmaceutical production

(2016) Fabian Steinebach et al.   Biotechnology Journal

Life-cycle and cost of goods assessment of fed-batch and perfusion-based manufacturing processes for mAbs

(2016) Phumthep Bunnak et al.   BIOTECHNOLOGY PROGRESS

Identifying a robust design space for glycosylation during monoclonal antibody production

(2016) Melissa M. St. Amand et al.   BIOTECHNOLOGY PROGRESS

Performance optimization of continuous countercurrent tangential chromatography for antibody capture

(2016) Amit K. Dutta et al.   BIOTECHNOLOGY PROGRESS

Biopharmaceuticals from microorganisms: from production to purification

(2016) Angela Faustino Jozala et al.   BRAZILIAN JOURNAL OF MICROBIOLOGY

Continuous viral inactivation at low pH value in antibody manufacturing

(2016) Stephan Klutz et al.   CHEMICAL ENGINEERING AND PROCESSING

Cost evaluation of antibody production processes in different operation modes

(2016) Stephan Klutz et al.   CHEMICAL ENGINEERING SCIENCE

Integrated Optimization of Upstream and Downstream Processing in Biopharmaceutical Manufacturing under Uncertainty: A Chance Constrained Programming Approach

(2016) Songsong Liu et al.   INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH

Advancing pharmaceutical quality: An overview of science and research in the U.S. FDA’s Office of Pharmaceutical Quality

(2016) Adam C. Fisher et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Concentrated fed-batch cell culture increases manufacturing capacity without additional volumetric capacity

(2016) William C. Yang et al.   JOURNAL OF BIOTECHNOLOGY

Integrating Design of Experiments and Principal Component Analysis to Reduce Downstream Cost of Goods in Monoclonal Antibody Production

(2016) Ying Fei Li et al.   Journal of Pharmaceutical Innovation

Decision-Support Method for the Choice Between Single-Use and Multi-Use Technologies in Sterile Drug Product Manufacturing

(2016) Haruku Shirahata et al.   Journal of Pharmaceutical Innovation

Integrated economic and experimental framework for screening of primary recovery technologies for high cell density CHO cultures

(2016) Daria Popova et al.   Biotechnology Journal

An integrated practical implementation of continuous aqueous two-phase systems for the recovery of human IgG: From the microdevice to a multistage bench-scale mixer-settler device

(2016) Edith Espitia-Saloma et al.   Biotechnology Journal

Continuous counter-current chromatography for capture and polishing steps in biopharmaceutical production

(2016) Fabian Steinebach et al.   Biotechnology Journal

A Single-use Strategy to Enable Manufacturing of Affordable Biologics

(2016) Renaud Jacquemart et al.   Computational and Structural Biotechnology Journal

Continuous downstream processing for high value biological products: A Review

(2015) Andrew L. Zydney   BIOTECHNOLOGY AND BIOENGINEERING

Economic analysis of uricase production under uncertainty: Contrast of chromatographic purification and aqueous two-phase extraction (with and without PEG recycle)

(2015) Mario A. Torres-Acosta et al.   BIOTECHNOLOGY PROGRESS

Economic analysis of royalactin production under uncertainty: Evaluating the effect of parameter optimization

(2015) Mario A. Torres-Acosta et al.   BIOTECHNOLOGY PROGRESS

Single-use in the biopharmaceutical industry: A review of current technology impact, challenges and limitations

(2015) Adriana G. Lopes   FOOD AND BIOPRODUCTS PROCESSING

Purification of monoclonal antibodies from clarified cell culture fluid using Protein A capture continuous countercurrent tangential chromatography

(2015) Amit K. Dutta et al.   JOURNAL OF BIOTECHNOLOGY

A new, integrated, continuous purification process template for monoclonal antibodies: Process modeling and cost of goods studies

(2015) Alex Xenopoulos   JOURNAL OF BIOTECHNOLOGY

The business impact of an integrated continuous biomanufacturing platform for recombinant protein production

(2015) Jason Walther et al.   JOURNAL OF BIOTECHNOLOGY

End-to-end integrated fully continuous production of recombinant monoclonal antibodies

(2015) Rahul Godawat et al.   JOURNAL OF BIOTECHNOLOGY

A straightforward methodology for designing continuous monoclonal antibody capture multi-column chromatography processes

(2015) Xhorxhi Gjoka et al.   JOURNAL OF CHROMATOGRAPHY A

Twin-column CaptureSMB: A novel cyclic process for protein A affinity chromatography

(2015) Monica Angarita et al.   JOURNAL OF CHROMATOGRAPHY A

White Paper on Continuous Bioprocessing May 20–21 2014 Continuous Manufacturing Symposium

(2015) Konstantin B. Konstantinov et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Continuous Processing for Production of Biopharmaceuticals

(2015) Anurag S. Rathore et al.   PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY

Economics of recombinant antibody production processes at various scales: Industry-standard compared to continuous precipitation

(2014) Nikolaus Hammerschmidt et al.   Biotechnology Journal

Perfusion seed cultures improve biopharmaceutical fed-batch production capacity and product quality

(2014) William C. Yang et al.   BIOTECHNOLOGY PROGRESS

Multi-Stage Aqueous Two-Phase Extraction for the Purification of Monoclonal Antibodies

(2014) Jan K. Eggersgluess et al.   CHEMICAL ENGINEERING & TECHNOLOGY

Single-use technologies in biopharmaceutical manufacturing: A 10-year review of trends and the future

(2014) Eric S. Langer et al.   ENGINEERING IN LIFE SCIENCES

The therapeutic monoclonal antibody market

(2014) Dawn M Ecker et al.   mAbs

Designing cost-effective biopharmaceutical facilities using mixed-integer optimization

(2013) Songsong Liu et al.   BIOTECHNOLOGY PROGRESS

Very high density of CHO cells in perfusion by ATF or TFF in WAVE bioreactor™. Part I. Effect of the cell density on the process

(2013) Marie-Françoise Clincke et al.   BIOTECHNOLOGY PROGRESS

Design of high productivity sequential multi-column chromatography for antibody capture

(2013) Candy K.S. Ng et al.   FOOD AND BIOPRODUCTS PROCESSING

Continuous aqueous two-phase systems devices for the recovery of biological products

(2013) Edith Espitia-Saloma et al.   FOOD AND BIOPRODUCTS PROCESSING

Optimising the design and operation of semi-continuous affinity chromatography for clinical and commercial manufacture

(2013) James Pollock et al.   JOURNAL OF CHROMATOGRAPHY A

Monoclonal antibody disulfide reduction during manufacturing

(2013) Katariina M. Hutterer et al.   mAbs

Continuous Countercurrent Tangential Chromatography for Monoclonal Antibody Purification

(2013) Boris Napadensky et al.   SEPARATION SCIENCE AND TECHNOLOGY

Continuous downstream processing of biopharmaceuticals

(2013) Alois Jungbauer   TRENDS IN BIOTECHNOLOGY

Fed-batch and perfusion culture processes: Economic, environmental, and operational feasibility under uncertainty

(2012) James Pollock et al.   BIOTECHNOLOGY AND BIOENGINEERING

Periodic counter-current chromatography - design and operational considerations for integrated and continuous purification of proteins

(2012) Rahul Godawat et al.   Biotechnology Journal

Continuous purification of antibodies from cell culture supernatant with aqueous two-phase systems: From concept to process

(2012) Paula A. J. Rosa et al.   Biotechnology Journal

Single-use disposable technologies for biopharmaceutical manufacturing

(2012) Abhinav A. Shukla et al.   TRENDS IN BIOTECHNOLOGY

Aqueous two-phase extraction as a platform in the biomanufacturing industry: Economical and environmental sustainability

(2011) P.A.J. Rosa et al.   BIOTECHNOLOGY ADVANCES

Process and economic evaluation for monoclonal antibody purification using a membrane-only process

(2011) Hemanthram Varadaraju et al.   BIOTECHNOLOGY PROGRESS

Economic comparison of diagnostic antibody production in perfusion stirred tank and in hollow fiber bioreactor processes

(2011) Raisa Vermasvuori et al.   BIOTECHNOLOGY PROGRESS

Continuous aqueous two-phase extraction of human antibodies using a packed column

(2011) P.A.J. Rosa et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Countercurrent tangential chromatography for large-scale protein purification

(2010) Oleg Shinkazh et al.   BIOTECHNOLOGY AND BIOENGINEERING

Industrialization of mAb production technology: The bioprocessing industry at a crossroads

(2010) Brian Kelley   mAbs

Recovery and purification process development for monoclonal antibody production

(2010) Hui F. Liu et al.   mAbs

Aqueous two-phase systems: A viable platform in the manufacturing of biopharmaceuticals

(2009) P.A.J. Rosa et al.   JOURNAL OF CHROMATOGRAPHY A

Chromatography-free recovery of biopharmaceuticals through aqueous two-phase processing

(2009) Ana M. Azevedo et al.   TRENDS IN BIOTECHNOLOGY

Upstream processes in antibody production: Evaluation of critical parameters

(2007) Era Jain et al.   BIOTECHNOLOGY ADVANCES