Exploring the functional roles of small-molecule metabolites in disease research: Recent advancements in metabolomics

A 3D-bioprinted gut anaerobic model for studying bacteria-host interactions

(2023) Liqin Cheng et al.   Research

Protein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase

(2023) Kevin G. Hicks et al.   SCIENCE

Editorial: Phospholipids and sphingolipids in nutrition, metabolism, and health

(2023) Ronan Lordan et al.   Frontiers in Nutrition

Simultaneous determination of indole metabolites of tryptophan in rat feces by chemical labeling assisted liquid chromatography-tandem mass spectrometry

(2022) Qin-Feng Zhang et al.   CHINESE CHEMICAL LETTERS

Application of machine learning algorithms to screen potential biomarkers under cadmium exposure based on human urine metabolic profiles

(2022) Ting Zeng et al.   CHINESE CHEMICAL LETTERS

Oncometabolite d -2HG alters T cell metabolism to impair CD8 + T cell function

(2022) Giulia Notarangelo et al.   SCIENCE

Muscle Amino Acid and Adenine Nucleotide Metabolism during Exercise and in Liver Cirrhosis: Speculations on How to Reduce the Harmful Effects of Ammonia

(2022) Milan Holeček   Metabolites

Metabolite activation of tumorigenic signaling pathways in the tumor microenvironment

(2022) Vivien Low et al.   Science Signaling

Microbial Regulation of Host Physiology by Short-chain Fatty Acids

(2021) Bart van der Hee et al.   TRENDS IN MICROBIOLOGY

Advances and Opportunities of Single-Cell Transcriptomics for Plant Research

(2021) Carolin Seyfferth et al.   Annual Review of Plant Biology

Database-assisted global metabolomics profiling of pleural effusion induced by tuberculosis and malignancy

(2021) Guodong Cao et al.   CHINESE CHEMICAL LETTERS

Single-cell lipidomics with high structural specificity by mass spectrometry

(2021) Zishuai Li et al.   Nature Communications

Acetyl-CoA Metabolism and Histone Acetylation in the Regulation of Aging and Lifespan

(2021) Patrick C. Bradshaw   Antioxidants

A novel strategy for high-specificity, high-sensitivity, and high-throughput study for gut microbiome metabolism of aromatic carboxylic acids

(2021) Ningning Zhao et al.   CHINESE CHEMICAL LETTERS

Trimester-specific urinary metabolome alterations associated with gestational diabetes mellitus: A study in different pregnancy stages

(2021) Hongzhi Zhao et al.   CHINESE CHEMICAL LETTERS

Feeding tricarboxylic acid (TCA) cycle intermediates improves lactate consumption and antibody production in CHO cell cultures

(2020) Xiaolin Zhang et al.   BIOTECHNOLOGY PROGRESS

Large-scale lipid analysis with C=C location and sn-position isomer resolving power

(2020) Wenbo Cao et al.   Nature Communications

Recent advances in the application of metabolomics for food safety control and food quality analyses

(2020) Shubo Li et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

SCFA: mechanisms and functional importance in the gut

(2020) Camille Martin-Gallausiaux et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Oncometabolites suppress DNA repair by disrupting local chromatin signalling

(2020) Parker L. Sulkowski et al.   NATURE

Branched-Chain Amino Acids and Branched-Chain Keto Acids in Hyperammonemic States: Metabolism and as Supplements

(2020) Milan Holeček   Metabolites

Acetylation-dependent regulation of PD-L1 nuclear translocation dictates the efficacy of anti-PD-1 immunotherapy

(2020) Yang Gao et al.   NATURE CELL BIOLOGY

Online photochemical derivatization enables comprehensive mass spectrometric analysis of unsaturated phospholipid isomers

(2019) Wenpeng Zhang et al.   Nature Communications

Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity

(2019) Kim Vriens et al.   NATURE

Indoles: metabolites produced by intestinal bacteria capable of controlling liver disease manifestation

(2019) T. Hendrikx et al.   JOURNAL OF INTERNAL MEDICINE

ACOT12-Dependent Alteration of Acetyl-CoA Drives Hepatocellular Carcinoma Metastasis by Epigenetic Induction of Epithelial-Mesenchymal Transition

(2019) Ming Lu et al.   Cell Metabolism

Cancer-associated mutation and beyond: The emerging biology of isocitrate dehydrogenases in human disease

(2019) Serena Tommasini-Ghelfi et al.   Science Advances

Synthesis and metabolism of methylglyoxal, S-D-lactoylglutathione and D-lactate in cancer and Alzheimer’s disease. Exploring the crossroad of eternal youth and premature aging

(2019) Lidia de Bari et al.   AGEING RESEARCH REVIEWS

Metabolic regulation of gene expression by histone lactylation

(2019) Di Zhang et al.   NATURE

Dietary α‐Ketoglutarate supplementation alleviates harmful effects of high environmental ammonia on grass carp, Ctenopharyngodon idella

(2019) Xiangbei Tang et al.   AQUACULTURE RESEARCH

Homogentisic acid γ -lactone suppresses the virulence factors of Pseudomonas aeruginosa by quenching its quorum sensing signal molecules

(2018) Shuihong Li et al.   CHINESE CHEMICAL LETTERS

How lipids contribute to ion channel function, a fat perspective on direct and indirect interactions

(2018) Julio F Cordero-Morales et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Omega-3 and omega-6 polyunsaturated fatty acids: Dietary sources, metabolism, and significance — A review

(2018) Ramesh Kumar Saini et al.   LIFE SCIENCES

Regulation of chromatin and gene expression by metabolic enzymes and metabolites

(2018) Xinjian Li et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Characterization of Brain Metabolism by Nuclear Magnetic Resonance

(2018) Daniel P. Downes et al.   CHEMPHYSCHEM

Omega-3 Fatty Acids Modulate TRPV4 Function through Plasma Membrane Remodeling

(2017) Rebeca Caires et al.   Cell Reports

The world of protein acetylation

(2016) Adrian Drazic et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Liver glucose metabolism in humans

(2016) M. M. Adeva-Andany et al.   BIOSCIENCE REPORTS

GPCR Dynamics: Structures in Motion

(2016) Naomi R. Latorraca et al.   CHEMICAL REVIEWS

Emerging applications of metabolomics in drug discovery and precision medicine

(2016) David S. Wishart   NATURE REVIEWS DRUG DISCOVERY

Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia

(2016) Xue Gao et al.   Nature Communications

Metabolomics Workbench: An international repository for metabolomics data and metadata, metabolite standards, protocols, tutorials and training, and analysis tools

(2015) Manish Sud et al.   NUCLEIC ACIDS RESEARCH

LDL, HDL, VLDL, and CVD Prevention: Lessons from Genetics?

(2015) Bernd Hewing et al.   Current Cardiology Reports

Pinpointing Double Bonds in Lipids by Paternò-Büchi Reactions and Mass Spectrometry

(2014) Xiaoxiao Ma et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Sirtuins, metabolism, and DNA repair

(2014) Jee-Eun Choi et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Regulation of Autophagy by Cytosolic Acetyl-Coenzyme A

(2014) Guillermo Mariño et al.   MOLECULAR CELL

Caloric restriction mimetics: towards a molecular definition

(2014) Frank Madeo et al.   NATURE REVIEWS DRUG DISCOVERY

The Glutamine–Glutamate/GABA Cycle: Function, Regional Differences in Glutamate and GABA Production and Effects of Interference with GABA Metabolism

(2014) Anne B. Walls et al.   NEUROCHEMICAL RESEARCH

The Human Gut Microbiome and Body Metabolism: Implications for Obesity and Diabetes

(2013) S. Devaraj et al.   CLINICAL CHEMISTRY

The Glutamate–Glutamine (GABA) Cycle: Importance of Late Postnatal Development and Potential Reciprocal Interactions between Biosynthesis and Degradation

(2013) Leif Hertz   Frontiers in Endocrinology

IDH1 and IDH2 Mutations in Tumorigenesis: Mechanistic Insights and Clinical Perspectives

(2012) H. Yang et al.   CLINICAL CANCER RESEARCH

Lipid metabolism in cancer

(2012) Claudio R. Santos et al.   FEBS Journal

Mechanisms of Gene Regulation by Fatty Acids

(2012) Anastasia Georgiadi et al.   Advances in Nutrition

Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

(2011) Wei Xu et al.   CANCER CELL

Glucose metabolism and cardiac hypertrophy

(2011) S. C. Kolwicz et al.   CARDIOVASCULAR RESEARCH

Genomics for the world

(2011) Carlos D. Bustamante et al.   NATURE

The autophagy conundrum in cancer: influence of tumorigenic metabolic reprogramming

(2011) C H Eng et al.   ONCOGENE

Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation

(2010) Maria E. Figueroa et al.   CANCER CELL

A general introduction to the biochemistry of mitochondrial fatty acid β-oxidation

(2010) Sander Michel Houten et al.   JOURNAL OF INHERITED METABOLIC DISEASE

GPR109A Is a G-protein-Coupled Receptor for the Bacterial Fermentation Product Butyrate and Functions as a Tumor Suppressor in Colon

(2009) M. Thangaraju et al.   CANCER RESEARCH

Understanding the role of tryptophan and serotonin metabolism in gastrointestinal function

(2009) d. keszthelyi et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Acetyl-CoA—Life at the metabolic nexus

(2009) David J. Oliver et al.   PLANT SCIENCE

Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1 

(2009) S. Zhao et al.   SCIENCE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

GPR109A, GPR109B and GPR81, a family of hydroxy-carboxylic acid receptors

(2009) Kashan Ahmed et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Gas chromatography/mass spectrometry in metabolic profiling of biological fluids

(2008) Kishore K. Pasikanti et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Fatty acid metabolism: target for metabolic syndrome

(2008) Salih J. Wakil et al.   JOURNAL OF LIPID RESEARCH