Cancer-associated mutation and beyond: The emerging biology of isocitrate dehydrogenases in human disease
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Cancer-associated mutation and beyond: The emerging biology of isocitrate dehydrogenases in human disease
Authors
Keywords
-
Journal
Science Advances
Volume 5, Issue 5, Pages eaaw4543
Publisher
American Association for the Advancement of Science (AAAS)
Online
2019-05-23
DOI
10.1126/sciadv.aaw4543
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- IDH3α regulates one-carbon metabolism in glioblastoma
- (2019) Jasmine L. May et al. Science Advances
- R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m 6 A/MYC/CEBPA Signaling
- (2018) Rui Su et al. CELL
- Nestin-expressing progenitor cells: function, identity and therapeutic implications
- (2018) Aurora Bernal et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Interfering peptides targeting protein–protein interactions: the next generation of drugs?
- (2018) Heriberto Bruzzoni-Giovanelli et al. DRUG DISCOVERY TODAY
- JAK2/IDH-mutant–driven myeloproliferative neoplasm is sensitive to combined targeted inhibition
- (2018) Anna Sophia McKenney et al. JOURNAL OF CLINICAL INVESTIGATION
- Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate
- (2018) Lukas Bunse et al. NATURE MEDICINE
- Modeling the diffusion of D-2-hydroxyglutarate from IDH1 mutant gliomas in the central nervous system
- (2018) Andreas Linninger et al. NEURO-ONCOLOGY
- Durable Remissions with Ivosidenib in IDH1-Mutated Relapsed or Refractory AML
- (2018) Courtney D. DiNardo et al. NEW ENGLAND JOURNAL OF MEDICINE
- Amazing Diversity in Biochemical Roles of Fe(II)/2-Oxoglutarate Oxygenases
- (2018) Caitlyn Q Herr et al. TRENDS IN BIOCHEMICAL SCIENCES
- Pharmacodynamics of mutant-IDH1 inhibitors in glioma patients probed by in vivo 3D MRS imaging of 2-hydroxyglutarate
- (2018) Ovidiu C. Andronesi et al. Nature Communications
- Metabolic Reprogramming in Amyotrophic Lateral Sclerosis
- (2018) M. Szelechowski et al. Scientific Reports
- Mutant IDH1 Promotes Glioma Formation In Vivo
- (2018) Beatrice Philip et al. Cell Reports
- The IDH1 Mutation-Induced Oncometabolite, 2-Hydroxyglutarate, May Affect DNA Methylation and Expression of PD-L1 in Gliomas
- (2018) Luyan Mu et al. Frontiers in Molecular Neuroscience
- Crystal structures of pan-IDH inhibitor AG-881 in complex with mutant human IDH1 and IDH2
- (2018) Rui Ma et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma
- (2018) Samuel K. McBrayer et al. CELL
- Ivosidenib (IVO; AG-120) in mutant IDH1 relapsed/refractory acute myeloid leukemia (R/R AML): Results of a phase 1 study.
- (2018) Daniel Aaron Pollyea et al. JOURNAL OF CLINICAL ONCOLOGY
- Acquired resistance to IDH inhibition through trans or cis dimer-interface mutations
- (2018) Andrew M. Intlekofer et al. NATURE
- Genotype-targeted local therapy of glioma
- (2018) Ganesh M. Shankar et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Molecular remission and response patterns in patients with mutant-IDH2 acute myeloid leukemia treated with enasidenib
- (2018) Eytan M. Stein et al. BLOOD
- Isoform Switching as a Mechanism of Acquired Resistance to Mutant Isocitrate Dehydrogenase Inhibition
- (2018) James J. Harding et al. Cancer Discovery
- Mutant IDH1 regulates the tumor-associated immune system in gliomas
- (2017) Nduka M. Amankulor et al. GENES & DEVELOPMENT
- Isocitrate dehydrogenase mutations suppress STAT1 and CD8+ T cell accumulation in gliomas
- (2017) Gary Kohanbash et al. JOURNAL OF CLINICAL INVESTIGATION
- BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation
- (2017) Simon Raffel et al. NATURE
- Homozygous mutation, p.Pro304His, in IDH3A, encoding isocitrate dehydrogenase subunit is associated with severe encephalopathy in infancy
- (2017) Aviva Fattal-Valevski et al. NEUROGENETICS
- Whole-Exome Sequencing Identifies Biallelic IDH3A Variants as a Cause of Retinitis Pigmentosa Accompanied by Pseudocoloboma
- (2017) Laurence H.M. Pierrache et al. OPHTHALMOLOGY
- Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq
- (2017) Andrew S. Venteicher et al. SCIENCE
- Discovery and Evaluation of Clinical Candidate IDH305, a Brain Penetrant Mutant IDH1 Inhibitor
- (2017) Young Shin Cho et al. ACS Medicinal Chemistry Letters
- Systematic discovery of mutation-specific synthetic lethals by mining pan-cancer human primary tumor data
- (2017) Subarna Sinha et al. Nature Communications
- Induction of synthetic lethality in IDH1-mutated gliomas through inhibition of Bcl-xL
- (2017) Georg Karpel-Massler et al. Nature Communications
- AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations
- (2017) Katharine Yen et al. Cancer Discovery
- The Krebs Cycle Enzyme Isocitrate Dehydrogenase 3A Couples Mitochondrial Metabolism to Synaptic Transmission
- (2017) Berrak Ugur et al. Cell Reports
- Cancer-Associated IDH1 Promotes Growth and Resistance to Targeted Therapies in the Absence of Mutation
- (2017) Andrea E. Calvert et al. Cell Reports
- Low-Grade Astrocytoma Mutations in IDH1, P53, and ATRX Cooperate to Block Differentiation of Human Neural Stem Cells via Repression of SOX2
- (2017) Aram S. Modrek et al. Cell Reports
- Editorial: The Metabolic-Inflammatory Axis in Brain Aging and Neurodegeneration
- (2017) Fei Yin et al. Frontiers in Aging Neuroscience
- Isocitrate protects DJ-1 null dopaminergic cells from oxidative stress through NADP+-dependent isocitrate dehydrogenase (IDH)
- (2017) Jinsung Yang et al. PLoS Genetics
- The β and γ subunits play distinct functional roles in the α2βγ heterotetramer of human NAD-dependent isocitrate dehydrogenase
- (2017) Tengfei Ma et al. Scientific Reports
- Studies on the regulatory mechanism of isocitrate dehydrogenase 2 using acetylation mimics
- (2017) Yuqun Xu et al. Scientific Reports
- Allosteric inhibitor remotely modulates the conformation of the orthestric pockets in mutant IDH2/R140Q
- (2017) Jiao Chen et al. Scientific Reports
- A Brain Penetrant Mutant IDH1 Inhibitor Provides In Vivo Survival Benefit
- (2017) Johnny Kopinja et al. Scientific Reports
- Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2
- (2016) Satoshi Inoue et al. CANCER CELL
- Expression of Idh1R132H in the Murine Subventricular Zone Stem Cell Niche Recapitulates Features of Early Gliomagenesis
- (2016) Chiara Bardella et al. CANCER CELL
- Glioblastoma Therapy Can Be Augmented by Targeting IDH1-Mediated NADPH Biosynthesis
- (2016) Daniel R. Wahl et al. CANCER RESEARCH
- IDH2 deficiency promotes mitochondrial dysfunction and dopaminergic neurotoxicity: implications for Parkinson’s disease
- (2016) Hyunjin Kim et al. FREE RADICAL RESEARCH
- Wilms tumor 1 mutations in the pathogenesis of acute myeloid leukemia
- (2016) R. Rampal et al. HAEMATOLOGICA
- Sterol Regulatory Element Binding Protein Regulates the Expression and Metabolic Functions of Wild-Type and OncogenicIDH1
- (2016) Stéphane J. H. Ricoult et al. MOLECULAR AND CELLULAR BIOLOGY
- Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma
- (2016) Itay Tirosh et al. NATURE
- IDH mutant gliomas escape natural killer cell immune surveillance by downregulation of NKG2D ligand expression
- (2016) Xiaoran Zhang et al. NEURO-ONCOLOGY
- IDH1 deficiency attenuates gluconeogenesis in mouse liver by impairing amino acid utilization
- (2016) Jing Ye et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Isocitrate Dehydrogenase Mutations Confer Dasatinib Hypersensitivity and SRC Dependence in Intrahepatic Cholangiocarcinoma
- (2016) S. K. Saha et al. Cancer Discovery
- Wilms tumor 1 mutations in the pathogenesis of acute myeloid leukemia
- (2016) R. Rampal et al. HAEMATOLOGICA
- Characteristics, clinical outcome, and prognostic significance of IDH mutations in AML
- (2015) Courtney D. DiNardo et al. AMERICAN JOURNAL OF HEMATOLOGY
- Extreme Vulnerability of IDH1 Mutant Cancers to NAD+ Depletion
- (2015) Kensuke Tateishi et al. CANCER CELL
- Adult Lineage-Restricted CNS Progenitors Specify Distinct Glioblastoma Subtypes
- (2015) Sheila R. Alcantara Llaguno et al. CANCER CELL
- Idh1 protects murine hepatocytes from endotoxin-induced oxidative stress by regulating the intracellular NADP+/NADPH ratio
- (2015) M Itsumi et al. CELL DEATH AND DIFFERENTIATION
- IDH2 deficiency promotes mitochondrial dysfunction and cardiac hypertrophy in mice
- (2015) Hyeong Jun Ku et al. FREE RADICAL BIOLOGY AND MEDICINE
- Protein Hydroxylation Catalyzed by 2-Oxoglutarate-dependent Oxygenases
- (2015) Suzana Markolovic et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- NADP+-IDH Mutations Promote Hypersuccinylation that Impairs Mitochondria Respiration and Induces Apoptosis Resistance
- (2015) Feng Li et al. MOLECULAR CELL
- Insulator dysfunction and oncogene activation in IDH mutant gliomas
- (2015) William A. Flavahan et al. NATURE
- New IDH1 mutant inhibitors for treatment of acute myeloid leukemia
- (2015) Ujunwa C Okoye-Okafor et al. Nature Chemical Biology
- Integrated genomic characterization of IDH1-mutant glioma malignant progression
- (2015) Hanwen Bai et al. NATURE GENETICS
- Isocitrate dehydrogenase 1 and 2 mutations induce BCL-2 dependence in acute myeloid leukemia
- (2015) Steven M Chan et al. NATURE MEDICINE
- Oncometabolic mutation IDH1 R132H confers a metformin-hypersensitive phenotype
- (2015) Elisabet Cuyàs et al. Oncotarget
- MiR-181a regulates lipid metabolism via IDH1
- (2015) Bo Chu et al. Scientific Reports
- Oncometabolite D-2-Hydroxyglutarate Inhibits ALKBH DNA Repair Enzymes and Sensitizes IDH Mutant Cells to Alkylating Agents
- (2015) Pu Wang et al. Cell Reports
- Metabolic Reprogramming of Cancer-Associated Fibroblasts by IDH3α Downregulation
- (2015) Daoxiang Zhang et al. Cell Reports
- Mutant IDH1: An immunotherapeutic target in tumors
- (2015) Theresa Schumacher et al. OncoImmunology
- Acetate Is a Bioenergetic Substrate for Human Glioblastoma and Brain Metastases
- (2014) Tomoyuki Mashimo et al. CELL
- Proto-Oncogenic Role of Mutant IDH2 in Leukemia Initiation and Maintenance
- (2014) Lev M. Kats et al. Cell Stem Cell
- Selective Inhibition of Mutant Isocitrate Dehydrogenase 1 (IDH1) via Disruption of a Metal Binding Network by an Allosteric Small Molecule
- (2014) Gejing Deng et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Aberrant IDH3α expression promotes malignant tumor growth by inducing HIF-1-mediated metabolic reprogramming and angiogenesis
- (2014) L Zeng et al. ONCOGENE
- Hominoid-specific enzyme GLUD2 promotes growth ofIDH1R132Hglioma
- (2014) Ruihuan Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Oxidation of Alpha-Ketoglutarate Is Required for Reductive Carboxylation in Cancer Cells with Mitochondrial Defects
- (2014) Andrew R. Mullen et al. Cell Reports
- Serum 2-hydroxyglutarate levels predict isocitrate dehydrogenase mutations and clinical outcome in acute myeloid leukemia
- (2013) C. D. DiNardo et al. BLOOD
- IDH1 and IDH2 Mutations in Gliomas
- (2013) Adam L. Cohen et al. Current Neurology and Neuroscience Reports
- What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer
- (2013) J.-A. Losman et al. GENES & DEVELOPMENT
- Prognostic significance of 2-hydroxyglutarate levels in acute myeloid leukemia in China
- (2013) J.-H. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- IDH1 and IDH2 Mutations in Tumorigenesis: Mechanistic Insights and Clinical Perspectives
- (2012) H. Yang et al. CLINICAL CANCER RESEARCH
- D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function
- (2012) M. Sasaki et al. GENES & DEVELOPMENT
- Progress in understanding 2-hydroxyglutaric acidurias
- (2012) Martijn Kranendijk et al. JOURNAL OF INHERITED METABOLIC DISEASE
- Adverse impact of IDH1 and IDH2 mutations in primary AML: Experience of the Spanish CETLAM group
- (2012) J. Nomdedéu et al. LEUKEMIA RESEARCH
- IDH mutation impairs histone demethylation and results in a block to cell differentiation
- (2012) Chao Lu et al. NATURE
- Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
- (2012) Peppi Koivunen et al. NATURE
- IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics
- (2012) Masato Sasaki et al. NATURE
- Overexpression of isocitrate dehydrogenase mutant proteins renders glioma cells more sensitive to radiation
- (2012) Sichen Li et al. NEURO-ONCOLOGY
- Reverse TCA cycle flux through isocitrate dehydrogenases 1 and 2 is required for lipogenesis in hypoxic melanoma cells
- (2012) Fabian V. Filipp et al. Pigment Cell & Melanoma Research
- Dysregulation of Glutathione Homeostasis in Neurodegenerative Diseases
- (2012) William M. Johnson et al. Nutrients
- Tet2 Loss Leads to Increased Hematopoietic Stem Cell Self-Renewal and Myeloid Transformation
- (2011) Kelly Moran-Crusio et al. CANCER CELL
- Mosaic Analysis with Double Markers Reveals Tumor Cell of Origin in Glioma
- (2011) Chong Liu et al. CELL
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Evidence for Sequenced Molecular Evolution of IDH1 Mutant Glioblastoma From a Distinct Cell of Origin
- (2011) Albert Lai et al. JOURNAL OF CLINICAL ONCOLOGY
- Ollier disease and Maffucci syndrome are caused by somatic mosaic mutations of IDH1 and IDH2
- (2011) M Fernanda Amary et al. NATURE GENETICS
- Tet Proteins Can Convert 5-Methylcytosine to 5-Formylcytosine and 5-Carboxylcytosine
- (2011) S. Ito et al. SCIENCE
- Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation
- (2010) Maria E. Figueroa et al. CANCER CELL
- Inhibition of Glutaminase Preferentially Slows Growth of Glioma Cells with Mutant IDH1
- (2010) M. J. Seltzer et al. CANCER RESEARCH
- Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-Related Hearing Loss under Caloric Restriction
- (2010) Shinichi Someya et al. CELL
- Molecular mechanisms of “off-on switch” of activities of human IDH1 by tumor-associated mutation R132H
- (2010) Bei Yang et al. CELL RESEARCH
- IDH2 Mutations in Patients with D-2-Hydroxyglutaric Aciduria
- (2010) M. Kranendijk et al. SCIENCE
- Selective acquisition of IDH1 R132C mutations in astrocytomas associated with Li-Fraumeni syndrome
- (2009) Takuya Watanabe et al. ACTA NEUROPATHOLOGICA
- Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
- (2009) Lenny Dang et al. NATURE
- IDH1andIDH2Mutations in Gliomas
- (2009) Hai Yan et al. NEW ENGLAND JOURNAL OF MEDICINE
- Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease
- (2008) P. A.C. Cloos et al. GENES & DEVELOPMENT
- Novel suppressors of α-synuclein toxicity identified using yeast
- (2008) Jun Liang et al. HUMAN MOLECULAR GENETICS
- Cytoplasmic Serine Hydroxymethyltransferase Regulates the Metabolic Partitioning of Methylenetetrahydrofolate but Is Not Essential in Mice
- (2008) Amanda J. MacFarlane et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Insights from retinitis pigmentosa into the roles of isocitrate dehydrogenases in the Krebs cycle
- (2008) Dyonne T Hartong et al. NATURE GENETICS
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started