Metabolite activation of tumorigenic signaling pathways in the tumor microenvironment

MTAP loss correlates with an immunosuppressive profile in GBM and its substrate MTA stimulates alternative macrophage polarization

(2022) Landon J. Hansen et al.   Scientific Reports

The Multifaced Role of STAT3 in Cancer and Its Implication for Anticancer Therapy

(2021) Manlio Tolomeo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cancer-associated fibroblasts: overview, progress, challenges, and directions

(2021) Qinrong Ping et al.   CANCER GENE THERAPY

Monocarboxylate transporter-1 (MCT1) protein expression in head and neck cancer affects clinical outcome

(2021) Martin Leu et al.   Scientific Reports

TGF-β1-mediated transition of resident fibroblasts to cancer-associated fibroblasts promotes cancer metastasis in gastrointestinal stromal tumor

(2021) Hyunho Yoon et al.   Oncogenesis

Obesity, oxidative DNA damage and vitamin D as predictors of genomic instability in children and adolescents

(2021) Moonisah Usman et al.   INTERNATIONAL JOURNAL OF OBESITY

NADK is activated by oncogenic signaling to sustain pancreatic ductal adenocarcinoma

(2021) Tanya Schild et al.   Cell Reports

The lactate receptor GPR81 promotes breast cancer growth via a paracrine mechanism involving antigen-presenting cells in the tumor microenvironment

(2020) Timothy P. Brown et al.   ONCOGENE

Tumor-Derived Retinoic Acid Regulates Intratumoral Monocyte Differentiation to Promote Immune Suppression

(2020) Samir Devalaraja et al.   CELL

Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine

(2020) Luis Felipe Campesato et al.   Nature Communications

Age-induced accumulation of methylmalonic acid promotes tumour progression

(2020) Ana P. Gomes et al.   NATURE

Concepts of extracellular matrix remodelling in tumour progression and metastasis

(2020) Juliane Winkler et al.   Nature Communications

STAT3 phosphorylation at Ser727 and Tyr705 differentially regulates the EMT–MET switch and cancer metastasis

(2020) Wei-Hsin Lin et al.   ONCOGENE

Prostaglandin E2 and Cancer: Insight into Tumor Progression and Immunity

(2020) Federica Finetti et al.   Biology-Basel

A stromal lysolipid-autotaxin signaling axis promotes pancreatic tumor progression

(2019) Francesca R. Auciello et al.   Cancer Discovery

Direct stimulation of NADP+ synthesis through Akt-mediated phosphorylation of NAD kinase

(2019) Gerta Hoxhaj et al.   SCIENCE

The oncometabolite 2-hydroxyglutarate inhibits microglial activation via the AMPK/mTOR/NF-κB pathway

(2019) Chao-jun Han et al.   ACTA PHARMACOLOGICA SINICA

Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39

(2019) Maisa C. Takenaka et al.   NATURE NEUROSCIENCE

Estrogen receptor signaling is reprogrammed during breast tumorigenesis

(2019) David Chi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of succinate dehydrogenase and role of succinate in cancer

(2019) Elisa Dalla Pozza et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Targeting Tumor-Associated Macrophages in Cancer

(2019) Paulina Pathria et al.   TRENDS IN IMMUNOLOGY

Tumor-associated macrophages: role in cancer development and therapeutic implications

(2019) Arash Salmaninejad et al.   CELLULAR ONCOLOGY

TGFβ1 is essential for MSCs-CAFs differentiation and promotes HCT116 cells migration and invasion via JAK/STAT3 signaling

(2019) Hao-Xiang Tan et al.   OncoTargets and Therapy

Cancer-associated fibroblasts: an emerging target of anti-cancer immunotherapy

(2019) Tongyan Liu et al.   Journal of Hematology & Oncology

Monocarboxylate transporter 4 (MCT4) is a high affinity transporter capable of exporting lactate in high-lactate microenvironments

(2019) Yasna Contreras-Baeza et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cancer-Derived Succinate Promotes Macrophage Polarization and Cancer Metastasis via Succinate Receptor

(2019) Jing-Yiing Wu et al.   MOLECULAR CELL

Prostaglandin E2/EP Signaling in the Tumor Microenvironment of Colorectal Cancer

(2019) Rei Mizuno et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Impact of Indoleamine 2,3-dioxygenase (IDO) Expression on Stage III Gastric Cancer

(2018) MASAAKI NISHI et al.   ANTICANCER RESEARCH

Tumor-derived lactate induces M2 macrophage polarization via the activation of the ERK/STAT3 signaling pathway in breast cancer

(2018) Xianmin Mu et al.   CELL CYCLE

Indoleamine 2,3-Dioxygenase Expression in Primary Cutaneous Melanoma Correlates with Breslow Thickness and Is of Significant Prognostic Value for Progression-Free Survival

(2018) Felicia Rubel et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Exosomes Induce Fibroblast Differentiation into Cancer-Associated Fibroblasts through TGFβ Signaling

(2018) Cassandra Ringuette Goulet et al.   MOLECULAR CANCER RESEARCH

Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate

(2018) Lukas Bunse et al.   NATURE MEDICINE

Notch Signaling in the Tumor Microenvironment

(2018) Olivier Meurette et al.   CANCER CELL

Trace derivatives of kynurenine potently activate the aryl hydrocarbon receptor (AHR)

(2017) Seung-Hyeon Seok et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tumor cell-derived lactate induces TAZ-dependent upregulation of PD-L1 through GPR81 in human lung cancer cells

(2017) J Feng et al.   ONCOGENE

COX2/mPGES1/PGE2pathway regulates PD-L1 expression in tumor-associated macrophages and myeloid-derived suppressor cells

(2017) Victor Prima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo imaging reveals a tumor-associated macrophage–mediated resistance pathway in anti–PD-1 therapy

(2017) Sean P. Arlauckas et al.   Science Translational Medicine

Adipocytes activate mitochondrial fatty acid oxidation and autophagy to promote tumor growth in colon cancer

(2017) Yang-An Wen et al.   Cell Death & Disease

Adipocytes promote malignant growth of breast tumours with monocarboxylate transporter 2 expression via β-hydroxybutyrate

(2017) Chun-Kai Huang et al.   Nature Communications

Cancer-associated Fibroblasts Promote Irradiated Cancer Cell Recovery Through Autophagy

(2017) Yongbin Wang et al.   EBioMedicine

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

(2016) Evanna L. Mills et al.   CELL

LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells

(2016) Almut Brand et al.   Cell Metabolism

β-Hydroxybutyrate: A signaling metabolite in starvation response?

(2016) Pedro Rojas-Morales et al.   CELLULAR SIGNALLING

Role of the monocarboxylate transporter MCT1 in the uptake of lactate during active recovery

(2016) Rocío Cupeiro et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Tryptophan-2,3-dioxygenase is regulated by prostaglandin E2 in malignant glioma via a positive signaling loop involving prostaglandin E receptor-4

(2016) Katharina Ochs et al.   JOURNAL OF NEUROCHEMISTRY

Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor

(2016) Veit Rothhammer et al.   NATURE MEDICINE

Tolerogenic nanoparticles inhibit T cell–mediated autoimmunity through SOCS2

(2016) Ada Yeste et al.   Science Signaling

The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway

(2016) Mélissa Carbonneau et al.   Nature Communications

Lung cancer-derived galectin-1 contributes to cancer associated fibroblast-mediated cancer progression and immune suppression through TDO2/kynurenine axis

(2016) Ya-Ling Hsu et al.   Oncotarget

Unique metabolic features of pancreatic cancer stroma: relevance to the tumor compartment, prognosis, and invasive potential

(2016) Erik S. Knudsen et al.   Oncotarget

Tolerogenic nanoparticles inhibit T cell–mediated autoimmunity through SOCS2

(2016) Ada Yeste et al.   Science Signaling

Suppressive effects of tumor cell-derived 5′-deoxy-5′-methylthioadenosine on human T cells

(2016) Frederik C. Henrich et al.   OncoImmunology

A TDO2-AhR Signaling Axis Facilitates Anoikis Resistance and Metastasis in Triple-Negative Breast Cancer

(2015) Nicholas C. D'Amato et al.   CANCER RESEARCH

Definition of Prostaglandin E2-EP2 Signals in the Colon Tumor Microenvironment That Amplify Inflammation and Tumor Growth

(2015) X. Ma et al.   CANCER RESEARCH

CD73 Is Associated with Poor Prognosis in High-Grade Serous Ovarian Cancer

(2015) Martin Turcotte et al.   CANCER RESEARCH

A Lactate-Induced Response to Hypoxia

(2015) Dong Chul Lee et al.   CELL

Epigenetic silencing of microRNA-149 in cancer-associated fibroblasts mediates prostaglandin E2/interleukin-6 signaling in the tumor microenvironment

(2015) Pu Li et al.   CELL RESEARCH

Prostaglandin E2 transactivates the colony-stimulating factor-1 receptor and synergizes with colony-stimulating factor-1 in the induction of macrophage migration via the mitogen-activated protein kinase ERK1/2

(2015) Graziana Digiacomo et al.   FASEB JOURNAL

T-cell exhaustion in the tumor microenvironment

(2015) Y Jiang et al.   Cell Death & Disease

TGFβ1 secreted by cancer-associated fibroblasts induces epithelial-mesenchymal transition of bladder cancer cells through lncRNA-ZEB2NAT

(2015) Junlong Zhuang et al.   Scientific Reports

IDH mutation status is associated with a distinct hypoxia/angiogenesis transcriptome signature which is non-invasively predictable with rCBV imaging in human glioma

(2015) Philipp Kickingereder et al.   Scientific Reports

Tumor hypoxia enhances Non-Small Cell Lung Cancer metastasis by selectively promoting macrophage M2 polarization through the activation of ERK signaling

(2015) Jun Zhang et al.   Oncotarget

A lactate shuttle system between tumour and stromal cells is associated with poor prognosis in prostate cancer

(2014) Nelma Pértega-Gomes et al.   BMC CANCER

Cell Surface Lactate Receptor GPR81 Is Crucial for Cancer Cell Survival

(2014) C. L. Roland et al.   CANCER RESEARCH

The metabolite 5′-methylthioadenosine signals through the adenosine receptor A2B in melanoma

(2014) Katharina Limm et al.   EUROPEAN JOURNAL OF CANCER

Tumor-Associated Macrophages: From Mechanisms to Therapy

(2014) Roy Noy et al.   IMMUNITY

Glutamine Oxidation Maintains the TCA Cycle and Cell Survival during Impaired Mitochondrial Pyruvate Transport

(2014) Chendong Yang et al.   MOLECULAR CELL

Aldehyde dehydrogenase 1A3 influences breast cancer progression via differential retinoic acid signaling

(2014) Paola Marcato et al.   Molecular Oncology

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

Targeting RAS–ERK signalling in cancer: promises and challenges

(2014) Ahmed A. Samatar et al.   NATURE REVIEWS DRUG DISCOVERY

L-2-Hydroxyglutarate: An Epigenetic Modifier and Putative Oncometabolite in Renal Cancer

(2014) E.-H. Shim et al.   Cancer Discovery

Extracellular matrix as a contextual determinant of transforming growth factor-β signaling in epithelial-mesenchymal transition and in cancer

(2014) Magdalena A Cichon et al.   Cell Adhesion & Migration

NF- B, an Active Player in Human Cancers

(2014) Y. Xia et al.   Cancer Immunology Research

Cancer-associated fibroblasts induce epithelial–mesenchymal transition of breast cancer cells through paracrine TGF-β signalling

(2013) Y Yu et al.   BRITISH JOURNAL OF CANCER

Colorectal carcinoma-derived fibroblasts modulate natural killer cell phenotype and antitumor cytotoxicity

(2013) Tuanjie Li et al.   MEDICAL ONCOLOGY

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Arginase II Expressed in Cancer-Associated Fibroblasts Indicates Tissue Hypoxia and Predicts Poor Outcome in Patients with Pancreatic Cancer

(2013) Yoshinori Ino et al.   PLoS One

Strengthened glycolysis under hypoxia supports tumor symbiosis and hexosamine biosynthesis in pancreatic adenocarcinoma

(2013) F. Guillaumond et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic reprogramming of cancer-associated fibroblasts by TGF-β drives tumor growth: Connecting TGF-β signaling with “Warburg-like” cancer metabolism and L-lactate production

(2012) Carmela Guido et al.   CELL CYCLE

The mTOR Signalling Pathway in Human Cancer

(2012) Helena Pópulo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Interaction between head and neck squamous cell carcinoma cells and fibroblasts in the biosynthesis of PGE2

(2012) Sonia Alcolea et al.   JOURNAL OF LIPID RESEARCH

Suppression of Oxidative Stress by  -Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor

(2012) T. Shimazu et al.   SCIENCE

Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

(2011) Wei Xu et al.   CANCER CELL

Evidence for a stromal-epithelial “lactate shuttle” in human tumors

(2011) Diana Whitaker-Menezes et al.   CELL CYCLE

Lactate is a mediator of metabolic cooperation between stromal carcinoma associated fibroblasts and glycolytic tumor cells in the tumor microenvironment

(2011) Yanique I. Rattigan et al.   EXPERIMENTAL CELL RESEARCH

Tumor lactic acidosis suppresses CTL function by inhibition of p38 and JNK/c-Jun activation

(2011) Anna N. Mendler et al.   INTERNATIONAL JOURNAL OF CANCER

An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

(2011) Christiane A. Opitz et al.   NATURE

Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth

(2011) Kristin M Nieman et al.   NATURE MEDICINE

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

An Interaction between Kynurenine and the Aryl Hydrocarbon Receptor Can Generate Regulatory T Cells

(2010) J. D. Mezrich et al.   JOURNAL OF IMMUNOLOGY

ERK2 but Not ERK1 Induces Epithelial-to-Mesenchymal Transformation via DEF Motif-Dependent Signaling Events

(2010) Sejeong Shin et al.   MOLECULAR CELL

Cancer as a metabolic disease

(2010) Thomas N Seyfried et al.   Nutrition & Metabolism

All-trans retinoic acid inhibits the differentiation, maturation, and function of human monocyte-derived dendritic cells

(2009) Chun-Ji Jin et al.   LEUKEMIA RESEARCH

The development and endocrine functions of adipose tissue

(2009) Sylvia P. Poulos et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Mitochondrial complex III regulates hypoxic activation of HIF

(2008) T Klimova et al.   CELL DEATH AND DIFFERENTIATION

Role and regulation of prolyl hydroxylase domain proteins

(2008) G-H Fong et al.   CELL DEATH AND DIFFERENTIATION

Stromal Fibroblasts Activated by Tumor Cells Promote Angiogenesis in Mouse Gastric Cancer

(2008) Xiaoying Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY