Identity, structure, and function of the mitochondrial permeability transition pore: controversies, consensus, recent advances, and future directions

Investigation of Properties of the Mitochondrial Permeability Transition Pore Using Whole-Mitoplast Patch-Clamp Technique

(2023) Maria A. Neginskaya et al.   DNA AND CELL BIOLOGY

Structure of the human ATP synthase

(2023) Yuezheng Lai et al.   MOLECULAR CELL

Rapid and Highly Stable Membrane Reconstitution by LAiR Enables the Study of Physiological Integral Membrane Protein Functions

(2023) Albert Godoy-Hernandez et al.   ACS Central Science

Mitochondrial ATP synthase c-subunit leak channel triggers cell death upon loss of its F1 subcomplex

(2022) Nelli Mnatsakanyan et al.   CELL DEATH AND DIFFERENTIATION

Ca2+-mediated mitochondrial inner membrane permeabilization induces cell death independently of Bax and Bak

(2022) Giovanni Quarato et al.   CELL DEATH AND DIFFERENTIATION

Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling

(2022) Hongxu Xian et al.   IMMUNITY

An ancestral interaction module promotes oligomerization in divergent mitochondrial ATP synthases

(2022) Ondřej Gahura et al.   Nature Communications

Both ANT and ATPase are essential for mitochondrial permeability transition but not depolarization

(2022) M.A. Neginskaya et al.   iScience

Cell death pathways: intricate connections and disease implications

(2021) Matthias Kist et al.   EMBO JOURNAL

ATP synthase hexamer assemblies shape cristae of Toxoplasma mitochondria

(2021) Alexander Mühleip et al.   Nature Communications

C subunit of the ATP synthase is an amyloidogenic calcium dependent channel-forming peptide with possible implications in mitochondrial permeability transition

(2021) Giuseppe Federico Amodeo et al.   Scientific Reports

A naturally occurring mutation in ATP synthase subunit c is associated with increased damage following hypoxia/reoxygenation in STEMI patients

(2021) Giampaolo Morciano et al.   Cell Reports

Mitochondrial Permeability Transition: A Pore Intertwines Brain Aging and Alzheimer’s Disease

(2021) Kun Jia et al.   Cells

Defining the molecular mechanisms of the mitochondrial permeability transition through genetic manipulation of F-ATP synthase

(2021) Andrea Carrer et al.   Nature Communications

The mitochondrial permeability transition pore activates the mitochondrial unfolded protein response and promotes aging

(2021) Suzanne Angeli et al.   eLife

The mitochondrial permeability transition: Recent progress and open questions

(2021) Paolo Bernardi et al.   FEBS Journal

Formation of High-Conductive C Subunit Channels upon Interaction with Cyclophilin D

(2021) Giuseppe Federico Amodeo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inhibition of the Anti-Apoptotic Bcl-2 Family by BH3 Mimetics Sensitize the Mitochondrial Permeability Transition Pore Through Bax and Bak

(2021) Pooja Patel et al.   Frontiers in Cell and Developmental Biology

Role of Mitochondrial Calcium and the Permeability Transition Pore in Regulating Cell Death

(2020) Tyler M. Bauer et al.   CIRCULATION RESEARCH

Macrophage activation as an archetype of mitochondrial repurposing

(2020) Anthony E. Jones et al.   MOLECULAR ASPECTS OF MEDICINE

Mechanisms for Ca2+-dependent permeability transition in mitochondria

(2020) Paolo Bernardi   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cryo-EM structures of undocked innexin-6 hemichannels in phospholipids

(2020) Batuujin Burendei et al.   Science Advances

Hexokinase 2 displacement from mitochondria‐associated membranes prompts Ca 2+ ‐dependent death of cancer cells

(2020) Francesco Ciscato et al.   EMBO REPORTS

Inefficient thermogenic mitochondrial respiration due to futile proton leak in a mouse model of fragile X syndrome

(2020) Keren K. Griffiths et al.   FASEB JOURNAL

Cardiac metabolism as a driver and therapeutic target of myocardial infarction

(2020) Coert J. Zuurbier et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Targeting mitochondrial fusion and fission proteins for cardioprotection

(2020) Sauri Hernandez‐Resendiz et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

A 20/20 view of ANT function in mitochondrial biology and necrotic cell death

(2020) Michael J. Bround et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mechanism of succinate efflux upon reperfusion of the ischemic heart

(2020) Hiran A Prag et al.   CARDIOVASCULAR RESEARCH

ATP Synthase c-Subunit Leak Causes Aberrant Cellular Metabolism in Fragile X Syndrome

(2020) Pawel Licznerski et al.   CELL

Molecular nature and regulation of the mitochondrial permeability transition pore(s), drug target(s) in cardioprotection

(2020) Michela Carraro et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

ATP synthase c-subunit ring as the channel of mitochondrial permeability transition: Regulator of metabolism in development and degeneration

(2020) Nelli Mnatsakanyan et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Hexokinase II dissociation alone cannot account for changes in heart mitochondrial function, morphology and sensitivity to permeability transition pore opening following ischemia

(2020) Gonçalo C. Pereira et al.   PLoS One

MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis

(2020) Andre L. Samson et al.   Nature Communications

Cyclophilin D: An Integrator of Mitochondrial Function

(2020) Georgios Amanakis et al.   Frontiers in Physiology

Mitochondria in acute myocardial infarction and cardioprotection

(2020) Chrishan J.A. Ramachandra et al.   EBioMedicine

TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS

(2020) Chien-Hsiung Yu et al.   CELL

Cyclophilin D–dependent oligodendrocyte mitochondrial ion leak contributes to neonatal white matter injury

(2020) Zoya Niatsetskaya et al.   JOURNAL OF CLINICAL INVESTIGATION

The very low number of calcium-induced permeability transition pores in the single mitochondrion

(2020) Maria A. Neginskaya et al.   JOURNAL OF GENERAL PHYSIOLOGY

Single-particle cryo-EM at atomic resolution

(2020) Takanori Nakane et al.   NATURE

Atomic-resolution protein structure determination by cryo-EM

(2020) Ka Man Yip et al.   NATURE

Cryo-EM structure of the entire mammalian F-type ATP synthase

(2020) Gergely Pinke et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mitochondrial F-ATP synthase as the permeability transition pore

(2020) Christoph Gerle   PHARMACOLOGICAL RESEARCH

Structure of the dimeric ATP synthase from bovine mitochondria

(2020) Tobias E. Spikes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type III ATP synthase is a symmetry-deviated dimer that induces membrane curvature through tetramerization

(2020) Rasmus Kock Flygaard et al.   Nature Communications

The Unique Cysteine of F-ATP Synthase OSCP Subunit Participates in Modulation of the Permeability Transition Pore

(2020) Michela Carraro et al.   Cell Reports

Electrophysiological properties of the mitochondrial permeability transition pores: Channel diversity and disease implication

(2020) M.A. Neginskaya et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Amyloid β, α-synuclein and the c subunit of the ATP synthase: Can these peptides reveal an amyloidogenic pathway of the permeability transition pore?

(2020) Giuseppe F. Amodeo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

ATP Synthase C-Subunit-Deficient Mitochondria Have a Small Cyclosporine A-Sensitive Channel, but Lack the Permeability Transition Pore

(2019) Maria A. Neginskaya et al.   Cell Reports

Dimers of mitochondrial ATP synthase induce membrane curvature and self-assemble into rows

(2019) Thorsten B. Blum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Permeability Uncouples Elevated Autophagy and Lifespan Extension

(2019) Ben Zhou et al.   CELL

Structure and Mechanisms of F-Type ATP Synthases

(2019) Werner Kühlbrandt   Annual Review of Biochemistry

Molecular and topological reorganizations in mitochondrial architecture interplay during Bax-mediated steps of apoptosis

(2019) Nicholas R Ader et al.   eLife

Structure of a bacterial ATP synthase

(2019) Hui Guo et al.   eLife

Arg-8 of yeast subunit e contributes to the stability of F-ATP synthase dimers and to the generation of the full-conductance mitochondrial megachannel

(2019) Lishu Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A cryo-FIB lift-out technique enables molecular-resolution cryo-ET within native Caenorhabditis elegans tissue

(2019) Miroslava Schaffer et al.   NATURE METHODS

Persistence of the permeability transition pore in human mitochondria devoid of an assembled ATP synthase

(2019) Joe Carroll et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rotary substates of mitochondrial ATP synthase reveal the basis of flexible F1-Fo coupling

(2019) Bonnie J. Murphy et al.   SCIENCE

Cryo-EM structure of the mammalian ATP synthase tetramer bound with inhibitory protein IF1

(2019) Jinke Gu et al.   SCIENCE

Parkinson’s disease protein DJ-1 regulates ATP synthase protein components to increase neuronal process outgrowth

(2019) Rongmin Chen et al.   Cell Death & Disease

Second‐Generation Inhibitors of the Mitochondrial Permeability Transition Pore with Improved Plasma Stability

(2019) Justina Šileikytė et al.   ChemMedChem

MCUB Regulates the Molecular Composition of the Mitochondrial Calcium Uniporter Channel to Limit Mitochondrial Calcium Overload During Stress

(2019) Jonathan P. Lambert et al.   CIRCULATION

Concerted metabolic shift in early forebrain alters the CSF proteome and depends on cMYC downregulation for mitochondrial maturation

(2019) Ryann M. Fame et al.   DEVELOPMENT

Inhibition of mitochondrial permeability transition by deletion of the ANT family and CypD

(2019) Jason Karch et al.   Science Advances

Cyclosporin A Increases Mitochondrial Buffering of Calcium: An Additional Mechanism in Delaying Mitochondrial Permeability Transition Pore Opening

(2019) Jyotsna Mishra et al.   Cells

Harnessing innate immunity in cancer therapy

(2019) Olivier Demaria et al.   NATURE

Response to Comment on “Protein assemblies ejected directly from native membranes yield complexes for mass spectrometry”

(2019) Dror S. Chorev et al.   SCIENCE

Comment on “Protein assemblies ejected directly from native membranes yield complexes for mass spectrometry”

(2019) Judy Hirst et al.   SCIENCE

Purified F-ATP synthase forms a Ca2+-dependent high-conductance channel matching the mitochondrial permeability transition pore

(2019) Andrea Urbani et al.   Nature Communications

Structure of a mitochondrial ATP synthase with bound native cardiolipin

(2019) Alexander Mühleip et al.   eLife

A mitochondrial megachannel resides in monomeric F1FO ATP synthase

(2019) Nelli Mnatsakanyan et al.   Nature Communications

Programmed necrosis in heart disease: Molecular mechanisms and clinical implications

(2018) Hong Zhu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

MLKL Requires the Inositol Phosphate Code to Execute Necroptosis

(2018) Cole M. Dovey et al.   MOLECULAR CELL

Structure, mechanism, and regulation of the chloroplast ATP synthase

(2018) Alexander Hahn et al.   SCIENCE

BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis

(2018) Kate McArthur et al.   SCIENCE

Structure of the human lipid-gated cation channel TRPC3

(2018) Chen Fan et al.   eLife

Visualizing Mitochondrial FoF1-ATP Synthase as the Target of the Immunomodulatory Drug Bz-423

(2018) Ilka Starke et al.   Frontiers in Physiology

Short-Term Mitochondrial Permeability Transition Pore Opening Modulates Histone Lysine Methylation at the Early Phase of Somatic Cell Reprogramming

(2018) Zhongfu Ying et al.   Cell Metabolism

Mitochondrial inner membrane permeabilisation enables mtDNA release during apoptosis

(2018) Joel S Riley et al.   EMBO JOURNAL

Molecular Communication of a Dying Neuron in Stroke

(2018) Berta Puig et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Arginine 107 of yeast ATP synthase subunit g mediates sensitivity of the mitochondrial permeability transition to phenylglyoxal

(2018) Lishu Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of Novel 1,3,8-Triazaspiro[4.5]decane Derivatives That Target the c Subunit of F1/FO-Adenosine Triphosphate (ATP) Synthase for the Treatment of Reperfusion Damage in Myocardial Infarction

(2018) Giampaolo Morciano et al.   JOURNAL OF MEDICINAL CHEMISTRY

Newly made mitochondrial DNA drives inflammation

(2018) Michael P. Murphy   NATURE

New mitochondrial DNA synthesis enables NLRP3 inflammasome activation

(2018) Zhenyu Zhong et al.   NATURE

Protein assemblies ejected directly from native membranes yield complexes for mass spectrometry

(2018) Dror S. Chorev et al.   SCIENCE

The role of succinate and ROS in reperfusion injury – A critical appraisal

(2017) Tatyana N. Andrienko et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The mitochondrial Na+/Ca2+ exchanger is essential for Ca2+ homeostasis and viability

(2017) Timothy S. Luongo et al.   NATURE

ΔN-Bcl-xL, a therapeutic target for neuroprotection

(2017) Han-A Park et al.   Neural Regeneration Research

Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes

(2017) Amit Agarwal et al.   NEURON

Persistence of the mitochondrial permeability transition in the absence of subunit c of human ATP synthase

(2017) Jiuya He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Permeability transition in human mitochondria persists in the absence of peripheral stalk subunits of ATP synthase

(2017) Jiuya He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atomistic simulations indicate the c-subunit ring of the F1Fo ATP synthase is not the mitochondrial permeability transition pore

(2017) Wenchang Zhou et al.   eLife

Mitochondrial Flash: Integrative Reactive Oxygen Species and pH Signals in Cell and Organelle Biology

(2016) Wang Wang et al.   ANTIOXIDANTS & REDOX SIGNALING

Ischaemic conditioning and targeting reperfusion injury: a 30 year voyage of discovery

(2016) Derek J. Hausenloy et al.   BASIC RESEARCH IN CARDIOLOGY

Quantification of active mitochondrial permeability transition pores using GNX-4975 inhibitor titrations provides insights into molecular identity

(2016) A. P. Richardson et al.   BIOCHEMICAL JOURNAL

On the structural possibility of pore-forming mitochondrial F o F 1 ATP synthase

(2016) Christoph Gerle   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells

(2016) Aaron M. Hosios et al.   DEVELOPMENTAL CELL

Impact of aging on mitochondrial function in cardiac and skeletal muscle

(2016) R.T. Hepple   FREE RADICAL BIOLOGY AND MEDICINE

Physiological roles of the mitochondrial permeability transition pore

(2016) Nelli Mnatsakanyan et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Sequential Engagement of Distinct MLKL Phosphatidylinositol-Binding Sites Executes Necroptosis

(2016) Giovanni Quarato et al.   MOLECULAR CELL

CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress–induced myocardial necroptosis

(2016) Ting Zhang et al.   NATURE MEDICINE

Forty years later: Mitochondria as therapeutic targets in muscle diseases

(2016) Alessandra Zulian et al.   PHARMACOLOGICAL RESEARCH

Deregulation of mitochondrial F1FO-ATP synthase via OSCP in Alzheimer’s disease

(2016) Simon J. Beck et al.   Nature Communications

Atomic structure of the innexin-6 gap junction channel determined by cryo-EM

(2016) Atsunori Oshima et al.   Nature Communications

Real-Time Fluorescence Measurements of ROS and [Ca2+] in Ischemic / Reperfused Rat Hearts: Detectable Increases Occur only after Mitochondrial Pore Opening and Are Attenuated by Ischemic Preconditioning

(2016) Tatyana Andrienko et al.   PLoS One

Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells

(2015) Lucas B. Sullivan et al.   CELL

Physiological and Pathological Roles of the Mitochondrial Permeability Transition Pore in the Heart

(2015) Jennifer Q. Kwong et al.   Cell Metabolism

Individual Cardiac Mitochondria Undergo Rare Transient Permeability Transition Pore OpeningsNovelty and Significance

(2015) Xiyuan Lu et al.   CIRCULATION RESEARCH

Mechanism of mitochondrial permeability transition pore induction and damage in the pancreas: inhibition prevents acute pancreatitis by protecting production of ATP

(2015) Rajarshi Mukherjee et al.   GUT

The mitochondrial permeability transition: A current perspective on its identity and role in ischaemia/reperfusion injury

(2015) Andrew P. Halestrap et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mitoflash altered by metabolic stress in insulin-resistant skeletal muscle

(2015) Yi Ding et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

GraDeR: Membrane Protein Complex Preparation for Single-Particle Cryo-EM

(2015) Florian Hauer et al.   STRUCTURE

Cell Death Signaling

(2015) Douglas R. Green et al.   Cold Spring Harbor Perspectives in Biology

The Mitochondrial Calcium Uniporter Matches Energetic Supply with Cardiac Workload during Stress and Modulates Permeability Transition

(2015) Timothy S. Luongo et al.   Cell Reports

Bovine F1Fo ATP synthase monomers bend the lipid bilayer in 2D membrane crystals

(2015) Chimari Jiko et al.   eLife

Necroptosis Interfaces with MOMP and the MPTP in Mediating Cell Death

(2015) Jason Karch et al.   PLoS One

The role of hexokinase in cardioprotection - mechanism and potential for translation

(2014) Andrew P Halestrap et al.   BRITISH JOURNAL OF PHARMACOLOGY

Genetic deletion of the mitochondrial phosphate carrier desensitizes the mitochondrial permeability transition pore and causes cardiomyopathy

(2014) J Q Kwong et al.   CELL DEATH AND DIFFERENTIATION

Regulation of the Mitochondrial Permeability Transition Pore by the Outer Membrane Does Not Involve the Peripheral Benzodiazepine Receptor (Translocator Protein of 18 kDa (TSPO))

(2014) Justina Šileikytė et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Channel Formation by Yeast F-ATP Synthase and the Role of Dimerization in the Mitochondrial Permeability Transition

(2014) Michela Carraro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulator of Calcineurin 1-1L Protects Cardiomyocytes Against Hypoxia-induced Apoptosis via Mitophagy

(2014) Lijie Yan et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Genetic manipulation of the cardiac mitochondrial phosphate carrier does not affect permeability transition

(2014) Manuel Gutiérrez-Aguilar et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

(2014) Huayi Wang et al.   MOLECULAR CELL

Overexpression of Rcan1-1L Inhibits Hypoxia-Induced Cell Apoptosis through Induction of Mitophagy

(2014) Lijun Sun et al.   MOLECULES AND CELLS

Cheng et al. reply

(2014) Heping Cheng et al.   NATURE

The ‘mitoflash’ probe cpYFP does not respond to superoxide

(2014) Markus Schwarzländer et al.   NATURE

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

(2014) Edward T. Chouchani et al.   NATURE

Mitoflash frequency in early adulthood predicts lifespan in Caenorhabditis elegans

(2014) En-Zhi Shen et al.   NATURE

An uncoupling channel within the c-subunit ring of the F1FO ATP synthase is the mitochondrial permeability transition pore

(2014) K. N. Alavian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Resolution Revolution

(2014) W. Kuhlbrandt   SCIENCE

MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates

(2014) Yves Dondelinger et al.   Cell Reports

The Mitochondrial Permeability Transition Pore and Cancer: Molecular Mechanisms Involved in Cell Death

(2014) Massimo Bonora et al.   Frontiers in Oncology

Involvement of the mitochondrial permeability transition pore in chronic ethanol-mediated liver injury in mice

(2013) Adrienne L. King et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Potential role of subunit c of F0F1-ATPase and subunit c of storage body in the mitochondrial permeability transition. Effect of the phosphorylation status of subunit c on pore opening

(2013) Tamara Azarashvili et al.   CELL CALCIUM

Role of the c subunit of the FOATP synthase in mitochondrial permeability transition

(2013) Massimo Bonora et al.   CELL CYCLE

Immune Sensing of DNA

(2013) Søren R. Paludan et al.   IMMUNITY

Enhancing Mitochondrial Calcium Buffering Capacity Reduces Aggregation of Misfolded SOD1 and Motor Neuron Cell Death without Extending Survival in Mouse Models of Inherited Amyotrophic Lateral Sclerosis

(2013) P. A. Parone et al.   JOURNAL OF NEUROSCIENCE

Changes in the mitochondrial permeability transition pore in aging and age-associated diseases

(2013) Giuseppe Paradies et al.   MECHANISMS OF AGEING AND DEVELOPMENT

A Bcl-xL–Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis

(2013) Hongmei Li et al.   NATURE CELL BIOLOGY

The mitochondrial permeability transition pore regulates Parkinson's disease development in mutant α-synuclein transgenic mice

(2013) Lee J. Martin et al.   NEUROBIOLOGY OF AGING

Dimers of mitochondrial ATP synthase form the permeability transition pore

(2013) V. Giorgio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Regulation of Cell Death

(2013) S. W. G. Tait et al.   Cold Spring Harbor Perspectives in Biology

Multiple Functions of BCL-2 Family Proteins

(2013) J. M. Hardwick et al.   Cold Spring Harbor Perspectives in Biology

Widespread Mitochondrial Depletion via Mitophagy Does Not Compromise Necroptosis

(2013) Stephen W.G. Tait et al.   Cell Reports

Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice

(2013) Jason Karch et al.   eLife

Extent of Mitochondrial Hexokinase II Dissociation During Ischemia Correlates With Mitochondrial Cytochrome c Release, Reactive Oxygen Species Production, and Infarct Size on Reperfusion

(2013) Philippe Pasdois et al.   Journal of the American Heart Association

AMPK Activation Stimulates Autophagy and Ameliorates Muscular Dystrophy in the mdx Mouse Diaphragm

(2012) Marion Pauly et al.   AMERICAN JOURNAL OF PATHOLOGY

The permeability transition pore as a Ca2+ release channel: New answers to an old question

(2012) Paolo Bernardi et al.   CELL CALCIUM

A New Class of Amphiphiles Bearing Rigid Hydrophobic Groups for Solubilization and Stabilization of Membrane Proteins

(2012) Pil Seok Chae et al.   CHEMISTRY-A EUROPEAN JOURNAL

Mitochondria in Control of Cell Fate

(2012) Clifford D.L. Folmes et al.   CIRCULATION RESEARCH

Voltage-dependent Anion Channels (VDACs) Recruit Parkin to Defective Mitochondria to Promote Mitochondrial Autophagy

(2012) Yu Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bax regulates primary necrosis through mitochondrial dynamics

(2012) R. S. Whelan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Superoxide Production Negatively Regulates Neural Progenitor Proliferation and Cerebral Cortical Development

(2012) Yan Hou et al.   STEM CELLS

Caspase Substrates and Cellular Remodeling

(2011) Emily D. Crawford et al.   Annual Review of Biochemistry

Silencing of PINK1 induces mitophagy via mitochondrial permeability transition in dopaminergic MN9D cells

(2011) Tao Cui et al.   BRAIN RESEARCH

Mitochondrial permeability transition in Ca2+-dependent apoptosis and necrosis

(2011) Andrea Rasola et al.   CELL CALCIUM

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

(2011) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

The Permeability Transition Pore Controls Cardiac Mitochondrial Maturation and Myocyte Differentiation

(2011) Jennifer R. Hom et al.   DEVELOPMENTAL CELL

Mitochondria and the Autophagy-Inflammation-Cell Death Axis in Organismal Aging

(2011) D. R. Green et al.   SCIENCE

Taking a “good” look at free radicals in the aging process

(2011) Siegfried Hekimi et al.   TRENDS IN CELL BIOLOGY

Cyclophilin D controls mitochondrial pore–dependent Ca2+ exchange, metabolic flexibility, and propensity for heart failure in mice

(2010) John W. Elrod et al.   JOURNAL OF CLINICAL INVESTIGATION

Increased susceptibility to Ca2+-induced permeability transition and to cytochrome c release in rat heart mitochondria with aging: effect of melatonin

(2010) Giuseppe Petrosillo et al.   JOURNAL OF PINEAL RESEARCH

Maltose–neopentyl glycol (MNG) amphiphiles for solubilization, stabilization and crystallization of membrane proteins

(2010) Pil Seok Chae et al.   NATURE METHODS

Debio-025 is more effective than prednisone in reducing muscular pathology in mdx mice

(2010) Erin R. Wissing et al.   NEUROMUSCULAR DISORDERS

DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function

(2010) L.-Y. Hao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The mitochondrial permeability transition pore and ischemia-reperfusion injury

(2009) Christopher P. Baines   BASIC RESEARCH IN CARDIOLOGY

The role of the mitochondrial permeability transition pore in heart disease

(2009) Andrew P. Halestrap et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial ATP-Synthase in the Entorhinal Cortex Is a Target of Oxidative Stress at Stages I/II of Alzheimer's Disease Pathology

(2009) Beatrice Terni et al.   BRAIN PATHOLOGY

SnapShot: BCL-2 Proteins

(2009) J. Marie Hardwick et al.   CELL

The mitochondrial permeability transition pore in motor neurons: Involvement in the pathobiology of ALS mice

(2009) Lee J. Martin et al.   EXPERIMENTAL NEUROLOGY

Mitochondrial calcium transport in the heart: Physiological and pathological roles

(2009) Elinor J. Griffiths   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

A CaPful of mechanisms regulating the mitochondrial permeability transition

(2009) Fabio Di Lisa et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The c13 Ring from a Thermoalkaliphilic ATP Synthase Reveals an Extended Diameter Due to a Special Structural Region

(2009) Doreen Matthies et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure of the BK potassium channel in a lipid membrane from electron cryomicroscopy

(2009) Liguo Wang et al.   NATURE

RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis

(2009) D.-W. Zhang et al.   SCIENCE

Deletion of the Mitochondrial Superoxide Dismutase sod-2 Extends Lifespan in Caenorhabditis elegans

(2009) Jeremy M. Van Raamsdonk et al.   PLoS Genetics

Superoxide Flashes in Single Mitochondria

(2008) Wang Wang et al.   CELL

Inhibition of Mitochondrial Permeability Transition Pore Opening by Ischemic Preconditioning Is Probably Mediated by Reduction of Oxidative Stress Rather Than Mitochondrial Protein Phosphorylation

(2008) Samantha J. Clarke et al.   CIRCULATION RESEARCH

Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans

(2008) R. Doonan et al.   GENES & DEVELOPMENT

Genetic and pharmacologic inhibition of mitochondrial-dependent necrosis attenuates muscular dystrophy

(2008) Douglas P Millay et al.   NATURE MEDICINE

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

(2008) Heng Du et al.   NATURE MEDICINE

How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?

(2008) Jerry E. Chipuk et al.   TRENDS IN CELL BIOLOGY