Molecular and topological reorganizations in mitochondrial architecture interplay during Bax-mediated steps of apoptosis

Embryogenesis and Adult Life in the Absence of Intrinsic Apoptosis Effectors BAX, BAK, and BOK

(2018) Francine F.S. Ke et al.   CELL

­­Mitochondrial ATP synthase dimers spontaneously associate due to a long-range membrane-induced force­

(2018) Claudio Anselmi et al.   JOURNAL OF GENERAL PHYSIOLOGY

High-resolution cryo-EM analysis of the yeast ATP synthase in a lipid membrane

(2018) Anurag P. Srivastava et al.   SCIENCE

Structure, mechanism, and regulation of the chloroplast ATP synthase

(2018) Alexander Hahn et al.   SCIENCE

BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis

(2018) Kate McArthur et al.   SCIENCE

Correlative Microscopy of Vitreous Sections Provides Insights into BAR-Domain Organization In Situ

(2018) Tanmay A.M. Bharat et al.   STRUCTURE

Mitochondrial inner membrane permeabilisation enables mtDNA release during apoptosis

(2018) Joel S Riley et al.   EMBO JOURNAL

Implementation of a cryo-electron tomography tilt-scheme optimized for high resolution subtomogram averaging

(2017) Wim J.H. Hagen et al.   JOURNAL OF STRUCTURAL BIOLOGY

3D visualization of mitochondrial solid-phase calcium stores in whole cells

(2017) Sharon Grayer Wolf et al.   eLife

Disordered clusters of Bak dimers rupture mitochondria during apoptosis

(2017) Rachel T Uren et al.   eLife

Bax assembly into rings and arcs in apoptotic mitochondria is linked to membrane pores

(2016) R. Salvador-Gallego et al.   EMBO JOURNAL

Bax assembles into large ring-like structures remodeling the mitochondrial outer membrane in apoptosis

(2016) L. Grosse et al.   EMBO JOURNAL

Diverting CERT-mediated ceramide transport to mitochondria triggers Bax-dependent apoptosis

(2016) Amrita Jain et al.   JOURNAL OF CELL SCIENCE

Sponge Phases and Nanoparticle Dispersions in Aqueous Mixtures of Mono- and Diglycerides

(2016) Maria Valldeperas et al.   LANGMUIR

Structure of a Complete ATP Synthase Dimer Reveals the Molecular Basis of Inner Mitochondrial Membrane Morphology

(2016) Alexander Hahn et al.   MOLECULAR CELL

Visualizing the molecular sociology at the HeLa cell nuclear periphery

(2016) J. Mahamid et al.   SCIENCE

In Situ Characterization of Bak Clusters Responsible for Cell Death Using Single Molecule Localization Microscopy

(2016) Yusuke Nasu et al.   Scientific Reports

Structure and function of mitochondrial membrane protein complexes

(2015) Werner Kühlbrandt   BMC BIOLOGY

Atomic structure of the apoptosome: mechanism of cytochromec- and dATP-mediated activation of Apaf-1

(2015) Mengying Zhou et al.   GENES & DEVELOPMENT

Visual and functional demonstration of growing Bax-induced pores in mitochondrial outer membranes

(2015) Laura A Gillies et al.   MOLECULAR BIOLOGY OF THE CELL

How cell death shapes cancer

(2015) V Labi et al.   Cell Death & Disease

Thei-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission

(2014) Ruchika Anand et al.   JOURNAL OF CELL BIOLOGY

Bak Core and Latch Domains Separate during Activation, and Freed Core Domains Form Symmetric Homodimers

(2014) Jason M. Brouwer et al.   MOLECULAR CELL

Structural Model of Active Bax at the Membrane

(2014) Stephanie Bleicken et al.   MOLECULAR CELL

Apoptotic pore formation is associated with in-plane insertion of Bak or Bax central helices into the mitochondrial outer membrane

(2014) Dana Westphal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein-Mediated Transformation of Lipid Vesicles into Tubular Networks

(2013) Mijo Simunovic et al.   BIOPHYSICAL JOURNAL

Bax Crystal Structures Reveal How BH3 Domains Activate Bax and Nucleate Its Oligomerization to Induce Apoptosis

(2013) Peter E. Czabotar et al.   CELL

Dynamics of nucleoid structure regulated by mitochondrial fission contributes to cristae reformation and release of cytochrome c

(2013) R. Ban-Ishihara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Age-dependent dissociation of ATP synthase dimers and loss of inner-membrane cristae in mitochondria

(2013) B. Daum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Correlated cryo-fluorescence and cryo-electron microscopy with high spatial precision and improved sensitivity

(2013) Martin Schorb et al.   ULTRAMICROSCOPY

Structure of the yeast F1Fo-ATP synthase dimer and its role in shaping the mitochondrial cristae

(2012) K. M. Davies et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bcl-xL Retrotranslocates Bax from the Mitochondria into the Cytosol

(2011) Frank Edlich et al.   CELL

Bax dimerizes via a symmetric BH3:groove interface during apoptosis

(2011) G Dewson et al.   CELL DEATH AND DIFFERENTIATION

Correlated fluorescence and 3D electron microscopy with high sensitivity and spatial precision

(2011) Wanda Kukulski et al.   JOURNAL OF CELL BIOLOGY

Macromolecular organization of ATP synthase and complex I in whole mitochondria

(2011) K. M. Davies et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Row-like organization of ATP synthase in intact mitochondria determined by cryo-electron tomography

(2009) Natalya V. Dudkina et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

New Insights into BAR Domain-Induced Membrane Remodeling

(2009) Gary S. Ayton et al.   BIOPHYSICAL JOURNAL

Bax Activates Endophilin B1 Oligomerization and Lipid Membrane Vesiculation

(2009) Tatiana K. Rostovtseva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Details of Bax Activation, Oligomerization, and Membrane Insertion

(2009) Stephanie Bleicken et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Outer Membrane Proteins Assist Bid in Bax-mediated Lipidic Pore Formation

(2009) Blanca Schafer et al.   MOLECULAR BIOLOGY OF THE CELL

Membrane Binding by tBid Initiates an Ordered Series of Events Culminating in Membrane Permeabilization by Bax

(2008) Jonathan F. Lovell et al.   CELL

Dimer ribbons of ATP synthase shape the inner mitochondrial membrane

(2008) Mike Strauss et al.   EMBO JOURNAL

Endophilin B1/Bif-1 Stimulates BAX Activation Independently from Its Capacity to Produce Large Scale Membrane Morphological Rearrangements

(2008) Aitor Etxebarria et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamics and structure of the Bax-Bak complex responsible for releasing mitochondrial proteins during apoptosis

(2008) L. Zhou et al.   JOURNAL OF CELL SCIENCE

To Trigger Apoptosis, Bak Exposes Its BH3 Domain and Homodimerizes via BH3:Groove Interactions

(2008) Grant Dewson et al.   MOLECULAR CELL

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY