Chimeric autoantibody receptor T cells deplete NMDA receptor-specific B cells

Precision targeting of autoantigen-specific B cells in muscle-specific tyrosine kinase myasthenia gravis with chimeric autoantibody receptor T cells

(2023) Sangwook Oh et al.   NATURE BIOTECHNOLOGY

NMDA-receptor-Fc-fusion constructs neutralize anti-NMDA receptor antibodies

(2023) Stephan Steinke et al.   BRAIN

CAR immune cells: design principles, resistance and the next generation

(2023) Louai Labanieh et al.   NATURE

Daratumumab for treatment‐refractory antibody‐mediated diseases in neurology

(2022) Franziska Scheibe et al.   EUROPEAN JOURNAL OF NEUROLOGY

SARS-CoV-2 Beta variant infection elicits potent lineage-specific and cross-reactive antibodies

(2022) S. Momsen Reincke et al.   SCIENCE

Rapid manufacturing of non-activated potent CAR T cells

(2022) Saba Ghassemi et al.   Nature Biomedical Engineering

Safety and efficacy of tisagenlecleucel in primary CNS lymphoma: a phase 1/2 clinical trial

(2022) Matthew J. Frigault et al.   BLOOD

Anti-CD19 CAR T cell therapy for refractory systemic lupus erythematosus

(2022) Andreas Mackensen et al.   NATURE MEDICINE

Molecular disease mechanisms of human antineuronal monoclonal autoantibodies

(2022) Sophie L. Duong et al.   TRENDS IN MOLECULAR MEDICINE

Adverse drug reactions of Rituximab in patients suffering from autoimmune neurological diseases

(2022) Niayesh Mohebbi et al.   DARU-Journal of Pharmaceutical Sciences

Comparison of Fixed and Live Cell-Based Assay for the Detection of AChR and MuSK Antibodies in Myasthenia Gravis

(2022) Gregorio Spagni et al.   Neurology-Neuroimmunology & Neuroinflammation

Use and Safety of Immunotherapeutic Management of N-Methyl-d-Aspartate Receptor Antibody Encephalitis

(2021) Margherita Nosadini et al.   JAMA Neurology

Multimodal electrophysiological analyses reveal that reduced synaptic excitatory neurotransmission underlies seizures in a model of NMDAR antibody-mediated encephalitis

(2021) Sukhvir K. Wright et al.   Communications Biology

Human Cerebrospinal Fluid Monoclonal LGI1 Autoantibodies Increase Neuronal Excitability

(2020) Hans‐Christian Kornau et al.   ANNALS OF NEUROLOGY

Structural Basis of Functional Transitions in Mammalian NMDA Receptors

(2020) Tsung-Han Chou et al.   CELL

Antigen-specific B cell depletion for precision therapy of mucosal pemphigus vulgaris

(2020) Jinmin Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

Adverse event profile differences between rituximab and ocrelizumab: Findings from the FDA Adverse Event Reporting Database

(2020) Natalia Gonzalez Caldito et al.   Multiple Sclerosis Journal

NMDA receptor dysfunction via unmutated human antibodies against the NR1 subunit

(2019) Nina Kerstin Wenke et al.   ANNALS OF NEUROLOGY

Membrane assembly of aquaporin-4 autoantibodies regulates classical complement activation in neuromyelitis optica

(2019) John Soltys et al.   JOURNAL OF CLINICAL INVESTIGATION

Human gestational NMDAR autoantibodies impair neonatal murine brain function

(2019) Betty Jurek et al.   ANNALS OF NEUROLOGY

An update on anti-NMDA receptor encephalitis for neurologists and psychiatrists: mechanisms and models

(2019) Josep Dalmau et al.   LANCET NEUROLOGY

The tyrosine kinase inhibitor dasatinib acts as a pharmacologic on/off switch for CAR T cells

(2019) Katrin Mestermann et al.   Science Translational Medicine

CD171- and GD2-specific CAR-T cells potently target retinoblastoma cells in preclinical in vitro testing

(2019) Lena Andersch et al.   BMC CANCER

N-methyl-D-aspartate receptor antibody production from germinal center reactions: Therapeutic implications

(2018) Mateusz Makuch et al.   ANNALS OF NEUROLOGY

Antibody-Mediated Encephalitis

(2018) Josep Dalmau et al.   NEW ENGLAND JOURNAL OF MEDICINE

Reducing Ex Vivo Culture Improves the Anti-leukemic Activity of Chimeric Antigen Receptor (CAR)-T Cells

(2018) Saba Ghassemi et al.   Cancer Immunology Research

A score that predicts 1-year functional status in patients with anti-NMDA receptor encephalitis

(2018) Ramani Balu et al.   NEUROLOGY

Intrathecal treatment trial of rituximab in progressive MS

(2018) Joakim Bergman et al.   NEUROLOGY

Human cerebrospinal fluid monoclonalN-methyl-D-aspartate receptor autoantibodies are sufficient for encephalitis pathogenesis

(2016) Jakob Kreye et al.   BRAIN

Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease

(2016) C. T. Ellebrecht et al.   SCIENCE

Epileptogenic effects of NMDAR antibodies in a passive transfer mouse model

(2015) Sukhvir Wright et al.   BRAIN

Cleavage efficient 2A peptides for high level monoclonal antibody expression in CHO cells

(2015) Jake Chng et al.   mAbs

Anti-NMDA Receptor Encephalitis in the Polar Bear (Ursus maritimus) Knut

(2015) H. Prüss et al.   Scientific Reports

Functional Tuning of CARs Reveals Signaling Threshold above Which CD8+ CTL Antitumor Potency Is Attenuated due to Cell Fas-FasL-Dependent AICD

(2015) A. Kunkele et al.   Cancer Immunology Research

Human N-methyl D-aspartate receptor antibodies alter memory and behaviour in mice

(2014) Jesús Planagumà et al.   BRAIN

Antibody titres at diagnosis and during follow-up of anti-NMDA receptor encephalitis: a retrospective study

(2013) Nuria Gresa-Arribas et al.   LANCET NEUROLOGY

NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease

(2013) Pierre Paoletti et al.   NATURE REVIEWS NEUROSCIENCE

Anti-NMDA Receptor Encephalitis Antibody Binding Is Dependent on Amino Acid Identity of a Small Region within the GluN1 Amino Terminal Domain

(2012) A. J. Gleichman et al.   JOURNAL OF NEUROSCIENCE

A transgene-encoded cell surface polypeptide for selection, in vivo tracking, and ablation of engineered cells

(2011) X. Wang et al.   BLOOD

Analysis of complement and plasma cells in the brain of patients with anti-NMDAR encephalitis

(2011) E. Martinez-Hernandez et al.   NEUROLOGY

Cellular and Synaptic Mechanisms of Anti-NMDA Receptor Encephalitis

(2010) E. G. Hughes et al.   JOURNAL OF NEUROSCIENCE

Clinical experience and laboratory investigations in patients with anti-NMDAR encephalitis

(2010) Josep Dalmau et al.   LANCET NEUROLOGY

Lentivirus-mediated bifunctional cell labeling for in vivo melanoma study

(2009) Chi-Ping Day et al.   Pigment Cell & Melanoma Research