Molecular disease mechanisms of human antineuronal monoclonal autoantibodies

Clonally Expanded B Cells in Multiple Sclerosis Bind EBV EBNA1 and GlialCAM

(2022) Tobias V. Lanz et al.   NATURE

Paraneoplastic Autoimmune Neurological Syndromes and the Role of Immune Checkpoint Inhibitors

(2022) Sophie L. Duong et al.   Neurotherapeutics

Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis

(2022) Kjetil Bjornevik et al.   SCIENCE

SARS-CoV-2 Beta variant infection elicits potent lineage-specific and cross-reactive antibodies

(2022) S. Momsen Reincke et al.   SCIENCE

Antineonatal Fc Receptor Antibody Treatment Ameliorates MOG-IgG–Associated Experimental Autoimmune Encephalomyelitis

(2022) Jana Remlinger et al.   Neurology-Neuroimmunology & Neuroinflammation

Patient-Derived Anti-NMDAR Antibody Disinhibits Cortical Neuronal Networks through Dysfunction of Inhibitory Neuron Output

(2022) Ewa Andrzejak et al.   JOURNAL OF NEUROSCIENCE

Structural mechanisms of GABAA receptor autoimmune encephalitis

(2022) Colleen M. Noviello et al.   CELL

Cross-reactivity of a pathogenic autoantibody to a tumor antigen in GABAA receptor encephalitis

(2021) Simone M. Brändle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct Comparative Analyses of 10X Genomics Chromium and Smart-seq2

(2021) Xiliang Wang et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

Multimodal electrophysiological analyses reveal that reduced synaptic excitatory neurotransmission underlies seizures in a model of NMDAR antibody-mediated encephalitis

(2021) Sukhvir K. Wright et al.   Communications Biology

Glial Fibrillary Acidic Protein Autoimmunity

(2021) Alice Gravier-Dumonceau et al.   NEUROLOGY

Human Cerebrospinal Fluid Monoclonal LGI1 Autoantibodies Increase Neuronal Excitability

(2020) Hans‐Christian Kornau et al.   ANNALS OF NEUROLOGY

Repeated follow-up of AQP4-IgG titer by cell-based assay in neuromyelitis optica spectrum disorders (NMOSD)

(2020) Tetsuya Akaishi et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Distinctive binding properties of human monoclonal LGI1 autoantibodies determine pathogenic mechanisms

(2020) Melanie Ramberger et al.   BRAIN

Single-cell approaches to investigate B cells and antibodies in autoimmune neurological disorders

(2020) Alicia Zou et al.   Cellular & Molecular Immunology

Hybridoma technology a versatile method for isolation of monoclonal antibodies, its applicability across species, limitations, advancement and future perspectives

(2020) Hilal Ahmed Parray et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The B cell immunobiology that underlies CNS autoantibody-mediated diseases

(2020) Bo Sun et al.   Nature Reviews Neurology

Brain antibody sequence evaluation (BASE): an easy-to-use software for complete data analysis in single cell immunoglobulin cloning

(2020) S. Momsen Reincke et al.   BMC BIOINFORMATICS

A Therapeutic Non-self-reactive SARS-CoV-2 Antibody Protects from Lung Pathology in a COVID-19 Hamster Model

(2020) Jakob Kreye et al.   CELL

Selective Depletion of Antigen-Specific Antibodies for the Treatment of Demyelinating Disease

(2020) Wei Sun et al.   MOLECULAR THERAPY

NMDA receptor dysfunction via unmutated human antibodies against the NR1 subunit

(2019) Nina Kerstin Wenke et al.   ANNALS OF NEUROLOGY

Early B cell tolerance defects in neuromyelitis optica favour anti-AQP4 autoantibody production

(2019) Elizabeth Cotzomi et al.   BRAIN

Membrane assembly of aquaporin-4 autoantibodies regulates classical complement activation in neuromyelitis optica

(2019) John Soltys et al.   JOURNAL OF CLINICAL INVESTIGATION

Eculizumab in Aquaporin-4–Positive Neuromyelitis Optica Spectrum Disorder

(2019) Sean J. Pittock et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Proteomic Screen of Neuronal Cell-Surface Molecules Reveals IgLONs as Structurally Conserved Interaction Modules at the Synapse

(2019) Fanomezana M. Ranaivoson et al.   STRUCTURE

Human gestational NMDAR autoantibodies impair neonatal murine brain function

(2019) Betty Jurek et al.   ANNALS OF NEUROLOGY

Glycine receptor autoantibodies disrupt inhibitory neurotransmission

(2019) Sarah J Crisp et al.   BRAIN

Selective depletion of plasma cells in vivo based on the specificity of their secreted antibodies

(2019) Qingyu Cheng et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The autoantibody-mediated encephalitides: from clinical observations to molecular pathogenesis

(2019) Sudarshini Ramanathan et al.   JOURNAL OF NEUROLOGY

Affinity-matured ‘aquaporumab’ anti-aquaporin-4 antibody for therapy of seropositive neuromyelitis optica spectrum disorders

(2019) Tianjiao Duan et al.   NEUROPHARMACOLOGY

Mechanisms of Caspr2 antibodies in autoimmune encephalitis and neuromyotonia

(2018) Kristina R. Patterson et al.   ANNALS OF NEUROLOGY

Pathogenicity of human antibodies against myelin oligodendrocyte glycoprotein

(2018) Melania Spadaro et al.   ANNALS OF NEUROLOGY

Cryo-EM in drug discovery: achievements, limitations and prospects

(2018) Jean-Paul Renaud et al.   NATURE REVIEWS DRUG DISCOVERY

Encephalitis with mGluR5 antibodies

(2018) Marianna Spatola et al.   NEUROLOGY

Antibody-Mediated Encephalitis

(2018) Josep Dalmau et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structural basis of epilepsy-related ligand–receptor complex LGI1–ADAM22

(2018) Atsushi Yamagata et al.   Nature Communications

NMDA Receptor Autoantibodies in Autoimmune Encephalitis Cause a Subunit-Specific Nanoscale Redistribution of NMDA Receptors

(2018) Laurent Ladépêche et al.   Cell Reports

A Spectrum of Neural Autoantigens, Newly Identified by Histo-Immunoprecipitation, Mass Spectrometry, and Recombinant Cell-Based Indirect Immunofluorescence

(2018) Madeleine Scharf et al.   Frontiers in Immunology

A New Classification System for IgG4 Autoantibodies

(2018) Inga Koneczny   Frontiers in Immunology

Monoclonal antibodies from a patient with anti-NMDA receptor encephalitis

(2018) Rashmi Sharma et al.   Annals of Clinical and Translational Neurology

Affinities of human NMDA receptor autoantibodies: implications for disease mechanisms and clinical diagnostics

(2018) Lam-Thanh Ly et al.   JOURNAL OF NEUROLOGY

Frequency, symptoms, risk factors, and outcomes of autoimmune encephalitis after herpes simplex encephalitis: a prospective observational study and retrospective analysis

(2018) Thaís Armangue et al.   LANCET NEUROLOGY

Structure of a human synaptic GABAA receptor

(2018) Shaotong Zhu et al.   NATURE

Complement-dependent bystander injury to neurons in AQP4-IgG seropositive neuromyelitis optica

(2018) Tianjiao Duan et al.   Journal of Neuroinflammation

Human antibodies against the myelin oligodendrocyte glycoprotein can cause complement-dependent demyelination

(2017) Patrick Peschl et al.   Journal of Neuroinflammation

Cryo-EM structures of the triheteromeric NMDA receptor and its allosteric modulation

(2017) Wei Lü et al.   SCIENCE

Glucose-regulated protein 78 autoantibody associates with blood-brain barrier disruption in neuromyelitis optica

(2017) Fumitaka Shimizu et al.   Science Translational Medicine

Engineered clearing agents for the selective depletion of antigen-specific antibodies

(2017) Siva Charan Devanaboyina et al.   Nature Communications

CNS Aquaporin-4-specific B cells connect with multiple B-cell compartments in neuromyelitis optica spectrum disorder

(2017) Markus C. Kowarik et al.   Annals of Clinical and Translational Neurology

NMDAR encephalitis: passive transfer from man to mouse by a recombinant antibody

(2017) Manish Malviya et al.   Annals of Clinical and Translational Neurology

Analysis of peripheral B cells and autoantibodies against the anti-nicotinic acetylcholine receptor derived from patients with myasthenia gravis using single-cell manipulation tools

(2017) Tomohiro Makino et al.   PLoS One

Human cerebrospinal fluid monoclonalN-methyl-D-aspartate receptor autoantibodies are sufficient for encephalitis pathogenesis

(2016) Jakob Kreye et al.   BRAIN

Cellular investigations with human antibodies associated with the anti-IgLON5 syndrome

(2016) Lidia Sabater et al.   Journal of Neuroinflammation

Caspr2-reactive antibody cloned from a mother of an ASD child mediates an ASD-like phenotype in mice

(2016) L Brimberg et al.   MOLECULAR PSYCHIATRY

Anti-LGI1–associated cognitive impairment

(2016) Helena Ariño et al.   NEUROLOGY

The clinical spectrum of Caspr2 antibody–associated disease

(2016) Agnes van Sonderen et al.   NEUROLOGY

Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease

(2016) C. T. Ellebrecht et al.   SCIENCE

Compromised fidelity of B-cell tolerance checkpoints in AChR and MuSK myasthenia gravis

(2016) Jae-Yun Lee et al.   Annals of Clinical and Translational Neurology

Human autoantibodies to amphiphysin induce defective presynaptic vesicle dynamics and composition

(2015) Christian Werner et al.   BRAIN

Droplet Barcoding for Single-Cell Transcriptomics Applied to Embryonic Stem Cells

(2015) Allon M. Klein et al.   CELL

Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets

(2015) Evan Z. Macosko et al.   CELL

The expanding field of IgG4-mediated neurological autoimmune disorders

(2015) M. G. Huijbers et al.   EUROPEAN JOURNAL OF NEUROLOGY

X-ray crystallography over the past decade for novel drug discovery – where are we heading next?

(2015) Heping Zheng et al.   Expert Opinion on Drug Discovery

The cerebrospinal fluid immunoglobulin transcriptome and proteome in neuromyelitis optica reveals central nervous system-specific B cell populations

(2015) Markus C Kowarik et al.   Journal of Neuroinflammation

Glycine receptor mechanism elucidated by electron cryo-microscopy

(2015) Juan Du et al.   NATURE

Antibodies to GABAA receptor  1 and  2 subunits: Clinical and serologic characterization

(2015) P. Pettingill et al.   NEUROLOGY

Surface plasmon resonance applications in clinical analysis

(2014) Stefano Mariani et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Identification and Characterization of GABAA Receptor Autoantibodies in Autoimmune Encephalitis

(2014) T. Ohkawa et al.   JOURNAL OF NEUROSCIENCE

Encephalitis with refractory seizures, status epilepticus, and antibodies to the GABAA receptor: a case series, characterisation of the antigen, and analysis of the effects of antibodies

(2014) Mar Petit-Pedrol et al.   LANCET NEUROLOGY

A novel non-rapid-eye movement and rapid-eye-movement parasomnia with sleep breathing disorder associated with antibodies to IgLON5: a case series, characterisation of the antigen, and post-mortem study

(2014) Lidia Sabater et al.   LANCET NEUROLOGY

Unique neuromyelitis optica pathology produced in naïve rats by intracerebral administration of NMO-IgG

(2013) Nithi Asavapanumas et al.   ACTA NEUROPATHOLOGICA

Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis: an observational cohort study

(2013) Maarten J Titulaer et al.   LANCET NEUROLOGY

Antibody titres at diagnosis and during follow-up of anti-NMDA receptor encephalitis: a retrospective study

(2013) Nuria Gresa-Arribas et al.   LANCET NEUROLOGY

Encephalitis and antibodies to dipeptidyl-peptidase-like protein-6, a subunit of Kv4.2 potassium channels

(2012) Anna Boronat et al.   ANNALS OF NEUROLOGY

N-methyl-D-aspartate receptor antibodies in herpes simplex encephalitis

(2012) Harald Prüss et al.   ANNALS OF NEUROLOGY

Immunopathology of autoantibody-associated encephalitides: clues for pathogenesis

(2012) C. G. Bien et al.   BRAIN

Complement-dependent Cytotoxicity in Neuromyelitis Optica Requires Aquaporin-4 Protein Assembly in Orthogonal Arrays

(2012) Puay-Wah Phuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuronal autoantigens—pathogenesis, associated disorders and antibody testing

(2012) Eric Lancaster et al.   Nature Reviews Neurology

Anti-Aquaporin-4 monoclonal antibody blocker therapy for neuromyelitis optica

(2011) Lukmanee Tradtrantip et al.   ANNALS OF NEUROLOGY

Binding Affinity and Specificity of Neuromyelitis Optica Autoantibodies to Aquaporin-4 M1/M23 Isoforms and Orthogonal Arrays

(2011) Jonathan M. Crane et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antibodies to metabotropic glutamate receptor 5 in the Ophelia syndrome

(2011) E. Lancaster et al.   NEUROLOGY

Human Stiff-Person Syndrome IgG Induces Anxious Behavior in Rats

(2011) Christian Geis et al.   PLoS One

Intravenous Neuromyelitis Optica Autoantibody in Mice Targets Aquaporin-4 in Peripheral Organs and Area Postrema

(2011) Julien Ratelade et al.   PLoS One

Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated protein-2 in limbic encephalitis, Morvan’s syndrome and acquired neuromyotonia

(2010) Sarosh R. Irani et al.   BRAIN

Cellular and Synaptic Mechanisms of Anti-NMDA Receptor Encephalitis

(2010) E. G. Hughes et al.   JOURNAL OF NEUROSCIENCE

Investigation of LGI1 as the antigen in limbic encephalitis previously attributed to potassium channels: a case series

(2010) Meizan Lai et al.   LANCET NEUROLOGY

Intrathecal pathogenic anti–aquaporin-4 antibodies in early neuromyelitis optica

(2009) Jeffrey L. Bennett et al.   ANNALS OF NEUROLOGY

Antibodies to native myelin oligodendrocyte glycoprotein in children with inflammatory demyelinating central nervous system disease

(2009) Fabienne Brilot et al.   ANNALS OF NEUROLOGY

AMPA receptor antibodies in limbic encephalitis alter synaptic receptor location

(2009) Meizan Lai et al.   ANNALS OF NEUROLOGY

Antibodies to glutamic acid decarboxylase define a form of limbic encephalitis

(2009) Michael P. Malter et al.   ANNALS OF NEUROLOGY

Antibodies to the GABAB receptor in limbic encephalitis with seizures: case series and characterisation of the antigen

(2009) Eric Lancaster et al.   LANCET NEUROLOGY

X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor

(2009) Alexander I. Sobolevsky et al.   NATURE

PROGRESSIVE ENCEPHALOMYELITIS, RIGIDITY, AND MYOCLONUS: A NOVEL GLYCINE RECEPTOR ANTIBODY

(2008) M. Hutchinson et al.   NEUROLOGY

Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloning

(2007) Thomas Tiller et al.   JOURNAL OF IMMUNOLOGICAL METHODS