Membrane assembly of aquaporin-4 autoantibodies regulates classical complement activation in neuromyelitis optica

The evolving mystery of why skeletal muscle is spared in seropositive neuromyelitis optica

(2018) Alan S. Verkman et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Recombinant IgG1 Fc hexamers block cytotoxicity and pathological changes in experimental in vitro and rat models of neuromyelitis optica

(2018) Lukmanee Tradtrantip et al.   NEUROPHARMACOLOGY

Mutations of Recombinant Aquaporin-4 Antibody in the Fc Domain Can Impair Complement-Dependent Cellular Cytotoxicity and Transplacental Transport

(2018) Simone Mader et al.   Frontiers in Immunology

An immunoaffinity-based method for isolating ultrapure adult astrocytes based on ATP1B2 targeting by the ACSA-2 antibody

(2017) Mykhailo Y. Batiuk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Safety and efficacy of eculizumab in anti-acetylcholine receptor antibody-positive refractory generalised myasthenia gravis (REGAIN): a phase 3, randomised, double-blind, placebo-controlled, multicentre study

(2017) James F Howard et al.   LANCET NEUROLOGY

Glucose-regulated protein 78 autoantibody associates with blood-brain barrier disruption in neuromyelitis optica

(2017) Fumitaka Shimizu et al.   Science Translational Medicine

Complement regulator CD59 prevents peripheral organ injury in rats made seropositive for neuromyelitis optica immunoglobulin G

(2017) Xiaoming Yao et al.   Acta Neuropathologica Communications

Antibodies That Efficiently Form Hexamers upon Antigen Binding Can Induce Complement-Dependent Cytotoxicity under Complement-Limiting Conditions

(2016) Erika M. Cook et al.   JOURNAL OF IMMUNOLOGY

Variable sensitivity to complement-dependent cytotoxicity in murine models of neuromyelitis optica

(2016) Yiting Liu et al.   Journal of Neuroinflammation

Molecular Basis of Assembly and Activation of Complement Component C1 in Complex with Immunoglobulin G1 and Antigen

(2016) Guanbo Wang et al.   MOLECULAR CELL

A Novel Platform for the Potentiation of Therapeutic Antibodies Based on Antigen-Dependent Formation of IgG Hexamers at the Cell Surface

(2016) Rob N. de Jong et al.   PLOS BIOLOGY

Expression of the Astrocyte Water Channel Aquaporin-4 in the Mouse Brain

(2015) Jacqueline A. Hubbard et al.   ASN Neuro

Superresolution Imaging of Aquaporin-4 Cluster Size in Antibody-Stained Paraffin Brain Sections

(2015) Alex J. Smith et al.   BIOPHYSICAL JOURNAL

Mutagenesis of the Aquaporin 4 Extracellular Domains Defines Restricted Binding Patterns of Pathogenic Neuromyelitis Optica IgG

(2015) Gregory P. Owens et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sialylation of IgG Fc domain impairs complement-dependent cytotoxicity

(2015) Isaak Quast et al.   JOURNAL OF CLINICAL INVESTIGATION

International consensus diagnostic criteria for neuromyelitis optica spectrum disorders

(2015) Dean M. Wingerchuk et al.   NEUROLOGY

Complement System Part I – Molecular Mechanisms of Activation and Regulation

(2015) Nicolas S. Merle et al.   Frontiers in Immunology

Complement and Its Receptors: New Insights into Human Disease

(2014) V. Michael Holers   Annual Review of Immunology

Longitudinally extensive NMO spinal cord pathology produced by passive transfer of NMO-IgG in mice lacking complement inhibitor CD59

(2014) Hua Zhang et al.   JOURNAL OF AUTOIMMUNITY

Treatment of neuromyelitis optica: state-of-the-art and emerging therapies

(2014) Marios C. Papadopoulos et al.   Nature Reviews Neurology

Complement Is Activated by IgG Hexamers Assembled at the Cell Surface

(2014) C. A. Diebolder et al.   SCIENCE

Deciphering the Fine Details of C1 Assembly and Activation Mechanisms: “Mission Impossible”?

(2014) Christine Gaboriaud et al.   Frontiers in Immunology

Neuromyelitis optica pathology in rats following intraperitoneal injection of NMO-IgG and intracerebral needle injury

(2014) Nithi Asavapanumas et al.   Acta Neuropathologica Communications

C1q-targeted monoclonal antibody prevents complement-dependent cytotoxicity and neuropathology in in vitro and mouse models of neuromyelitis optica

(2013) Puay-Wah Phuan et al.   ACTA NEUROPATHOLOGICA

Unique neuromyelitis optica pathology produced in naïve rats by intracerebral administration of NMO-IgG

(2013) Nithi Asavapanumas et al.   ACTA NEUROPATHOLOGICA

Presence of six different lesion types suggests diverse mechanisms of tissue injury in neuromyelitis optica

(2013) Tatsuro Misu et al.   ACTA NEUROPATHOLOGICA

Complement associated pathogenic mechanisms in myasthenia gravis

(2013) Erdem Tüzün et al.   AUTOIMMUNITY REVIEWS

Detection of complement activation using monoclonal antibodies against C3d

(2013) Joshua M. Thurman et al.   JOURNAL OF CLINICAL INVESTIGATION

The Role of the Complement System in Acute Kidney Injury

(2013) James W. McCullough et al.   SEMINARS IN NEPHROLOGY

Meningococcal disease and the complement system

(2013) Lisa A Lewis et al.   Virulence

Aquaporin 4 Expression and Tissue Susceptibility to Neuromyelitis Optica

(2013) Marcelo Matiello et al.   JAMA Neurology

Enzymatic deglycosylation converts pathogenic neuromyelitis optica anti-aquaporin-4 immunoglobulin G into therapeutic antibody

(2012) Lukmanee Tradtrantip et al.   ANNALS OF NEUROLOGY

Isolation and characterization of living primary astroglial cells using the new GLAST-specific monoclonal antibody ACSA-1

(2012) Melanie Jungblut et al.   GLIA

Neuromyelitis optica: Aquaporin-4 based pathogenesis mechanisms and new therapies

(2012) Julien Ratelade et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Astrocytic autoantibody of neuromyelitis optica (NMO-IgG) binds to aquaporin-4 extracellular loops, monomers, tetramers and high order arrays

(2012) Raffaele Iorio et al.   JOURNAL OF AUTOIMMUNITY

Complement-dependent Cytotoxicity in Neuromyelitis Optica Requires Aquaporin-4 Protein Assembly in Orthogonal Arrays

(2012) Puay-Wah Phuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Super-resolution imaging of aquaporin-4 orthogonal arrays of particles in cell membranes

(2012) A. Rossi et al.   JOURNAL OF CELL SCIENCE

Serologic diagnosis of NMO: A multicenter comparison of aquaporin-4-IgG assays

(2012) P. J. Waters et al.   NEUROLOGY

A unique series of reversibly switchable fluorescent proteins with beneficial properties for various applications

(2012) H. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aquaporin-4: orthogonal array assembly, CNS functions and role in neuromyelitis optica

(2011) Alan S Verkman et al.   ACTA PHARMACOLOGICA SINICA

Anti-Aquaporin-4 monoclonal antibody blocker therapy for neuromyelitis optica

(2011) Lukmanee Tradtrantip et al.   ANNALS OF NEUROLOGY

Aquaporins in Clinical Medicine

(2011) A.S. Verkman   Annual Review of Medicine

Evidence against Cellular Internalizationin Vivoof NMO-IgG, Aquaporin-4, and Excitatory Amino Acid Transporter 2 in Neuromyelitis Optica

(2011) Julien Ratelade et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Binding Affinity and Specificity of Neuromyelitis Optica Autoantibodies to Aquaporin-4 M1/M23 Isoforms and Orthogonal Arrays

(2011) Jonathan M. Crane et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysis of complement and plasma cells in the brain of patients with anti-NMDAR encephalitis

(2011) E. Martinez-Hernandez et al.   NEUROLOGY

Intravenous Neuromyelitis Optica Autoantibody in Mice Targets Aquaporin-4 in Peripheral Organs and Area Postrema

(2011) Julien Ratelade et al.   PLoS One

Molecular outcomes of neuromyelitis optica (NMO)-IgG binding to aquaporin-4 in astrocytes

(2011) S. R. Hinson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular and Synaptic Mechanisms of Anti-NMDA Receptor Encephalitis

(2010) E. G. Hughes et al.   JOURNAL OF NEUROSCIENCE

Engineered Fc variant antibodies with enhanced ability to recruit complement and mediate effector functions

(2010) Gregory L. Moore et al.   mAbs

Complement: a key system for immune surveillance and homeostasis

(2010) Daniel Ricklin et al.   NATURE IMMUNOLOGY

AQP4 antibodies in neuromyelitis optica: diagnostic and pathogenetic relevance

(2010) Sven Jarius et al.   Nature Reviews Neurology

Intrathecal pathogenic anti–aquaporin-4 antibodies in early neuromyelitis optica

(2009) Jeffrey L. Bennett et al.   ANNALS OF NEUROLOGY

Prediction of Neuromyelitis Optica Attack Severity by Quantitation of Complement-Mediated Injury to Aquaporin-4–Expressing Cells

(2009) Shannon R. Hinson et al.   ARCHIVES OF NEUROLOGY

High-resolution structures of collagen-like peptides [(Pro-Pro-Gly)4-Xaa-Yaa-Gly-(Pro-Pro-Gly)4]: Implications for triple-helix hydration and Hyp(X) puckering

(2009) Kenji Okuyama et al.   BIOPOLYMERS

Paths reunited: Initiation of the classical and lectin pathways of complement activation

(2009) Russell Wallis et al.   IMMUNOBIOLOGY

Live Cell Analysis of Aquaporin-4 M1/M23 Interactions and Regulated Orthogonal Array Assembly in Glial Cells

(2009) Jonathan M. Crane et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Determinants of aquaporin-4 assembly in orthogonal arrays revealed by live-cell single-molecule fluorescence imaging

(2009) J. M. Crane et al.   JOURNAL OF CELL SCIENCE

Crystal structure of human aquaporin 4 at 1.8 A and its mechanism of conductance

(2009) J. D. Ho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A statistically derived parameterization for the collagen triple-helix

(2002) Jan K. Rainey et al.   PROTEIN SCIENCE