Precision targeting of autoantigen-specific B cells in muscle-specific tyrosine kinase myasthenia gravis with chimeric autoantibody receptor T cells

Skull and vertebral bone marrow are myeloid cell reservoirs for the meninges and CNS parenchyma

(2021) Andrea Cugurra et al.   SCIENCE

Short- and Long-Lived Autoantibody-Secreting Cells in Autoimmune Neurological Disorders

(2021) C. Zografou et al.   Frontiers in Immunology

Long-Lasting Rituximab-Induced Reduction of Specific—But Not Total—IgG4 in MuSK-Positive Myasthenia Gravis

(2020) Mariapaola Marino et al.   Frontiers in Immunology

FcγR Binding and ADCC Activity of Human IgG Allotypes

(2020) Steven W. de Taeye et al.   Frontiers in Immunology

Muscle-Specific Kinase Myasthenia Gravis

(2020) Lucia S. Borges et al.   Frontiers in Immunology

Single-cell repertoire tracing identifies rituximab-resistant B cells during myasthenia gravis relapses

(2020) Ruoyi Jiang et al.   JCI Insight

Antigen-specific B cell depletion for precision therapy of mucosal pemphigus vulgaris

(2020) Jinmin Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

The Neuromuscular Junction in Health and Disease: Molecular Mechanisms Governing Synaptic Formation and Homeostasis

(2020) Pedro M. Rodríguez Cruz et al.   Frontiers in Molecular Neuroscience

Modulation of Target Antigen Density Improves CAR T Cell Functionality and Persistence

(2019) Sneha Ramakrishna et al.   CLINICAL CANCER RESEARCH

Mechanisms underlying B cell immune dysregulation and autoantibody production in MuSK myasthenia gravis

(2018) Panos Stathopoulos et al.   Annals of the New York Academy of Sciences

Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia

(2018) Shannon L. Maude et al.   NEW ENGLAND JOURNAL OF MEDICINE

Potential of Murine IgG1 and Human IgG4 to Inhibit the Classical Complement and Fcγ Receptor Activation Pathways

(2018) Gina-Maria Lilienthal et al.   Frontiers in Immunology

Tisagenlecleucel in Adult Relapsed or Refractory Diffuse Large B-Cell Lymphoma

(2018) Stephen J. Schuster et al.   NEW ENGLAND JOURNAL OF MEDICINE

Longitudinal epitope mapping in MuSK myasthenia gravis: implications for disease severity

(2016) Maartje G. Huijbers et al.   JOURNAL OF NEUROIMMUNOLOGY

Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease

(2016) C. T. Ellebrecht et al.   SCIENCE

Dental follicle mesenchymal stem cell administration ameliorates muscle weakness in MuSK-immunized mice

(2015) Canan Ulusoy et al.   Journal of Neuroinflammation

Preferential production of IgG1, IL-4 and IL-10 in MuSK-immunized mice

(2014) Canan Ulusoy et al.   CLINICAL IMMUNOLOGY

MuSK Myasthenia Gravis IgG4 Disrupts the Interaction of LRP4 with MuSK but Both IgG4 and IgG1-3 Can Disperse Preformed Agrin-Independent AChR Clusters

(2013) Inga Koneczny et al.   PLoS One

MuSK IgG4 autoantibodies cause myasthenia gravis by inhibiting binding between MuSK and Lrp4

(2013) M. G. Huijbers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Passive and active immunization models of MuSK-Ab positive myasthenia: Electrophysiological evidence for pre and postsynaptic defects

(2012) Stuart Viegas et al.   EXPERIMENTAL NEUROLOGY

Structural basis of agrin-LRP4-MuSK signaling

(2012) Y. Zong et al.   GENES & DEVELOPMENT

Antibodies against Muscle-Specific Kinase Impair Both Presynaptic and Postsynaptic Functions in a Murine Model of Myasthenia Gravis

(2011) Shuuichi Mori et al.   AMERICAN JOURNAL OF PATHOLOGY

Adoptive transfer of syngeneic T cells transduced with a chimeric antigen receptor that recognizes murine CD19 can eradicate lymphoma and normal B cells

(2010) J. N. Kochenderfer et al.   BLOOD

Lrp4 Regulates Initiation of Ureteric Budding and Is Crucial for Kidney Formation – A Mouse Model for Cenani-Lenz Syndrome

(2010) Courtney M. Karner et al.   PLoS One

Lrp4 Is a Receptor for Agrin and Forms a Complex with MuSK

(2008) Natalie Kim et al.   CELL

LRP4 Serves as a Coreceptor of Agrin

(2008) Bin Zhang et al.   NEURON

Lrp4 Modulates Extracellular Integration of Cell Signaling Pathways in Development

(2008) Atsushi Ohazama et al.   PLoS One