NMDA-receptor-Fc-fusion constructs neutralize anti-NMDA receptor antibodies

Development and characterization of functional antibodies targeting NMDA receptors

(2022) Nami Tajima et al.   Nature Communications

Anti-NMDAR encephalitis induced in mice by active immunization with a peptide from the amino-terminal domain of the GluN1 subunit

(2021) Yuewen Ding et al.   Journal of Neuroinflammation

Limitations of a Commercial Assay as Diagnostic Test of Autoimmune Encephalitis

(2021) Raquel Ruiz-García et al.   Frontiers in Immunology

Structural Basis of Functional Transitions in Mammalian NMDA Receptors

(2020) Tsung-Han Chou et al.   CELL

Generate-Boost: study protocol for a prospective, multicenter, randomized controlled, double-blinded phase II trial to evaluate efficacy and safety of bortezomib in patients with severe autoimmune encephalitis

(2020) Jonathan Wickel et al.   Trials

Allosteric modulation of NMDA receptors prevents the antibody effects of patients with anti-NMDAR encephalitis

(2020) Francesco Mannara et al.   BRAIN

Autoimmune encephalitis: novel therapeutic targets at the preclinical level

(2020) Josefine Sell et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Human gestational NMDAR autoantibodies impair neonatal murine brain function

(2019) Betty Jurek et al.   ANNALS OF NEUROLOGY

An update on anti-NMDA receptor encephalitis for neurologists and psychiatrists: mechanisms and models

(2019) Josep Dalmau et al.   LANCET NEUROLOGY

Autoimmune receptor encephalitis in mice induced by active immunization with conformationally stabilized holoreceptors

(2019) Brian E. Jones et al.   Science Translational Medicine

Clinical and pathogenic significance of IgG, IgA, and IgM antibodies against the NMDA receptor

(2018) Makoto Hara et al.   NEUROLOGY

Affinities of human NMDA receptor autoantibodies: implications for disease mechanisms and clinical diagnostics

(2018) Lam-Thanh Ly et al.   JOURNAL OF NEUROLOGY

Autoantibodies to Synaptic Receptors and Neuronal Cell Surface Proteins in Autoimmune Diseases of the Central Nervous System

(2017) Josep Dalmau et al.   PHYSIOLOGICAL REVIEWS

Ephrin-B2 prevents N-methyl-D-aspartate receptor antibody effects on memory and neuroplasticity

(2016) Jesús Planagumà et al.   ANNALS OF NEUROLOGY

Human cerebrospinal fluid monoclonalN-methyl-D-aspartate receptor autoantibodies are sufficient for encephalitis pathogenesis

(2016) Jakob Kreye et al.   BRAIN

All naturally occurring autoantibodies against the NMDA receptor subunit NR1 have pathogenic potential irrespective of epitope and immunoglobulin class

(2016) E Castillo-Gómez et al.   MOLECULAR PSYCHIATRY

Bortezomib for treatment of therapy-refractory anti-NMDA receptor encephalitis

(2016) Franziska Scheibe et al.   NEUROLOGY

Crystal structure of a heterotetrameric NMDA receptor ion channel

(2014) E. Karakas et al.   SCIENCE

Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis: an observational cohort study

(2013) Maarten J Titulaer et al.   LANCET NEUROLOGY

Rapid Single-Step Induction of Functional Neurons from Human Pluripotent Stem Cells

(2013) Yingsha Zhang et al.   NEURON

Disrupted surface cross-talk between NMDA and Ephrin-B2 receptors in anti-NMDA encephalitis

(2012) Lenka Mikasova et al.   BRAIN

Anti-NMDA Receptor Encephalitis Antibody Binding Is Dependent on Amino Acid Identity of a Small Region within the GluN1 Amino Terminal Domain

(2012) A. J. Gleichman et al.   JOURNAL OF NEUROSCIENCE

Analysis of complement and plasma cells in the brain of patients with anti-NMDAR encephalitis

(2011) E. Martinez-Hernandez et al.   NEUROLOGY

Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target

(2011) Y. J. Yu et al.   Science Translational Medicine