Cinchonine exerts anti-tumor and immunotherapy sensitizing effects in lung cancer by impairing autophagic-lysosomal degradation

Immunogenic hypofractionated radiotherapy sensitising head and neck squamous cell carcinoma to anti-PD-L1 therapy in MDSC-dependent manner

(2023) Liang Mao et al.   BRITISH JOURNAL OF CANCER

Combination strategies with PD-1/PD-L1 blockade: current advances and future directions

(2022) Ming Yi et al.   Molecular Cancer

A Paradigm of Cancer Immunotherapy Based on 2-[18F]FDG and Anti–PD-L1 mAb Combination to Enhance the Antitumor Effect

(2022) Xuejun Wen et al.   CLINICAL CANCER RESEARCH

13-Methyl-palmatrubine shows an anti-tumor role in non-small cell lung cancer via shifting M2 to M1 polarization of tumor macrophages

(2022) Zhihui Wu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

NCCN Guidelines Insights: Non–Small Cell Lung Cancer, Version 2.2021

(2021) David S. Ettinger et al.   Journal of the National Comprehensive Cancer Network

G Protein-Coupled Estrogen Receptor in Cancer and Stromal Cells: Functions and Novel Therapeutic Perspectives

(2021) Richard A. Pepermans et al.   Cells

Chitosan-based nanoparticle co-delivery of docetaxel and curcumin ameliorates anti-tumor chemoimmunotherapy in lung cancer

(2021) Xiongjie Zhu et al.   CARBOHYDRATE POLYMERS

Autophagy in major human diseases

(2021) Daniel J Klionsky et al.   EMBO JOURNAL

Apatinib triggers autophagic and apoptotic cell death via VEGFR2/STAT3/PD-L1 and ROS/Nrf2/p62 signaling in lung cancer

(2021) Chunfeng Xie et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Pharmacodynamic measures within tumors expose differential activity of PD(L)-1 antibody therapeutics

(2021) Dhiraj Kumar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative immunohistochemistry (IHC) analysis of biomarker combinations for human esophageal squamous cell carcinoma

(2021) Jiebing Gao et al.   Annals of Translational Medicine

Full-coverage regulations of autophagy by ROS: from induction to maturation

(2021) Jing Zhou et al.   Autophagy

Increased ROS-Dependent Fission of Mitochondria Causes Abnormal Morphology of the Cell Powerhouses in a Murine Model of Amyotrophic Lateral Sclerosis

(2021) Jan Stein et al.   Oxidative Medicine and Cellular Longevity

Yeast β-D-glucan exerts anti-tumour activity in liver cancer through impairing autophagy and lysosomal function, promoting reactive oxygen species production and apoptosis

(2020) Ningning Wang et al.   Redox Biology

Lysosome biology in autophagy

(2020) Willa Wen-You Yim et al.   Cell Discovery

Autophagy triggers CTSD (cathepsin D) maturation and localization inside cells to promote apoptosis

(2020) Yu-Qin Di et al.   Autophagy

PD-L1 engagement on T cells promotes self-tolerance and suppression of neighboring macrophages and effector T cells in cancer

(2020) Brian Diskin et al.   NATURE IMMUNOLOGY

Natural Compounds with Potential to Modulate Cancer Therapies and Self-Reactive Immune Cells

(2020) Rhiane Moody et al.   Cancers

Repurposing of quinoline alkaloids identifies their ability to induce sub G0/G1 phase cell cycle arrest and enhance doxorubicin‐induced apoptosis in cervical and hepatocellular carcinoma cells

(2020) Mohamed El‐Mesery et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Autophagosomes are formed at a distinct cellular structure

(2020) David M. Hollenstein et al.   CURRENT OPINION IN CELL BIOLOGY

Cinchonine inhibits osteoclast differentiation by regulating TAK1 and AKT, and promotes osteogenesis

(2020) You‐Jin Jo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The Ins and Outs of Cathepsins: Physiological Function and Role in Disease Management

(2020) Tulasi Yadati et al.   Cells

Autophagy and Its Regulators in Response to Stress in Plants

(2020) Wanlong Su et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeting autophagy to overcome drug resistance: further developments

(2020) Haocai Chang et al.   Journal of Hematology & Oncology

Regulation of PD-L1 Expression by NF-κB in Cancer

(2020) Fabrizio Antonangeli et al.   Frontiers in Immunology

The relationship between autophagy and the immune system and its applications for tumor immunotherapy

(2019) Guan-Min Jiang et al.   Molecular Cancer

Autophagy inhibition enhances PD-L1 expression in gastric cancer

(2019) Xiaojuan Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Role of tumor and host autophagy in cancer metabolism

(2019) Laura Poillet-Perez et al.   GENES & DEVELOPMENT

Evaluation of ellagic acid as an inhibitor of sphingosine kinase 1: A targeted approach towards anticancer therapy

(2019) Preeti Gupta et al.   BIOMEDICINE & PHARMACOTHERAPY

iNOS Interacts with Autophagy Receptor p62 and is Degraded by Autophagy in Macrophages

(2019) Jing Wang et al.   Cells

PD-L1 regulates tumorigenesis and autophagy of ovarian cancer by activating mTORC signaling

(2019) Hongmin Gao et al.   BIOSCIENCE REPORTS

Identification of compound CA-5f as a novel late-stage autophagy inhibitor with potent anti-tumor effect against non-small cell lung cancer

(2018) Lu Zhang et al.   Autophagy

Autophagy Inhibitor (LY294002) and 5-fluorouracil (5-FU) Combination-Based Nanoliposome for Enhanced Efficacy Against Esophageal Squamous Cell Carcinoma

(2018) Ye Feng et al.   Nanoscale Research Letters

Cinchonine induces apoptosis of HeLa and A549 cells through targeting TRAF6

(2017) Yonghao Qi et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

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(2017) Siyuan Chen et al.   Oncotarget

Research progress of hydroxychloroquine and autophagy inhibitors on cancer

(2016) Ting-Ting Shi et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Enhanced Tumor Control with Combination mTOR and PD-L1 Inhibition in Syngeneic Oral Cavity Cancers

(2016) E. C. Moore et al.   Cancer Immunology Research

Safety and Biologic Response of Pre-operative Autophagy Inhibition in Combination with Gemcitabine in Patients with Pancreatic Adenocarcinoma

(2015) Brian A. Boone et al.   ANNALS OF SURGICAL ONCOLOGY

Elaiophylin, a novel autophagy inhibitor, exerts antitumor activity as a single agent in ovarian cancer cells

(2015) Xuejiao Zhao et al.   Autophagy

A novel autophagy/mitophagy inhibitor liensinine sensitizes breast cancer cells to chemotherapy through DNM1L-mediated mitochondrial fission

(2015) Jing Zhou et al.   Autophagy

Bafilomycin A1 disrupts autophagic flux by inhibiting both V-ATPase-dependent acidification and Ca-P60A/SERCA-dependent autophagosome-lysosome fusion

(2015) Caroline Mauvezin et al.   Autophagy

Autophagy, Metabolism, and Cancer

(2015) E. White et al.   CLINICAL CANCER RESEARCH

The natural compound oblongifolin C inhibits autophagic flux and enhances antitumor efficacy of nutrient deprivation

(2014) Yuanzhi Lao et al.   Autophagy

Effect of toll-like receptor 7 and 9 targeted therapy to prevent the development of hepatocellular carcinoma

(2014) Fatma E. Mohamed et al.   LIVER INTERNATIONAL

Dual inhibition of REV-ERBβ and autophagy as a novel pharmacological approach to induce cytotoxicity in cancer cells

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Chloroquine has tumor-inhibitory and tumor-promoting effects in triple-negative breast cancer

(2013) JOHANNA TUOMELA et al.   Oncology Letters

Targeting autophagy potentiates chemotherapy-induced apoptosis and proliferation inhibition in hepatocarcinoma cells

(2012) Xian-ling Guo et al.   CANCER LETTERS

miR-375 Inhibits Autophagy and Reduces Viability of Hepatocellular Carcinoma Cells Under Hypoxic Conditions

(2012) Ying Chang et al.   GASTROENTEROLOGY

Autophagy inhibition in cancer therapy: metabolic considerations for antitumor immunity

(2012) Katelin N. Townsend et al.   IMMUNOLOGICAL REVIEWS

Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency

(2012) Q. McAfee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Active autophagy in the tumor microenvironment: A novel mechanism for cancer metastasis

(2012) YINGHUA XU et al.   Oncology Letters

The Role of Autophagy in Cancer: Therapeutic Implications

(2011) Z. J. Yang et al.   MOLECULAR CANCER THERAPEUTICS

Hydrocinchonine, cinchonine, and quinidine potentiate paclitaxel-induced cytotoxicity and apoptosis via multidrug resistance reversal in MES-SA/DX5 uterine sarcoma cells

(2010) Sang-Yun Lee et al.   ENVIRONMENTAL TOXICOLOGY

Lucanthone Is a Novel Inhibitor of Autophagy That Induces Cathepsin D-mediated Apoptosis

(2010) Jennifer S. Carew et al.   JOURNAL OF BIOLOGICAL CHEMISTRY