G Protein-Coupled Estrogen Receptor in Cancer and Stromal Cells: Functions and Novel Therapeutic Perspectives
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
G Protein-Coupled Estrogen Receptor in Cancer and Stromal Cells: Functions and Novel Therapeutic Perspectives
Authors
Keywords
-
Journal
Cells
Volume 10, Issue 3, Pages 672
Publisher
MDPI AG
Online
2021-03-17
DOI
10.3390/cells10030672
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- GPER1 is required to protect fetal health from maternal inflammation
- (2021) Alfred T. Harding et al. SCIENCE
- GPER and Testicular Germ Cell Cancer
- (2021) Nicolas Chevalier et al. Frontiers in Endocrinology
- GPER-1 expression is associated with a decreased response rate to primary tamoxifen therapy of breast cancer patients
- (2020) Tanja Ignatov et al. ARCHIVES OF GYNECOLOGY AND OBSTETRICS
- Preclinical efficacy of the GPER-selective agonist G-1 in mouse models of obesity and diabetes
- (2020) Geetanjali Sharma et al. Science Translational Medicine
- Adipocytes in Breast Cancer, the Thick and the Thin
- (2020) Ilona Rybinska et al. Cells
- Pharmacologic Activation of the G Protein–Coupled Estrogen Receptor Inhibits Pancreatic Ductal Adenocarcinoma
- (2020) Christopher A. Natale et al. Cellular and Molecular Gastroenterology and Hepatology
- G Protein-Coupled Estrogen Receptor in Immune Cells and Its Role in Immune-Related Diseases
- (2020) George Notas et al. Frontiers in Endocrinology
- Role of GPER-Mediated Signaling in Testicular Functions and Tumorigenesis
- (2020) Adele Chimento et al. Cells
- GPER Mediates a Feedforward FGF2/FGFR1 Paracrine Activation Coupling CAFs to Cancer Cells Toward Breast Tumor Progression
- (2019) Maria Francesca Santolla et al. Cells
- GPER‐induced signaling is essential for the survival of breast cancer stem cells
- (2019) Yu‐Tzu Chan et al. INTERNATIONAL JOURNAL OF CANCER
- Tumor-associated macrophages in tumor metastasis: biological roles and clinical therapeutic applications
- (2019) Yuxin Lin et al. Journal of Hematology & Oncology
- EMERALD: Phase III trial of elacestrant (RAD1901) vs endocrine therapy for previously treated ER+ advanced breast cancer
- (2019) Aditya Bardia et al. Future Oncology
- Five-Year Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma
- (2019) James Larkin et al. NEW ENGLAND JOURNAL OF MEDICINE
- G protein-coupled estrogen receptor in colon function, immune regulation and carcinogenesis
- (2019) Damian Jacenik et al. WORLD JOURNAL OF GASTROENTEROLOGY
- ERα-targeted endocrine therapy, resistance and the role of GPER
- (2019) Richard A. Pepermans et al. STEROIDS
- Abstract PD5-10: A first-in-human phase I study to evaluate the oral selective estrogen receptor degrader (SERD), GDC-0927, in postmenopausal women with estrogen receptor positive (ER+) HER2-negative metastatic breast cancer (BC)
- (2018) MN Dickler et al. CANCER RESEARCH
- Abstract P5-21-04: Phase I/Ib study of the SERD LSZ102 alone or in combination with ribociclib in ER+ breast cancer
- (2018) D Juric et al. CANCER RESEARCH
- Roles of G protein-coupled estrogen receptor GPER in metabolic regulation
- (2018) Geetanjali Sharma et al. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Adipocyte/breast cancer cell crosstalk in obesity interferes with the anti-proliferative efficacy of tamoxifen
- (2018) Lauriane Bougaret et al. PLoS One
- Why do women with melanoma do better than men?
- (2018) Keiran SM Smalley eLife
- Activation of G protein-coupled estrogen receptor signaling inhibits melanoma and improves response to immune checkpoint blockade
- (2018) Christopher A Natale et al. eLife
- GPER and ERα mediate estradiol enhancement of mitochondrial function in inflamed adipocytes through a PKA dependent mechanism
- (2018) Marco Bauzá-Thorbrügge et al. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
- A Series of Indole-Thiazole Derivatives Act as GPER Agonists and Inhibit Breast Cancer Cell Growth
- (2018) Austin O’Dea et al. ACS Medicinal Chemistry Letters
- G-protein-coupled estrogen receptor GPER-1 expression in hormone receptor-positive breast cancer is associated with poor benefit of tamoxifen
- (2018) Tanja Ignatov et al. BREAST CANCER RESEARCH AND TREATMENT
- G protein-coupled estrogen receptor enhances melanogenesis via cAMP-protein kinase (PKA) by upregulating microphthalmia-related transcription factor-tyrosinase in melanoma
- (2017) Min Sun et al. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
- A genetic polymorphism repurposes the G-protein coupled and membrane-associated estrogen receptor GPER to a transcription factor-like molecule promoting paracrine signaling between stroma and breast carcinoma cells
- (2017) Marco Pupo et al. Oncotarget
- The effects of 17 alpha-estradiol to inhibit inflammation in vitro
- (2017) Roberta S. Santos et al. Biology of Sex Differences
- Obesity and Breast Cancer: Current Insights on the Role of Fatty Acids and Lipid Metabolism in Promoting Breast Cancer Growth and Progression
- (2017) Christina Blücher et al. Frontiers in Endocrinology
- G protein-coupled estrogen receptor deficiency accelerates liver tumorigenesis by enhancing inflammation and fibrosis
- (2016) Tao Wei et al. CANCER LETTERS
- Tamoxifen has a proliferative effect in endometrial carcinoma mediated via the GPER/EGFR/ERK/cyclin D1 pathway: A retrospective study and an in vitro study
- (2016) Lizhi Zhang et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- The G protein-coupled estrogen receptor as a modulator of neoplastic transformation
- (2016) Damian Jacenik et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Sex steroids regulate skin pigmentation through nonclassical membrane-bound receptors
- (2016) Christopher A Natale et al. eLife
- Obesity and cancer: the role of adipose tissue and adipo-cytokines-induced chronic inflammation
- (2016) Rosa Divella et al. Journal of Cancer
- GPER signalling in both cancer-associated fibroblasts and breast cancer cells mediates a feedforward IL1β/IL1R1 response
- (2016) Paola De Marco et al. Scientific Reports
- Extranuclear Steroid Receptors Are Essential for Steroid Hormone Actions
- (2015) Ellis R. Levin Annual Review of Medicine
- Optimization of a Novel Binding Motif to (E)-3-(3,5-Difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)acrylic Acid (AZD9496), a Potent and Orally Bioavailable Selective Estrogen Receptor Downregulator and Antagonist
- (2015) Chris De Savi et al. JOURNAL OF MEDICINAL CHEMISTRY
- ESR1 mutations—a mechanism for acquired endocrine resistance in breast cancer
- (2015) Rinath Jeselsohn et al. Nature Reviews Clinical Oncology
- GPER in CAFs regulates hypoxia-driven breast cancer invasion in a CTGF-dependent manner
- (2015) JUAN REN et al. ONCOLOGY REPORTS
- The Role of the Insulin/IGF System in Cancer: Lessons Learned from Clinical Trials and the Energy Balance-Cancer Link
- (2015) Laura W. Bowers et al. Frontiers in Endocrinology
- Tamoxifen through GPER upregulates aromatase expression: a novel mechanism sustaining tamoxifen-resistant breast cancer cell growth
- (2014) Stefania Catalano et al. BREAST CANCER RESEARCH AND TREATMENT
- GPER Mediates Activation of HIF1 /VEGF Signaling by Estrogens
- (2014) E. M. De Francesco et al. CANCER RESEARCH
- GPER-mediated proliferation and estradiol production in breast cancer-associated fibroblasts
- (2014) Haojun Luo et al. ENDOCRINE-RELATED CANCER
- Sexually dimorphic role of G protein-coupled estrogen receptor (GPER) in modulating energy homeostasis
- (2014) Kathryn E. Davis et al. HORMONES AND BEHAVIOR
- GPER functions as a tumor suppressor in MCF-7 and SK-BR-3 breast cancer cells
- (2014) Christine Weißenborn et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- GPER functions as a tumor suppressor in triple-negative breast cancer cells
- (2014) Christine Weißenborn et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- GPER mediates enhanced cell viability and motility via non-genomic signaling induced by 17β-estradiol in triple-negative breast cancer cells
- (2014) Tenghua Yu et al. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
- G Protein–Coupled Estrogen Receptor Regulates Mammary Tumorigenesis and Metastasis
- (2014) Nicole A. Marjon et al. MOLECULAR CANCER RESEARCH
- The activation of G protein-coupled receptor 30 (GPR30) inhibits proliferation of estrogen receptor-negative breast cancer cells in vitro and in vivo
- (2014) W Wei et al. Cell Death & Disease
- G Protein-coupled Estrogen Receptor Protects from Atherosclerosis
- (2014) Matthias R. Meyer et al. Scientific Reports
- Pigmentation disorders: hyperpigmentation and hypopigmentation
- (2013) Electra Nicolaidou et al. CLINICS IN DERMATOLOGY
- GPER Deficiency in Male Mice Results in Insulin Resistance, Dyslipidemia, and a Proinflammatory State
- (2013) Geetanjali Sharma et al. ENDOCRINOLOGY
- GPER mediates the inhibitory actions of estrogen on adipogenesis in 3T3-L1 cells through perturbation of mitotic clonal expansion
- (2013) Pei Zhu et al. GENERAL AND COMPARATIVE ENDOCRINOLOGY
- Sex Is an Independent Prognostic Indicator for Survival and Relapse/Progression-Free Survival in Metastasized Stage III to IV Melanoma: A Pooled Analysis of Five European Organisation for Research and Treatment of Cancer Randomized Controlled Trials
- (2013) Arjen Joosse et al. JOURNAL OF CLINICAL ONCOLOGY
- The G Protein-coupled Estrogen Receptor (GPER) Agonist G-1 Expands the Regulatory T-cell Population Under TH17-polarizing Conditions
- (2013) Ryan L. Brunsing et al. JOURNAL OF IMMUNOTHERAPY
- The nuclear localization signal is required for nuclear GPER translocation and function in breast Cancer-Associated Fibroblasts (CAFs)
- (2013) Marco Pupo et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Recent insights into non-nuclear actions of estrogen receptor alpha
- (2013) Subhashis Banerjee et al. STEROIDS
- 4-Hydroxytamoxifen-stimulated processing of cyclin E is mediated via G protein-coupled receptor 30 (GPR30) and accompanied by enhanced migration in MCF-7 breast cancer cells
- (2013) Yang Li et al. TOXICOLOGY
- Inactivation of GPR30 reduces growth of triple-negative breast cancer cells: possible application in targeted therapy
- (2012) Rainer Girgert et al. BREAST CANCER RESEARCH AND TREATMENT
- Two Novel GPER Agonists Induce Gene Expression Changes and Growth Effects in Cancer Cells
- (2012) R. Lappano et al. CURRENT CANCER DRUG TARGETS
- Dual Roles of Immune Cells and Their Factors in Cancer Development and Progression
- (2012) Brian F. Zamarron et al. International Journal of Biological Sciences
- G-protein-coupled estrogen receptor GPR30 and tamoxifen resistance in breast cancer
- (2011) Atanas Ignatov et al. BREAST CANCER RESEARCH AND TREATMENT
- Sex Disparities in Cancer Mortality and Survival
- (2011) M. B. Cook et al. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
- Induction of interleukin-10 in the T helper type 17 effector population by the G protein coupled estrogen receptor (GPER) agonist G-1
- (2011) Ryan L. Brunsing et al. IMMUNOLOGY
- Identification of a GPER/GPR30 antagonist with improved estrogen receptor counterselectivity
- (2011) Megan K. Dennis et al. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
- The G-protein-coupled estrogen receptor GPER in health and disease
- (2011) Eric R. Prossnitz et al. Nature Reviews Endocrinology
- Nuclear Alternate Estrogen Receptor GPR30 Mediates 17 -Estradiol-Induced Gene Expression and Migration in Breast Cancer-Associated Fibroblasts
- (2010) A. Madeo et al. CANCER RESEARCH
- The G Protein-Coupled Receptor GPR30 Inhibits Proliferation of Estrogen Receptor-Positive Breast Cancer Cells
- (2010) E. A. Ariazi et al. CANCER RESEARCH
- Activation of GPR30 inhibits the growth of prostate cancer cells through sustained activation of Erk1/2, c-jun/c-fos-dependent upregulation of p21 and induction of G2 cell-cycle arrest
- (2010) Q K Y Chan et al. CELL DEATH AND DIFFERENTIATION
- Estrogen Receptors: Therapies Targeted to Receptor Subtypes
- (2010) S Nilsson et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Tamoxifen vs. non-tamoxifen treatment for advanced melanoma: a meta-analysis
- (2010) Julieta Ruiz Beguerie et al. INTERNATIONAL JOURNAL OF DERMATOLOGY
- Estradiol Attenuates EGF-Induced Rapid uPAR Mobilization and Cell Migration via the G-protein-Coupled Receptor 30 in Ovarian Cancer Cells
- (2010) Emir Henic et al. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
- Non-nuclear estrogen receptor α signaling promotes cardiovascular protection but not uterine or breast cancer growth in mice
- (2010) Ken L. Chambliss et al. JOURNAL OF CLINICAL INVESTIGATION
- Role of GPR30 in the mechanisms of tamoxifen resistance in breast cancer MCF-7 cells
- (2009) Atanas Ignatov et al. BREAST CANCER RESEARCH AND TREATMENT
- Estrogenic G protein-coupled receptor 30 signaling is involved in regulation of endometrial carcinoma by promoting proliferation, invasion potential, and interleukin-6 secretion via the MEK/ERK mitogen-activated protein kinase pathway
- (2009) Yin-Yan He et al. CANCER SCIENCE
- Tamoxifen inhibits tumor cell invasion and metastasis in mouse melanoma through suppression of PKC/MEK/ERK and PKC/PI3K/Akt pathways
- (2009) Hiroshi Matsuoka et al. EXPERIMENTAL CELL RESEARCH
- GPR30 predicts poor survival for ovarian cancer
- (2009) Harriet O. Smith et al. GYNECOLOGIC ONCOLOGY
- Membrane Estrogen Receptor Regulates Experimental Autoimmune Encephalomyelitis through Up-regulation of Programmed Death 1
- (2009) C. Wang et al. JOURNAL OF IMMUNOLOGY
- Beneficial role of the GPR30 agonist G-1 in an animal model of multiple sclerosis
- (2009) Eric Blasko et al. JOURNAL OF NEUROIMMUNOLOGY
- Mechanisms of estrogen signaling and gene expression via GPR30
- (2009) Eric R. Prossnitz et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- In vivo effects of a GPR30 antagonist
- (2009) Megan K Dennis et al. Nature Chemical Biology
- Estrogen Receptor Signaling in Lung Cancer
- (2009) Jill M. Siegfried et al. SEMINARS IN ONCOLOGY
- Expression Pattern of G Protein-Coupled Receptor 30 in LacZ Reporter Mice
- (2008) Jörg Isensee et al. ENDOCRINOLOGY
- GPR30 Contributes to Estrogen-Induced Thymic Atrophy
- (2007) Chunhe Wang et al. MOLECULAR ENDOCRINOLOGY
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started