Pharmacodynamic measures within tumors expose differential activity of PD(L)-1 antibody therapeutics

A single molecular descriptor to predict solution behavior of therapeutic antibodies

(2020) Jonathan S. Kingsbury et al.   Science Advances

A single dose of neoadjuvant PD-1 blockade predicts clinical outcomes in resectable melanoma

(2019) Alexander C. Huang et al.   NATURE MEDICINE

Clinical Pharmacokinetics and Pharmacodynamics of Immune Checkpoint Inhibitors

(2019) Maddalena Centanni et al.   CLINICAL PHARMACOKINETICS

8O89Zr-labeled anti-PD-L1 CX-072 PET imaging in human xenograft and syngeneic tumors

(2019) D Giesen et al.   ANNALS OF ONCOLOGY

Comparison of Biomarker Modalities for Predicting Response to PD-1/PD-L1 Checkpoint Blockade

(2019) Steve Lu et al.   JAMA Oncology

Trends in clinical development for PD-1/PD-L1 inhibitors

(2019) Jia Xin Yu et al.   NATURE REVIEWS DRUG DISCOVERY

Digesting a Path Forward: The Utility of Collagenase Tumor Treatment for Improved Drug Delivery

(2018) Aaron Dolor et al.   MOLECULAR PHARMACEUTICS

Cancer immunotherapy using checkpoint blockade

(2018) Antoni Ribas et al.   SCIENCE

Bifunctional immune checkpoint-targeted antibody-ligand traps that simultaneously disable TGFβ enhance the efficacy of cancer immunotherapy

(2018) Rajani Ravi et al.   Nature Communications

Tumor drug penetration measurements could be the neglected piece of the personalized cancer treatment puzzle

(2018) Imke H. Bartelink et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Peptide-based PET quantifies target engagement of PD-L1 therapeutics

(2018) Dhiraj Kumar et al.   JOURNAL OF CLINICAL INVESTIGATION

89Zr-atezolizumab imaging as a non-invasive approach to assess clinical response to PD-L1 blockade in cancer

(2018) Frederike Bensch et al.   NATURE MEDICINE

Integrating molecular nuclear imaging in clinical research to improve anticancer therapy

(2018) Elisabeth G. E. de Vries et al.   Nature Reviews Clinical Oncology

Whole body PD-1 and PD-L1 positron emission tomography in patients with non-small-cell lung cancer

(2018) A. N. Niemeijer et al.   Nature Communications

Clinical Pharmacology Considerations for the Development of Immune Checkpoint Inhibitors

(2017) Jennifer Sheng et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Synthesis and Biologic Evaluation of a Novel18F-Labeled Adnectin as a PET Radioligand for Imaging PD-L1 Expression

(2017) David J. Donnelly et al.   JOURNAL OF NUCLEAR MEDICINE

In vivo imaging reveals a tumor-associated macrophage–mediated resistance pathway in anti–PD-1 therapy

(2017) Sean P. Arlauckas et al.   Science Translational Medicine

Distinct PD-L1 binding characteristics of therapeutic monoclonal antibody durvalumab

(2017) Shuguang Tan et al.   Protein & Cell

Combination Cancer Therapies with Immune Checkpoint Blockade: Convergence on Interferon Signaling

(2016) Andy J. Minn et al.   CELL

Physiologically-based pharmacokinetic modeling to predict the clinical pharmacokinetics of monoclonal antibodies

(2016) Patrick M. Glassman et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Imaging approaches to optimize molecular therapies

(2016) Ralph Weissleder et al.   Science Translational Medicine

A humanized antibody for imaging immune checkpoint ligand PD-L1 expression in tumors

(2016) Samit Chatterjee et al.   Oncotarget

Quantitative Assessment of the Heterogeneity of PD-L1 Expression in Non–Small-Cell Lung Cancer

(2016) Joseph McLaughlin et al.   JAMA Oncology

Immune Checkpoint Blockade: A Common Denominator Approach to Cancer Therapy

(2015) Suzanne L. Topalian et al.   CANCER CELL

Noninvasive Imaging of Tumor PD-L1 Expression Using Radiolabeled Anti-PD-L1 Antibodies

(2015) S. Heskamp et al.   CANCER RESEARCH

Engineering high-affinity PD-1 variants for optimized immunotherapy and immuno-PET imaging

(2015) Roy L. Maute et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Determining target engagement in living systems

(2013) Gabriel M Simon et al.   Nature Chemical Biology

Translational PET imaging research

(2013) Richard J. Hargreaves et al.   NEUROBIOLOGY OF DISEASE

Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay

(2013) D. M. Molina et al.   SCIENCE

Colocalization of Inflammatory Response with B7-H1 Expression in Human Melanocytic Lesions Supports an Adaptive Resistance Mechanism of Immune Escape

(2012) J. M. Taube et al.   Science Translational Medicine

Improved18F Labeling of Peptides with a Fluoride-Aluminum-Chelate Complex

(2010) William J. McBride et al.   BIOCONJUGATE CHEMISTRY

Effects of Charge on Antibody Tissue Distribution and Pharmacokinetics

(2010) C. Andrew Boswell et al.   BIOCONJUGATE CHEMISTRY