Therapeutics of osteoarthritis and pharmacological mechanisms: A focus on RANK/RANKL signaling

The STING inhibitor C‐176 attenuates osteoclast‐related osteolytic diseases by inhibiting osteoclast differentiation

(2023) Zhen‐cheng Yu et al.   FASEB JOURNAL

Anatomy, molecular structures, and hyaluronic acid – Gelatin injectable hydrogels as a therapeutic alternative for hyaline cartilage recovery: A review

(2023) Juan Jairo Vaca‐González et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

Eplerenone modulates the inflammatory response in monosodium iodoacetate-induced knee osteoarthritis in rats: Involvement of RANKL/OPG axis

(2023) Rasha E. Mostafa et al.   LIFE SCIENCES

Microstructural and cellular characterisation of the subchondral trabecular bone in human knee and hip osteoarthritis using synchrotron tomography

(2023) Dzenita Muratovic et al.   OSTEOARTHRITIS AND CARTILAGE

Mitochondrial Genome Editing to Treat Human Osteoarthritis—A Narrative Review

(2022) Gang Zhong et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Melatonin prevents cartilage degradation in early‐stage osteoarthritis through activation of miR ‐146a/ NRF2 / HO ‐1 axis

(2022) Xinfeng Zhou et al.   JOURNAL OF BONE AND MINERAL RESEARCH

PPARα−ACOT12 axis is responsible for maintaining cartilage homeostasis through modulating de novo lipogenesis

(2022) Sujeong Park et al.   Nature Communications

LSD1 metabolically integrates osteoclast differentiation and inflammatory bone resorption through HIF ‐1α and E2F1

(2022) Kohei Doi et al.   Arthritis & Rheumatology

Inflammasome Activation in the Hip Synovium of Rapidly Destructive Coxopathy Patients and Its Relationship with the Development of Synovitis and Bone Loss

(2022) Shunichi Yokota et al.   AMERICAN JOURNAL OF PATHOLOGY

Mutation in the CCAL1 locus accounts for bidirectional process of human subchondral bone turnover and cartilage mineralization

(2022) Alejandro Rodríguez Ruiz et al.   RHEUMATOLOGY

Alpha-7 Nicotinic Receptor Dampens Murine Osteoblastic Response to Inflammation and Age-Related Osteoarthritis

(2022) Alice Courties et al.   Frontiers in Immunology

Chitosan-based biomaterials for the treatment of bone disorders

(2022) Mahdi Rahimi et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Mechanisms of joint destruction in rheumatoid arthritis — immune cell–fibroblast–bone interactions

(2022) Noriko Komatsu et al.   Nature Reviews Rheumatology

A hyaluronic acid/platelet-rich plasma hydrogel containing MnO2 nanozymes efficiently alleviates osteoarthritis in vivo

(2022) Tong Zhou et al.   CARBOHYDRATE POLYMERS

PD0325901, an ERK inhibitor, attenuates RANKL‐induced osteoclast formation and mitigates cartilage inflammation by inhibiting the NF-κB and MAPK pathways

(2022) Ting Jiang et al.   BIOORGANIC CHEMISTRY

Frugoside delays osteoarthritis progression via inhibiting miR-155-modulated synovial macrophage M1 polarisation

(2021) Hao Wang et al.   RHEUMATOLOGY

Role of Synovial Exosomes in Osteoclast Differentiation in Inflammatory Arthritis

(2021) Ji Eun Song et al.   Cells

Characterization of CRISPR/Cas9 RANKL knockout mesenchymal stem cell clones based on single-cell printing technology and Emulsion Coupling assay as a low-cellularity workflow for single-cell cloning

(2021) Tobias Gross et al.   PLoS One

Characterization and Function of Tumor Necrosis Factor alpha and Interleukin‐6‐Induced Osteoclasts in Rheumatoid Arthritis

(2021) Kazuhiro Yokota et al.   Arthritis & Rheumatology

The role of TNFRSF11B in development of osteoarthritic cartilage

(2021) Alejandro Rodríguez Ruiz et al.   RHEUMATOLOGY

Diterbutyl phthalate attenuates osteoarthritis in ACLT mice via suppressing ERK/c-fos/NFATc1 pathway, and subsequently inhibiting subchondral osteoclast fusion

(2021) Chao Fang et al.   ACTA PHARMACOLOGICA SINICA

Self-assembled hyaluronic acid nanoparticles for osteoarthritis treatment

(2021) Li-Jung Kang et al.   BIOMATERIALS

Blockade of adiponectin receptor 1 signaling inhibits synovial inflammation and alleviates joint damage in collagen-induced arthritis

(2021) Yani Wang et al.   CLINICAL RHEUMATOLOGY

Voluntary running attenuates behavioural signs of low back pain: dimorphic regulation of intervertebral disc inflammation in male and female SPARC-null mice

(2021) S. Lee et al.   OSTEOARTHRITIS AND CARTILAGE

Exercise to Mend Aged-tissue Crosstalk in Bone Targeting Osteoporosis & Osteoarthritis

(2021) Sarah E. Little-Letsinger et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The JAK inhibitor Tofacitinib inhibits structural damage in osteoarthritis by modulating JAK1/TNF-alpha/IL-6 signaling through Mir-149-5p

(2021) Yen-Shuo Chiu et al.   BONE

Chitosan oligosaccharides packaged into rat adipose mesenchymal stem cells-derived extracellular vesicles facilitating cartilage injury repair and alleviating osteoarthritis

(2021) Shenglong Li et al.   JOURNAL OF NANOBIOTECHNOLOGY

MicroRNA-9 ameliorates destructive arthritis through down-regulation of NF-κB1-RANKL pathway in fibroblast-like synoviocytes

(2020) Wen Shi Lee et al.   CLINICAL IMMUNOLOGY

Osthole‐loaded N‐octyl‐O‐sulfonyl chitosan micelles (NSC‐OST) inhibits RANKL‐induced osteoclastogenesis and prevents ovariectomy‐induced bone loss in rats

(2020) Lining Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Esculentoside A protects against osteoarthritis by ameliorating inflammation and repressing osteoclastogenesis

(2020) Qing Shao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Human dendritic cell-derived osteoclasts with high bone resorption capacity and T cell stimulation ability

(2020) Manabu Narisawa et al.   BONE

Emerging Gene-Editing Modalities for Osteoarthritis

(2020) Alekya S. Tanikella et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Signaling pathways affected by mutations causing osteogenesis imperfecta

(2020) Julia Etich et al.   CELLULAR SIGNALLING

An Overview of the NF-kB mechanism of pathophysiology in rheumatoid arthritis, investigation of the NF-kB ligand RANKL and related nutritional interventions

(2020) Desislava (Daisy) Ilchovska et al.   AUTOIMMUNITY REVIEWS

Exploration of CRISPR/Cas9-based gene editing as therapy for osteoarthritis

(2019) Lan Zhao et al.   ANNALS OF THE RHEUMATIC DISEASES

Applications of RNA interference in the treatment of arthritis

(2019) Muhammad Farooq Rai et al.   Translational Research

Berberine coated mannosylated liposomes curtail RANKL stimulated osteoclastogenesis through the modulation of GSK3β pathway via upregulating miR-23a

(2019) Sali Sujitha et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Regulatory Effects and Interactions of the Wnt and OPG-RANKL-RANK Signaling at the Bone-Cartilage Interface in Osteoarthritis

(2019) Béla Kovács et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Th1/Th17/Th22 immune response and their association with joint pain, imagenological bone loss, RANKL expression and osteoclast activity in temporomandibular joint osteoarthritis: A preliminary report

(2018) G. Monasterio et al.   JOURNAL OF ORAL REHABILITATION

3D printing hydrogel with graphene oxide is functional in cartilage protection by influencing the signal pathway of Rank/Rankl/OPG

(2018) Zhong Cheng et al.   Materials Science & Engineering C-Materials for Biological Applications

Targeting of chondrocyte plasticity via connexin43 modulation attenuates cellular senescence and fosters a pro-regenerative environment in osteoarthritis

(2018) Marta Varela-Eirín et al.   Cell Death & Disease

Subchondral bone osteoclasts induce sensory innervation and osteoarthritis pain

(2018) Shouan Zhu et al.   JOURNAL OF CLINICAL INVESTIGATION

Osteoimmunology: The Conceptual Framework Unifying the Immune and Skeletal Systems

(2017) Kazuo Okamoto et al.   PHYSIOLOGICAL REVIEWS

Formulation andin vitroandin vivoevaluation of a new osteoprotegerin-chitosan gel for bone tissue regeneration

(2016) Soher Nagi Jayash et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Osteoclasts are recruited to the subchondral bone in naturally occurring post-traumatic equine carpal osteoarthritis and may contribute to cartilage degradation

(2016) A. Bertuglia et al.   OSTEOARTHRITIS AND CARTILAGE

Osteoarthritis

(2016) Johanne Martel-Pelletier et al.   Nature Reviews Disease Primers

Wnt5a/Ror2 Mediates Temporomandibular Joint Subchondral Bone Remodeling

(2015) T. Yang et al.   JOURNAL OF DENTAL RESEARCH

Osteoarthritis

(2015) S Glyn-Jones et al.   LANCET

Inflammation in joint injury and post-traumatic osteoarthritis

(2015) J. Lieberthal et al.   OSTEOARTHRITIS AND CARTILAGE

Parathyroid hormone (1-34) prevents cartilage degradation and preserves subchondral bone micro-architecture in guinea pigs with spontaneous osteoarthritis

(2014) J.-y. Yan et al.   OSTEOARTHRITIS AND CARTILAGE

New and emerging treatments for osteoarthritis management: will the dream come true with personalized medicine?

(2013) Camille Roubille et al.   EXPERT OPINION ON PHARMACOTHERAPY

High molecular weight hyaluronic acid regulates osteoclast formation by inhibiting receptor activator of NF-κB ligand through Rho kinase

(2013) W. Ariyoshi et al.   OSTEOARTHRITIS AND CARTILAGE

Inhibition of osteoclastogenesis by RNA interference targeting RANK

(2012) Ruofan Ma et al.   BMC MUSCULOSKELETAL DISORDERS

In vivo reduction or blockade of interleukin-1β in primary osteoarthritis influences expression of mediators implicated in pathogenesis

(2012) K.S. Santangelo et al.   OSTEOARTHRITIS AND CARTILAGE

Intravenously delivered glucocorticoid liposomes inhibit osteoclast activity and bone erosion in murine antigen-induced arthritis

(2011) Wouter Hofkens et al.   JOURNAL OF CONTROLLED RELEASE

Subchondral bone loss following orthodontically induced cartilage degradation in the mandibular condyles of rats

(2010) Kai Jiao et al.   BONE

Modulation of OPG, RANK and RANKL by human chondrocytes and their implication during osteoarthritis

(2009) S. Kwan Tat et al.   RHEUMATOLOGY

Differential modulation of RANKL isoforms by human osteoarthritic subchondral bone osteoblasts: Influence of osteotropic factors

(2008) Steeve Kwan Tat et al.   BONE