Mitochondrial Genome Editing to Treat Human Osteoarthritis—A Narrative Review

Osteoarthritis of the Knee

(2021) Leena Sharma   NEW ENGLAND JOURNAL OF MEDICINE

Mitochondrial DNA editing in mice with DddA-TALE fusion deaminases

(2021) Hyunji Lee et al.   Nature Communications

Osteoarthritis year in review 2021: epidemiology & therapy

(2021) J.G. Quicke et al.   OSTEOARTHRITIS AND CARTILAGE

The cell biology of mitochondrial membrane dynamics

(2020) Marta Giacomello et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

CRISPR-engineered T cells in patients with refractory cancer

(2020) Edward A. Stadtmauer et al.   SCIENCE

A bacterial cytidine deaminase toxin enables CRISPR-free mitochondrial base editing

(2020) Beverly Y. Mok et al.   NATURE

Editing the Mitochondrial Genome

(2020) Maria Falkenberg et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mechanisms of replication and repair in mitochondrial DNA deletion formation

(2020) Gabriele A Fontana et al.   NUCLEIC ACIDS RESEARCH

A New Class of Medicines through DNA Editing

(2019) Matthew H. Porteus   NEW ENGLAND JOURNAL OF MEDICINE

Osteoarthritis

(2019) David J Hunter et al.   LANCET

Modulation of mtDNA copy number ameliorates the pathological consequences of a heteroplasmic mtDNA mutation in the mouse

(2019) R. Filograna et al.   Science Advances

CRISPR-Edited Stem Cells in a Patient with HIV and Acute Lymphocytic Leukemia

(2019) Lei Xu et al.   NEW ENGLAND JOURNAL OF MEDICINE

CRISPR-Cas9 gene editing for patients with haemoglobinopathies

(2019) The Lancet Haematology   Lancet Haematology

Mitochondrial Dynamics and Its Involvement in Disease

(2019) David C. Chan   Annual Review of Pathology-Mechanisms of Disease

mitoTev‐TALE: a monomeric DNA editing enzyme to reduce mutant mitochondrial DNA levels

(2018) Claudia V Pereira et al.   EMBO Molecular Medicine

Mitochondrial DNA variation and the pathogenesis of osteoarthritis phenotypes

(2018) Francisco J. Blanco et al.   Nature Reviews Rheumatology

Mitochondrial Genome Engineering: The Revolution May Not Be CRISPR-Ized

(2018) Payam A. Gammage et al.   TRENDS IN GENETICS

Targeted elimination of mutant mitochondrial DNA in MELAS-iPSCs by mitoTALENs

(2018) Yi Yang et al.   Protein & Cell

Reactive oxygen species, aging and articular cartilage homeostasis

(2018) Jesalyn A. Bolduc et al.   FREE RADICAL BIOLOGY AND MEDICINE

Genome editing in mitochondria corrects a pathogenic mtDNA mutation in vivo

(2018) Payam A. Gammage et al.   NATURE MEDICINE

Biomaterial-guided delivery of gene vectors for targeted articular cartilage repair

(2018) Magali Cucchiarini et al.   Nature Reviews Rheumatology

Intra-articular treatment options for knee osteoarthritis

(2018) Ian A. Jones et al.   Nature Reviews Rheumatology

Current strategies towards therapeutic manipulation of mtDNA heteroplasmy

(2017) Carlos T Moraes   Frontiers in Bioscience-Landmark

Molecular remission of infant B-ALL after infusion of universal TALEN gene-edited CAR T cells

(2017) Waseem Qasim et al.   Science Translational Medicine

TALEN-mediated shift of mitochondrial DNA heteroplasmy in MELAS-iPSCs with m.13513G>A mutation

(2017) Naoki Yahata et al.   Scientific Reports

Selective mitochondrial DNA degradation following double-strand breaks

(2017) Amandine Moretton et al.   PLoS One

Controlled release strategies for rAAV-mediated gene delivery

(2016) Ana Rey-Rico et al.   Acta Biomaterialia

CRISPR gene-editing tested in a person for the first time

(2016) David Cyranoski   NATURE

Ageing and the pathogenesis of osteoarthritis

(2016) Richard F. Loeser et al.   Nature Reviews Rheumatology

Near-complete elimination of mutant mtDNA by iterative or dynamic dose-controlled treatment with mtZFNs

(2016) Payam A. Gammage et al.   NUCLEIC ACIDS RESEARCH

Mitochondrial transfer of mesenchymal stem cells effectively protects corneal epithelial cells from mitochondrial damage

(2016) Dan Jiang et al.   Cell Death & Disease

Osteoarthritis

(2016) Johanne Martel-Pelletier et al.   Nature Reviews Disease Primers

Mitochondrial diseases

(2016) Gráinne S. Gorman et al.   Nature Reviews Disease Primers

Prevalence of nuclear and mitochondrial DNA mutations related to adult mitochondrial disease

(2015) Gráinne S. Gorman et al.   ANNALS OF NEUROLOGY

Mitochondria in the Regulation of Innate and Adaptive Immunity

(2015) Samuel E. Weinberg et al.   IMMUNITY

MitoTALEN: A General Approach to Reduce Mutant mtDNA Loads and Restore Oxidative Phosphorylation Function in Mitochondrial Diseases

(2015) Masami Hashimoto et al.   MOLECULAR THERAPY

Efficient Mitochondrial Genome Editing by CRISPR/Cas9

(2015) Areum Jo et al.   Biomed Research International

Mitochondrially targeted ZFNs for selective degradation of pathogenic mitochondrial genomes bearing large-scale deletions or point mutations

(2014) P. A. Gammage et al.   EMBO Molecular Medicine

Modeling of Antigenomic Therapy of Mitochondrial Diseases by Mitochondrially Addressed RNA Targeting a Pathogenic Point Mutation in Mitochondrial DNA

(2014) Yann Tonin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Emerging regulators of the inflammatory process in osteoarthritis

(2014) Ru Liu-Bryan et al.   Nature Reviews Rheumatology

Classification and evolution of type II CRISPR-Cas systems

(2014) Krzysztof Chylinski et al.   NUCLEIC ACIDS RESEARCH

Mitochondrial Channels: Ion Fluxes and More

(2014) Ildiko Szabo et al.   PHYSIOLOGICAL REVIEWS

Specific elimination of mutant mitochondrial genomes in patient-derived cells by mitoTALENs

(2013) Sandra R Bacman et al.   NATURE MEDICINE

No recombination of mtDNA after heteroplasmy for 50 generations in the mouse maternal germline

(2013) E. Hagstrom et al.   NUCLEIC ACIDS RESEARCH

Mitochondrial dysfunction in osteoarthritis is associated with down-regulation of superoxide dismutase 2

(2012) Christos Gavriilidis et al.   ARTHRITIS AND RHEUMATISM

Structural Basis for Sequence-Specific Recognition of DNA by TAL Effectors

(2012) D. Deng et al.   SCIENCE

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

(2012) M. Jinek et al.   SCIENCE

Manipulation of mtDNA heteroplasmy in all striated muscles of newborn mice by AAV9-mediated delivery of a mitochondria-targeted restriction endonuclease

(2011) S R Bacman et al.   GENE THERAPY

Osteoarthritis: an update with relevance for clinical practice

(2011) Johannes WJ Bijlsma et al.   LANCET

The role of mitochondria in osteoarthritis

(2011) Francisco J. Blanco et al.   Nature Reviews Rheumatology

From joint anatomy to clinical outcomes in osteoarthritis and cartilage repair: summary of the fifth annual osteoarthritis imaging workshop

(2011) D.J. Hunter et al.   OSTEOARTHRITIS AND CARTILAGE

Organ-specific shifts in mtDNA heteroplasmy following systemic delivery of a mitochondria-targeted restriction endonuclease

(2010) S R Bacman et al.   GENE THERAPY

Celecoxib versus omeprazole and diclofenac in patients with osteoarthritis and rheumatoid arthritis (CONDOR): a randomised trial

(2010) Francis KL Chan et al.   LANCET

A TALE nuclease architecture for efficient genome editing

(2010) Jeffrey C Miller et al.   NATURE BIOTECHNOLOGY

Genome editing with engineered zinc finger nucleases

(2010) Fyodor D. Urnov et al.   NATURE REVIEWS GENETICS

Role of proinflammatory cytokines in the pathophysiology of osteoarthritis

(2010) Mohit Kapoor et al.   Nature Reviews Rheumatology

Mitochondrial DNA damage is involved in apoptosis caused by pro-inflammatory cytokines in human OA chondrocytes

(2009) J. Kim et al.   OSTEOARTHRITIS AND CARTILAGE

Mitochondrial Dysregulation of Osteoarthritic Human Articular Chondrocytes Analyzed by Proteomics

(2008) Cristina Ruiz-Romero et al.   MOLECULAR & CELLULAR PROTEOMICS

Comparison of Zinc Finger Nucleases for Use in Gene Targeting in Mammalian Cells

(2008) Shondra M Pruett-Miller et al.   MOLECULAR THERAPY

Development of a single-chain, quasi-dimeric zinc-finger nuclease for the selective degradation of mutated human mitochondrial DNA

(2008) Michal Minczuk et al.   NUCLEIC ACIDS RESEARCH

Diminished mitochondrial DNA integrity and repair capacity in OA chondrocytes

(2008) V.I. Grishko et al.   OSTEOARTHRITIS AND CARTILAGE

Metabolic Flexibility Permits Mesenchymal Stem Cell Survival in an Ischemic Environment

(2008) Louise A. Mylotte et al.   STEM CELLS