Subchondral bone osteoclasts induce sensory innervation and osteoarthritis pain

Peripheral Mechanisms Contributing to Osteoarthritis Pain

(2018) Delfien Syx et al.   Current Rheumatology Reports

Chemogenetic Inhibition of Pain Neurons in a Mouse Model of Osteoarthritis

(2017) Rachel E. Miller et al.   Arthritis & Rheumatology

Visualization of Peripheral Neuron Sensitization in a Surgical Mouse Model of Osteoarthritis by In Vivo Calcium Imaging

(2017) Rachel E. Miller et al.   Arthritis & Rheumatology

Systemic neutralization of TGF-β attenuates osteoarthritis

(2016) Liang Xie et al.   Annals of the New York Academy of Sciences

PKCδnull mutations in a mouse model of osteoarthritis alter osteoarthritic pain independently of joint pathology by augmenting NGF/TrkA-induced axonal outgrowth

(2016) Ranjan Kc et al.   ANNALS OF THE RHEUMATIC DISEASES

Bone-protective Functions of Netrin 1 Protein

(2016) Kenta Maruyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nociceptive phenotype alterations of dorsal root ganglia neurons innervating the subchondral bone in osteoarthritic rat knee joints

(2016) K. Aso et al.   OSTEOARTHRITIS AND CARTILAGE

Updated Projected Prevalence of Self-Reported Doctor-Diagnosed Arthritis and Arthritis-Attributable Activity Limitation Among US Adults, 2015-2040

(2016) Jennifer M. Hootman et al.   Arthritis & Rheumatology

Blocking the tropomyosin receptor kinase A (TrkA) receptor inhibits pain behaviour in two rat models of osteoarthritis

(2015) Lilian N Nwosu et al.   ANNALS OF THE RHEUMATIC DISEASES

Halofuginone attenuates osteoarthritis by inhibition of TGF-β activity and H-type vessel formation in subchondral bone

(2015) Zhuang Cui et al.   ANNALS OF THE RHEUMATIC DISEASES

Changes in peptidergic fiber density in the synovium of mice with collagenase-induced acute arthritis

(2015) Kohei Murakami et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Netrin-1 as a novel therapeutic target in cardiovascular disease: to activate or inhibit?

(2015) Kerry Layne et al.   CARDIOVASCULAR RESEARCH

CD146 acts as a novel receptor for netrin-1 in promoting angiogenesis and vascular development

(2015) Tao Tu et al.   CELL RESEARCH

Netrin-1 Is a Critical Autocrine/Paracrine Factor for Osteoclast Differentiation

(2015) Aránzazu Mediero et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Netrin-1 Contributes to Myelinated Afferent Fiber Sprouting and Neuropathic Pain

(2015) Cai-Hua Wu et al.   MOLECULAR NEUROBIOLOGY

Drug developers reboot anti-NGF pain programmes

(2015) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Dissecting the contribution of knee joint NGF to spinal nociceptive sensitization in a model of OA pain in the rat

(2015) D.R. Sagar et al.   OSTEOARTHRITIS AND CARTILAGE

Visualization of Sensory Neurons and Their Projections in an Upper Motor Neuron Reporter Line

(2015) Barış Genç et al.   PLoS One

Evidence for central sensitization in patients with osteoarthritis pain: A systematic literature review

(2014) E. Lluch et al.   EUROPEAN JOURNAL OF PAIN

PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis

(2014) Hui Xie et al.   NATURE MEDICINE

Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing

(2014) Dmitry Usoskin et al.   NATURE NEUROSCIENCE

Mouse models of osteoarthritis: modelling risk factors and assessing outcomes

(2014) Hang Fang et al.   Nature Reviews Rheumatology

Central Terminal Sensitization of TRPV1 by Descending Serotonergic Facilitation Modulates Chronic Pain

(2014) Yu Shin Kim et al.   NEURON

Targeting TGFβ signaling in subchondral bone and articular cartilage homeostasis

(2014) Gehua Zhen et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Effect of bisphosphonate use in patients with symptomatic and radiographic knee osteoarthritis: data from the Osteoarthritis Initiative

(2013) Laura L Laslett et al.   ANNALS OF THE RHEUMATIC DISEASES

Augmented pain behavioural responses to intra-articular injection of nerve growth factor in two animal models of osteoarthritis

(2013) Sadaf Ashraf et al.   ANNALS OF THE RHEUMATIC DISEASES

Targeted loss of the ATR-X syndrome protein in the limb mesenchyme of mice causes brachydactyly

(2013) Lauren A. Solomon et al.   HUMAN MOLECULAR GENETICS

Interplay between Cartilage and Subchondral Bone Contributing to Pathogenesis of Osteoarthritis

(2013) Ashish Sharma et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Charcot Neuroarthropathy of the Foot and Ankle: A Review

(2013) Ajit Kumar Varma   Journal of Foot & Ankle Surgery

Protective role for netrin-1 during diabetic nephropathy

(2013) Eunyoung Tak et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Sema3A regulates bone-mass accrual through sensory innervations

(2013) Toru Fukuda et al.   NATURE

Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis

(2013) Gehua Zhen et al.   NATURE MEDICINE

Towards a mechanism-based approach to pain management in osteoarthritis

(2013) Anne-Marie Malfait et al.   Nature Reviews Rheumatology

Adverse Effects of Analgesics Commonly Used by Older Adults With Osteoarthritis: Focus on Non-Opioid and Opioid Analgesics

(2012) Christine K. O'Neil et al.   American Journal Geriatric Pharmacotherapy

Zoledronic acid reduces knee pain and bone marrow lesions over 1 year: a randomised controlled trial

(2012) Laura Louise Laslett et al.   ANNALS OF THE RHEUMATIC DISEASES

Nociceptive sensory innervation of the posterior cruciate ligament in osteoarthritic knees

(2012) M. Ikeuchi et al.   ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY

Interleukin-17 sensitizes joint nociceptors to mechanical stimuli and contributes to arthritic pain through neuronal interleukin-17 receptors in rodents

(2012) Frank Richter et al.   ARTHRITIS AND RHEUMATISM

The role of interleukin-1β in arthritic pain: Main involvement in thermal, but not mechanical, hyperalgesia in rat antigen-induced arthritis

(2012) Matthias Ebbinghaus et al.   ARTHRITIS AND RHEUMATISM

Netrin-1 Attracts Axons through FAK-Dependent Mechanotransduction

(2012) S. W. Moore et al.   JOURNAL OF NEUROSCIENCE

Neuronal IL-17 receptor upregulates TRPV4 but not TRPV1 receptors in DRG neurons and mediates mechanical but not thermal hyperalgesia

(2012) Gisela Segond von Banchet et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Clinical relevance of bone marrow lesions in OA

(2012) C. Kent Kwoh   Nature Reviews Rheumatology

Mechanisms and targets of angiogenesis and nerve growth in osteoarthritis

(2012) Paul I. Mapp et al.   Nature Reviews Rheumatology

Quantitative sensory testing in painful osteoarthritis: a systematic review and meta-analysis

(2012) A.K. Suokas et al.   OSTEOARTHRITIS AND CARTILAGE

CCR2 chemokine receptor signaling mediates pain in experimental osteoarthritis

(2012) R. E. Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee

(2012) Marc C. Hochberg et al.   ARTHRITIS CARE & RESEARCH

Subchondral bone as a key target for osteoarthritis treatment

(2011) Santos Castañeda et al.   BIOCHEMICAL PHARMACOLOGY

Matrix-embedded cells control osteoclast formation

(2011) Jinhu Xiong et al.   NATURE MEDICINE

Evidence for osteocyte regulation of bone homeostasis through RANKL expression

(2011) Tomoki Nakashima et al.   NATURE MEDICINE

FAK

(2011) Mariola R. Chacón et al.   Cell Adhesion & Migration

Do knee abnormalities visualised on MRI explain knee pain in knee osteoarthritis? A systematic review

(2010) E. Yusuf et al.   ANNALS OF THE RHEUMATIC DISEASES

In vivo microfocal computed tomography and micro-magnetic resonance imaging evaluation of antiresorptive and antiinflammatory drugs as preventive treatments of osteoarthritis in the rat

(2010) Michael D. Jones et al.   ARTHRITIS AND RHEUMATISM

Molecular effects of interleukin-1β on dorsal root ganglion neurons: Prevention of ligand-induced internalization of the bradykinin 2 receptor and downregulation of G protein-coupled receptor kinase 2

(2010) Gisela Segond von Banchet et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Assessment of stone composition in the management of urinary stones

(2010) Kittinut Kijvikai et al.   Nature Reviews Urology

Tanezumab for the Treatment of Pain from Osteoarthritis of the Knee

(2010) Nancy E. Lane et al.   NEW ENGLAND JOURNAL OF MEDICINE

Signaling from Axon Guidance Receptors

(2010) G. J. Bashaw et al.   Cold Spring Harbor Perspectives in Biology

Cellular Strategies of Axonal Pathfinding

(2010) J. Raper et al.   Cold Spring Harbor Perspectives in Biology

Bidirectional Signaling through EphrinA2-EphA2 Enhances Osteoclastogenesis and Suppresses Osteoblastogenesis

(2009) Naoko Irie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia-inducible factor–dependent induction of netrin-1 dampens inflammation caused by hypoxia

(2009) Peter Rosenberger et al.   NATURE IMMUNOLOGY

TGF-β1–induced migration of bone mesenchymal stem cells couples bone resorption with formation

(2009) Yi Tang et al.   NATURE MEDICINE

Experimental arthritis causes tumor necrosis factor-α-dependent infiltration of macrophages into rat dorsal root ganglia which correlates with pain-related behavior

(2009) Gisela Segond von Banchet et al.   PAIN

Joint pain

(2009) Hans-Georg Schaible et al.   EXPERIMENTAL BRAIN RESEARCH

The Effects of Bone Remodeling Inhibition by Alendronate on Three-Dimensional Microarchitecture of Subchondral Bone Tissues in Guinea Pig Primary Osteoarthrosis

(2008) Ming Ding et al.   CALCIFIED TISSUE INTERNATIONAL

Pirt, a Phosphoinositide-Binding Protein, Functions as a Regulatory Subunit of TRPV1

(2008) Andrew Y. Kim et al.   CELL

The Symptoms of Osteoarthritis and the Genesis of Pain

(2008) David J. Hunter et al.   MEDICAL CLINICS OF NORTH AMERICA

Semaphorin 3B Is a 1,25-Dihydroxyvitamin D3-Induced Gene in Osteoblasts that Promotes Osteoclastogenesis and Induces Osteopenia in Mice

(2008) Amelia L. M. Sutton et al.   MOLECULAR ENDOCRINOLOGY