New and emerging treatments for osteoarthritis management: will the dream come true with personalized medicine?

Treatment With Platelet-Rich Plasma Is More Effective Than Placebo for Knee Osteoarthritis

(2013) Sandeep Patel et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Long-Term Detection of Human Adipose-Derived Mesenchymal Stem Cells After Intraarticular Injection in SCID Mice

(2013) Karine Toupet et al.   ARTHRITIS AND RHEUMATISM

Mesenchymal Stem Cell Injections Improve Symptoms of Knee Osteoarthritis

(2013) Yong-Gon Koh et al.   ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY

Denosumab, a new pharmacotherapy option for postmenopausal osteoporosis

(2013) Robert Josse et al.   CURRENT MEDICAL RESEARCH AND OPINION

Current concepts in stem cell therapy for articular cartilage repair

(2013) Hayat Muhammad et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Safety concerns with the long-term management of osteoporosis

(2013) Jean-Yves Reginster et al.   Expert Opinion On Drug Safety

Effect of Vitamin D Supplementation on Progression of Knee Pain and Cartilage Volume Loss in Patients With Symptomatic Osteoarthritis

(2013) Timothy McAlindon et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Mesenchymal stem cells for the treatment of cartilage lesions: from preclinical findings to clinical application in orthopaedics

(2013) Giuseppe Filardo et al.   KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY

Biotherapeutic potential of microRNAs in rheumatic diseases

(2013) Yves-Marie Pers et al.   Nature Reviews Rheumatology

Biologic agents in osteoarthritis: hopes and disappointments

(2013) Xavier Chevalier et al.   Nature Reviews Rheumatology

IL-1 receptor antagonist gene as a predictive biomarker of progression of knee osteoarthritis in a population cohort

(2013) X. Wu et al.   OSTEOARTHRITIS AND CARTILAGE

Arthritis gene therapy and its tortuous path into the clinic

(2013) Christopher H. Evans et al.   Translational Research

Treatment of Knee Joint Osteoarthritis with Autologous Platelet-Rich Plasma in Comparison with Hyaluronic Acid

(2012) Tímea Spaková et al.   AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION

Zoledronic acid reduces knee pain and bone marrow lesions over 1 year: a randomised controlled trial

(2012) Laura Louise Laslett et al.   ANNALS OF THE RHEUMATIC DISEASES

Efficacy and safety of strontium ranelate in the treatment of knee osteoarthritis: results of a double-blind, randomised placebo-controlled trial

(2012) Jean-Yves Reginster et al.   ANNALS OF THE RHEUMATIC DISEASES

Strontium ranelate reduces the progression of experimental dog osteoarthritis by inhibiting the expression of key proteases in cartilage and of IL-1β in the synovium

(2012) Jean-Pierre Pelletier et al.   ANNALS OF THE RHEUMATIC DISEASES

A 2-year randomised, double-blind, placebo-controlled, multicentre study of oral selective iNOS inhibitor, cindunistat (SD-6010), in patients with symptomatic osteoarthritis of the knee

(2012) Marie-Pierre Hellio le Graverand et al.   ANNALS OF THE RHEUMATIC DISEASES

Antiinflammatory and chondroprotective effects of intraarticular injection of adipose-derived stem cells in experimental osteoarthritis

(2012) Menno ter Huurne et al.   ARTHRITIS AND RHEUMATISM

A Randomized Clinical Trial Evaluating Plasma Rich in Growth Factors (PRGF-Endoret) Versus Hyaluronic Acid in the Short-Term Treatment of Symptomatic Knee Osteoarthritis

(2012) Mikel Sánchez et al.   ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY

Platelet-rich plasma vs hyaluronic acid to treat knee degenerative pathology: study design and preliminary results of a randomized controlled trial

(2012) Giuseppe Filardo et al.   BMC MUSCULOSKELETAL DISORDERS

Inhibition of cathepsin K reduces cartilage degeneration in the anterior cruciate ligament transection rabbit and murine models of osteoarthritis

(2012) Tadashi Hayami et al.   BONE

Stem cell-based therapies for osteoarthritis

(2012) Brian O. Diekman et al.   CURRENT OPINION IN RHEUMATOLOGY

Initial phase I safety of retrovirally transduced human chondrocytes expressing transforming growth factor-beta-1 in degenerative arthritis patients

(2012) Chul-Won Ha et al.   CYTOTHERAPY

scAAV-mediated gene transfer of interleukin-1-receptor antagonist to synovium and articular cartilage in large mammalian joints

(2012) R S Watson et al.   GENE THERAPY

Infrapatellar fat pad-derived mesenchymal stem cell therapy for knee osteoarthritis

(2012) Yong-Gon Koh et al.   KNEE

siRNA-based therapeutic approaches for rheumatic diseases

(2012) Florence Apparailly et al.   Nature Reviews Rheumatology

Macro view of microRNA function in osteoarthritis

(2012) Shigeru Miyaki et al.   Nature Reviews Rheumatology

Serum adipokines in osteoarthritis; comparison with controls and relationship with local parameters of synovial inflammation and cartilage damage

(2012) T.N. de Boer et al.   OSTEOARTHRITIS AND CARTILAGE

Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!)

(2012) F. Berenbaum   OSTEOARTHRITIS AND CARTILAGE

Impact of treatments for osteoporosis on osteoarthritis progression

(2012) C. Roux et al.   OSTEOPOROSIS INTERNATIONAL

MiR-194 Regulates Chondrogenic Differentiation of Human Adipose-Derived Stem Cells by Targeting Sox5

(2012) Jun Xu et al.   PLoS One

Effects of calcitonin on knee osteoarthritis and quality of life

(2012) Meltem Esenyel et al.   RHEUMATOLOGY INTERNATIONAL

Functional folate receptor beta-expressing macrophages in osteoarthritis synovium and their M1/M2 expression profiles

(2012) Y Tsuneyoshi et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

A Stem Cell-Based Approach to Cartilage Repair

(2012) K. Johnson et al.   SCIENCE

Vitamin D supplementation in the management of knee osteoarthritis: study protocol for a randomized controlled trial

(2012) Yuelong Cao et al.   Trials

Targeting tumour necrosis factor alleviates signs and symptoms of inflammatory osteoarthritis of the knee

(2012) Walter P Maksymowych et al.   ARTHRITIS RESEARCH & THERAPY

Platelet-rich plasma therapy - future or trend?

(2012) Robinder S Dhillon et al.   ARTHRITIS RESEARCH & THERAPY

Mesenchymal stem cells for cartilage repair in osteoarthritis

(2012) Pawan K Gupta et al.   Stem Cell Research & Therapy

Chondrogenesis, chondrocyte differentiation, and articular cartilage metabolism in health and osteoarthritis

(2012) Mary B. Goldring   Therapeutic Advances in Musculoskeletal Disease

Tumour necrosis factor blockade for the treatment of erosive osteoarthritis of the interphalangeal finger joints: a double blind, randomised trial on structure modification

(2011) Gust Verbruggen et al.   ANNALS OF THE RHEUMATIC DISEASES

Association between leptin, adiponectin and resistin and long-term progression of hand osteoarthritis

(2011) E. Yusuf et al.   ANNALS OF THE RHEUMATIC DISEASES

Platelet-Rich Plasma Intra-Articular Injection Versus Hyaluronic Acid Viscosupplementation as Treatments for Cartilage Pathology: From Early Degeneration to Osteoarthritis

(2011) Elizaveta Kon et al.   ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY

Strontium ranelate inhibits key factors affecting bone remodeling in human osteoarthritic subchondral bone osteoblasts

(2011) Steeve Kwan Tat et al.   BONE

Future therapeutics for osteoarthritis

(2011) Johanne Martel-Pelletier et al.   BONE

Osteochondral alterations in osteoarthritis

(2011) Sunita Suri et al.   BONE

A Systematic Review of the Use of Platelet-Rich Plasma in Sports Medicine as a New Treatment for Tendon and Ligament Injuries

(2011) Drew W Taylor et al.   CLINICAL JOURNAL OF SPORT MEDICINE

Obesity short-circuits stemness gene network in human adipose multipotent stem cells

(2011) Mar Roldan et al.   FASEB JOURNAL

Mesenchymal stem cell therapy for knee osteoarthritis. Preliminary report of four patients

(2011) Fereydoun DAVATCHI et al.   International Journal of Rheumatic Diseases

Osteoarthritis accelerates and exacerbates Alzheimer's disease pathology in mice

(2011) Stephanos Kyrkanides et al.   Journal of Neuroinflammation

A fully automated human knee 3D MRI bone segmentation using the ray casting technique

(2011) Pierre Dodin et al.   MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING

Effective reduction of the interleukin-1β transcript in osteoarthritis-prone guinea pig chondrocytes via short hairpin RNA mediated RNA interference influences gene expression of mediators implicated in disease pathogenesis

(2011) K.S. Santangelo et al.   OSTEOARTHRITIS AND CARTILAGE

65 A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTICENTER STUDY OF RHFGF18 ADMINISTERED INTRAARTICULARLY USING SINGLE OR MULTIPLE ASCENDING DOSES IN PATIENTS WFTH PRIMARY KNEE OSTEOARTHRITIS (OA), NOT EXPECTED TO REQUIRE KNEE SURGERY WITHIN 1 YEAR

(2011) R. McPherson et al.   OSTEOARTHRITIS AND CARTILAGE

64 ORAL CALCITONIN DEMONSTRATED SYMPTOM-MODIFYING EFFICACY AND INCREASED CARTILAGE VOLUME: RESULTS FROM A 2-YEAR PHASE 3 TRIAL IN PATIENTS WITH OSTEOARTHRITIS OF THE KNEE

(2011) M.A. Karsdal et al.   OSTEOARTHRITIS AND CARTILAGE

Mesenchymal stem cells in osteoarticular diseases

(2011) Christian Jorgensen et al.   Regenerative Medicine

Teriparatide as a Chondroregenerative Therapy for Injury-Induced Osteoarthritis

(2011) E. R. Sampson et al.   Science Translational Medicine

Desperately looking for the right target in osteoarthritis: the anti-IL-1 strategy

(2011) Xavier Chevalier et al.   ARTHRITIS RESEARCH & THERAPY

A randomized, double-blind study of AMG 108 (a fully human monoclonal antibody to IL-1R1) in patients with osteoarthritis of the knee

(2011) Stanley B Cohen et al.   ARTHRITIS RESEARCH & THERAPY

Tiludronate treatment improves structural changes and symptoms of osteoarthritis in the canine anterior cruciate ligament model

(2011) Maxim Moreau et al.   ARTHRITIS RESEARCH & THERAPY

Injection of Platelet-Rich Plasma in Patients with Primary and Secondary Knee Osteoarthritis

(2010) Steven Sampson et al.   AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION

Targeting subchondral bone for treating osteoarthritis: what is the evidence?

(2010) Steeve Kwan Tat et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Phase 1 safety and tolerability study of BMP-7 in symptomatic knee osteoarthritis

(2010) David J Hunter et al.   BMC MUSCULOSKELETAL DISORDERS

MicroRNA-140 plays dual roles in both cartilage development and homeostasis

(2010) S. Miyaki et al.   GENES & DEVELOPMENT

Automatic Human Knee Cartilage Segmentation From 3-D Magnetic Resonance Images

(2010) P Dodin et al.   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

Effects of Low Concentration BMP-7 on Human Osteoarthritic Chondrocytes: Comparison of Different Applications

(2010) Karsten Gavenis et al.   JOURNAL OF BIOMATERIALS APPLICATIONS

Treatment with Tiludronic Acid Helps Reduce the Development of Experimental Osteoarthritis Lesions in Dogs with Anterior Cruciate Ligament Transection Followed by Reconstructive Surgery: A 1-Year Study with Quantitative Magnetic Resonance Imaging

(2010) J.-P. PELLETIER et al.   JOURNAL OF RHEUMATOLOGY

Isolation of adipose-derived stem cells and their induction to a chondrogenic phenotype

(2010) Bradley T Estes et al.   Nature Protocols

Role of proinflammatory cytokines in the pathophysiology of osteoarthritis

(2010) Mohit Kapoor et al.   Nature Reviews Rheumatology

Fully automated system for the quantification of human osteoarthritic knee joint effusion volume using magnetic resonance imaging

(2010) Wei Li et al.   ARTHRITIS RESEARCH & THERAPY

Erosive osteoarthritis of the hand: clinical experience with anakinra

(2009) L Bacconnier et al.   ANNALS OF THE RHEUMATIC DISEASES

Intraarticular injection of anakinra in osteoarthritis of the knee: A multicenter, randomized, double-blind, placebo-controlled study

(2009) X. Chevalier et al.   ARTHRITIS AND RHEUMATISM

Expression of MicroRNA-146a in osteoarthritis cartilage

(2009) Keiichiro Yamasaki et al.   ARTHRITIS AND RHEUMATISM

Regulation of the IGFBP-5 and MMP-13 genes by the microRNAs miR-140 and miR-27a in human osteoarthritic chondrocytes

(2009) Ginette Tardif et al.   BMC MUSCULOSKELETAL DISORDERS

Intra-articular gene delivery and expression of interleukin-1Ra mediated by self-complementary adeno-associated virus

(2009) Jesse D. Kay et al.   JOURNAL OF GENE MEDICINE

Platelet-rich plasma: intra-articular knee injections produced favorable results on degenerative cartilage lesions

(2009) Elizaveta Kon et al.   KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY

A single injection of anakinra for treating knee OA?

(2009) Johanne Martel-Pelletier et al.   Nature Reviews Rheumatology

Modulation of OPG, RANK and RANKL by human chondrocytes and their implication during osteoarthritis

(2009) S. Kwan Tat et al.   RHEUMATOLOGY

Treatment of erosive osteoarthritis of the hands by intra-articular infliximab injections: a pilot study

(2009) Antonella Fioravanti et al.   RHEUMATOLOGY INTERNATIONAL

Osteoarthritis Treated with Mesenchymal Stem Cells on Hyaluronan-Based Scaffold in Rabbit

(2009) Brunella Grigolo et al.   TISSUE ENGINEERING PART C-METHODS

Osteoprotegerin inhibits cartilage degradation through an effect on trabecular bone in murine experimental osteoarthritis

(2008) A. Kadri et al.   ARTHRITIS AND RHEUMATISM

Denosumab treatment effects on structural damage, bone mineral density, and bone turnover in rheumatoid arthritis: A twelve-month, multicenter, randomized, double-blind, placebo-controlled, phase II clinical trial

(2008) Stanley B. Cohen et al.   ARTHRITIS AND RHEUMATISM

High levels of synovial fluid osteoprotegerin (OPG) and increased serum ratio of receptor activator of nuclear factor-κB ligand (RANKL) to OPG correlate with disease severity in patients with primary knee osteoarthritis

(2008) Anastasia Pilichou et al.   CLINICAL BIOCHEMISTRY

Chondrogenic differentiation of adipose tissue-derived mesenchymal stem cells: Greater doses of growth factor are necessary

(2008) Hye-Joung Kim et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Autologous conditioned serum (Orthokine) is an effective treatment for knee osteoarthritis

(2008) A.W.A. Baltzer et al.   OSTEOARTHRITIS AND CARTILAGE

Autologous interleukin-1 receptor antagonist improves function and symptoms in osteoarthritis when compared to placebo in a prospective randomized controlled trial

(2007) K.G. Auw Yang et al.   OSTEOARTHRITIS AND CARTILAGE

Suppression of early experimental osteoarthritis by in vivo delivery of the adenoviral vector-mediated NF-κBp65-specific siRNA

(2007) L.X. Chen et al.   OSTEOARTHRITIS AND CARTILAGE