Longitudinal characterization of behavioral, morphological and transcriptomic changes in a tauopathy mouse model

Inhibition of histone methyltransferase Smyd3 rescues NMDAR and cognitive deficits in a tauopathy mouse model

(2023) Jamal B. Williams et al.   Nature Communications

Tau seeding and spreading in vivo is supported by both AD-derived fibrillar and oligomeric tau

(2023) Anastasie Mate De Gerando et al.   ACTA NEUROPATHOLOGICA

Hippocampus and its involvement in Alzheimer’s disease: a review

(2022) Y. Lakshmisha Rao et al.   3 Biotech

Targeting histone demethylase LSD1 for treatment of deficits in autism mouse models

(2022) Maximiliano Rapanelli et al.   MOLECULAR PSYCHIATRY

PSEN1 c.1292C<A Variant and Early-Onset Alzheimer’s Disease: A Scoping Review

(2022) Maribel Orozco-Barajas et al.   Frontiers in Aging Neuroscience

Alzheimer's Disease: Tau Pathology and Dysfunction of Endocytosis

(2021) Kunie Ando et al.   Frontiers in Molecular Neuroscience

Mechanisms of synaptic transmission dysregulation in the prefrontal cortex: pathophysiological implications

(2021) Zhen Yan et al.   MOLECULAR PSYCHIATRY

Epigenetic treatment of behavioral and physiological deficits in a tauopathy mouse model

(2021) Wei Wang et al.   AGING CELL

ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids

(2021) Kathryn R. Bowles et al.   CELL

Consequences of hyperphosphorylated tau on the morphology and excitability of hippocampal neurons in aged tau transgenic micew

(2020) Lennart Müller-Thomsen et al.   NEUROBIOLOGY OF AGING

Modulating TRADD to restore cellular homeostasis and inhibit apoptosis

(2020) Daichao Xu et al.   NATURE

A standardized social preference protocol for measuring social deficits in mouse models of autism

(2020) Benjamin Rein et al.   Nature Protocols

A combinatorial native MS and LC-MS/MS approach reveals high intrinsic phosphorylation of human tau but minimal levels of other key modifications

(2020) Friedel Drepper et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disrupted prefrontal neuronal oscillations and morphology induced by sleep deprivation in young APP/PS1 transgenic AD mice

(2020) Sidra Tabassum et al.   BRAIN RESEARCH BULLETIN

Dendritic Spine Remodeling and Synaptic Tau Levels in PS19 Tauopathy Mice

(2020) Courtney K. Walker et al.   NEUROSCIENCE

Targeting histone K4 trimethylation for treatment of cognitive and synaptic deficits in mouse models of Alzheimer’s disease

(2020) Qing Cao et al.   Science Advances

Pathological Tau From Alzheimer’s Brain Induces Site-Specific Hyperphosphorylation and SDS- and Reducing Agent-Resistant Aggregation of Tau in vivo

(2019) Jin Miao et al.   Frontiers in Aging Neuroscience

Inhibition of EHMT1/2 rescues synaptic and cognitive functions for Alzheimer’s disease

(2019) Yan Zheng et al.   BRAIN

Immune Signaling in Neurodegeneration

(2019) Timothy R. Hammond et al.   IMMUNITY

Phosphorylation of different tau sites during progression of Alzheimer’s disease

(2018) Joerg Neddens et al.   Acta Neuropathologica Communications

Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia

(2018) Vivek Swarup et al.   NATURE MEDICINE

The molecular basis of Alzheimer's plaques

(2017) Sabrina Pospich et al.   SCIENCE

Memory retrieval by activating engram cells in mouse models of early Alzheimer’s disease

(2016) Dheeraj S. Roy et al.   NATURE

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

Tau in physiology and pathology

(2015) Yipeng Wang et al.   NATURE REVIEWS NEUROSCIENCE

Staining neurons with Golgi techniques in degenerative diseases of the brain

(2015) StavrosJ Baloyannis   Neural Regeneration Research

Tau Hyperphosphorylation and Oxidative Stress, a Critical Vicious Circle in Neurodegenerative Tauopathies?

(2015) Seyedeh Maryam Alavi Naini et al.   Oxidative Medicine and Cellular Longevity

Gene expression parallels synaptic excitability and plasticity changes in Alzheimer’s disease

(2015) Carlos A. Saura et al.   Frontiers in Cellular Neuroscience

Autism-like Deficits in Shank3-Deficient Mice Are Rescued by Targeting Actin Regulators

(2015) Lara J. Duffney et al.   Cell Reports

Neuronal morphometry directly from bitmap images

(2014) Tiago A Ferreira et al.   NATURE METHODS

Dendritic Structural Degeneration Is Functionally Linked to Cellular Hyperexcitability in a Mouse Model of Alzheimer’s Disease

(2014) Zuzana Šišková et al.   NEURON

Memory deficits correlate with tau and spine pathology in P301SMAPTtransgenic mice

(2014) Hong Xu et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Early-onset cognitive deficits and axonal transport dysfunction in P301S mutant tau transgenic mice

(2014) Tomohiro Onishi et al.   NEUROSCIENCE RESEARCH

Increased Hippocampal Excitability in the 3xTgAD Mouse Model for Alzheimer's Disease In Vivo

(2014) Katherine E. Davis et al.   PLoS One

Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models

(2014) Scott J. Webster et al.   Frontiers in Genetics

Frequent and symmetric deposition of misfolded tau oligomers within presynaptic and postsynaptic terminals in Alzheimer’s disease

(2014) Hwan-Ching Tai et al.   Acta Neuropathologica Communications

Synthetic Tau Fibrils Mediate Transmission of Neurofibrillary Tangles in a Transgenic Mouse Model of Alzheimer's-Like Tauopathy

(2013) M. Iba et al.   JOURNAL OF NEUROSCIENCE

Comprehensive behavioral characterization of an APP/PS-1 double knock-in mouse model of Alzheimer's disease

(2013) Scott J Webster et al.   Alzheimers Research & Therapy

Brain imaging and fluid biomarker analysis in young adults at genetic risk for autosomal dominant Alzheimer's disease in the presenilin 1 E280A kindred: a case-control study

(2012) Eric M Reiman et al.   LANCET NEUROLOGY

The ageing cortical synapse: hallmarks and implications for cognitive decline

(2012) John H. Morrison et al.   NATURE REVIEWS NEUROSCIENCE

Synaptic genes are extensively downregulated across multiple brain regions in normal human aging and Alzheimer's disease

(2012) Nicole C. Berchtold et al.   NEUROBIOLOGY OF AGING

P301S Mutant Human Tau Transgenic Mice Manifest Early Symptoms of Human Tauopathies with Dementia and Altered Sensorimotor Gating

(2011) Hiroki Takeuchi et al.   PLoS One

Concerted changes in transcripts in the prefrontal cortex precede neuropathology in Alzheimer's disease

(2010) Koen Bossers et al.   BRAIN

Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration

(2010) Brian R. Hoover et al.   NEURON

Hyperphosphorylation of Microtubule-Associated Protein Tau: A Promising Therapeutic Target for Alzheimer Disease

(2008) C.-X. Gong et al.   CURRENT MEDICINAL CHEMISTRY

The Potential for -Structure in the Repeat Domain of Tau Protein Determines Aggregation, Synaptic Decay, Neuronal Loss, and Coassembly with Endogenous Tau in Inducible Mouse Models of Tauopathy

(2008) M.-M. Mocanu et al.   JOURNAL OF NEUROSCIENCE

Pyramidal neurons: dendritic structure and synaptic integration

(2008) Nelson Spruston   NATURE REVIEWS NEUROSCIENCE