Targeting histone K4 trimethylation for treatment of cognitive and synaptic deficits in mouse models of Alzheimer’s disease

Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease

(2020) Yingyue Zhou et al.   NATURE MEDICINE

Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer’s Disease Progression

(2020) Bing Bai et al.   NEURON

Amelioration of autism-like social deficits by targeting histone methyltransferases EHMT1/2 in Shank3-deficient mice

(2019) Zi-Jun Wang et al.   MOLECULAR PSYCHIATRY

Inhibition of EHMT1/2 rescues synaptic and cognitive functions for Alzheimer’s disease

(2019) Yan Zheng et al.   BRAIN

Single-cell transcriptomic analysis of Alzheimer’s disease

(2019) Hansruedi Mathys et al.   NATURE

Inhibition of Histone Methyltransferases EHMT1/2 Reverses Amyloid-β-Induced Loss of AMPAR Currents in Human Stem Cell-Derived Cortical Neurons

(2019) Lin Lin et al.   JOURNAL OF ALZHEIMERS DISEASE

Behavioral, circuitry, and molecular aberrations by region-specific deficiency of the high-risk autism gene Cul3

(2019) Maximiliano Rapanelli et al.   MOLECULAR PSYCHIATRY

Complement C3 Is Activated in Human AD Brain and Is Required for Neurodegeneration in Mouse Models of Amyloidosis and Tauopathy

(2019) Tiffany Wu et al.   Cell Reports

Tau-mediated synaptic and neuronal dysfunction in neurodegenerative disease

(2018) Tara E Tracy et al.   CURRENT OPINION IN NEUROBIOLOGY

Social deficits in Shank3-deficient mouse models of autism are rescued by histone deacetylase (HDAC) inhibition

(2018) Luye Qin et al.   NATURE NEUROSCIENCE

Tau-targeting therapies for Alzheimer disease

(2018) Erin E. Congdon et al.   Nature Reviews Neurology

Epigenetic Regulation in Neurodegenerative Diseases

(2018) Amit Berson et al.   TRENDS IN NEUROSCIENCES

Abnormal Hyperphosphorylation of Tau: Sites, Regulation, and Molecular Mechanism of Neurofibrillary Degeneration

(2018) Jian-Zhi Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

Converging pathways in neurodegeneration, from genetics to mechanisms

(2018) Li Gan et al.   NATURE NEUROSCIENCE

Epigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory

(2018) Janine L. Kwapis et al.   Nature Communications

ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

(2017) Yang Shi et al.   NATURE

Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity

(2017) Vincenzo Sorrentino et al.   NATURE

Structural basis for activity regulation of MLL family methyltransferases

(2016) Yanjing Li et al.   NATURE

From cellular senescence to Alzheimer’s disease: The role of telomere shortening

(2015) Virginia Boccardi et al.   AGEING RESEARCH REVIEWS

Mechanisms of Mitochondrial Dysfunction in Alzheimer’s Disease

(2015) Chris Cadonic et al.   MOLECULAR NEUROBIOLOGY

Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer’s disease

(2015) Elizabeta Gjoneska et al.   NATURE

Immune attack: the role of inflammation in Alzheimer disease

(2015) Frank L. Heppner et al.   NATURE REVIEWS NEUROSCIENCE

The epigenetics of aging and neurodegeneration

(2015) Roy Lardenoije et al.   PROGRESS IN NEUROBIOLOGY

DNA repair factor BRCA1 depletion occurs in Alzheimer brains and impairs cognitive function in mice

(2015) Elsa Suberbielle et al.   Nature Communications

Autism-like Deficits in Shank3-Deficient Mice Are Rescued by Targeting Actin Regulators

(2015) Lara J. Duffney et al.   Cell Reports

Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria

(2014) Bruno Dubois et al.   LANCET NEUROLOGY

The contribution of de novo coding mutations to autism spectrum disorder

(2014) Ivan Iossifov et al.   NATURE

Apoptosis in Alzheimer’s Disease: An Understanding of the Physiology, Pathology and Therapeutic Avenues

(2014) M. Obulesu et al.   NEUROCHEMICAL RESEARCH

DNA Damage and Its Links to Neurodegeneration

(2014) Ram Madabhushi et al.   NEURON

Regulation of histone H3K4 methylation in brain development and disease

(2014) E. Shen et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

RTP801/REDD1: a stress coping regulator that turns into a troublemaker in neurodegenerative disorders

(2014) Mercè Canal et al.   Frontiers in Cellular Neuroscience

Barnes Maze Testing Strategies with Small and Large Rodent Models

(2014) Cheryl S. Rosenfeld et al.   Jove-Journal of Visualized Experiments

Histone H3 lysine methylation in cognition and intellectual disability disorders

(2013) S. Parkel et al.   LEARNING & MEMORY

Genome-wide approaches reveal EGR1-controlled regulatory networks associated with neurodegeneration

(2013) Radosveta Koldamova et al.   NEUROBIOLOGY OF DISEASE

The cell survival kinase SGK1 and its targets FOXO3a and NDRG1 in aged human brain

(2013) P. Sahin et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Histone lysine methylation: critical regulator of memory and behavior

(2013) Timothy J. Jarome et al.   REVIEWS IN THE NEUROSCIENCES

Association between prefrontal activity and volume change in prefrontal and medial temporal lobes in aging and dementia: A review

(2012) David Maillet et al.   AGEING RESEARCH REVIEWS

De Novo Mutations in MLL Cause Wiedemann-Steiner Syndrome

(2012) Wendy D. Jones et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5

(2012) Guillermo Senisterra et al.   BIOCHEMICAL JOURNAL

Repeated Stress Causes Cognitive Impairment by Suppressing Glutamate Receptor Expression and Function in Prefrontal Cortex

(2012) Eunice Y. Yuen et al.   NEURON

Epigenetic Regulation of Gene Expression in Physiological and Pathological Brain Processes

(2011) Johannes Gräff et al.   PHYSIOLOGICAL REVIEWS

Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans

(2010) Eric L. Greer et al.   NATURE

Exome sequencing identifies MLL2 mutations as a cause of Kabuki syndrome

(2010) Sarah B Ng et al.   NATURE GENETICS

Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy

(2010) Sang-Won Min et al.   NEURON

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Multiple roles of HDAC inhibition in neurodegenerative conditions

(2009) De-Maw Chuang et al.   TRENDS IN NEUROSCIENCES

Cytoskeletal pathologies of Alzheimer disease

(2009) James R. Bamburg et al.   CELL MOTILITY AND THE CYTOSKELETON

Development of a Small-Molecule Serum- and Glucocorticoid-Regulated Kinase-1 Antagonist and Its Evaluation as a Prostate Cancer Therapeutic

(2008) A. B. Sherk et al.   CANCER RESEARCH

Hyperphosphorylation of Microtubule-Associated Protein Tau: A Promising Therapeutic Target for Alzheimer Disease

(2008) C.-X. Gong et al.   CURRENT MEDICINAL CHEMISTRY

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Presynaptic glutamate receptors: physiological functions and mechanisms of action

(2008) Paulo S. Pinheiro et al.   NATURE REVIEWS NEUROSCIENCE

Epigenetic principles and mechanisms underlying nervous system functions in health and disease

(2008) M MEHLER   PROGRESS IN NEUROBIOLOGY