Targeting histone demethylase LSD1 for treatment of deficits in autism mouse models

Mechanisms of synaptic transmission dysregulation in the prefrontal cortex: pathophysiological implications

(2021) Zhen Yan et al.   MOLECULAR PSYCHIATRY

Rescue of histone hypoacetylation and social deficits by ketogenic diet in a Shank3 mouse model of autism

(2021) Luye Qin et al.   NEUROPSYCHOPHARMACOLOGY

Projection-specific deficits in synaptic transmission in adult Sapap3-knockout mice

(2020) Lotfi C. Hadjas et al.   NEUROPSYCHOPHARMACOLOGY

A standardized social preference protocol for measuring social deficits in mouse models of autism

(2020) Benjamin Rein et al.   Nature Protocols

Amelioration of autism-like social deficits by targeting histone methyltransferases EHMT1/2 in Shank3-deficient mice

(2019) Zi-Jun Wang et al.   MOLECULAR PSYCHIATRY

Single-cell genomics identifies cell type–specific molecular changes in autism

(2019) Dmitry Velmeshev et al.   SCIENCE

Roles and regulation of histone methylation in animal development

(2019) Ashwini Jambhekar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Behavioral, circuitry, and molecular aberrations by region-specific deficiency of the high-risk autism gene Cul3

(2019) Maximiliano Rapanelli et al.   MOLECULAR PSYCHIATRY

Recapitulation and Reversal of Schizophrenia-Related Phenotypes in Setd1a-Deficient Mice

(2019) Jun Mukai et al.   NEURON

LSD1 inhibition exerts its antileukemic effect by recommissioning PU.1- and C/EBPα-dependent enhancers in AML

(2018) Monica Cusan et al.   BLOOD

ORY-1001, a Potent and Selective Covalent KDM1A Inhibitor, for the Treatment of Acute Leukemia

(2018) Tamara Maes et al.   CANCER CELL

Social deficits in Shank3-deficient mouse models of autism are rescued by histone deacetylase (HDAC) inhibition

(2018) Luye Qin et al.   NATURE NEUROSCIENCE

Histone deacetylase inhibitor MS-275 restores social and synaptic function in a Shank3-deficient mouse model of autism

(2018) Kaijie Ma et al.   NEUROPSYCHOPHARMACOLOGY

Neurodevelopmental disease genes implicated by de novo mutation and copy number variation morbidity

(2018) Bradley P. Coe et al.   NATURE GENETICS

Striatopallidal dysfunction underlies repetitive behavior in Shank3-deficient model of autism

(2017) Wenting Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeted sequencing identifies 91 neurodevelopmental-disorder risk genes with autism and developmental-disability biases

(2017) Holly A F Stessman et al.   NATURE GENETICS

Cell-Type-Specific Epigenetic Editing at the Fosb Gene Controls Susceptibility to Social Defeat Stress

(2017) Peter J Hamilton et al.   NEUROPSYCHOPHARMACOLOGY

Viral-mediated Zif268 expression in the prefrontal cortex protects against gonadectomy-induced working memory, long-term memory, and social interaction deficits in male rats

(2017) Amanda M. Dossat et al.   NEUROSCIENCE

Novel Shank3 mutant exhibits behaviors with face validity for autism and altered striatal and hippocampal function

(2016) Thomas C. Jaramillo et al.   Autism Research

LSD1 modulates stress-evoked transcription of immediate early genes and emotional behavior

(2016) Francesco Rusconi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autism-Associated Insertion Mutation (InsG) of Shank3 Exon 21 Causes Impaired Synaptic Transmission and Behavioral Deficits

(2015) H. E. Speed et al.   JOURNAL OF NEUROSCIENCE

Gene hunting in autism spectrum disorder: on the path to precision medicine

(2015) Daniel H Geschwind et al.   LANCET NEUROLOGY

Autism-like Deficits in Shank3-Deficient Mice Are Rescued by Targeting Actin Regulators

(2015) Lara J. Duffney et al.   Cell Reports

De novoANKRD11andKDM1Agene mutations in a male with features of KBG syndrome and Kabuki syndrome

(2014) Sanjin Tunovic et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Lower Expression of Glutamic Acid Decarboxylase 67 in the Prefrontal Cortex in Schizophrenia: Contribution of Altered Regulation by Zif268

(2014) Sohei Kimoto et al.   AMERICAN JOURNAL OF PSYCHIATRY

Chromatin regulation: How complex does it get?

(2014) Karin Meier et al.   Epigenetics

Synaptic, transcriptional and chromatin genes disrupted in autism

(2014) Silvia De Rubeis et al.   NATURE

Patches of Disorganization in the Neocortex of Children with Autism

(2014) Rich Stoner et al.   NEW ENGLAND JOURNAL OF MEDICINE

Regulation of histone H3K4 methylation in brain development and disease

(2014) E. Shen et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Meta-analysis of SHANK Mutations in Autism Spectrum Disorders: A Gradient of Severity in Cognitive Impairments

(2014) Claire S. Leblond et al.   PLoS Genetics

The emerging family of CULLIN3-RING ubiquitin ligases (CRL3s): cellular functions and disease implications

(2013) Pascal Genschik et al.   EMBO JOURNAL

A Core Chromatin Remodeling Factor Instructs Global Chromatin Signaling through Multivalent Reading of Nucleosome Codes

(2013) Sujit S. Nair et al.   MOLECULAR CELL

Genome-wide approaches reveal EGR1-controlled regulatory networks associated with neurodegeneration

(2013) Radosveta Koldamova et al.   NEUROBIOLOGY OF DISEASE

Repeated Cortico-Striatal Stimulation Generates Persistent OCD-Like Behavior

(2013) S. E. Ahmari et al.   SCIENCE

SHANK3 haploinsufficiency: a “common” but underdiagnosed highly penetrant monogenic cause of autism spectrum disorders

(2013) Catalina Betancur et al.   Molecular Autism

Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function

(2012) Hyejung Won et al.   NATURE

Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations

(2012) Brian J. O’Roak et al.   NATURE

EPAC Null Mutation Impairs Learning and Social Interactions via Aberrant Regulation of miR-124 and Zif268 Translation

(2012) Ying Yang et al.   NEURON

Epigenetic Signatures of Autism

(2011) Hennady P. Shulha   ARCHIVES OF GENERAL PSYCHIATRY

Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3

(2011) Xiaoming Wang et al.   HUMAN MOLECULAR GENETICS

Shank3 mutant mice display autistic-like behaviours and striatal dysfunction

(2011) João Peça et al.   NATURE

Antidepressant Effect of Optogenetic Stimulation of the Medial Prefrontal Cortex

(2010) H. E. Covington et al.   JOURNAL OF NEUROSCIENCE

Essential Role of the Histone Methyltransferase G9a in Cocaine-Induced Plasticity

(2010) I. Maze et al.   SCIENCE

Cullin Mediates Degradation of RhoA through Evolutionarily Conserved BTB Adaptors to Control Actin Cytoskeleton Structure and Cell Movement

(2009) Yuezhou Chen et al.   MOLECULAR CELL

Sex Differences in Social Interaction in Rats: Role of the Immediate-Early Gene zif268

(2009) Ashley Stack et al.   NEUROPSYCHOPHARMACOLOGY

Habits, Rituals, and the Evaluative Brain

(2008) Ann M. Graybiel   Annual Review of Neuroscience