Epigenetic treatment of behavioral and physiological deficits in a tauopathy mouse model

Mechanisms of synaptic transmission dysregulation in the prefrontal cortex: pathophysiological implications

(2021) Zhen Yan et al.   MOLECULAR PSYCHIATRY

Neural circuits and activity dynamics underlying sex-specific effects of chronic social isolation stress

(2021) Tao Tan et al.   Cell Reports

Two conserved epigenetic regulators prevent healthy ageing

(2020) Jie Yuan et al.   NATURE

Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease

(2020) Yingyue Zhou et al.   NATURE MEDICINE

Epigenome signatures landscaped by histone H3K9me3 are associated with the synaptic dysfunction in Alzheimer's disease

(2020) Min Young Lee et al.   AGING CELL

Targeting histone K4 trimethylation for treatment of cognitive and synaptic deficits in mouse models of Alzheimer’s disease

(2020) Qing Cao et al.   Science Advances

Amelioration of autism-like social deficits by targeting histone methyltransferases EHMT1/2 in Shank3-deficient mice

(2019) Zi-Jun Wang et al.   MOLECULAR PSYCHIATRY

Inhibition of EHMT1/2 rescues synaptic and cognitive functions for Alzheimer’s disease

(2019) Yan Zheng et al.   BRAIN

Single-cell transcriptomic analysis of Alzheimer’s disease

(2019) Hansruedi Mathys et al.   NATURE

Epigenetic dysregulation of enhancers in neurons is associated with Alzheimer’s disease pathology and cognitive symptoms

(2019) Peipei Li et al.   Nature Communications

Axonal transport: Driving synaptic function

(2019) Pedro Guedes-Dias et al.   SCIENCE

Chemogenetic Activation of Prefrontal Cortex Rescues Synaptic and Behavioral Deficits in a Mouse Model of 16p11.2 Deletion Syndrome

(2018) Wei Wang et al.   JOURNAL OF NEUROSCIENCE

Imbalance between firing homeostasis and synaptic plasticity drives early-phase Alzheimer’s disease

(2018) Boaz Styr et al.   NATURE NEUROSCIENCE

Dysregulation of the epigenetic landscape of normal aging in Alzheimer’s disease

(2018) Raffaella Nativio et al.   NATURE NEUROSCIENCE

Epigenetic Regulation in Neurodegenerative Diseases

(2018) Amit Berson et al.   TRENDS IN NEUROSCIENCES

Stress Exposure in Dopamine D4 Receptor Knockout Mice Induces Schizophrenia-Like Behaviors via Disruption of GABAergic Transmission

(2018) Tao Tan et al.   SCHIZOPHRENIA BULLETIN

Aβ mediates F-actin disassembly in dendritic spines leading to cognitive deficits in Alzheimer's disease

(2017) Reddy Peera Kommaddi et al.   JOURNAL OF NEUROSCIENCE

Tau Pathology Induces Excitatory Neuron Loss, Grid Cell Dysfunction, and Spatial Memory Deficits Reminiscent of Early Alzheimer’s Disease

(2017) Hongjun Fu et al.   NEURON

Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy

(2017) Sarah L. DeVos et al.   Science Translational Medicine

Association of Plasma Total Tau Level With Cognitive Decline and Risk of Mild Cognitive Impairment or Dementia in the Mayo Clinic Study on Aging

(2017) Michelle M. Mielke et al.   JAMA Neurology

Epigenetic Mechanisms of Longevity and Aging

(2016) Payel Sen et al.   CELL

Targeting the histone methyltransferase G9a activates imprinted genes and improves survival of a mouse model of Prader–Willi syndrome

(2016) Yuna Kim et al.   NATURE MEDICINE

Network abnormalities and interneuron dysfunction in Alzheimer disease

(2016) Jorge J. Palop et al.   NATURE REVIEWS NEUROSCIENCE

Hippocampal–prefrontal input supports spatial encoding in working memory

(2015) Timothy Spellman et al.   NATURE

Tau in physiology and pathology

(2015) Yipeng Wang et al.   NATURE REVIEWS NEUROSCIENCE

Pathological Tau Disrupts Ongoing Network Activity

(2015) Noa Menkes-Caspi et al.   NEURON

Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria

(2014) Bruno Dubois et al.   LANCET NEUROLOGY

Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease

(2014) Zhentao Zhang et al.   NATURE MEDICINE

Synaptic tagging during memory allocation

(2014) Thomas Rogerson et al.   NATURE REVIEWS NEUROSCIENCE

Discovery of an in Vivo Chemical Probe of the Lysine Methyltransferases G9a and GLP

(2013) Feng Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Epigenetic changes in the progression of Alzheimer's disease

(2013) M.A. Bradley-Whitman et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Association between prefrontal activity and volume change in prefrontal and medial temporal lobes in aging and dementia: A review

(2012) David Maillet et al.   AGEING RESEARCH REVIEWS

REST-dependent epigenetic remodeling promotes the developmental switch in synaptic NMDA receptors

(2012) Alma Rodenas-Ruano et al.   NATURE NEUROSCIENCE

Epigenetic Regulation of Learning and Memory by Drosophila EHMT/G9a

(2011) Jamie M. Kramer et al.   PLOS BIOLOGY

Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration

(2010) Brian R. Hoover et al.   NEURON

Essential Role of the Histone Methyltransferase G9a in Cocaine-Induced Plasticity

(2010) I. Maze et al.   SCIENCE