Glycosaminoglycans: What Remains To Be Deciphered?

A Useful Guide to Lectin Binding: Machine-Learning Directed Annotation of 57 Unique Lectin Specificities

(2022) Daniel Bojar et al.   ACS Chemical Biology

Methods for Isolating and Analyzing Physiological Hyaluronan: A Review

(2022) Felipe Rivas et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Resolving Heparan Sulfate Oligosaccharide Positional Isomers Using Hydrophilic Interaction Liquid Chromatography-Cyclic Ion Mobility Mass Spectrometry

(2022) Gustavo J. Cavallero et al.   ANALYTICAL CHEMISTRY

Towards a Systematic Understanding of the Influence of Temperature on Glycosylation Reactions

(2022) Owen T. Tuck et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

On resin synthesis of sulfated oligosaccharides

(2022) Theodore Tyrikos-Ergas et al.   Chemical Science

Chemical Modification of Hyaluronan and Their Biomedical Applications

(2022) Vera Hintze et al.   Frontiers in Chemistry

The glycosaminoglycan interactome 2.0

(2022) Sylvain D. Vallet et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Synthesis and Characterization of Regioselectively Functionalized Mono-Sulfated and -Phosphorylated Anionic Poly-Amido-Saccharides

(2022) Maria Varghese et al.   BIOMACROMOLECULES

Modeling glycosaminoglycan–protein complexes

(2022) Małgorzata M. Kogut et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Glycosaminoglycan interaction networks and databases

(2022) Sylvie Ricard-Blum et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Molecular dynamics simulations to understand glycosaminoglycan interactions in the free- and protein-bound states

(2022) Balaji Nagarajan et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

NMR spectroscopy and chemometric models to detect a specific non-porcine ruminant contaminant in pharmaceutical heparin

(2022) Erika Colombo et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Effect of Sulfation on the Conformational Dynamics of Dermatan Sulfate Glycosaminoglycan: A Gaussian Accelerated Molecular Dynamics Study

(2022) Rajarshi Roy et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Optimizing the sensitivity and resolution of hyaluronan analysis with solid-state nanopores

(2022) Felipe Rivas et al.   Scientific Reports

Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 by Disrupting the Spike–ACE2 Interaction

(2022) Scott E. Guimond et al.   ACS Central Science

Production, characteristics and applications of microbial heparinases

(2022) Angela Boyce et al.   BIOCHIMIE

Multifaceted Computational Modeling in Glycoscience

(2022) Serge Perez et al.   CHEMICAL REVIEWS

Molecular simulations of complex carbohydrates and glycoconjugates

(2022) Elisa Fadda   CURRENT OPINION IN CHEMICAL BIOLOGY

A quartz crystal microbalance method to quantify the size of hyaluronan and other glycosaminoglycans on surfaces

(2022) Sumitra Srimasorn et al.   Scientific Reports

Chemoenzymatic Synthesis of Heparan Sulfate Oligosaccharides having a Domain Structure**

(2022) Lifeng Sun et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Insights into the source, mechanism and biotechnological applications of hyaluronidases

(2022) Yue-Sheng Zhang et al.   BIOTECHNOLOGY ADVANCES

Metal Binding to Sodium Heparin Monitored by Quadrupolar NMR

(2022) Daniel Sieme et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Controlling Superselectivity of Multivalent Interactions with Cofactors and Competitors

(2022) Tine Curk et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Identification and Structural Characterization of Novel Chondroitin/Dermatan Sulfate Hexassacharide Domains in Human Decorin by Ion Mobility Tandem Mass Spectrometry

(2022) Mirela Sarbu et al.   MOLECULES

Comprehensive structural assignment of glycosaminoglycan oligo- and polysaccharides by protein nanopore

(2022) Parisa Bayat et al.   Nature Communications

A Systems View of the Heparan Sulfate Interactome

(2021) Alejandro Gómez Toledo et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Characterization of defined sulfated heparin‐like oligosaccharides by electrospray ionization ion trap mass spectrometry

(2021) Katharina Lemmnitzer et al.   JOURNAL OF MASS SPECTROMETRY

Strong Reduction of the Chain Rigidity of Hyaluronan by Selective Binding of Ca2+ Ions

(2021) Giulia Giubertoni et al.   MACROMOLECULES

Engineered Sulfated Polysaccharides for Biomedical Applications

(2021) Øystein Arlov et al.   ADVANCED FUNCTIONAL MATERIALS

Heparan Sulfate Mimetics Differentially Affect Homologous Chemokines and Attenuate Cancer Development

(2021) Chethan D. Shanthamurthy et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthetic heparan sulfate standards and machine learning facilitate the development of solid-state nanopore analysis

(2021) Ke Xia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polysulfates block SARS‐CoV‐2 uptake via electrostatic interactions

(2021) Chuanxiong Nie et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Investigation of the structure of regulatory proteins interacting with glycosaminoglycans by combining NMR spectroscopy and molecular modeling – the beginning of a wonderful friendship

(2021) Georg Künze et al.   BIOLOGICAL CHEMISTRY

Martini 3: a general purpose force field for coarse-grained molecular dynamics

(2021) Paulo C. T. Souza et al.   NATURE METHODS

A Bittersweet Computational Journey among Glycosaminoglycans

(2021) Giulia Paiardi et al.   Biomolecules

NMR Characterization of the Interactions Between Glycosaminoglycans and Proteins

(2021) Changkai Bu et al.   Frontiers in Molecular Biosciences

Developments in the Chemical Synthesis of Heparin and Heparan Sulfate

(2021) Imlirenla Pongener et al.   CHEMICAL RECORD

Mass Spectrometry-Based Techniques to Elucidate the Sugar Code

(2021) Márkó Grabarics et al.   CHEMICAL REVIEWS

GAG Multivalent Systems to interact with Langerin

(2021) Javier Rojo et al.   CURRENT MEDICINAL CHEMISTRY

Modeling Protein–Glycosaminoglycan Complexes: Does the Size Matter?

(2021) Mateusz Marcisz et al.   Journal of Chemical Information and Modeling

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

Correcting for sparsity and interdependence in glycomics by accounting for glycan biosynthesis

(2021) Bokan Bao et al.   Nature Communications

Multifrequency STD NMR Unveils the Interactions of Antibiotics With Burkholderia multivorans Biofilm Exopolysaccharide

(2021) Ridvan Nepravishta et al.   Frontiers in Molecular Biosciences

Sulfation Code and Conformational Plasticity of l-Iduronic Acid Homo-Oligosaccharides Mimic the Biological Functions of Heparan Sulfate

(2021) Chethan D. Shanthamurthy et al.   ACS Chemical Biology

Gas-phase infrared spectroscopy of glycans and glycoconjugates

(2021) Kim Greis et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The binding of heparin to spike glycoprotein inhibits SARS-CoV-2 infection by three mechanisms

(2021) Giulia Paiardi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

State‐of‐the‐art glycosaminoglycan characterization

(2021) Andreas Zappe et al.   MASS SPECTROMETRY REVIEWS

Dealing with the Ambiguity of Glycan Substructure Search

(2021) Vincenzo Daponte et al.   MOLECULES

The case for post-predictional modifications in the AlphaFold Protein Structure Database

(2021) Haroldas Bagdonas et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Fine-tuning the spike: role of the nature and topology of the glycan shield in the structure and dynamics of the SARS-CoV-2 S

(2021) Aoife M. Harbison et al.   Chemical Science

On the Selectivity of Heparan Sulfate Recognition by SARS-CoV-2 Spike Glycoprotein

(2021) John E. Chittum et al.   ACS Medicinal Chemistry Letters

GlycoGrip: Cell Surface-Inspired Universal Sensor for Betacoronaviruses

(2021) Sang Hoon Kim et al.   ACS Central Science

Exploring Multi‐Subsite Binding Pockets in Proteins: DEEP‐STD NMR Fingerprinting and Molecular Dynamics Unveil a Cryptic Subsite at the GM1 Binding Pocket of Cholera Toxin B

(2020) Serena Monaco et al.   CHEMISTRY-A EUROPEAN JOURNAL

Role of Glycosaminoglycans in Procathepsin B Maturation: Molecular Mechanism Elucidated by a Computational Study

(2020) Krzysztof K. Bojarski et al.   Journal of Chemical Information and Modeling

Total Synthesis of Polysaccharides by Automated Glycan Assembly

(2020) A. Abragam Joseph et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Shotgun ion mobility mass spectrometry sequencing of heparan sulfate saccharides

(2020) Rebecca L. Miller et al.   Nature Communications

The TRUST Principles for digital repositories

(2020) Dawei Lin et al.   Scientific Data

Glycosaminoglycan–Protein Interactions: The First Draft of the Glycosaminoglycan Interactome

(2020) Sylvain D. Vallet et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Constructing 3-Dimensional Atomic-Resolution Models of Nonsulfated Glycosaminoglycans with Arbitrary Lengths Using Conformations from Molecular Dynamics

(2020) Elizabeth K. Whitmore et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Author Correction: Metabolism of multiple glycosaminoglycans by Bacteroides thetaiotaomicron is orchestrated by a versatile core genetic locus

(2020) Didier Ndeh et al.   Nature Communications

Deep-Learning Resources for Studying Glycan-Mediated Host-Microbe Interactions

(2020) Daniel Bojar et al.   Cell Host & Microbe

GAG-DB, the New Interface of the Three-Dimensional Landscape of Glycosaminoglycans

(2020) Serge Pérez et al.   Biomolecules

Glycosaminoglycans in Tissue Engineering: A Review

(2020) Harkanwalpreet Sodhi et al.   Biomolecules

Current state on the enzymatic synthesis of glycosaminoglycans

(2020) Johannes Gottschalk et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Stress management in composite biopolymer networks

(2019) Federica Burla et al.   Nature Physics

Molecular Origin of the Elastic State of Aqueous Hyaluronic Acid

(2019) Giulia Giubertoni et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Single Molecule Identification and Quantification of Glycosaminoglycans using Solid State Nanopores

(2019) JongOne Im et al.   ACS Nano

Development of Semisynthetic, Regioselective Pathways for Accessing the Missing Sulfation Patterns of Chondroitin Sulfate

(2019) Giulia Vessella et al.   BIOMACROMOLECULES

Towards a standardized bioinformatics infrastructure for N- and O-glycomics

(2019) Miguel A. Rojas-Macias et al.   Nature Communications

Chemoenzymatic Synthesis of Glycosaminoglycans

(2019) Xing Zhang et al.   ACCOUNTS OF CHEMICAL RESEARCH

Expedient Synthesis of Core Disaccharide Building Blocks from Natural Polysaccharides for Heparan Sulfate Oligosaccharide Assembly

(2019) Nitin J. Pawar et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Heparin and heparan sulfate proteoglycans promote HIV-1 p17 matrix protein oligomerization: computational, biochemical and biological implications

(2019) Antonella Bugatti et al.   Scientific Reports

IR action spectroscopy of glycosaminoglycan oligosaccharides

(2019) Maike Lettow et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Synthesis and in silico characterization of artificially phosphorylated glycosaminoglycans

(2019) Krzysztof K. Bojarski et al.   JOURNAL OF MOLECULAR STRUCTURE

Multiscale modeling of glycosaminoglycan structure and dynamics: current methods and challenges

(2018) Andrew Almond   CURRENT OPINION IN STRUCTURAL BIOLOGY

Glycosaminoglycans in extracellular matrix organisation: are concepts from soft matter physics key to understanding the formation of perineuronal nets?

(2018) Ralf P Richter et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

So you think computational approaches to understanding glycosaminoglycan–protein interactions are too dry and too rigid? Think again!

(2018) Nehru Viji Sankaranarayanan et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Unraveling the unknown areas of the human metabolome: the role of infrared ion spectroscopy

(2018) Jonathan Martens et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Analysis of Sulfate Patterns in Glycosaminoglycan Oligosaccharides by MSn Coupled to Infrared Ion Spectroscopy: the Case of GalNAc4S and GalNAc6S

(2018) G. Renois-Predelus et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Programmable one-pot synthesis of heparin pentasaccharides enabling access to regiodefined sulfate derivatives

(2018) Supriya Dey et al.   Chemical Science

Inhibition of Herpes Simplex Virus-1 Entry into Human Cells by Nonsaccharide Glycosaminoglycan Mimetics

(2018) Rahaman Navaz Gangji et al.   ACS Medicinal Chemistry Letters

Label-free analysis of physiological hyaluronan size distribution with a solid-state nanopore sensor

(2018) Felipe Rivas et al.   Nature Communications

Synthesis of Fucosylated Chondroitin Sulfate Nonasaccharide as a Novel Anticoagulant Targeting Intrinsic Factor Xase Complex

(2018) Xiao Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Glycosaminoglycan-Protein Interactions by Nuclear Magnetic Resonance (NMR) Spectroscopy

(2018) Vitor Pomin et al.   MOLECULES

The GAGOme: a cell-based library of displayed glycosaminoglycans

(2018) Yen-Hsi Chen et al.   NATURE METHODS

Deriving Ligand Orientation in Weak Protein–Ligand Complexes by DEEP‐STD NMR Spectroscopy in the Absence of Protein Chemical‐Shift Assignment

(2018) Ridvan Nepravishta et al.   CHEMBIOCHEM

Solution Conformation of Heparin Tetrasaccharide. DFT Analysis of Structure and Spin–Spin Coupling Constants

(2018) Miloš Hricovíni et al.   MOLECULES

GlyTouCan: an accessible glycan structure repository

(2017) Michael Tiemeyer et al.   GLYCOBIOLOGY

WURCS 2.0 Update To Encapsulate Ambiguous Carbohydrate Structures

(2017) Masaaki Matsubara et al.   Journal of Chemical Information and Modeling

Heparan Sulfate Microarray Reveals That Heparan Sulfate–Protein Binding Exhibits Different Ligand Requirements

(2017) Chengli Zong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Sequencing of glycosaminoglycans with potential to interrogate sequence-specific interactions

(2017) Toin H. van Kuppevelt et al.   Scientific Reports

Differential structural remodelling of heparan sulfate by chemokines: the role of chemokine oligomerization

(2017) Douglas P. Dyer et al.   Open Biology

Catch bond interaction allows cells to attach to strongly hydrated interfaces

(2016) Maximilian Hanke-Roos et al.   Biointerphases

Extension and validation of the GLYCAM force field parameters for modeling glycosaminoglycans

(2016) Arunima Singh et al.   CANADIAN JOURNAL OF CHEMISTRY

Chemical Synthesis of Glycosaminoglycans

(2016) Marco Mende et al.   CHEMICAL REVIEWS

Chemical Derivatization of Sulfated Glycosaminoglycans

(2016) Emiliano Bedini et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

MS/IR, a new MS-based hyphenated method for analysis of hexuronic acid epimers in glycosaminoglycans

(2016) Baptiste Schindler et al.   GLYCOCONJUGATE JOURNAL

Glycosaminoglycanomics: where we are

(2016) Sylvie Ricard-Blum et al.   GLYCOCONJUGATE JOURNAL

Heparan Sulfate Domains Required for Fibroblast Growth Factor 1 and 2 Signaling through Fibroblast Growth Factor Receptor 1c

(2016) Victor Schultz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Binding of Hyaluronan to the Native Lymphatic Vessel Endothelial Receptor LYVE-1 Is Critically Dependent on Receptor Clustering and Hyaluronan Organization

(2016) William Lawrance et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ion chromatography for the separation of heparin and structurally related glycoaminoglycans: A review

(2016) Jennifer M. Fasciano et al.   JOURNAL OF SEPARATION SCIENCE

Catch bond interaction allows cells to attach to strongly hydrated interfaces

(2016) Maximilian Hanke-Roos et al.   Biointerphases

The FAIR Guiding Principles for scientific data management and stewardship

(2016) Mark D. Wilkinson et al.   Scientific Data

A single molecule assay to probe monovalent and multivalent bonds between hyaluronan and its key leukocyte receptor CD44 under force

(2016) Fouzia Bano et al.   Scientific Reports

Catch Bond Interaction between Cell-Surface Sulfatase Sulf1 and Glycosaminoglycans

(2015) Alexander Harder et al.   BIOPHYSICAL JOURNAL

Symbol Nomenclature for Graphical Representations of Glycans

(2015) Ajit Varki et al.   GLYCOBIOLOGY

Solution Structure of Heparin Pentasaccharide: NMR and DFT Analysis

(2015) Miloš Hricovíni   JOURNAL OF PHYSICAL CHEMISTRY B

Langerin–Heparin Interaction: Two Binding Sites for Small and Large Ligands As Revealed by a Combination of NMR Spectroscopy and Cross-Linking Mapping Experiments

(2015) Juan C. Muñoz-García et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

SugarBindDB, a resource of glycan-mediated host–pathogen interactions

(2015) Julien Mariethoz et al.   NUCLEIC ACIDS RESEARCH

Cytokines and growth factors cross-link heparan sulfate

(2015) Elisa Migliorini et al.   Open Biology

GlycoRDF: an ontology to standardize glycomics data in RDF

(2014) Rene Ranzinger et al.   BIOINFORMATICS

A quartz crystal microbalance method to study the terminal functionalization of glycosaminoglycans

(2014) Dhruv Thakar et al.   CHEMICAL COMMUNICATIONS

Profiling sulfation/epimerization pattern of full-length heparan sulfate by NMR following cell culture 13C-glucose metabolic labeling

(2014) Mathieu Pegeot et al.   GLYCOBIOLOGY

Fibroblast Growth Factor-based Signaling through Synthetic Heparan Sulfate Blocks Copolymers Studied Using High Cell Density Three-dimensional Cell Printing

(2014) Eric Sterner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coarse-Grained Model of Glycosaminoglycans

(2014) Sergey A. Samsonov et al.   Journal of Chemical Information and Modeling

NMR and DFT Analysis of Trisaccharide from Heparin Repeating Sequence

(2014) Miloš Hricovíni et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Automated Solid-Phase Synthesis of Chondroitin Sulfate Glycosaminoglycans

(2013) Steffen Eller et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Heparin–protein interactions: From affinity and kinetics to biological roles. Application to an interaction network regulating angiogenesis

(2013) Franck Peysselon et al.   MATRIX BIOLOGY

Using chemical shift perturbation to characterise ligand binding

(2013) Mike P. Williamson   PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

The GlycanBuilder and GlycoWorkbench glycoinformatics tools: updates and new developments

(2012) David Damerell et al.   BIOLOGICAL CHEMISTRY

Films of End-Grafted Hyaluronan Are a Prototype of a Brush of a Strongly Charged, Semiflexible Polyelectrolyte with Intrinsic Excluded Volume

(2012) Seetharamaiah Attili et al.   BIOMACROMOLECULES

Effect of the Substituents of the Neighboring Ring in the Conformational Equilibrium of Iduronate in Heparin-like Trisaccharides

(2012) Juan Carlos Muñoz-García et al.   CHEMISTRY-A EUROPEAN JOURNAL

Articular Cartilage Proteoglycans As Boundary Lubricants: Structure and Frictional Interaction of Surface-Attached Hyaluronan and Hyaluronan–Aggrecan Complexes

(2011) Jasmine Seror et al.   BIOMACROMOLECULES

Size determination of hyaluronan using a gas-phase electrophoretic mobility molecular analysis

(2011) L. Malm et al.   GLYCOBIOLOGY

A Systems Biology Approach for the Investigation of the Heparin/Heparan Sulfate Interactome

(2011) Alessandro Ori et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of Solvent and Counterions upon Structure and NMR Spin−Spin Coupling Constants in Heparin Disaccharide

(2011) Miloš Hricovíni   JOURNAL OF PHYSICAL CHEMISTRY B

GlycoCT—a unifying sequence format for carbohydrates

(2008) S. Herget et al.   CARBOHYDRATE RESEARCH