Loss of fatty acid degradation by astrocytic mitochondria triggers neuroinflammation and neurodegeneration

Lipid metabolism and Alzheimer's disease: clinical evidence, mechanistic link and therapeutic promise

(2022) Fei Yin   FEBS Journal

ApoE Cascade Hypothesis in the pathogenesis of Alzheimer’s disease and related dementias

(2022) Yuka A. Martens et al.   NEURON

Molecular basis of astrocyte diversity and morphology across the CNS in health and disease

(2022) Fumito Endo et al.   SCIENCE

ApoE4 Impairs Neuron-Astrocyte Coupling of Fatty Acid Metabolism

(2021) Guoyuan Qi et al.   Cell Reports

Oxidized phosphatidylcholines found in multiple sclerosis lesions mediate neurodegeneration and are neutralized by microglia

(2021) Yifei Dong et al.   NATURE NEUROSCIENCE

Reactive astrocyte nomenclature, definitions, and future directions

(2021) Carole Escartin et al.   NATURE NEUROSCIENCE

Astrocyte-neuron metabolic cooperation shapes brain activity

(2021) Gilles Bonvento et al.   Cell Metabolism

Astrocytic interleukin-3 programs microglia and limits Alzheimer’s disease

(2021) Cameron S. McAlpine et al.   NATURE

Enhancing myelin renewal reverses cognitive dysfunction in a murine model of Alzheimer’s disease

(2021) Jing-Fei Chen et al.   NEURON

Exercise plasma boosts memory and dampens brain inflammation via clusterin

(2021) Zurine De Miguel et al.   NATURE

Neurotoxic reactive astrocytes induce cell death via saturated lipids

(2021) Kevin A. Guttenplan et al.   NATURE

Multi-omic analysis of selectively vulnerable motor neuron subtypes implicates altered lipid metabolism in ALS

(2021) Hojae Lee et al.   NATURE NEUROSCIENCE

Systematic phenotyping and characterization of the 5xFAD mouse model of Alzheimer’s disease

(2021) Stefania Forner et al.   Scientific Data

Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain

(2020) Julia Marschallinger et al.   NATURE NEUROSCIENCE

Cellular Specificity and Inter-cellular Coordination in the Brain Bioenergetic System: Implications for Aging and Neurodegeneration

(2020) Guoyuan Qi et al.   Frontiers in Physiology

Triple Negative Breast Cancer Detection Using LC–MS/MS Lipidomic Profiling

(2020) Ryan Eghlimi et al.   JOURNAL OF PROTEOME RESEARCH

Mitochondria dysfunction in the pathogenesis of Alzheimer’s disease: recent advances

(2020) Wenzhang Wang et al.   Molecular Neurodegeneration

Large-scale proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation

(2020) Erik C. B. Johnson et al.   NATURE MEDICINE

Comprehensive Isotopic Targeted Mass Spectrometry: Reliable Metabolic Flux Analysis with Broad Coverage

(2020) Xiaojian Shi et al.   ANALYTICAL CHEMISTRY

Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing

(2020) Stephen C. Cunnane et al.   NATURE REVIEWS DRUG DISCOVERY

Astrocyte Crosstalk in CNS Inflammation

(2020) Mathias Linnerbauer et al.   NEURON

Astrocyte Reactivity: Subtypes, States, and Functions in CNS Innate Immunity

(2020) Michael V. Sofroniew   TRENDS IN IMMUNOLOGY

Metabolic Reprogramming in Astrocytes Distinguishes Region-Specific Neuronal Susceptibility in Huntington Mice

(2019) Aris A. Polyzos et al.   Cell Metabolism

CNS myelination and remyelination depend on fatty acid synthesis by oligodendrocytes

(2019) Penelope Dimas et al.   eLife

A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer's Disease

(2019) Sung Hoon Baik et al.   Cell Metabolism

Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity

(2019) Caroline Fecher et al.   NATURE NEUROSCIENCE

MRtrix3: A fast, flexible and open software framework for medical image processing and visualisation

(2019) J-Donald Tournier et al.   NEUROIMAGE

Loss of mtDNA activates astrocytes and leads to spongiotic encephalopathy

(2018) Olesia Ignatenko et al.   Nature Communications

Automatic Removal of False Connections in Diffusion MRI Tractography Using Topology-Informed Pruning (TIP)

(2018) Fang-Cheng Yeh et al.   Neurotherapeutics

PPARβ/δ-agonist GW0742 ameliorates dysfunction in fatty acid oxidation in PSEN1ΔE9 astrocytes

(2018) Henna Konttinen et al.   GLIA

Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment

(2018) Saranna Fanning et al.   MOLECULAR CELL

Dynamics and functions of lipid droplets

(2018) James A. Olzmann et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Astrocyte lipid metabolism is critical for synapse development and function in vivo

(2017) Anne-Lieke F. van Deijk et al.   GLIA

AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance

(2017) Daniel Garcia et al.   MOLECULAR CELL

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Brain energy metabolism spurns fatty acids as fuel due to their inherent mitotoxicity and potential capacity to unleash neurodegeneration

(2017) Peter Schönfeld et al.   NEUROCHEMISTRY INTERNATIONAL

Oligodendroglial myelination requires astrocyte-derived lipids

(2017) Nutabi Camargo et al.   PLOS BIOLOGY

Maintenance and Expression of Mammalian Mitochondrial DNA

(2016) Claes M. Gustafsson et al.   Annual Review of Biochemistry

The complex STATes of astrocyte reactivity: How are they controlled by the JAK–STAT3 pathway?

(2016) Kelly Ceyzériat et al.   NEUROSCIENCE

Complex I assembly into supercomplexes determines differential mitochondrial ROS production in neurons and astrocytes

(2016) Irene Lopez-Fabuel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alzheimer’s Disease Risk Genes and Mechanisms of Disease Pathogenesis

(2015) Celeste M. Karch et al.   BIOLOGICAL PSYCHIATRY

Fatty Acid Trafficking in Starved Cells: Regulation by Lipid Droplet Lipolysis, Autophagy, and Mitochondrial Fusion Dynamics

(2015) Angelika S. Rambold et al.   DEVELOPMENTAL CELL

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

The perimenopausal aging transition in the female rat brain: decline in bioenergetic systems and synaptic plasticity

(2015) Fei Yin et al.   NEUROBIOLOGY OF AGING

Dynamics of Oligodendrocyte Generation and Myelination in the Human Brain

(2014) Maggie S.Y. Yeung et al.   CELL

Permutation inference for the general linear model

(2014) Anderson M. Winkler et al.   NEUROIMAGE

A Phenotypic Change But Not Proliferation Underlies Glial Responses in Alzheimer Disease

(2013) Alberto Serrano-Pozo et al.   AMERICAN JOURNAL OF PATHOLOGY

The Alzheimer's disease mitochondrial cascade hypothesis: Progress and perspectives

(2013) Russell H. Swerdlow et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitochondrial Reactive Oxygen Species Promote Epidermal Differentiation and Hair Follicle Development

(2013) R. B. Hamanaka et al.   Science Signaling

Adipose-Specific Deletion of TFAM Increases Mitochondrial Oxidation and Protects Mice against Obesity and Insulin Resistance

(2012) Cecile Vernochet et al.   Cell Metabolism

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

(2011) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

REVIGO Summarizes and Visualizes Long Lists of Gene Ontology Terms

(2011) Fran Supek et al.   PLoS One

Phosphorylation status of pyruvate dehydrogenase distinguishes metabolic phenotypes of cultured rat brain astrocytes and neurons

(2010) Nader D. Halim et al.   GLIA

Amyloid-  Aggregates Cause Alterations of Astrocytic Metabolic Phenotype: Impact on Neuronal Viability

(2010) I. Allaman et al.   JOURNAL OF NEUROSCIENCE

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

Pten Deletion in Adult Neural Stem/Progenitor Cells Enhances Constitutive Neurogenesis

(2009) C. Gregorian et al.   JOURNAL OF NEUROSCIENCE

ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation

(2009) K. E. Wellen et al.   SCIENCE