Oxidized phosphatidylcholines found in multiple sclerosis lesions mediate neurodegeneration and are neutralized by microglia

TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge

(2020) Alicia A. Nugent et al.   NEURON

Microglia response following acute demyelination is heterogeneous and limits infiltrating macrophage dispersion

(2020) Jason R. Plemel et al.   Science Advances

CD70 defines a subset of proinflammatory and CNS-pathogenic TH1/TH17 lymphocytes and is overexpressed in multiple sclerosis

(2019) Tessa Dhaeze et al.   Cellular & Molecular Immunology

Transcriptional profiling of human microglia reveals grey–white matter heterogeneity and multiple sclerosis-associated changes

(2019) Marlijn van der Poel et al.   Nature Communications

Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation

(2019) Marta Joana Costa Jordão et al.   SCIENCE

Astrocytes Do Not Forfeit Their Neuroprotective Roles After Surviving Intense Oxidative Stress

(2019) Tarun N. Bhatia et al.   Frontiers in Molecular Neuroscience

When encephalitogenic T cells collaborate with microglia in multiple sclerosis

(2019) Yifei Dong et al.   Nature Reviews Neurology

Microglia Biology: One Century of Evolving Concepts

(2019) Marco Prinz et al.   CELL

Neutralization of Oxidized Phospholipids Ameliorates Non-alcoholic Steatohepatitis

(2019) Xiaoli Sun et al.   Cell Metabolism

Endogenous oxidized phospholipids reprogram cellular metabolism and boost hyperinflammation

(2019) Marco Di Gioia et al.   NATURE IMMUNOLOGY

Deficient Surveillance and Phagocytic Activity of Myeloid Cells Within Demyelinated Lesions in Ageing Mice Visualized byEx VivoLive Multiphoton Imaging

(2018) Khalil S. Rawji et al.   JOURNAL OF NEUROSCIENCE

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

Multiple Sclerosis Pathology

(2018) Hans Lassmann   Cold Spring Harbor Perspectives in Medicine

Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice

(2018) Xuchu Que et al.   NATURE

Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes

(2018) Timothy R. Hammond et al.   IMMUNITY

Mechanisms of lysophosphatidylcholine-induced demyelination: A primary lipid disrupting myelinopathy

(2017) Jason R. Plemel et al.   GLIA

MIF and D-DT are potential disease severity modifiers in male MS subjects

(2017) Gil Benedek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An updated histological classification system for multiple sclerosis lesions

(2016) Tanja Kuhlmann et al.   ACTA NEUROPATHOLOGICA

An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells

(2016) Ivan Zanoni et al.   SCIENCE

An inhibitor of chondroitin sulfate proteoglycan synthesis promotes central nervous system remyelination

(2016) Michael B. Keough et al.   Nature Communications

Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke

(2016) Gergely Szalay et al.   Nature Communications

A Pneumocyte–Macrophage Paracrine Lipid Axis Drives the Lung toward Fibrosis

(2015) Freddy Romero et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

(2015) Yaming Wang et al.   CELL

TREM2 sustains microglial expansion during aging and response to demyelination

(2015) Pietro Luigi Poliani et al.   JOURNAL OF CLINICAL INVESTIGATION

1,25-Dihydroxyvitamin D3 Protects against Immune-Mediated Killing of Neurons in Culture and in Experimental Autoimmune Encephalomyelitis

(2015) Scott Sloka et al.   PLoS One

Laquinimod reduces neuroaxonal injury through inhibiting microglial activation

(2014) Manoj Kumar Mishra et al.   Annals of Clinical and Translational Neurology

New Markers of Early Cardiovascular Risk in Multiple Sclerosis Patients: Oxidized-LDL Correlates with Clinical Staging

(2013) Filipe Palavra et al.   DISEASE MARKERS

Overcoming neurite-inhibitory chondroitin sulfate proteoglycans in the astrocyte matrix

(2013) Rowena C. Cua et al.   GLIA

Determinants of binding of oxidized phospholipids on apolipoprotein (a) and lipoprotein (a)

(2013) Gregor Leibundgut et al.   JOURNAL OF LIPID RESEARCH

Trapping of oxidized LDL in lysosomes of Kupffer cells is a trigger for hepatic inflammation

(2013) Veerle Bieghs et al.   LIVER INTERNATIONAL

Chondroitin sulfate proteoglycans in demyelinated lesions impair remyelination

(2012) Lorraine W. Lau et al.   ANNALS OF NEUROLOGY

Toxicity of oxidized phospholipids in cultured macrophages

(2012) Ute Stemmer et al.   Lipids in Health and Disease

Diagnostic criteria for multiple sclerosis: 2010 Revisions to the McDonald criteria

(2011) Chris H. Polman et al.   ANNALS OF NEUROLOGY

Oxidative damage in multiple sclerosis lesions

(2011) L. Haider et al.   BRAIN

Microglial cystatin F expression is a sensitive indicator for ongoing demyelination with concurrent remyelination

(2011) Jianmei Ma et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Progranulin expression in brain tissue and cerebrospinal fluid levels in multiple sclerosis

(2011) Marco Vercellino et al.   Multiple Sclerosis Journal

Oxidatively modified fatty acyl chain determines physicochemical properties of aggregates of oxidized phospholipids

(2010) Abhay H. Pande et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Structural Basis for the Recognition of Oxidized Phospholipids in Oxidized Low Density Lipoproteins by Class B Scavenger Receptors CD36 and SR-BI

(2009) Detao Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidation-specific epitopes are dominant targets of innate natural antibodies in mice and humans

(2009) Meng-Yun Chou et al.   JOURNAL OF CLINICAL INVESTIGATION

Oxidized phosphatidylcholine formation and action in oligodendrocytes

(2009) Jingdong Qin et al.   JOURNAL OF NEUROCHEMISTRY

Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury

(2008) Yumiko Imai et al.   CELL

Pivotal Advance: HMGB1 expression in active lesions of human and experimental multiple sclerosis

(2008) Åsa Andersson et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A novel function of lipoprotein [a] as a preferential carrier of oxidized phospholipids in human plasma

(2008) Claes Bergmark et al.   JOURNAL OF LIPID RESEARCH

Microglia Cells Protect Neurons by Direct Engulfment of Invading Neutrophil Granulocytes: A New Mechanism of CNS Immune Privilege

(2008) J. Neumann et al.   JOURNAL OF NEUROSCIENCE