PPARβ/δ-agonist GW0742 ameliorates dysfunction in fatty acid oxidation in PSEN1ΔE9 astrocytes

GW0742 (PPAR-beta agonist) attenuates hepatic endoplasmic reticulum stress by improving hepatic energy metabolism in high-fat diet fed mice

(2018) Flavia Maria Silva-Veiga et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Developmental regulation and localization of carnitine palmitoyltransferases (CPTs) in rat brain

(2017) Jennifer N. Jernberg et al.   JOURNAL OF NEUROCHEMISTRY

Astrocyte dysfunction in Alzheimer disease

(2017) Crystal Acosta et al.   JOURNAL OF NEUROSCIENCE RESEARCH

A Fatty Acid Oxidation-Dependent Metabolic Shift Regulates Adult Neural Stem Cell Activity

(2017) Marlen Knobloch et al.   Cell Reports

APP Function and Lipids: A Bidirectional Link

(2017) Marcus O. W. Grimm et al.   Frontiers in Molecular Neuroscience

PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer's Disease

(2017) Minna Oksanen et al.   Stem Cell Reports

Neuronally-directed effects of RXR activation in a mouse model of Alzheimer’s disease

(2017) M. M. Mariani et al.   Scientific Reports

Human tau increases amyloid β plaque size but not amyloid β-mediated synapse loss in a novel mouse model of Alzheimer's disease

(2016) Rosemary J. Jackson et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Pharmacological Activation of Peroxisome Proliferator-Activated Receptor {Delta} Increases Sphingomyelin Synthase Activity in THP-1 Macrophage-Derived Foam Cell

(2016) Dongsheng Mou et al.   INFLAMMATION

Metabolic and Inflammatory Adaptation of Reactive Astrocytes: Role of PPARs

(2016) José Iglesias et al.   MOLECULAR NEUROBIOLOGY

Medium-chain plasma acylcarnitines, ketone levels, cognition, and gray matter volumes in healthy elderly, mildly cognitively impaired, or Alzheimer's disease subjects

(2016) Domenico Ciavardelli et al.   NEUROBIOLOGY OF AGING

Astrocytes from old Alzheimer's disease mice are impaired in Aβ uptake and in neuroprotection

(2016) Tal Iram et al.   NEUROBIOLOGY OF DISEASE

Elevation of cortical C26:0 due to the decline of peroxisomal β-oxidation potentiates amyloid β generation and spatial memory deficits via oxidative stress in diabetic rats

(2016) Y. Shi et al.   NEUROSCIENCE

Hippocampal PPARδ Overexpression or Activation Represses Stress-Induced Depressive Behaviors and Enhances Neurogenesis

(2015) Miao-Jin Ji et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

The PPARβ/δ Agonist GW0742 Induces Early Neuronal Maturation of Cortical Post-Mitotic Neurons: Role of PPARβ/δ in Neuronal Maturation

(2015) Elisabetta Benedetti et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Regulation of peroxisome proliferator-activated receptors (PPAR) α and -γ of rat brain astrocytes in the course of activation by toll-like receptor agonists

(2015) Dmitry V. Chistyakov et al.   JOURNAL OF NEUROCHEMISTRY

Activation of the nuclear receptor PPARδ is neuroprotective in a transgenic mouse model of Alzheimer’s disease through inhibition of inflammation

(2015) Tarja Malm et al.   Journal of Neuroinflammation

Neural Stem Cells in the Adult Subventricular Zone Oxidize Fatty Acids to Produce Energy and Support Neurogenic Activity

(2015) Elizabeth A. Stoll et al.   STEM CELLS

A PPAR-β/δ Agonist is Neuroprotective and Decreases Cognitive Impairment in a Rodent Model of Parkinson’s Disease

(2014) Nihar Das et al.   CURRENT NEUROVASCULAR RESEARCH

Peroxisome proliferator-activated receptor β/δ (PPARβ/δ) protects against ceramide-induced cellular toxicity in rat brain astrocytes and neurons by activation of ceramide kinase

(2014) Stepan Aleshin et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Nrf2 Regulates Neurogenesis and Protects Neural Progenitor Cells Against Aβ Toxicity

(2014) Virve Kärkkäinen et al.   STEM CELLS

The PPARδ agonist GW0742 inhibits neuroinflammation, but does not restore neurogenesis or prevent early delayed hippocampal-dependent cognitive impairment after whole-brain irradiation

(2013) Caroline I. Schnegg et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cell Survival during Complete Nutrient Deprivation Depends on Lipid Droplet-fueled β-Oxidation of Fatty Acids

(2013) Ainara G. Cabodevilla et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Decoding Alzheimer's disease from perturbed cerebral glucose metabolism: Implications for diagnostic and therapeutic strategies

(2013) Zhichun Chen et al.   PROGRESS IN NEUROBIOLOGY

Brain Environment and Alzheimer’s Disease Mutations Affect the Survival, Migration and Differentiation of Neural Progenitor Cells

(2012) Virve Karkkainen et al.   Current Alzheimer Research

Effects of human intravenous immunoglobulin on amyloid pathology and neuroinflammation in a mouse model of Alzheimer’s disease

(2012) Lakshman Puli et al.   Journal of Neuroinflammation

Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis

(2012) Marlen Knobloch et al.   NATURE

GFAP Isoforms in Adult Mouse Brain with a Focus on Neurogenic Astrocytes and Reactive Astrogliosis in Mouse Models of Alzheimer Disease

(2012) Willem Kamphuis et al.   PLoS One

Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation

(2011) Akinobu Suzuki et al.   CELL

The role of APP proteolytic processing in lipid metabolism

(2011) Marcus O. W. Grimm et al.   EXPERIMENTAL BRAIN RESEARCH

Brain Glucose Hypometabolism and Oxidative Stress in Preclinical Alzheimer's Disease

(2010) Lisa Mosconi et al.   Annals of the New York Academy of Sciences

Signal transduction pathways involved in PPARβ/δ-induced neuronal differentiation

(2010) B. D'Angelo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Amyloid-  Aggregates Cause Alterations of Astrocytic Metabolic Phenotype: Impact on Neuronal Viability

(2010) I. Allaman et al.   JOURNAL OF NEUROSCIENCE

Expression of fatty acid-binding proteins in adult hippocampal neurogenic niche of postischemic monkeys

(2009) Nadezhda B. Boneva et al.   HIPPOCAMPUS

Rescue of Aβ1-42-induced memory impairment in day-old chick by facilitation of astrocytic oxidative metabolism: implications for Alzheimer’s disease

(2009) Marie E. Gibbs et al.   JOURNAL OF NEUROCHEMISTRY

Inhibitors of Class 1 Histone Deacetylases Reverse Contextual Memory Deficits in a Mouse Model of Alzheimer's Disease

(2009) Mark Kilgore et al.   NEUROPSYCHOPHARMACOLOGY

Modulation of astrocytic metabolic phenotype by proinflammatory cytokines

(2008) Mathilde Gavillet et al.   GLIA

Age-related decrease in stimulated glutamate release and vesicular glutamate transporters in APP/PS1 transgenic and wild-type mice

(2008) R. Minkeviciene et al.   JOURNAL OF NEUROCHEMISTRY

Episodic memory deficits are not related to altered glutamatergic synaptic transmission and plasticity in the CA1 hippocampus of the APPswe/PS1ΔE9-deleted transgenic mice model of β-amyloidosis

(2008) Arturas Volianskis et al.   NEUROBIOLOGY OF AGING

Impairments in remote memory stabilization precede hippocampal synaptic and cognitive failures in 5XFAD Alzheimer mouse model

(2008) Ryoichi Kimura et al.   NEUROBIOLOGY OF DISEASE