Multi-omic analysis of selectively vulnerable motor neuron subtypes implicates altered lipid metabolism in ALS

Childhood amyotrophic lateral sclerosis caused by excess sphingolipid synthesis

(2021) Payam Mohassel et al.   NATURE MEDICINE

G4C2 Repeat RNA Initiates a POM121-Mediated Reduction in Specific Nucleoporins in C9orf72 ALS/FTD

(2020) Alyssa N. Coyne et al.   NEURON

Neutral lipid cacostasis contributes to disease pathogenesis in amyotrophic lateral sclerosis

(2020) James C. Dodge et al.   JOURNAL OF NEUROSCIENCE

Lipid alterations in human frontal cortex in ALS‐FTLD‐TDP43 proteinopathy spectrum are partly related to peroxisome impairment

(2020) Pol Andrés‐Benito et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration

(2019) Ze’ev Melamed et al.   NATURE NEUROSCIENCE

Establishment and characterization of an iPSC line (FRIMOi001-A) derived from a retinitis pigmentosa patient carrying PDE6A mutations

(2019) Marina Riera et al.   Stem Cell Research

Beyond leukotriene formation – the noncanonical functions of 5-lipoxygenase

(2019) Ann-Kathrin Häfner et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Modeling Motor Neuron Resilience in ALS Using Stem Cells

(2019) Ilary Allodi et al.   Stem Cell Reports

Stem cell-derived cranial and spinal motor neurons reveal proteostatic differences between ALS resistant and sensitive motor neurons

(2019) Disi An et al.   eLife

Arachidonic acid in health and disease with focus on hypertension and diabetes mellitus: A review

(2018) Undurti N. Das   Journal of Advanced Research

Arachidonic acid: Physiological roles and potential health benefits – A review

(2018) Hatem Tallima et al.   Journal of Advanced Research

Modeling sporadic ALS in iPSC-derived motor neurons identifies a potential therapeutic agent

(2018) Koki Fujimori et al.   NATURE MEDICINE

Poly(GP) proteins are a useful pharmacodynamic marker for C9ORF72 -associated amyotrophic lateral sclerosis

(2017) Tania F. Gendron et al.   Science Translational Medicine

Lipidomics Reveals Cerebrospinal-Fluid Signatures of ALS

(2017) H. Blasco et al.   Scientific Reports

Functional Coupling with Cardiac Muscle Promotes Maturation of hPSC-Derived Sympathetic Neurons

(2016) Yohan Oh et al.   Cell Stem Cell

Connexin 43 in astrocytes contributes to motor neuron toxicity in amyotrophic lateral sclerosis

(2016) Akshata A. Almad et al.   GLIA

Defective cholesterol metabolism in amyotrophic lateral sclerosis

(2016) Jonas Abdel-Khalik et al.   JOURNAL OF LIPID RESEARCH

Reduction of cytosolic phospholipase A2α upregulation delays the onset of symptoms in SOD1G93A mouse model of amyotrophic lateral sclerosis

(2016) Yulia Solomonov et al.   Journal of Neuroinflammation

Decoding ALS: from genes to mechanism

(2016) J. Paul Taylor et al.   NATURE

Poly(GR) in C9ORF72 -Related ALS/FTD Compromises Mitochondrial Function and Increases Oxidative Stress and DNA Damage in iPSC-Derived Motor Neurons

(2016) Rodrigo Lopez-Gonzalez et al.   NEURON

Differential neuronal vulnerability identifies IGF-2 as a protective factor in ALS

(2016) Ilary Allodi et al.   Scientific Reports

Concordant but Varied Phenotypes among Duchenne Muscular Dystrophy Patient-Specific Myoblasts Derived using a Human iPSC-Based Model

(2016) In Young Choi et al.   Cell Reports

Genome-wide RNA-Seq of Human Motor Neurons Implicates Selective ER Stress Activation in Spinal Muscular Atrophy

(2015) Shi-Yan Ng et al.   Cell Stem Cell

Slit and Semaphorin signaling governed by Islet transcription factors positions motor neuron somata within the neural tube

(2015) Hojae Lee et al.   EXPERIMENTAL NEUROLOGY

Retinoic Acid-Mediated Regulation of GLI3 Enables Efficient Motoneuron Derivation from Human ESCs in the Absence of Extrinsic SHH Activation

(2015) Elizabeth L. Calder et al.   JOURNAL OF NEUROSCIENCE

Acute Activation of Oxidative Pentose Phosphate Pathway as First-Line Response to Oxidative Stress in Human Skin Cells

(2015) Andreas Kuehne et al.   MOLECULAR CELL

Metabolomic Analysis Reveals Increased Aerobic Glycolysis and Amino Acid Deficit in a Cellular Model of Amyotrophic Lateral Sclerosis

(2015) Gabriel N. Valbuena et al.   MOLECULAR NEUROBIOLOGY

Glycosphingolipids are modulators of disease pathogenesis in amyotrophic lateral sclerosis

(2015) James C. Dodge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathways Disrupted in Human ALS Motor Neurons Identified through Genetic Correction of Mutant SOD1

(2014) Evangelos Kiskinis et al.   Cell Stem Cell

Cholestenoic acids regulate motor neuron survival via liver X receptors

(2014) Spyridon Theofilopoulos et al.   JOURNAL OF CLINICAL INVESTIGATION

Neuronal Matrix Metalloproteinase-9 Is a Determinant of Selective Neurodegeneration

(2014) Artem Kaplan et al.   NEURON

The pentose phosphate pathway and cancer

(2014) Krushna C. Patra et al.   TRENDS IN BIOCHEMICAL SCIENCES

Plasma metabolomic biomarker panel to distinguish patients with amyotrophic lateral sclerosis from disease mimics

(2014) Kay A. Lawton et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

5-Lipoxygenase Antagonist therapy: a new approach towards targeted cancer chemotherapy

(2013) K. Bishayee et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Temporal and spatial requirements of Smoothened in ventral midbrain neuronal development

(2013) Mianzhi Tang et al.   Neural Development

Expanded GGGGCC repeat RNA associated with amyotrophic lateral sclerosis and frontotemporal dementia causes neurodegeneration

(2013) Z. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multifunctional essentiality of succinate metabolism in adaptation to hypoxia in Mycobacterium tuberculosis

(2013) H. Eoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA-Guided Human Genome Engineering via Cas9

(2013) P. Mali et al.   SCIENCE

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Global gene expression profiling of somatic motor neuron populations with different vulnerability identify molecules and pathways of degeneration and protection

(2011) Eva Hedlund et al.   BRAIN

Presenilin-Dependent Receptor Processing Is Required for Axon Guidance

(2011) Ge Bai et al.   CELL

Specific and integrated roles of Lmx1a, Lmx1b and Phox2a in ventral midbrain development

(2011) Qiaolin Deng et al.   DEVELOPMENT

Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease

(2011) Sonja Kriks et al.   NATURE

Genetic engineering of human pluripotent cells using TALE nucleases

(2011) Dirk Hockemeyer et al.   NATURE BIOTECHNOLOGY

Selective Neuronal Vulnerability in Neurodegenerative Diseases: from Stressor Thresholds to Degeneration

(2011) Smita Saxena et al.   NEURON

Guidelines for preclinical animal research in ALS/MND: A consensus meeting

(2010) Albert C. Ludolph et al.   Amyotrophic Lateral Sclerosis

MetPA: a web-based metabolomics tool for pathway analysis and visualization

(2010) J. Xia et al.   BIOINFORMATICS

PHOX2A regulation of oculomotor complex nucleogenesis

(2010) K. B. Hasan et al.   DEVELOPMENT

5-Lipoxygenase inhibitors: a review of recent developments and patents

(2010) Carlo Pergola et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

TDP-43 Mediates Degeneration in a Novel Drosophila Model of Disease Caused by Mutations in VCP/p97

(2010) G. P. Ritson et al.   JOURNAL OF NEUROSCIENCE

Testing significance relative to a fold-change threshold is a TREAT

(2009) D. J. McCarthy et al.   BIOINFORMATICS

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Islet-to-LMO stoichiometries control the function of transcription complexes that specify motor neuron and V2a interneuron identity

(2009) M.-R. Song et al.   DEVELOPMENT

Nkx6-1 controls the identity and fate of red nucleus and oculomotor neurons in the mouse midbrain

(2009) N. Prakash et al.   DEVELOPMENT

Protection of Mouse Brain from Aluminum-induced Damage by Caffeic Acid

(2008) Jun-Qing Yang et al.   CNS Neuroscience & Therapeutics