Targeting pyroptosis in breast cancer: biological functions and therapeutic potentials on It
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Title
Targeting pyroptosis in breast cancer: biological functions and therapeutic potentials on It
Authors
Keywords
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Journal
Cell Death Discovery
Volume 9, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2023-02-24
DOI
10.1038/s41420-023-01370-9
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Note: Only part of the references are listed.- Pathologic complete response (pCR) to neoadjuvant treatment with or without atezolizumab in triple negative, early high-risk and locally advanced breast cancer. NeoTRIP Michelangelo randomized study.
- (2022) L. Gianni et al. ANNALS OF ONCOLOGY
- Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis
- (2022) Wanyan Deng et al. NATURE
- Hallmarks of Cancer: New Dimensions
- (2022) Douglas Hanahan Cancer Discovery
- The microbial metabolite trimethylamine N-oxide promotes antitumor immunity in triple-negative breast cancer
- (2022) Hai Wang et al. Cell Metabolism
- Targeting regulated cell death (RCD) with small-molecule compounds in triple-negative breast cancer: a revisited perspective from molecular mechanisms to targeted therapies
- (2022) Minru Liao et al. Journal of Hematology & Oncology
- A novel 3-acyl isoquinolin-1(2H)-one induces G2 phase arrest, apoptosis and GSDME-dependent pyroptosis in breast cancer
- (2022) Lei Ma et al. PLoS One
- Ferroptosis, necroptosis, and pyroptosis in the tumor microenvironment: Perspectives for immunotherapy of SCLC
- (2022) Xing Niu et al. SEMINARS IN CANCER BIOLOGY
- Antitumor Effect of Simvastatin in Combination With DNA Methyltransferase Inhibitor on Gastric Cancer via GSDME-Mediated Pyroptosis
- (2022) Ying Xia et al. Frontiers in Pharmacology
- Engineering prodrug nanomicelles as pyroptosis inducer for codelivery of PI3K/mTOR and CDK inhibitors to enhance antitumor immunity
- (2022) Qichao Yang et al. Acta Pharmaceutica Sinica B
- Pyroptosis and Its Role in SARS-CoV-2 Infection
- (2022) Zsofia Agnes Bittner et al. Cells
- Mitochondria-Targeting Polymer Micelle of Dichloroacetate Induced Pyroptosis to Enhance Osteosarcoma Immunotherapy
- (2022) Jiakang Jin et al. ACS Nano
- The cross-talk of autophagy and apoptosis in breast carcinoma: implications for novel therapies?
- (2022) Kamil Seyrek et al. BIOCHEMICAL JOURNAL
- Ionizing radiation triggers the antitumor immunity by inducing GSDME-mediated pyroptosis in tumor cells
- (2022) Wei Cao et al. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
- Targeting of GSDMD sensitizes HCC to anti-PD-1 by activating cGAS pathway and downregulating PD-L1 expression
- (2022) Tingting Lv et al. Journal for ImmunoTherapy of Cancer
- Cyclin-Dependent Kinase Inhibitors Function as Potential Immune Regulators via Inducing Pyroptosis in Triple Negative Breast Cancer
- (2022) Tao Xu et al. Frontiers in Oncology
- Engineered Magnetic Polymer Nanoparticles Can Ameliorate Breast Cancer Treatment Inducing Pyroptosis–Starvation along with Chemotherapy
- (2022) Yixuan Liu et al. ACS Applied Materials & Interfaces
- Gasdermin D is involved in switching from apoptosis to pyroptosis in TLR4-mediated renal tubular epithelial cells injury in diabetic kidney disease
- (2022) Shuguang Yuan et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- LINC00511/hsa-miR-573 axis-mediated high expression of Gasdermin C associates with dismal prognosis and tumor immune infiltration of breast cancer
- (2022) Kai Sun et al. Scientific Reports
- Carrier-Free Nanoplatform via Evoking Pyroptosis and Immune Response against Breast Cancer
- (2022) Lei Li et al. ACS Applied Materials & Interfaces
- Ultrasound‐Amplified Enzyodynamic Tumor Therapy by Perovskite Nanoenzyme‐Enabled Cell Pyroptosis and Cascade Catalysis
- (2022) Meiqi Chang et al. ADVANCED MATERIALS
- A Dual‐Responsive STAT3 Inhibitor Nanoprodrug Combined with Oncolytic Virus Elicits Synergistic Antitumor Immune Responses by Igniting Pyroptosis
- (2022) Wen Su et al. ADVANCED MATERIALS
- Natural product preferentially targets redox and metabolic adaptations and aberrantly active STAT3 to inhibit breast tumor growth in vivo
- (2022) Yinsong Zhu et al. Cell Death & Disease
- Bacterial outer membrane vesicles-based therapeutic platform eradicates triple-negative breast tumor by combinational photodynamic/chemo-/immunotherapy
- (2022) Yongjiang Li et al. Bioactive Materials
- Downregulation of miR-155-5p enhances the anti-tumor effect of cetuximab on triple-negative breast cancer cells via inducing cell apoptosis and pyroptosis
- (2021) Wen Xu et al. Aging-US
- Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
- (2021) Hyuna Sung et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Dihydroartemisinin induces pyroptosis by promoting the AIM2/caspase-3/DFNA5 axis in breast cancer cells
- (2021) Yaqiong Li et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Pembrolizumab versus investigator-choice chemotherapy for metastatic triple-negative breast cancer (KEYNOTE-119): a randomised, open-label, phase 3 trial
- (2021) Eric P Winer et al. LANCET ONCOLOGY
- Broadening horizons: the role of ferroptosis in cancer
- (2021) Xin Chen et al. Nature Reviews Clinical Oncology
- Channelling inflammation: gasdermins in physiology and disease
- (2021) Xing Liu et al. NATURE REVIEWS DRUG DISCOVERY
- Tetraarsenic hexoxide enhances generation of mitochondrial ROS to promote pyroptosis by inducing the activation of caspase-3/GSDME in triple-negative breast cancer cells
- (2021) Haein An et al. Cell Death & Disease
- Paradigms on Immunotherapy Combinations with Chemotherapy
- (2021) Diego Salas-Benito et al. Cancer Discovery
- Tumor mutational burden as a predictor of immunotherapy response in breast cancer
- (2021) Tess A. O’Meara et al. Oncotarget
- Biological Functions of Gasdermins in Cancer: From Molecular Mechanisms to Therapeutic Potential
- (2021) Man Wang et al. Frontiers in Cell and Developmental Biology
- Nobiletin promotes the pyroptosis of breast cancer via regulation of miR ‐200b/ JAZF1 axis
- (2021) Ji‐Guo Wang et al. KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
- Breast cancer
- (2021) Sibylle Loibl et al. LANCET
- Celastrol attenuates the inflammatory response by inhibiting IL‑1β expression in triple‑negative breast cancer cells
- (2021) Daeun You et al. ONCOLOGY REPORTS
- Therapeutic Targeting of the Tumor Microenvironment
- (2021) Leire Bejarano et al. Cancer Discovery
- IL-1β Promotes Vasculogenic Mimicry of Breast Cancer Cells Through p38/MAPK and PI3K/Akt Signaling Pathways
- (2021) Muhammad Azhar Nisar et al. Frontiers in Oncology
- NLRP3 induces the autocrine secretion of IL-1β to promote epithelial–mesenchymal transition and metastasis in breast cancer
- (2021) Yuhao Wang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Regulated lytic cell death in breast cancer
- (2021) Mingcheng Liu et al. CELL BIOLOGY INTERNATIONAL
- Differential Expression and Copy Number Variation of Gasdermin (GSDM) Family Members, Pore-Forming Proteins in Pyroptosis, in Normal and Malignant Serous Ovarian Tissue
- (2021) Caglar Berkel et al. INFLAMMATION
- Caspase‐3‐mediated GSDME induced Pyroptosis in breast cancer cells through the ROS/JNK signalling pathway
- (2021) Ziwen Zhang et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Punching Holes in Cellular Membranes: Biology and Evolution of Gasdermins
- (2021) Elke De Schutter et al. TRENDS IN CELL BIOLOGY
- Triclabendazole Induces Pyroptosis by Activating Caspase-3 to Cleave GSDME in Breast Cancer Cells
- (2021) Liang Yan et al. Frontiers in Pharmacology
- Restoring the Immunity in the Tumor Microenvironment: Insights into Immunogenic Cell Death in Onco-Therapies
- (2021) Ángela-Patricia Hernández et al. Cancers
- p53–GSDME Elevation: A Path for CDK7 Inhibition to Suppress Breast Cancer Cell Survival
- (2021) Yueyuan Wang et al. Frontiers in Molecular Biosciences
- Molecular Characteristics, Clinical Implication, and Cancer Immunity Interactions of Pyroptosis-Related Genes in Breast Cancer
- (2021) Dandan Xu et al. Frontiers in Medicine
- The multifaceted roles of gasdermins in cancer biology and oncologic therapies
- (2021) David Sarrió et al. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
- Acute cadmium exposure induces GSDME-mediated pyroptosis in triple-negative breast cancer cells through ROS generation and NLRP3 inflammasome pathway activation
- (2021) Jie Tang et al. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
- The Antitriple Negative Breast cancer Efficacy of Spatholobus suberectus Dunn on ROS-Induced Noncanonical Inflammasome Pyroptotic Pathway
- (2021) Feng Zhang et al. Oxidative Medicine and Cellular Longevity
- Emerging role of ferroptosis in breast cancer: New dawn for overcoming tumor progression
- (2021) Shiyao Sui et al. PHARMACOLOGY & THERAPEUTICS
- High Expression of GSDMC Is Associated with Poor Survival in Kidney Clear Cell Cancer
- (2021) Yun-Qian Cui et al. Biomed Research International
- Hypoxia-Induced Intracellular and Extracellular Heat Shock Protein gp96 Increases Paclitaxel-Resistance and Facilitates Immune Evasion in Breast Cancer
- (2021) Tian Tian et al. Frontiers in Oncology
- Breast cancer cell-derived soluble CD44 promotes tumor progression by triggering macrophage IL-1β production
- (2020) Jeong-Hoon Jang et al. CANCER RESEARCH
- Pembrolizumab for Early Triple-Negative Breast Cancer
- (2020) Peter Schmid et al. NEW ENGLAND JOURNAL OF MEDICINE
- Globular Adiponectin Inhibits Breast Cancer Cell Growth through Modulation of Inflammasome Activation: Critical Role of Sestrin2 and AMPK Signaling
- (2020) Duc-Vinh Pham et al. Cancers
- Metformin activates AMPK/SIRT1/NF-κB pathway and induces mitochondrial dysfunction to drive caspase3/GSDME-mediated cancer cell pyroptosis
- (2020) Zhaodi Zheng et al. CELL CYCLE
- Toward targeting inflammasomes: insights into their regulation and activation
- (2020) Shelbi Christgen et al. CELL RESEARCH
- Gasdermin E suppresses tumour growth by activating anti-tumour immunity
- (2020) Zhibin Zhang et al. NATURE
- A bioorthogonal system reveals antitumour immune function of pyroptosis
- (2020) Qinyang Wang et al. NATURE
- Targeting apoptosis in cancer therapy
- (2020) Benedito A. Carneiro et al. Nature Reviews Clinical Oncology
- Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells
- (2020) Zhiwei Zhou et al. SCIENCE
- The Role of Caspase-4 and NLRP1 in MCF7 Cell Pyroptosis Induced by hUCMSC-Secreted Factors
- (2020) Yang Jiao et al. Stem Cells International
- Programming cell pyroptosis with biomimetic nanoparticles for solid tumor immunotherapy
- (2020) Pengfei Zhao et al. BIOMATERIALS
- Roles of IL-1 in Cancer: From Tumor Progression to Resistance to Targeted Therapies
- (2020) Valerio Gelfo et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Neoadjuvant atezolizumab in combination with sequential nab-paclitaxel and anthracycline-based chemotherapy versus placebo and chemotherapy in patients with early-stage triple-negative breast cancer (IMpassion031): a randomised, double-blind, phase 3 trial
- (2020) Elizabeth A Mittendorf et al. LANCET
- PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis
- (2020) Junwei Hou et al. NATURE CELL BIOLOGY
- Anti‐pyroptotic function of TGF‐β is suppressed by a synthetic dsRNA analogue in triple negative breast cancer cells
- (2020) Yusuke Tamura et al. Molecular Oncology
- Endogenous production of IL-1B by breast cancer cells drives metastasis and colonisation of the bone microenvironment.
- (2019) Claudia Tulotta et al. CLINICAL CANCER RESEARCH
- Breast Cancer Treatment
- (2019) Adrienne G. Waks et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Intracellular delivery of an antibody targeting Gasdermin-B reduces HER2 breast cancer aggressiveness
- (2019) Angela Molina-Crespo et al. CLINICAL CANCER RESEARCH
- Immune induction strategies in metastatic triple-negative breast cancer to enhance the sensitivity to PD-1 blockade: the TONIC trial
- (2019) Leonie Voorwerk et al. NATURE MEDICINE
- Methylation analysis of Gasdermin E shows great promise as a biomarker for colorectal cancer
- (2019) Joe Ibrahim et al. Cancer Medicine
- High-frequency irreversible electroporation is an effective tumor ablation strategy that induces immunologic cell death and promotes systemic anti-tumor immunity
- (2019) Veronica M. Ringel-Scaia et al. EBioMedicine
- Caspases in Cell Death, Inflammation, and Disease
- (2019) Nina Van Opdenbosch et al. IMMUNITY
- Epigenetics-Based Tumor Cells Pyroptosis for Enhancing the Immunological Effect of Chemotherapeutic Nanocarriers
- (2019) Jin-Xuan Fan et al. NANO LETTERS
- NLRP3 inflammasome in fibroblasts links tissue damage with inflammation in breast cancer progression and metastasis
- (2019) Nour Ershaid et al. Nature Communications
- Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling
- (2019) Rachel Eyre et al. Nature Communications
- Roles of autophagy in breast cancer treatment: Target, bystander or benefactor
- (2019) Liliya Tyutyunyk-Massey et al. SEMINARS IN CANCER BIOLOGY
- IL-1 receptor antagonist controls transcriptional signature of inflammation in patients with metastatic breast cancer
- (2018) Te-Chia Wu et al. CANCER RESEARCH
- Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
- (2018) Lorenzo Galluzzi et al. CELL DEATH AND DIFFERENTIATION
- Omega-3 docosahexaenoic acid induces pyroptosis cell death in triple-negative breast cancer cells
- (2018) Nathalia Pizato et al. Scientific Reports
- Large-scale analysis of DFNA5 methylation reveals its potential as biomarker for breast cancer
- (2018) Lieselot Croes et al. Clinical Epigenetics
- Therapeutically active RIG-I agonist induces immunogenic tumor cell killing in breast cancers
- (2018) David L Elion et al. CANCER RESEARCH
- IL-1β inflammatory response driven by primary breast cancer prevents metastasis-initiating cell colonization
- (2018) Zafira Castaño et al. NATURE CELL BIOLOGY
- Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection
- (2018) Joseph Sarhan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Blocking IL-1β reverses the immunosuppression in mouse breast cancer and synergizes with anti–PD-1 for tumor abrogation
- (2018) Irena Kaplanov et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin
- (2017) Yupeng Wang et al. NATURE
- Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death
- (2017) Jianjin Shi et al. TRENDS IN BIOCHEMICAL SCIENCES
- Tumor-derived IL-18 induces PD-1 expression on immunosuppressive NK cells in triple-negative breast cancer
- (2017) In Hae Park et al. Oncotarget
- DFNA5 promoter methylation a marker for breast tumorigenesis
- (2017) Lieselot Croes et al. Oncotarget
- Role of DNA methylation in expression control of the IKZF3-GSDMA region in human epithelial cells
- (2017) Sanny Moussette et al. PLoS One
- Leptin promotes breast cancer cell migration and invasion via IL-18 expression and secretion
- (2016) KUANGFA LI et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Pembrolizumab in Patients With Advanced Triple-Negative Breast Cancer: Phase Ib KEYNOTE-012 Study
- (2016) Rita Nanda et al. JOURNAL OF CLINICAL ONCOLOGY
- Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
- (2016) Xing Liu et al. NATURE
- IL-1 drives breast cancer growth and bone metastasis in vivo
- (2016) Ingunn Holen et al. Oncotarget
- Gasdermin B expression predicts poor clinical outcome in HER2-positive breast cancer
- (2016) Marta Hergueta-Redondo et al. Oncotarget
- Interleukin-18 enhances breast cancer cell migration via down-regulation of claudin-12 and induction of the p38 MAPK pathway
- (2015) Yoolhee Yang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion
- (2015) Wan-ting He et al. CELL RESEARCH
- Dormancy and growth of metastatic breast cancer cells in a bone-like microenvironment
- (2015) Donna M. Sosnoski et al. CLINICAL & EXPERIMENTAL METASTASIS
- Caspase-11 activates a canonical NLRP3 inflammasome by promoting K+efflux
- (2015) Sebastian Rühl et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Caspase-4 mediates non-canonical activation of the NLRP3 inflammasome in human myeloid cells
- (2015) Jonathan L. Schmid-Burgk et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Caspase-11 Requires the Pannexin-1 Channel and the Purinergic P2X7 Pore to Mediate Pyroptosis and Endotoxic Shock
- (2015) Dahai Yang et al. IMMUNITY
- Blocking IL1 Pathway Following Paclitaxel Chemotherapy Slightly Inhibits Primary Tumor Growth but Promotes Spontaneous Metastasis
- (2015) T. Voloshin et al. MOLECULAR CANCER THERAPEUTICS
- Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
- (2015) Nobuhiko Kayagaki et al. NATURE
- Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
- (2015) Jianjin Shi et al. NATURE
- A novel β-catenin signaling pathway activated by IL-1β leads to the onset of epithelial–mesenchymal transition in breast cancer cells
- (2014) Eloy Andres Perez-Yepez et al. CANCER LETTERS
- Inflammatory caspases are innate immune receptors for intracellular LPS
- (2014) Jianjin Shi et al. NATURE
- Zerumbone Suppresses IL-1β-induced Cell Migration and Invasion by Inhibiting IL-8 and MMP-3 Expression in Human Triple-negative Breast Cancer Cells
- (2014) Jeonghun Han et al. PHYTOTHERAPY RESEARCH
- Gasdermin-B Promotes Invasion and Metastasis in Breast Cancer Cells
- (2014) Marta Hergueta-Redondo et al. PLoS One
- PD-L1 Expression in Triple-Negative Breast Cancer
- (2014) E. A. Mittendorf et al. Cancer Immunology Research
- Non-canonical inflammasome activation targets caspase-11
- (2011) Nobuhiko Kayagaki et al. NATURE
- Autophagy as a target for anticancer therapy
- (2011) Filip Janku et al. Nature Reviews Clinical Oncology
- Genomic screening for genes upregulated by demethylation revealed novel targets of epigenetic silencing in breast cancer
- (2009) Tomoko Fujikane et al. BREAST CANCER RESEARCH AND TREATMENT
- Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors
- (2009) François Ghiringhelli et al. NATURE MEDICINE
- Methylation of the DFNA5 increases risk of lymph node metastasis in human breast cancer
- (2008) Myoung Sook Kim et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Distinctive expression and function of fourGSDMfamily genes (GSDMA-D) in normal and malignant upper gastrointestinal epithelium
- (2008) Norihisa Saeki et al. GENES CHROMOSOMES & CANCER
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