Engineering prodrug nanomicelles as pyroptosis inducer for codelivery of PI3K/mTOR and CDK inhibitors to enhance antitumor immunity

Immunogenic cell death-inducing chemotherapeutic nanoformulations potentiate combination chemoimmunotherapy

(2021) Jianhua Liu et al.   MATERIALS & DESIGN

Tumor microenvironments self-activated nanoscale metal organic frameworks for ferroptosis based cancer chemodynamic/photothermal/chemo therapy

(2021) Yu Liang et al.   Acta Pharmaceutica Sinica B

Ultrasound-Augmented Mitochondrial Calcium Ion Overload by Calcium Nanomodulator to Induce Immunogenic Cell Death

(2021) Pan Zheng et al.   NANO LETTERS

GSH-sensitive polymeric prodrug: Synthesis and loading with photosensitizers as nanoscale chemo-photodynamic anti-cancer nanomedicine

(2021) Lei Luo et al.   Acta Pharmaceutica Sinica B

Microenvironment‐Responsive Prodrug‐Induced Pyroptosis Boosts Cancer Immunotherapy

(2021) Yao Xiao et al.   Advanced Science

Bioresponsive immune-booster-based prodrug nanogel for cancer immunotherapy

(2021) Xianbin Ma et al.   Acta Pharmaceutica Sinica B

Engineering Stimuli‐Activatable Boolean Logic Prodrug Nanoparticles for Combination Cancer Immunotherapy

(2020) Bo Hou et al.   ADVANCED MATERIALS

Recent Advances in Tumor Microenvironment Hydrogen Peroxide-Responsive Materials for Cancer Photodynamic Therapy

(2020) Nan Yang et al.   Nano-Micro Letters

Self‐Boosting Catalytic Nanoreactor Integrated with Triggerable Crosslinking Membrane Networks for Initiation of Immunogenic Cell Death by Pyroptosis

(2020) Junjie Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Delivery of triptolide with reduction-sensitive polymer nanoparticles for liver cancer therapy on patient-derived xenografts models

(2020) Mengxue He et al.   CHINESE CHEMICAL LETTERS

Gasdermin E suppresses tumour growth by activating anti-tumour immunity

(2020) Zhibin Zhang et al.   NATURE

A bioorthogonal system reveals antitumour immune function of pyroptosis

(2020) Qinyang Wang et al.   NATURE

Prodrug‐Based Versatile Nanomedicine for Enhancing Cancer Immunotherapy by Increasing Immunogenic Cell Death

(2020) Shuang Bai et al.   Small

Polypeptide nanoformulation-induced immunogenic cell death and remission of immunosuppression for enhanced chemoimmunotherapy

(2020) Xiangru Feng et al.   Science Bulletin

Role of nanoparticle-mediated immunogenic cell death in cancer immunotherapy

(2020) Yajie Sun et al.   Asian Journal of Pharmaceutical Sciences

Cell Death Mediated by the Pyroptosis Pathway with the Aid of Nanotechnology: Prospects for Cancer Therapy

(2020) Dan Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Programming cell pyroptosis with biomimetic nanoparticles for solid tumor immunotherapy

(2020) Pengfei Zhao et al.   BIOMATERIALS

Oxaliplatin-/NLG919 prodrugs-constructed liposomes for effective chemo-immunotherapy of colorectal cancer

(2020) Fengyun Shen et al.   BIOMATERIALS

Breaking the Intracellular Redox Balance with Diselenium Nanoparticles for Maximizing Chemotherapy Efficacy on Patient-Derived Xenograft Models

(2020) Dengshuai Wei et al.   ACS Nano

Immunomodulation by targeted anticancer agents

(2020) Giulia Petroni et al.   CANCER CELL

Bioresponsive prodrug nanogel-based polycondensate strategy deepens tumor penetration and potentiates oxidative stress

(2020) Xianbin Ma et al.   CHEMICAL ENGINEERING JOURNAL

Challenges for the Clinical Development of PI3K Inhibitors: Strategies to Improve Their Impact in Solid Tumors

(2019) Ariella B. Hanker et al.   Cancer Discovery

Cancer Cell Membrane Camouflaged Nanoparticles to Realize Starvation Therapy Together with Checkpoint Blockades for Enhancing Cancer Therapy

(2019) Wei Xie et al.   ACS Nano

Light-Activatable Prodrug and AIEgen Copolymer Nanoparticle for Dual-Drug Monitoring and Combination Therapy

(2019) Peng Wu et al.   ACS Applied Materials & Interfaces

Nanobuffering of pH-Responsive Polymers: A Known but Sometimes Overlooked Phenomenon and Its Biological Applications

(2019) Wei Tao et al.   ACS Nano

Immunomodulatory Nanosystems

(2019) Xiangru Feng et al.   Advanced Science

Responsive Exosome Nano-bioconjugates for Synergistic Cancer Therapy

(2019) Weidong Nie et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mutant BRAF and MEK Inhibitors Regulate the Tumor Immune Microenvironment via Pyroptosis

(2019) Dan A. Erkes et al.   Cancer Discovery

A targeting theranostics nanomedicine as an alternative approach for hyperthermia perfusion

(2018) Tao Sun et al.   BIOMATERIALS

Cancer-Cell-Intrinsic Mechanisms Shaping the Tumor Immune Landscape

(2018) Max D. Wellenstein et al.   IMMUNITY

Combined Inhibition of mTOR and CDK4/6 Is Required for Optimal Blockade of E2F Function and Long-term Growth Inhibition in Estrogen Receptor–positive Breast Cancer

(2018) Chrysiis Michaloglou et al.   MOLECULAR CANCER THERAPEUTICS

A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade

(2018) Livnat Jerby-Arnon et al.   CELL

Tumor-pH-Responsive Dissociable Albumin-Tamoxifen Nanocomplexes Enabling Efficient Tumor Penetration and Hypoxia Relief for Enhanced Cancer Photodynamic Therapy

(2018) Zhijuan Yang et al.   Small

Loss of PTEN Is Associated with Resistance to Anti-PD-1 Checkpoint Blockade Therapy in Metastatic Uterine Leiomyosarcoma

(2017) Suzanne George et al.   IMMUNITY

Biologically Inspired Design of Nanoparticle Artificial Antigen-Presenting Cells for Immunomodulation

(2017) John W. Hickey et al.   NANO LETTERS

Acidity-Triggered Ligand-Presenting Nanoparticles To Overcome Sequential Drug Delivery Barriers to Tumors

(2017) Tingting Wang et al.   NANO LETTERS

Acidity-triggered TAT-presenting nanocarriers augment tumor retention and nuclear translocation of drugs

(2017) Wei Jiang et al.   Nano Research

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death

(2017) Corey Rogers et al.   Nature Communications

Antitumor Activity of Pembrolizumab in Biomarker-Unselected Patients With Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma: Results From the Phase Ib KEYNOTE-012 Expansion Cohort

(2016) Laura Q.M. Chow et al.   JOURNAL OF CLINICAL ONCOLOGY

The PI3K/mTOR inhibitor PF-04691502 induces apoptosis and inhibits microenvironmental signaling in CLL and the E -TCL1 mouse model

(2015) M. D. Blunt et al.   BLOOD

Immune Checkpoint Blockade in Cancer Therapy

(2015) Michael A. Postow et al.   JOURNAL OF CLINICAL ONCOLOGY

Sequential Intra-Intercellular Nanoparticle Delivery System for Deep Tumor Penetration

(2014) Caoyun Ju et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

CDK 4/6 Inhibitors Sensitize PIK3CA Mutant Breast Cancer to PI3K Inhibitors

(2014) Sadhna R. Vora et al.   CANCER CELL

PI3K and cancer: lessons, challenges and opportunities

(2014) David A. Fruman et al.   NATURE REVIEWS DRUG DISCOVERY

pH-Sensitive nano-systems for drug delivery in cancer therapy

(2013) Juan Liu et al.   BIOTECHNOLOGY ADVANCES

PI3Kγ kinase activity is required for optimal T-cell activation and differentiation

(2013) Nadia Ladygina et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Mutational landscape and significance across 12 major cancer types

(2013) Cyriac Kandoth et al.   NATURE

Development of self-immolative dendrimers for drug delivery and sensing

(2011) Rongsheng E. Wang et al.   JOURNAL OF CONTROLLED RELEASE

PI3K Pathway Mutations and PTEN Levels in Primary and Metastatic Breast Cancer

(2011) A. M. Gonzalez-Angulo et al.   MOLECULAR CANCER THERAPEUTICS

Delivery of Molecular and Nanoscale Medicine to Tumors: Transport Barriers and Strategies

(2011) Vikash P. Chauhan et al.   Annual Review of Chemical and Biomolecular Engineering

Chemotherapy induces ATP release from tumor cells

(2010) Isabelle Martins et al.   CELL CYCLE